Did You Know...
...that in the early 1940s GE engineer James Wright was charged with a task of utmost importance to the war effort: develop a cheap substitute for rubber that could be used to produce tires, gas masks and a whole host of military gear. Wright tackled the task diligently -- and wound up inventing Silly Putty.
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| Number | Title | Issue Date |
| 6485984 | CALIXCROWN DERIVATIVES, A PROCESS FOR THE PREPARATION THEREOF, A SELF-ASSEMBLED MONO-LAYER OF THE CALIXCROWN DERIVATIVES PREPARED BY USING THE SAME AND A PROCESS FOR IMMOBILIZING A PROTEIN MONO-LAYER BY USING THE SELF-ASSEMBLED MONO-LAYER OF THE CALIXCROWN DERIVATIVES The present invention is to provide calixcrown derivatives of formulae 1 to 3 requisite for the preparation of a self-assembled monolayer as well as a process for the preparation thereof. Further the present invention is to provide a self-assembled monola... | 11/26/2002 |
| 6479303 | Fluorescent labeling complexes with large Stokes shift formed by coupling together cyanine and other fluorochromes capable of resonance energy transfer The present invention provides low molecular weight fluorescent labeling complexes with large wavelength shifts between absorption of one dye in the complex and emission from another dye in the complex. These complexes can be used, for example, for multip... | 11/12/2002 |
| 6479302 | Method for the immunological determination of an analyte The invention concerns a method for the immunological determination of an analyte in a sample using magnetic particles coated with the analyte to be determined or analyte-specific bonding partners and directly detectable non-magnetic particles coated with... | 11/12/2002 |
| 6479301 | Methods for fabricating an array for use in multiplexed biochemical analysis The invention provides devices for preparing a reaction substrate for use as an assay device, and methods of using these devices. The devices prepare reaction substrates comprising arrays of biosites bound to reaction substrates. The devices have a plural... | 11/12/2002 |
| 6475808 | Arrays of proteins and methods of use thereof Protein arrays for the parallel, in vitro screening of biomolecular activity are provided. Methods of using the protein arrays are also disclosed. On the arrays, a plurality of different proteins, such as different members of a single protein family, are ... | 11/05/2002 |
| 6475721 | Sequence specific detection of nucleic acids using a solid carrier bound with nucleic acid analog probes A method for the detection of point mutation and polymorphisms in nucleic acids or for sequencing of unknown nucleic acids by a simple procedure using arrays uses nucleic acid analoges as sequence discriminators. This procedure simplifies the working mode... | 11/05/2002 |
| 6465183 | Multidentate arrays A method of evaluating for the presence of a target polynucleotide in a sample, using an addressable array of multiple polynucleotide probes linked to a substrate. The sample is exposed to the array and a set of polynucleotide target probes, such that tar... | 10/15/2002 |
| 6458966 | Dye intermediate and method Various classes of dyes are provided having acid, ester or amide groups for covalent linking to biomolecules. The dyes may be prepared by use of a compound of formula (I) ##STR1## where R1 comprises a linker and a carboxy including acid, salt, ... | 10/01/2002 |
| 6458548 | Containers and kits for the determination of cell functions, and method for the determination thereof A container for measurement of cell functions, for use in the determination of a physiologically active substance produced by blood cells, is constituted such that an amount of material capable of inducing production of the physiologically active substanc... | 10/01/2002 |
| 6458547 | Apparatus and method for detecting and identifying infectious agents Solid phase methods for the identification of an analyte in a biological medium, such as a body fluid, using bioluminescence are provided. A chip designed for performing the method and detecting the bioluminescence is also provided. Methods employing biom... | 10/01/2002 |
| 6455263 | Small molecule library screening using FACS The present invention relates to methods of screening libraries of small molecules such as combinatorial chemical libraries of organic molecules, including peptides and other chemical libraries, for binding to target molecules, using fluoroscence-activate... | 09/24/2002 |
| 6451545 | Monoclonal antibody specific to anti-human fibrin monomer, process for producing the same, hybridomas, and immunoassay method Provided are a monoclonal antibody making it possible to detect a native fibrin monomer, which is produced at the initial state of blood coagulation, and soluble fibrin; a hybridoma; and an immunoassay for detecting the initial stage of blood coagulation ... | 09/17/2002 |
| 6447991 | Smart aerogel Smart aerogel, an aerogel material doped with special bio-affinity compounds to providing means of unique collection, detection and identification of bioaerosols, including bacteria, viruses, toxins, and other bioaerosols. Aerogels, extremely low density ... | 09/10/2002 |
| 6436722 | Device and method for integrated diagnostics with multiple independent flow paths Invention performs an assay to determine presence or quantity of specific analyte in fluid sample. Representative device has two separate flow paths established sequentially in device with a single user activation step. First flow path delivers sample, an... | 08/20/2002 |
| 6436662 | Device and method for cytology slide preparation This invention provides a novel device and method for preparing cytology slides. The device comprises a book-like form including an absorbent material and filter attached to the inside surface of a front cover and a cytology slide removeably attached to a... | 08/20/2002 |
| 6436652 | Method of detecting a pathogen using a virus A bacteriophage linked to an enzyme can replace an antibody in a system for detecting the presence of a bacteria in a sample. Specifically Brucella abortus (a pathogen which causes brucellosis in cattle) can be detected using Brucella bacteriophage for th... | 08/20/2002 |
| 6436651 | Optical diffraction biosensor The present invention provides an inexpensive and sensitive device and method for detecting and quantifying analytes present in a medium. The device comprises a metalized film upon which is printed a specific, predetermined pattern of analyte-specific rec... | 08/20/2002 |
| 6436649 | Method for detecting and/or quantifying a hapten in a homogeneous phase and device for implementation thereof The invention discloses a method for detecting and/or quantifying a hapten in a homogeneous phase, comprising the following steps: adding a known quantity of a hapten inhibitor complex to the solution containing the hapten to be detected and/or quantified... | 08/20/2002 |
| 6423551 | Organo luminescent semiconductor nanocrystal probes for biological applications and process for making and using such probes A semiconductor nanocrystal compound is described capable of linking to an affinity molecule. The compound comprises (1) a semiconductor nanocrystal capable of emitting electromagnetic radiation and/or absorbing energy, and/or scattering or diffracting el... | 07/23/2002 |
| 6417010 | Methods and apparatus for synthesizing labeled combinatorial chemistry libraries The present invention provides labeled synthetic libraries of random oligomers and methods and apparatus for generating labeled synthetic oligomer libraries. Each member of such a library is labeled with a unique identifier tag that specifies the structur... | 07/09/2002 |
| 6413786 | Binding assays using optical resonance of colloidal particles A device and a method enable the rapid, quantitative evaluation of a large collection of ligands for binding affinity with a certain immobilized receptor, the improvements being that binding pan be detected without the need for a label and that binding is... | 07/02/2002 |
| 6410696 | Cyclosporin immunoassay A method of measuring the amount of cyclosporin in a sample suspected of containing cyclosporin is disclosed. A method of inactivating interfering cross-reactive material in an assay for measuring the amount of cyclosporin in a sample suspected of contain... | 06/25/2002 |
| 6406921 | Protein arrays for high-throughput screening Protein arrays and protein-coated substrates for the parallel, in vitro screening of biomolecular activity are provided. Methods of using the protein-coated substrates and protein arrays are also disclosed. A plurality of different members of a single pro... | 06/18/2002 |
| 6406844 | Very large scale immobilized polymer synthesis A method and apparatus for preparation of a substrate containing a plurality of sequences. Photoremovable groups are attached to a surface of a substrate. Selected regions of the substrate are exposed to light so as to activate the selected areas. A monom... | 06/18/2002 |
| 6399295 | Use of wicking agent to eliminate wash steps for optical diffraction-based biosensors The present invention provides an inexpensive and sensitive system and method for detecting analytes present in a medium. The system comprises a diffraction enhancing element, such as functionalized microspheres, which are modified such that they are capa... | 06/04/2002 |
| 6395561 | Polymeric assay film for direct colorimetric detection A lipid bilayer with affinity to an analyte, which directly signals binding by a changes in the light absorption spectra. This novel assay means and method has special applications in the drug development and medical testing fields. Using a spectrometer, ... | 05/28/2002 |
| 6391653 | Acoustic standing-wave enhancement of a fiber-optic salmonella biosensor A fluorescent fiber-optic biosensor system using ultrasonic concentration of particles and cells for the detection of Salmonella typhimurium. A biosensor test chamber serves as an ultrasonic standing-wave cell that allows microspheres or cells to be conce... | 05/21/2002 |
| 6391559 | Method of sampling, amplifying and quantifying segment of nucleic acid, polymerase chain reaction assembly having nanoliter-sized sample chambers, and method of filling assembly Methods of detecting and quantifying genomic nucliec acid molecule sequences are provided using the simultaneous amplification of a plurality of discrete nanoliter-sized samples. A miniaturized closed assembly is also provided for carrying out amplificati... | 05/21/2002 |
| 6391541 | Apparatus for analyzing a fluid sample A cartridge for separating a desired analyte from a fluid sample has a sample flow path and a lysing chamber in the sample flow path. The lysing chamber contains at least one filter for capturing cells or viruses from the sample as the sample flows throug... | 05/21/2002 |
| 6376256 | Rapid process for arraying and synthesizing bead-based combinatorial libraries A mixture of beads of uniform size from is deposited in an array by establishing discrete attachment areas each consisting either of a droplet of adhesive or a small area of a continuous adhesive layer exposed through an aperture in a mask. Beads which ar... | 04/23/2002 |
| 6376187 | Electronically-indexed solid-phase assay for biomolecules Disclosed are materials and methods for detecting biomolecules in samples employing transponders associated with the bead(s) used as the solid phase in the assay, and information pertinent to the assay is encoded on the transponders memory elements. A ded... | 04/23/2002 |
| 6372514 | Even fluid front for liquid sample on test strip device Test strip device for accepting a liquid sample and forming an even fluid front across the test strip. When the sample is applied to a contacting surface, it runs down the surface where it collects between the contacting surface and a slope surface. As th... | 04/16/2002 |
| 6372407 | Photocurable and photopatternable hydrogel matrix based on azlactone copolymers Photocurable and photopatternable compositions are disclosed which comprise a) at least one copolymer derived from 1 to 99 parts by weight of at least one azlactone-functional monomer and 0 to 99 parts of at least one co-monomer; and b) at least one photo... | 04/16/2002 |
| 6368877 | Self-assembling peptide surfaces for cell patterning and interactions This invention describes self assembled monolayers (SAMs) manufactured by imprinting reactive peptides onto solid supports. The invention further relates to methods of preparing and using these improved SAMs.... | 04/09/2002 |
| 6368800 | Kits for isolating biological target materials using silica magnetic particles The present invention provides methods for isolating biological target materials, particularly nucleic acids, such as DNA or RNA or hybrid molecules of DNA and RNA, from other substances in a medium using silica magnetic particles. The methods of the pres... | 04/09/2002 |
| 6365418 | Arrays of protein-capture agents and methods of use thereof Arrays of protein-capture agents useful for the simultaneous detection of a plurality of proteins which are the expression products, or fragments thereof, of a cell or population of cells in an organism are provided. A variety of antibody arrays, in parti... | 04/02/2002 |
| 6362010 | Methods and compositions for release of CD3430 cells from affinity matrices Compounds and methods are provided for use in purification of CD34+ cells and specific surface antigens thereof. The present invention discloses methods for releasing CD34+ cells, as well as compounds having a carbohydrate epitope of... | 03/26/2002 |
| 6362009 | Solid phase synthesis of heterocycles Methods for solid phase and combinatorial synthesis using a resin activation/capture approach are provided. In particular, methods for the production of dihydropyridones, N-acyidihydropyridones, tetrahydropyridones, pyridines, aminopyridines, N-acyltetrah... | 03/26/2002 |
| 6355490 | Attached tags for use in combinatorial chemistry synthesis The present invention relates to a process of coding and identifying individual members of a chemical combinatorial library synthesized on a plurality of solid supports which undergo mix and split synthesis. The process provides for tagging the solid supp... | 03/12/2002 |
| 6355445 | Method of detecting a pathogen using a virus A bacteriophage linked to an enzyme can replace an antibody in a system for detecting the presence of a bacteria in a sample. Specifically Brucella abortus (a pathogen which causes brucellosis in cattle) can be detected using Brucella bacteriophage for th... | 03/12/2002 |
