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| Number | Title | Issue Date |
| 5470713 | Method and element for measuring analytes in biological fluids using immobilized binder-analyte labeled complex The method of measuring analytes in biological fluids is disclosed wherein a specific binder to a given analyte is covalently immobilized onto a solid support to which a labeled analyte is pre-reacted and stabilized to form a binder-labeled analyte comple... | 11/28/1995 |
| 5466610 | Immunoassays for insulin sensitivity enhancers, insulin sensitivity enhancer antibodies, and non-thiazolidinedione insulin sensitivity enhancer compositions Methods have been developed to produce novel compounds by covalently coupling thiazolidinedione insulin sensitivity enhancers (ISEs) to proteins. These novel compounds are well suited for producing antibodies, which are specific for thiazolidinedione ISEs... | 11/14/1995 |
| 5459041 | Campylobacter pylori antigens and uses thereof for detection of Campylobacter pylori infection Antigenic compositions are disclosed for use in diagnostic kits and the like for detecting the presence of antibodies specific for Campylobacter pylori, bacteria often associated with the occurrence of Type B gastritis and peptic ulcer disease. Samples of... | 10/17/1995 |
| 5459079 | Support for biologically active molecules which itself may be biologically active, process for its preparation and its biological applications A support for biological molecules comprising a porous inorganic matrix and particles of a water-insoluble polymer, and a biologically active support comprising a porous inorganic matrix and particles of a water-insoluble polymer "sensitized" by biologica... | 10/17/1995 |
| 5451528 | Methods for providing homogeneous reagents A method for modifiying a liquid assay reagent to provide prolonged homogeneity thereof, particularly where the liquid assay reagent comprises microparticles for performing a heterogeneous immunoassay, is provided wherein the addition of an inert material... | 09/19/1995 |
| 5445936 | Method for non-competitive binding assays A novel non-competitive immunoassay technique has been developed which not only improves sensitivity, but also is convenient and less susceptible to interfering factors. It is compatible with existing instruments and is an assay that can be run in one tes... | 08/29/1995 |
| 5441894 | Device containing a light absorbing element for automated chemiluminescent immunoassays An improved device is used for performing solid-phase chemiluminescent immunoassays. The device comprises a container having a fibrous matrix and a porous absorbent material. An improvement in the device is the use of light absorbing material as the absor... | 08/15/1995 |
| 5439830 | Method of performing at immunoassay using photothermal deflection spectroscopy In an immunoassay for determining the amount of a target substance in a sample using photothermal deflection spectroscopy to determine the amount of bound label, a sandwich procedure is used which comprises reacting the target substance with two antibodie... | 08/08/1995 |
| 5437983 | Heterogeneous binding assays A method for carrying out a binding assay is described wherein a member of a specific binding pair (sbp) and a sample are combined with a matrix of non-porous beads in a liquid medium under conditions such that the beads bind to the sbp member. The liquid... | 08/01/1995 |
| 5436126 | Synthetic peptides specific for the detection of antibodies to HCV, diagnosis of HCV infection and prevention thereof as vaccines The present invention relates to a method for the detection in body fluids of antibodies to hepatitis C virus (HCV), also known as a non-A non-B hepatitis (NANBH) virus and to the diagnosis of NANBH by the use of a composition of synthetic peptides. Each ... | 07/25/1995 |
| 5432100 | Diagnostic system employing a unitary substrate to immobilize microspheres In a diagnostic apparatus system, a one piece porous substrate is provided in a container. The substrate serves both to extract an antigen in or on a top layer thereof with the remainder of the substrate serving as a reservoir. The pores in the top surfac... | 07/11/1995 |
| 5429803 | Liquid specimen container and attachable testing modules A biological fluid collection container comprising a cup member, a lid assembly removably mounted to the cup member having a housing with a downwardly extending cylindrical skirt, a luer lock with a throughgoing bore extending from one side of the lid hou... | 07/04/1995 |
| 5427913 | Methods for determining platelet function The invention provides a method for determining platelet function in a mammal comprising providing platelets from the mammal, contacting the platelets in suspension with at least one immobilised ECM protein or an effective fragment or analog thereof while... | 06/27/1995 |
| 5427959 | Apparatus and method for measuring specimen On a slab-like board formed of a transparent material is closely attached a wedge-shaped transparent cover member provided with a recess in a central inner portion, thereby to form a clearance. The height of the clearance between the recess and the board ... | 06/27/1995 |
| 5424221 | Kit for detection of islet amyloid polypeptide (IAPP) This invention is directed to kits for the detection of human islet amyloid polypeptide (IAPP) comprising (a) purified preparations of antibodies which react specifically with insulin or calcitonin gene-related peptides and (b) a preselected amount of hum... | 06/13/1995 |
| 5422239 | Immunoassay utilizing monoclonal high affinity IgM antibodies Hybridomally produced monoclonal IgM antibodies having high affinity are useful for the immunoassay and purification of vital antigens.... | 06/06/1995 |
| 5422283 | Solid-phase interferometric immunoassay system The present invention relates to a solid-phase immunoassay system for the determination of an antibody or an antigen in a sample which consists of an interferometric signal from an optical source, a solid support coated with an antibody or an antigen and ... | 06/06/1995 |
| 5405784 | Agglutination method for the determination of multiple ligands The invention provides a method capable of determining the presence or absence of each of a plurality of different ligands in a specimen. The specimen is contacted with a predetermined number of different homogeneous populations of fluorescence beads havi... | 04/11/1995 |
| 5403721 | Precipitate test for microorganisms There is disclosed an improved method for testing for the presence of a particular microorganism or group of microorganisms characterized by a particular enzyme. The method uses a dye-forming substrate throughout a polymer matrix or on the surface of a so... | 04/04/1995 |
| 5401633 | Biologically active reagent prepared from aldehyde-containing polymer, test kit, analytical element and methods of use A biologically active reagent is prepared by reacting a biologically active substance covalently to a polymeric particle having pendant aldehyde groups. Such groups are provided by a polymerizable monomer represented by the structure: ##STR1## w... | 03/28/1995 |
| 5401636 | Enhanced sensitivity agglutination assays multivalent ligands An agglutination-based method for detecting and/or an analyte by allowing the agglutination reaction between the analyte, a carrier reagent, and an agglutinating agent to occur in the presence of a multivalent ligand.... | 03/28/1995 |
| 5399316 | Reaction vessel for conducting an immunological assay A sample solution is dripped on an injection region with a pipette. The sample solution immediately spreads in a reaction region by a capillary phenomenon. The sample solution is left for a predetermined period of time to bind a biological associated mate... | 03/21/1995 |
| 5395754 | Membrane-based immunoassay method The present invention is directed to a membrane-based immunoassay method for an analyte of interest having at least two sterically separate antigenic sites. The method comprises providing a reactive membrane having a calibration zone and a test zone, wher... | 03/07/1995 |
| 5380825 | AZT immunoassays, derivatives, conjugates and antibodies This invention relates to a method for the immunoassay of AZT (3'-azido-3'-deoxythymidine), also known as zidovudine, in biological fluids such as serum, semen, plasma and urine, as well as other body fluids. The invention also includes (1) various novel ... | 01/10/1995 |
| 5374516 | Avidin-and biotin immobilized reagents and methods of use Reagents have been prepared from water-insoluble polymeric particles to which are covalently attached avidin, biotin or an avidin or biotin derivative. The polymeric particles comprise a polymer on at least the outer surface which is derived from at least... | 12/20/1994 |
| 5374531 | Immunoassay for determination of cells Methods and test kits are provided for the quantitative or qualitative determination of selected analytes, e.g., cell subsets in a mixed cell population, using a particulate separation reagent and a particulate detection reagent. The invention enables cel... | 12/20/1994 |
| 5369037 | Simultaneous multiple assays A particle agglutination-based, stable kinetic method for simultaneously determining the concentrations of multiple analytes in a single fluid sample with the addition of a single reagent, that entails the use of a novel high resolution sheath flow cell, ... | 11/29/1994 |
| 5366895 | Method for lysing liposomes using polyethyleneglycol monononylphenyl ethers A method for rapidly lysing liposomes having transition temperatures in the range of 35° to 65° C. is provided. Such liposomes are treated with a surfactant including ##STR1## wherein x represents an average of 9 or 12. The method is applicable to ... | 11/22/1994 |
| 5364591 | Device for moving a target-bearing solid through a liquid for detection while being contained There are described a device and method for doing confined reactions such as PCR amplification and detection, wherein solids (e.g., beads) used to obtain separation between bound and "free" label reagents, are transferred from region to region, specifical... | 11/15/1994 |
| 5342760 | Determination of estradiol by competitive immunoassay The present invention relates to the measurement of estradiol using competitive immunoassay methods. The inventors unexpectedly discovered that estrone and its derivatives conjugated to a label is a particularly effective tracer when used in conjunction w... | 08/30/1994 |
| 5338661 | Monoclonal antibody specific for a human tumour-associated antigen The present invention provides a human monoclonal antibody (C-OU1) which specifically binds a human adenocarcinoma tumor-associated antigen with an apparent molecular weight of about 43 kD and an isoelectric point of about 5.4-6.2. Screening assays using ... | 08/16/1994 |
| 5320725 | Electrode and method for the detection of hydrogen peroxide An amperometric biosensor and method for the detection of hydrogen peroxide, NADH, or NADPH with high sensitivity includes an electrode having on its testing surface a three-dimensional redox polymer network in which peroxidase is immobilized.... | 06/14/1994 |
| 5308749 | Method of preparing biologically active reagents from succinimide-containing polymers, analytical element and methods of use Biologically active reagents are prepared from particles of copolymers having highly active succinimid groups. The reagents are prepared by covalently attaching biologically active substances, for example antibodies, to the particles, directly or indirect... | 05/03/1994 |
| 5306632 | Porous acrylonitrile polymer substrate for bonding ligands and separating biologically active substances A porous shaped substrate such as a porous bead is formed from polyacrylonitrile or a copolymer thereof containing nitrile groups. The substrate has a hydrophilic surface containing amide groups constituting about 1.8 mole percent to less than about 15 mo... | 04/26/1994 |
| 5302512 | Agglutinant complex as blood typing reagent The invention includes an agglutinant complex which is useful for the investigation of the antigens present on erythrocytes, and which results from affinity couplings between nonagglutinant IgG type antibodies specific for the antigen to be identified, a ... | 04/12/1994 |
| 5290707 | Method for detection of microorganisms A microorganism detection system provides initial warning, confirmation of dentity, and recognition of pathogenic factors in microorganisms from environmental samples. The method and apparatus of the invention uses different sized antibody coated microsphe... | 03/01/1994 |
| 5288609 | Capture sandwich hybridization method and composition This invention provides methods and compositions for the detection of a target genetic material having a desired base sequence or gene. Also disclosed are methods and compositions for the detection of mutants. The methods and compositions are based in par... | 02/22/1994 |
| 5288610 | Detecting reagent for antiplatelet antibody A detecting reagent for an antiplatelet antibody, comprises a carrier particle, and a platelet antigen component immobilized on a surface of the carrier particle. The reagent particles do not agglutinate with each other, contrary to the platelets subjecte... | 02/22/1994 |
| 5286452 | Simultaneous multiple assays A particle agglutination-based, stable kinetic method for simultaneously determining the concentrations of multiple analytes in a single fluid sample with the addition of a single reagent, that entails the use of a novel high resolution sheath flow cell, ... | 02/15/1994 |
| 5284752 | Methods of preparing a polymeric latex composition and water-insoluble biological reagent A polymeric latex composition having a hydrophobe incorporated therein can be prepared using a novel latex "loading" method. This method includes providing a loadable latex, providing a hydrophobe dissolved in a water-miscible organic solvent, heating the... | 02/08/1994 |
