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| Number | Title | Issue Date |
| 6599473 | Electrochemilumiscence method for detecting analytes A method for analyzing a liquid test sample by electrochemiluminescence. The method includes at least one specific biochemical binding reaction that leads to the formation of a complex which contains a chemiluminescence marker and the binding of the compl... | 07/29/2003 |
| 6596162 | Vessel and rod The invention relates to a vessel and to a rod used with the vessel for collecting magnetic particles from a liquid containing the particles in the vessel, or for releasing the particles into a liquid in the vessel. The minimum distance from the rod, when... | 07/22/2003 |
| 6597176 | Method and apparatus for making measurements of patterns of magnetic particles in lateral flow membranes and microfluidic systems An apparatus is provided for quantitatively determining amounts and identities of substances whithin patterns of magnetic particles, such as within lateral flow membranes, microfludic systems, and the like. Magnetic particles are complexed with substances... | 07/22/2003 |
| 6589799 | Supported aldehydic silanes and method of manufacture A method for producing a derivatized aldehydic support matrix material includes activating surface hydroxyl groups on the support matrix material and reacting the activated hydroxyl groups with an aldehydic alkoxy silane. The derivatized aldehydic support... | 07/08/2003 |
| 6586259 | Platelet/leukocyte interaction assay and reagent therefor A platelet/leukocyte interaction assay method and reagent therefor are provided using the presence of a solid-phase stimulus, such as magnetic or non-magnetic particles or mixtures thereof, having bound to the surface thereof one or more ligands that inte... | 07/01/2003 |
| 6582969 | Microdevices for high-throughput screening of biomolecules Methods for the parallel, in vitro screening of biomolecular activity using miniaturized microfabricated devices are provided. The biomolecules that can be immobilized on the surface of the devices of the present invention include proteins, polypeptides, ... | 06/24/2003 |
| 6562239 | Magnetic separation device A magnetic biological particle separation device comprising positioning a magnetic arrangement comprising a first magnet to generate a first north-south magnetic field in a plane co-planer with a horizontal cross-sectional plane of a container, positionin... | 05/13/2003 |
| 6558961 | Immunodiagnostics using particle delivery methods Methods for assessing immunocompetence, cellular or humoral immunity, antigen exposure, or allergic conditions in an individual by accelerating diagnostic particles into a target skin site in the individual are provided.... | 05/06/2003 |
| 6552784 | Disposable optical cuvette cartridge A cuvette cartridge for optical measurements is disclosed herein, the cartridge comprising a flat, adhesive sheet having a selected thickness that defines an optical path length perpendicular to the longitudinal axis of such sheet; wherein a portion of th... | 04/22/2003 |
| 6552554 | Testing current perpendicular to plane giant magnetoresistance multilayer devices A wafer suitable to be tested for current-perpendicular to the plane resistance includes a substrate, a conductive base layer on the substrate, a magnetic multilayer on the conductive base layer, and a top conductive layer. A testing ring is formed on the... | 04/22/2003 |
| 6551843 | Methods for enhancing binding interactions between members of specific binding pairs Disclosed is a method that improves the efficiency of reactions between specific binding pairs. By translating one member of the pair through a suspension of the second member, or across a surface to which the second member is immobilized, collision and b... | 04/22/2003 |
| 6548311 | Device and method for detecting analytes The invention relates to a method for detecting analytes and to a device for carrying out the method, for use for analysis or diagnosis in the fields of chemistry, biochemistry, molecular genetics, food chemistry, biotechnology, the environment and medici... | 04/15/2003 |
| 6548264 | Coated nanoparticles Disclosed are silica-coated nanoparticles and a process for producing silica-coated nanoparticles. Silica-coated nanoparticles are prepared by precipitating nano-sized cores from reagents dissolved in the aqueous compartment of a water-in-oil microemulsio... | 04/15/2003 |
| 6534282 | Detection of hypertension using immunoreactive metabolic products A method to assess hypertension by measuring the amount of free and conjugated hydroxyeicosatrienoic acids (DHETs) and metabolites of DHETs, which are metabolites of arachidonic acid (AA) epoxygenases and epoxide hydrolases, in a biological sample which c... | 03/18/2003 |
| 6518747 | Method and apparatus for quantitative determination of accumulations of magnetic particles Apparatus for detection and measurement of agglutinations of magnetic particles employing Hall sensors. A low frequency AC signal is employed to excite or bias the Hall sensors which reside in a DC magnetic field. The particles are moved into operative re... | 02/11/2003 |
| 6514771 | Light-controlled electrokinetic assembly of particles near surfaces A method and apparatus for the manipulation of colloidal particulates and biomolecules at the interface between an insulating electrode such as silicon oxide and an electrolyte solution. Light-controlled electrokinetic assembly of particles near surfaces ... | 02/04/2003 |
| 6514416 | Method and apparatus for magnetic separation of particles A method and apparatus for magnetic separation of particles within a container. In one embodiment, a plurality of magnets are arranged in a first row and in a second row on a frame, wherein the plurality of magnets are oriented in a plane coplanar with a ... | 02/04/2003 |
| 6514415 | Method and apparatus for magnetic separation of particles A method and apparatus for magnetic separation of particles within a container. In one embodiment, a container contains a number of particles and a number of magnetically susceptible particles. A number of magnets are arranged in a plane and is placed clo... | 02/04/2003 |
| 6509450 | Immunoassay for quantification of C-terminal telopeptides of type I collagen in human serum An immunoassay kit for the quantification of degradation products of carboxy-terminal telopeptides of type I collagen in a human serum sample, including an antibody that is characterized by binding to at least one peptide derived from the carboxy-terminal... | 01/21/2003 |
| 6503762 | Magnetic carrier, preparation thereof, and method of extraction of nucleic acid A novel magnetic carrier is provided which comprises particulate silica containing a magnetic material, having polyacrylamide on the surface thereof in an amount ranging from 0.3 to 5 mmol/g in terms of monomeric acrylamide. A process for producing the ma... | 01/07/2003 |
| 6503761 | Selective removal of contaminants from a surface using articles having magnets A system and method for removing contaminants from a surface. The system is designed to use particles having means thereon which are capable of selectively binding to a contaminant or contaminants of interest. The particles are applied to the surface wher... | 01/07/2003 |
| 6500343 | Method for mixing and separation employing magnetic particles An apparatus and method for carrying out the affinity separation of a target substance from a liquid test medium by mixing magnetic particles having surface immobilized ligand or receptor within the test medium to promote an affinity binding reaction betw... | 12/31/2002 |
| 6491842 | Anticorrosive magnetic nanocolloids protected by precious metals The invention relates to new single- or multi-metallic magnetic colloid particles (for example, Fe, Co, Ni, Fe/Co) having a size of up to 20 nm, the surface of which is protected against corrosion by precious metals, such as Pd, Ag, Pt or Au. The inventio... | 12/10/2002 |
| 6485985 | Processes and compounds for magnetorelaxometric detection of analytes and their use A process for magnetorelaxometric quantitative detection of analytes in the liquid and solid phases, compounds for magnetorelaxometric detection, and their use in analysis and immunomagnetography is described.... | 11/26/2002 |
| 6483303 | Computer program for making measurements of accumulations of magnetic particles An apparatus is provided for quantitatively measuring groups of magnetic particles. The particles are complexed with substances to be determined and are excited in a magnetic field. The magnetizations of the magnetic particles are thereby caused to oscill... | 11/19/2002 |
| 6482602 | Reagent for the detection of Staphylococcus aureus by agglutination Reagents and methods for the detection of Staphylococcus aureus are provided. The reagents contain an antibody that binds to a capsular polysaccharide of type 5 of Staphylococcus aureus, and can be used in methods for detection of oxacillin resistant Stap... | 11/19/2002 |
| 6482328 | Method and apparatus for magnetically separating selected particles, particularly biological cells A method and apparatus for magnetically separating target particles of a selected type from a sample in order to produce a concentration of the target particles in the sample, or a depletion of the sample with respect to the target particles, by producing... | 11/19/2002 |
| 6479302 | Method for the immunological determination of an analyte The invention concerns a method for the immunological determination of an analyte in a sample using magnetic particles coated with the analyte to be determined or analyte-specific bonding partners and directly detectable non-magnetic particles coated with... | 11/12/2002 |
| 6472228 | Composition and methods for synthesis of novel tracers for detecting amphetamine and methamphetamine in samples This invention relates to novel tracers and their synthesis and use in an immunoassay for the detection of controlled drugs such as amphetamine (APM), methamphetamine (MAPM) and their derivatives, in a biological or aqueous sample. In particular, this inv... | 10/29/2002 |
| 6468810 | Magnetic particle transfer device and method A device for transfer suitable for capturing and releasing microparticles binding an immobilized substance, which includes a magnet as well as either an extendable membrane, shapable membrane or magnet's coating such that the membrane or coating pressing ... | 10/22/2002 |
| 6468809 | High efficiency magnetic sensor for magnetic particles A magnetic sensing element detects the presence of magnetic particles in a binding assay. The magnetic sensing element has at least one planar layer of electrically conductive ferromagnetic material that has an initial state in which the material has a ci... | 10/22/2002 |
| 6468432 | Methods of modification of selected cells in a magnetic cell separation column A method is provided for modifying cells retained in a high gradient magnetic cell separation column (HGMS). Selected cells within a heterogeneous mixture are labeled with a label comprising a magnetic particle and specific for the selected cells. The lab... | 10/22/2002 |
| 6461874 | Stabilization of particles and reduction of sample discordance in immunoassays using casein coating of particles It has been found that casein and salts of casein are useful as replacements for, or in addition to, BSA as materials for coating solid phases, particularly magnetic particles, used in immunoassays and other binding assays for separation of the desired an... | 10/08/2002 |
| 6461809 | Methods of improving infectivity of cells for viruses The present invention relates to cells which have improved receptivity to viruses which are capable of infecting them. Receptivity to such viruses is improved by selecting cells from a population which express the receptor(s) that enable a virus to attach... | 10/08/2002 |
| 6455325 | Liquid processing method making use of pipette device and apparatus for same Technological preposition of the present invention is a liquid processing method making use of a pipette device which sucks a liquid containing a target high molecular substance from inside of a vessel through a chip detachably set on a sucking port or a ... | 09/24/2002 |
| 6451207 | Magnetic cell separation device The magnetic pole device of the present invention has four polar magnets and any number of interpolar magnets adjacent to and in between said polar magnets. The interpolar magnets are positioned to progressively rotate towards the orientation of the four ... | 09/17/2002 |
| 6448092 | Separation device for microparticles involving a magnetic rod The invention relates to a means for separating magnetic particles from a composition. The means comprises an elongated protective cover (1) that comprises a recess (2) extending from the upper end towards the lower end thereof, the recess comprising a mo... | 09/10/2002 |
| 6448091 | Method and apparatus for improved luminescence assays using particle concentration chemiluminescence detection Methods and apparatus for performing a binding assay for an analyte of interest present in a sample are described. The methods include the steps of: forming a composition containing the sample, an assay-performance-substance which contains a component lin... | 09/10/2002 |
| 6447729 | Method and means for magnetic particle specific binding assay An apparatus for separating magnetic particles from a solution includes a vessel with a smaller diameter lower portion and larger diameter upper portion, a magnetic remover and a positioner for the magnetic remover. The transition between the small and la... | 09/10/2002 |
| 6440682 | Detection of hypertension using immunoreactive metabolic products A method to assess hypertension by measuring the amount of free and conjugated hydroxyeicosatrienoic acids (DHETS) and metabolites of DHETs, which are metabolites of arachidonic acid (AA) epoxygenases and epoxide hydrolases, in a biological sample which c... | 08/27/2002 |
