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| Number | Title | Issue Date |
| 4207075 | Rabbit immunoglobulin-N-(3-pyrene)-maleimide conjugate for fluorescent immunoassay A fluorometric technique which uses a detecting fluorophore for determining the quantitative levels of human immunoglobulin. The detecting fluorophore is an N-(3-pyrene)-maleimide conjugated immunoglobulin which shows enhanced quantum yield in the presenc... | 06/10/1980 |
| 4200690 | Immunoassay with membrane immobilized antibody The presence of antigens is detected with a device having an antibody immunochemically reactive with the antigen bound to a first microporous membrane coated with an inert proteinaceous material and an antibody immunochemically non-reactive with the antig... | 04/29/1980 |
| 4200625 | Immobilized binder for automated assay In an automated assay employing a reusable immobilized binder in a flow-through chamber, the binder is supported on a cotton support preferably mercerized absorbent cotton. Such cotton support prevents plugging when using free serum or plasma samples, and... | 04/29/1980 |
| 4197088 | Method for qualitative and quantitative determination of immunological reactions A method for qualitative and quantitative determination of agglutination in immunoreactive systems, and for determining the concentration of the immunoreactive components of such system, which method comprises introducing a fluid biological test specimen ... | 04/08/1980 |
| 4193983 | Labeled liposome particle compositions and immunoassays therewith The subject invention concerns novel compositions for use in immunoassays, as well as immunoassays employing such novel compositions. The compositions comprise discrete charged colloidal particles comprised of small molecules which particles are capable o... | 03/18/1980 |
| 4184847 | Method of indicating rheumatoid factors A method of indicating rheumatoid factors, primarily such rheumatoid factors which belong to immunoglobulin classes other than the immunoglobulin class IgM, in an aqueous sample. The sample is reacted in the presence of the complement factor C1q in non-bo... | 01/22/1980 |
| 4182856 | Reagents for use in binding assays to determine diphenylhydantoin Reagents for use in binding assays, particularly immunoassays, to determine diphenylhydantoin and for preparing reagents employed in such assays, including ଲ-galactosyl-umbelliferone-diphenylhydantoin conjugates, diphenylhydantoin immunogens, and N | 01/08/1980 |
| 4163779 | Test for quantitation of immunoglobulin and identification of abnormal immunoglobulin A combined test for quantitating immunoglobulin and identifying the presence of abnormal homogeneous immunoglobulin usually of myeloma origin. In a direct test, a first fraction of serum sample is adsorbed to a solid surface and the adsorbed immunoglobuli... | 08/07/1979 |
| 4158703 | T3 uptake test employing covalently bound bovine serum albumin An improved T3 uptake test procedure characterized in that the separating agent employed therein comprises bovine serum albumin covalently coupled to a derivatized polysaccharide matrix by a bifunctional coupling agent selected from a group con... | 06/19/1979 |
| 4158547 | Method of separating components in a biological fluid Insolubilized serum protein adsorbent, for example bovine serum albumin, of small particle size is an excellent adsorbent for adsorbable components in a biological fluid such as serum. Macroaggregated and polymerized albumin are particularly suited as ads... | 06/19/1979 |
| 4157895 | RIA reagents and processes This application relates to thyroxine (T4) immunoassay procedures and, in particular, to the preparation of a novel filter-paper test substrate and a novel standard reagent used in preparation of the test substrate. The standard reagent used in... | 06/12/1979 |
| 4153417 | Method of indicating rheumatoid factors A method of indicating rheumatoid factors belonging to at least one of the immunoglobulin classes IgM, IgG and IgA in an aqueous sample is disclosed. According to this method any complement factor C1q present in the sample is pacified in a manner known pe... | 05/08/1979 |
| 4152411 | High specific activity labeled substances A new diagnostic labeled spine tool is disclosed for use in immunoassay techniques, e.g., determination of a component of the antigen-antibody reaction. The new tool is a labeled-spine material product of the formula ##STR1## where R is an organic gr... | 05/01/1979 |
| 4143124 | Antigen-antibody analysis with solid phase RF and C1q Biological fluids, such as serum, are analyzed for the presence, nature and/or amount of antibodies, antigens and antibody:antigen complexes therein using as a reagent, insolubilized rheumatoid factor or insolubilized C1q. These reagents are themselves no... | 03/06/1979 |
| 4122078 | Antigens and antibodies of catecholamines An antigen consisting essentially of a catecholamine and a protein of polypeptide, wherein the protein or polypeptide is bonded to the phenyl nucleus of the catecholamine.... | 10/24/1978 |
| 4108975 | Radioimmunoassay system An improved radioimmunoassey procedure involves the use of an improved reusable immunoadsorbent through which a sample of an antigen and radioactive labelled antigen is flowed to form a bound and unbound fraction. The bound fraction is releasably coupled ... | 08/22/1978 |
| 4107157 | Barbituric acid antigens and antibodies specific therefor Barbituric acid antigens are prepared by coupling 5- or 5,5-substituted barbituric acid to immunogenic carrier materials. In preferred embodiments, proteins are used as the carrier materials and the coupling is effected by an amide linkage between the 5-s... | 08/15/1978 |
| 4100268 | Preparation of gentamicin sensitized particles for agglutination tests Detection of gentamicin is made possible by preparing an analytical body comprising a macromolecule which carries gentamicin, attached to a particle.... | 07/11/1978 |
| 4098876 | Reverse sandwich immunoassay Method of determining the presence and/or concentration of a polyvalent antigenic substance in a fluid. The method comprises the steps of incubating the fluid with labeled antibodies to the substance to form a first labeled immunochemical complex and then... | 07/04/1978 |
| 4075194 | Novel synthetic undecapeptide and clinical assay A novel synthetic peptide corresponding to the eleven amino acid residues of the NH2 -terminal portion in the sequence of carcinoembrionic antigen (CEA) has been synthesized and this was attached by means of a water-soluble carbodiimide reagent... | 02/21/1978 |
| 4046871 | Compositions and serological methods including bovine serum albumin polymers New serological albumin compositions are provided which have greater potentiating capabilities than existing compositions in agglutination reactions of the IgG class of immune globulins. The essential component is at least one covalently bonded serum albu... | 09/06/1977 |
| 4016146 | Phenethylamine antigenic conjugates, their preparation, antibodies, and use Antigenic phenethylamine conjugates are produced by blocking the amine of the phenethylamine hapten with a group, coupling of the phenethylamine to a carrier, and removal of the blocking group. Specific phenethylamines useful in this invention are ampheta... | 04/05/1977 |
| 4000252 | Immunoscintillation cell A means and method of radioimmunoassay is disclosed whereby an insolubilized or solid phosphor and binding agent such as an antibody are associated by chemical or physical means to provide a solid scintillating immunoadsorbent cell. This cell is capable o... | 12/28/1976 |
| 3995018 | Method of binding immunoglobulin employing a polypeptide from microorganisms A method of binding, in the presence of a liquid, at least one immunoglobulin or its free Fc-fragment, the immunoglobulin being in free form or with its Fab-part bound to an antigen to which is optionally in turn bound one or more groups or substances, to... | 11/30/1976 |
| 3980765 | Halogenated immunoadsorbent An immunoadsorbent in which the specific immunologically reactive protein is polymerized with a halogenated proteinaceous material. The halogenated immunoadsorbent is a fine granular, filterable material having generally stable characteristics.... | 09/14/1976 |
| 3975162 | Applying reagent to medium and device therefor Device for applying a measured quantity of water-soluble or water-dispersible reagent to a water-containing solid medium for use in molecular diffusion or affinity separation procedures is provided in the form of a film consisting essentially of a film-fo... | 08/17/1976 |
| 3951748 | Sensitized matrix for detection of disease A specific sensitized matrix for diagnosing both infectious and non-infectious disease is disclosed comprised of an insoluble, inert, pliable and wettable matrix having a network of pores, and a protein polymer network immobilized in the network of pores ... | 04/20/1976 |
