Did You Know...
...that to encourage use of his new invention, the shopping cart, market owner Sylvan Goldman hired fake shoppers to push the carts around his store in Oklahoma City? Seems his customers were reluctant to give up their hand-carried baskets.
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| Number | Title | Issue Date |
| 6235488 | Surface preparation for chemical-specific binding A mass biosensor uses an intermediate avidin layer to facilitate binding of a biotinylated antibody to a measurement surface of the biosensor. The avidin layer can be added by the manufacturer of the biosensor, while the biotinylated layer can be added by... | 05/22/2001 |
| 6235464 | Immunoassay on a preblocked solid surface A method for immunoassay of a viral antigen is performed on a membrane precoated with an inert protein. Nonimmunological capture of antigen takes place by absorption onto the coated membrane. Captured antigen binds to a tracer which includes a label conju... | 05/22/2001 |
| 6218194 | Analytical methods and apparatus employing an optical sensor device with refractive index modulation A method for monitoring the interaction of molecular species utilizes a sensor device comprising a substrate (1) with a waveguide (2) formed on the surface thereof. A grating (3) is formed in one of the surfaces of the waveguide (2). A beam of light (6) i... | 04/17/2001 |
| 6214560 | Analyte assay using particulate labels Method for specific detection of one or more analytes in a sample. The method includes specifically associating any one or more analytes in the sample with a scattered-light detectable particle, illuminating any particle associated with the analytes with ... | 04/10/2001 |
| 6214541 | Process for detecting specific antibodies acting against HPV proteins The present invention relates to a method of detecting specific antibodies directed against HPV proteins in body fluids, comprising the following steps: (I) incubating a native carrier material-bound HPV protein with body fluids, and (II) reacting specifi... | 04/10/2001 |
| 6210910 | Optical fiber biosensor array comprising cell populations confined to microcavities A biosensor, sensor array, sensing method and sensing apparatus are provided in which individual cells or randomly mixed populations of cells, having unique response characteristics to chemical and biological materials, are deployed in a plurality of micr... | 04/03/2001 |
| 6210908 | Activated peptides and conjugates Novel activated peptides and conjugates thereof, useful in diagnostic assays and therapeutics, and processes for the preparation thereof are disclosed.... | 04/03/2001 |
| 6210906 | Specific antibodies to kringle 5 of apo(a) and methods of use therefor The present invention provides monoclonal antibodies specific for kringle 5 of apo(a) and hybridomas secreting such antibodies. The invention also relates to assay methods for directly measuring concentrations of lipoprotein(a) [Lp(a)] in a plasma sample.... | 04/03/2001 |
| 6207464 | Rigidized monomethine cyanines Boron complexes of certain bis-heterocyclic compounds are provided. The complexes resemble monomethine cyanines and are useful for imparting fluorescent properties to materials by covalent and noncovalent association. The compounds have the following gene... | 03/27/2001 |
| 6207398 | Cyclosporine derivatives and uses thereof The present invention provides novel cyclosporine C (CsC) derivatives having improved protein conjugatibility and hydrolytic stability. The present invention further provides a CsC derivative conjugated to a carrier, e.g., a solid support. Preferably, the... | 03/27/2001 |
| 6205263 | Distributed optical fiber sensor with controlled response Distributed fiber optic chemical and physical sensors provide a relatively highly uniform response over the length of the fiber by, for example, varying such properties as the core/cladding index of refraction ratio to compensate for the non-linearity in ... | 03/20/2001 |
| 6200820 | Light scatter-based immunoassay Disclosed are an optical flow particle apparatus and method for conducting a particle light scatter-based immunoassay for simultaneously measuring the presence or amount of one or more analytes in a fluid sample which involves the use of a reagent set for... | 03/13/2001 |
| 6194552 | Immunosorbents with developed binding efficiency and method of manufacture The antitope of an antibody is masked with a masking agent, followed by immobilization on a support. The masking agent is then eluted to produce an improved immunosorbent, which is capable of binding more than double the amount of an antigen than existing... | 02/27/2001 |
| 6194223 | Method for the simultaneous determination of biomolecular interactions by means of plasmon resonance and fluoresence detection A method for the detection of an analyte is described which is characterized in that the binding of the analyte to a solid phase is determined by the independent analysis of the signals from a plasmon resonance measurement and a fluorescence measurement.... | 02/27/2001 |
| 6180378 | Immobilization of bioactive protein in phyllosilicates Immobilized bioactive protein compositions are prepared containing a bioactive protein such as an enzyme intercalated into galleries of a phyllosilicate, and a crosslinking compound crosslinking the phyllosilicate and the bioactive protein. The phyllosili... | 01/30/2001 |
| 6169194 | High surface density covalent immobilization of oligonucleotide monolayers using a 1-(thiotrifluoroacetato)-11-(trichlorososilyl)-undecane linker Oligonucleotides and other biomolecules are immobilized in high density on solid substrates through covalent forces using either a permanent thioether bond, or a chemoselectively reversible disulfide bond to a surface thiol. Substrates which have hydroxyl... | 01/02/2001 |
| 6159749 | Highly sensitive bead-based multi-analyte assay system using optical tweezers An apparatus and method for chemical and biological analysis, the apparatus having an optical trapping means to manipulate the reaction substrate, and a measurement means. The optical trapping means is essentially a laser source capable of emitting a beam... | 12/12/2000 |
| 6154706 | Apparatus and method for kinetic analysis of the intraoperative assay for parathyroid hormone An apparatus for predicting a residual hormone concentration in a patient after a removal of a portion of the patient's glandular tissue which secretes the hormone, includes an input device constructed to receive a plurality of measured hormone concentrat... | 11/28/2000 |
| 6153440 | Simultaneous measurement of free triiodothyronine and free thyroxine by equilibrium dialysis and immunoassay The present invention provides methods for the simultaneous measurement of triiodothyronine (T3) and thyroxine (T4) in biological fluids such as serum by direct equilibrium dialysis and immunoassay. Specifically, the method comprises... | 11/28/2000 |
| 6150147 | Biological array fabrication methods with reduction of static charge The present invention provides modified methods and apparatus for the preparation of arrays of material wherein each array includes a preselected collection of polymers, small molecules or inorganic materials associated with a surface of a substrate. The ... | 11/21/2000 |
| 6143576 | Non-porous diagnostic devices for the controlled movement of reagents The assay devices, assay systems and device components of this invention comprise at least two opposing surfaces disposed a capillary distance apart, at least one of which is capable of immobilizing at least one target ligand or a conjugate in an amount r... | 11/07/2000 |
| 6143574 | Method of determining affinity or kinetic properties in solution A method of determining affinity and kinetic properties for the solution interaction between an analyte and a binding partner therefor, which method comprises: (a) mixing a solution of said analyte with a solution of said binding partner, contacting the r... | 11/07/2000 |
| 6143496 | Method of sampling, amplifying and quantifying segment of nucleic acid, polymerase chain reaction assembly having nanoliter-sized sample chambers, and method of filling assembly Methods of detecting and quantifying genomic nucleic acid molecule sequences are provided using the simultaneous amplification of a plurality of discrete nanoliter-sized samples. A miniaturized closed assembly is also provided for carrying out amplificati... | 11/07/2000 |
| 6140044 | Method and apparatus for packaging a probe array A body 300 having a cavity 310 for mounting a substrate 120 fabricated with probe sequences at known locations according to the methods disclosed in U.S. Pat. No. 5,143,854 and PCT WO 92/10092 or others, is provided. The cavity includes inlets 350 and 360... | 10/31/2000 |
| 6136611 | Assay methods and apparatus An optical assay apparatus is described which includes a light source module and an optical sensing element coupled by an interrogation module. The light source module produces light having propagation angles ranging from a lower, non-zero limit. This is ... | 10/24/2000 |
| 6133046 | Microsystems for biological analyses, their use for detecting analytes, and method for producing them An apparatus for detecting an analyte in a sample, including a cell with at least one fixed electrode, at least one mobile electrode opposite the fixed electrode, the mobile electrode being configured to move with respect to the fixed electrode, and a sam... | 10/17/2000 |
| 6124103 | Arrangement and method of examining hydrophilic macromolecules in an aqueous solution An arrangement for the investigation of hydrophilic macromolecules (1) in an aqueous solution having a solid carrier surface (5) onto which a lipid film (24) is disposed, wherein the molecules (1) to be investigated are bound, by means of a molecular coup... | 09/26/2000 |
| 6121056 | Random detection of antigens with antibodies immobilized on soluble submicron particles Methods, compositions and articles of manufacture are provided for conducting specific binding assays to determine the concentration or presence of at least one analyte in a sample. At least two dendrimer-reagent preparations with different analyte specif... | 09/19/2000 |
| 6114179 | Method and test kit for detecting antigens and/or antibodies A suspension of inert particles is prepared in an aqueous solution, to which an antibody or an antigen and a carrier-bound antigen or antibody, respectively, are added in any desired order. After centrifuging, the positive, weakly positive, or negative re... | 09/05/2000 |
| 6110749 | System for simultaneously conducting multiple ligand binding assays A system for simultaneously conducting multiple ligand assays on a sample potentially containing target analytes uses as a detector a waveguide having a planar surface with a plurality of probes of known recognition to the target analytes thereon. The pro... | 08/29/2000 |
| 6110674 | Apparatus and method for nucleic acid isolation using supercritical fluids A method for detecting the presence of a microorganism in an environmental sample involves contacting the sample with a supercritical fluid to isolate nucleic acid from the microorganism, then detecting the presence of a particular sequence within the iso... | 08/29/2000 |
| 6103537 | Capillary assays involving separation of free and bound species The present invention concerns methods for masking inhomogeneity of a member of a specific binding pair (sbp) employed in a capillary electroseparation. The method comprises binding the sbp member to synthetic particles that become localized during capill... | 08/15/2000 |
| 6103535 | Optical fiber evanescent field excited fluorosensor and method of manufacture An optical fiber is tapered, preferably adiabatically, and has a material coated on it for chemical bonding with fluorophores. When the fluorophores couple with the material, evanescent radiation generated fibers causes the fluorophores to fluoresce, and ... | 08/15/2000 |
| 6103479 | Miniaturized cell array methods and apparatus for cell-based screening The present invention discloses devices and methods of performing high throughput screening of the physiological response of cells to biologically active compounds and methods of combining high-throughput with high-content spatial information at the cellu... | 08/15/2000 |
| 6096562 | Multi-slide assembly including slide, frame and strip cap, and methods thereof A multi-slide assembly includes various components that alone or in combination facilitate testing of test samples with minimal manipulation of assay components. Moreover, the various device components permit centrifugation, culturing and analysis of each... | 08/01/2000 |
| 6093546 | Process for preparing test elements The invention relates to a process for making a test element, such as an analytical test element. Compositions of matter, such as analyte specific receptors, are treated to carry a charge. These are then applied to test carriers treated to carry a charge ... | 07/25/2000 |
| 6087186 | Methods and apparatus for synthesizing labeled combinatorial chemistry libraries The present invention provides labeled synthetic libraries of random oligomers and methods and apparatus for generating labeled synthetic oligomer libraries. Each member of such a library is labeled with a unique identifier tag that specifies the structur... | 07/11/2000 |
| 6087185 | Integrated packaging holder device for immunochromatographic assays in flow-through or dipstick formats The prevent invention relates to an integrated package-holder assay devices for detecting the presence of analyte in a sample. The device serves the dual roles of supporting and protecting an immunochromatographic assay. The device is compatible with any ... | 07/11/2000 |
| 6087114 | Optoelectronic sensor A device for detecting the presence of an antigen including (1) a cell having antibodies which are expressed on the surface of the cell and are specific for the antigen to be detected, where binding of the antigen to the antibodies results in an increase ... | 07/11/2000 |
| 6083763 | Multiplexed molecular analysis apparatus and method A method and apparatus for analyzing molecular structures within a sample substance using an array having a plurality of test sites upon which the sample substance is applied. The invention is also directed to a method and apparatus for constructing molec... | 07/04/2000 |
