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| Number | Title | Issue Date |
| 7208134 | Bioprocesses enhanced by magnetic nanoparticles One aspect of the present invention relates to magnetic nanoparticles colloidally stabilized in aqueous milieu by association with an organic phase. The organic phase may be either a fluorinated polymer or an organic hydrocarbon bilayer, wherein the two layers are c... | 04/24/2007 |
| RE39571 | Methods and apparatus for synthesizing labeled combinatorial chemistry libraries The present invention provides labeled synthetic libraries of random oligomers and methods and apparatus for generating labeled synthetic oligomer libraries. Each member of such a library is labeled with a unique identifier tag that specifies the structure or sequen... | 04/17/2007 |
| 7205160 | Multiplex flow assays preferably with magnetic particles as solid phase Heterogeneous assays for different analytes in a single biological sample are performed simultaneously in a multiplexed assay that combines flow cytometry with the use of magnetic particles as the solid phase and yields an individual result for each analyte. The par... | 04/17/2007 |
| 7206667 | Robot alignment system and method The robot alignment system is used for establishing a predetermined alignment position between a movable robot member and an article that is processed by the robot. The system includes a laser transmitter that emits a focused laser beam and a target against which th... | 04/17/2007 |
| RE39545 | Methods and apparatus for synthesizing labeled combinatorial chemistry libraries The present invention provides labeled synthetic libraries of random oligomers and methods and apparatus for generating labeled synthetic oligomer libraries. Each member of such a library is labeled with a unique identifier tag that specifies the structure or sequen... | 04/03/2007 |
| 7199015 | Rare earth-oxides, rare earth-nitrides, rare earth-phosphides and ternary alloys with silicon Atomic layer epitaxy (ALE) is applied to the fabrication of new forms of rare-earth oxides, rare-earth nitrides and rare-earth phosphides. Further, ternary compounds composed of binary (rare-earth oxides, rare-earth nitrides and rare-earth phosphides) mixed with sil... | 04/03/2007 |
| 7195919 | Hematology controls for reticulocytes and nucleated red blood cells The present invention is drawn to a hematology control made from particles a particle having a biopolymer attached to a surface of the particle. The particle simulates a component of a blood sample, such as a reticulocyte or nucleated red blood cell component of a b... | 03/27/2007 |
| 7192557 | Methods and systems for releasing intracellular material from cells within microfluidic samples of fluids The present invention relates to a microfluidic system for processing a cell-containing liquid. The system includes a lysing zone to receive the cell-containing sample and a positioning element to position the cell-containing sample in a lysing position in the vicin... | 03/20/2007 |
| 7189560 | Methods and apparatuses of separating cells using magnets and droplet type cell suspension Disclosed are methods and apparatuses for separating cells using magnets and droplet type cell suspension according to the present invention, which may effectively separate cells by forming droplet type cell suspension with cell suspension sample containing cells to... | 03/13/2007 |
| 7189359 | Electrowetting electrode device with electromagnetic field for actuation of magnetic-bead biochemical detection system A detecting device for biochemical detections is provided. The detecting device includes a first substrate, a magnetic layer located on the first substrate, an isolation layer located on the magnetic layer, at least a first electrode located on the isolation layer, ... | 03/13/2007 |
| 7186518 | Method and composition useful for determining FK 506 New derivatives of FK 506 are disclosed. These new derivatives and other derivatives that are useful for determining the levels of FK 506 in a sample are also provided as are assay procedures and kits for use in determining the levels of FK 506 or other macrophilin ... | 03/06/2007 |
| 7183002 | Porous ferro- or ferrimagnetic glass particles for isolating molecules Porous, ferro- or ferrimagnetic, glass particles are described that selectively bind molecules of interest, especially nucleic acid molecules, under appropriate conditions. Methods of preparing the porous, ferro- or ferrimagnetic, glass particles and their use of id... | 02/27/2007 |
| 7183120 | Etch-stop material for improved manufacture of magnetic devices A method for fabricating a magnetoresistive device having at least one active region, which may be formed into a magnetic memory bit, sensor element and/or other device, is provided. In forming the magnetoresistive device, a magnetoresistive stack, such as a giant m... | 02/27/2007 |
| 7179383 | Method and apparatus for magnetoresistive monitoring of analytes in flow streams Method and apparatus for manipulating and monitoring analyte flowing in fluid streams. A giant magnetoresistive sensor has an array of sensing elements that produce electrical output signals which vary in dependence on changes in the magnetic field proximate the sen... | 02/20/2007 |
| 7179658 | Particle based homogeneous assays using capillary electrophoresis with laser-induced fluorescence detection The invention provides highly sensitive and rapid homogeneous assays which employ particle-enhanced assay formats in concert with capillary electrophoresis and laser-induced fluorescence (LIF) detection to determine the concentration of an analyte of interest in a s... | 02/20/2007 |
| 7176036 | Electroactive microspheres and methods Methods and devices for electrochemical detection of a specific binding pair member utilizing a microsphere with an incorporated electroactive marker, wherein a member of the specific binding pair to be detected is bound, directly or through one or more intermediate... | 02/13/2007 |
| 7175642 | Methods and apparatus for lancet actuation A lancet driver is provided wherein the driver exerts a driving force on a lancet during a lancing cycle and is used on a tissue site. The driver comprises of a drive force generator for advancing the lancet along a path into the tissue site, and a sensor configured... | 02/13/2007 |
| 7172904 | High sensitivity sensor for tagged magnetic bead bioassays The preferred embodiments of the present invention use MRAM technology to detect a shift in the magnetic switching field of a sensor. The shift in the magnetic switching field is caused by the presence of magnetic tagged beads. By measuring the magnitude of the shif... | 02/06/2007 |
| 7169571 | Methods for measurement of lymphocyte function A method for measuring the responses of sets or subsets of lymphocytes to mitogens or antigens in a sample is disclosed comprising incubating a population of cells with a mitogen or antigen, separating the desired subset of cells by means of the interaction of a spe... | 01/30/2007 |
| 7169618 | Magnetic particles and methods of producing coated magnetic particles An improved method for separating materials is provided, using colloidal, magnetizable aggregates, optionally silanized, and coated with a one or more layers of novel polysaccharide derivatives. Materials separated by the aggregates of the invention include inorgani... | 01/30/2007 |
| 7166325 | Carbon nanotube devices Nanotubes and nanotube-based devices are implemented in a variety of applications. According to an example embodiment of the present invention, a nanotube device is manufactured having a nanotube extending between two conductive elements. In one implementation, each... | 01/23/2007 |
| 7159740 | Method and apparatus for parallel dispensing of defined volumes of solid particles A sample preparation system provides an automated process that dispenses appropriate amounts of solid material into wells of a microtiter plate for mixing into a suspension. The system utilizes an array of hollow tubes that are lowered into a particle reservoir such... | 01/09/2007 |
| 7158693 | Molecular detection using an optical waveguide fixed to a cantilever The invention relates to devices and methods for detecting a ligand in a liquid, based on deflection of one or more microscopic cantilevers. Each cantilever has an optical waveguide fixed thereto or integral therewith. Deflection of the cantilever is detected by ass... | 01/02/2007 |
| 7148778 | High performance hybrid magnetic structure for biotechnology applications The present disclosure provides a high performance hybrid magnetic structure made from a combination of permanent magnets and ferromagnetic pole materials which are assembled in a predetermined array. The hybrid magnetic structure provides for separation and other b... | 12/12/2006 |
| 7148017 | High sensitivity mechanical resonant sensor A system and method for detecting mass based on a frequency differential of a resonating micromachined structure, such as a cantilever beam. A high aspect ratio cantilever beam is coated with an immobilized binding partner that couples to a predetermined cell or mol... | 12/12/2006 |
| 7141385 | Microcantilever apparatus and methods for detection of enzymes, enzyme substrates, and enzyme effectors An apparatus and a method are provided for detecting an enzyme, or or for detecting a substrate of an enzyme or for detecting an enzyme effector such as an inhibitor, by measuring a change in deflection of a microcantilever having a substrate or an enzyme, respectiv... | 11/28/2006 |
| 7141415 | Method for the controlled transport of magnetic beads and device for executing said method The present invention is related to a method and corresponding devices for controlled transport of magnetic beads between a position X and different position Y, such that the magnetic beads are manipulated or transported by applying successively a series of N local ... | 11/28/2006 |
| 7141436 | Immunoassay and reagents and kits for performing the same A sandwich immunoassay is disclosed that provides simple to perform yet sensitive identification of analytes in samples. All assay constituents needed (except analyte to be detected) for one assay are dried. Upon reconstitution with sample, a 10 to 15 minute incubat... | 11/28/2006 |
| 7138455 | Acrylic polymer powder, acrylic sol and molding An acrylic polymer powder obtained by coagulating and drying a latex containing acrylic polymer particles, in which acrylic polymer powder, the average particle size of the powder is 5 to 10 μm, the percentage of void is 70% or less, and the integral void volume on... | 11/21/2006 |
| 7138280 | Masking of the background fluorescence and luminescence in the optical analysis of biomedical assays In a process for the quantitative optical analysis of biological cells labelled with a fluorescent dye, the sensitivity of analytical detection can be considerably improved if a masking dye, which absorbs the excitation light for the fluorescent dye and/or its emiss... | 11/21/2006 |
| 7138269 | Microflow system for particle separation and analysis A micro flow system is provided for separating particles, comprising a microfabricated member having a flow channel (5) defined therein for guiding a flow of a fluid containing the particles through the flow channel, first inlet means (2) positioned at... | 11/21/2006 |
| 7135145 | Device for agitating the fluid contents of a container An automated analyzer for performing multiple diagnostic assays simultaneously includes multiple stations, or modules, in which discrete aspects of the assay are performed on fluid samples contained in reaction receptacles. The analyzer includes stations for automat... | 11/14/2006 |
| 7115423 | Fluidic structures within an array package A package for an addressable array of multiple features carried on a first side of a substrate, and a method of using such package. The package includes a housing which receives the substrate such that the housing and received substrate define a chamber into which t... | 10/03/2006 |
| 7112453 | Retentate chromatography and protein chip arrays with applications in biology and medicine This invention provides methods of retentate chromatography for resolving analytes in a sample. The methods involve adsorbing the analytes to a substrate under a plurality of different selectivity conditions, and detecting the analytes retained on the substrate by d... | 09/26/2006 |
| 7108472 | Cartridge loader and methods A device for transporting cartridges comprises a housing for holding a plurality of cartridges in a temperature controlled environment. A transport system is also provided and has a grasping mechanism for grasping one of the cartridges. The transport system is furth... | 09/19/2006 |
| 7105358 | Apparatus and method for visually identifying micro-forces with a palette of cantilever array blocks An apparatus to measure micro-forces includes a cantilever palette with a set of cantilever array blocks. Each cantilever array block includes a set of cantilevers, with each cantilever including a set of cantilever fingers surrounded by a frame with frame fingers. ... | 09/12/2006 |
| 7105052 | Ordered array of magnetized nanorods and associated methods An ordered array of magnetized nanorods includes a plurality of metallic nanorods generally cylindrical in shape and including a nickel portion coated with a positively charged polyelectrolyte and a gold portion coated with an alkanethiolate; and a layer of a harden... | 09/12/2006 |
| 7105357 | Method and device for processing extremely small substance quantities For processing of substances in the reservoir (3) of a microdroplet dosing device (1), movement of a solid carrier material with a binding-active surface takes place in the reservoir, and binding of the substance takes place on the surface of the carri... | 09/12/2006 |
| 7105359 | Specific coupling reaction measuring method and reagent kit and specific coupling reaction measuring apparatus for use in the same A specific coupling reaction measuring method of this invention for measuring a content of a subject substance in a sample includes the steps of (a) constructing a reaction system including the sample and a magnetic particle on which a specific coupling substance fo... | 09/12/2006 |
| 7094528 | Magnetic enzyme detection techniques A diagnostic test kit for detecting the presence or quantity of an enzyme or enzyme inhibitor is provided. The diagnostic kit utilizes reactive complexes to facilitate the detection of the enzyme or enzyme inhibitor. The reactive complexes include a substrate joined... | 08/22/2006 |
