Quotables
"To place a man in a multi-stage rocket and project him into the controlling gravitational field of the moon where the passengers can make scientific observations, perhaps land alive, and then return to earth--all that constitutes a wild dream worthy of Jules Verne. I am bold enough to say that such a man-made voyage will never occur regardless of all future advances."
Lee deForest, American radio pioneer ; 1957
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| Number | Title | Issue Date |
| 6274121 | Superparamagnetic particles, process for their manufacture and use Superparamagnetic particles consist of superparamagnetic one-domain particles and aggregates of superparamagnetic one-domain particles to whose surfaces are bound inorganic and optionally organic substances optionally having further binding sites for coup... | 08/14/2001 |
| 6274387 | Magnetic carrier, preparation thereof, and method of extraction of nucleic acid A novel magnetic carrier is provided which comprises particulate silica containing a magnetic material, having polyacrylamide on the surface thereof in an amount ranging from 0.3 to 5 mmol/g in terms of monomeric acrylamide. A process for producing the ma... | 08/14/2001 |
| 6275031 | Method and apparatus for making quantitative measurements of localized accumulations of magnetic particles Apparatus for quantitatively measuring groups of magnetic particles. The particles are complexed with substances to be determined and are excited in a magnetic field. The magnetic particles are thereby caused to oscillate at the excitation frequency in th... | 08/14/2001 |
| 6274386 | Reagent preparation containing magnetic particles in tablet form Subject matter of the invention is a reagent preparation for binding components of a sample in the form of a tablet comprising a multitude of magnetic particles which are held together with the aid of excipients, and the use of this reagent preparation in... | 08/14/2001 |
| 6274325 | Method for carrying out a homogeneous-immunoassay based on agglutination The invention concerns a homogeneous immunoassay based on agglutination using an Fab'-biotin material and agglutinatable particles which carry streptavidin or avidin. The invention also concerns the Fab'-biotin which is bound or linked via linkage groups ... | 08/14/2001 |
| 6268123 | Direct and biochemically functional detection process of retrovirus in biological samples The present invention relates to processes for the direct detection of biochemically functional retroviruses in biological samples. The processes of the invention are characterized by the structure-specific extraction of retrovirus particles and a subsequ... | 07/31/2001 |
| 6268223 | Assay for detecting damage to the central nervous system A method is disclosed for the rapid diagnosis of disorders characterized by an ischemic event, such as stroke, transient ischemic attack, head trauma, myocardial infarction or other insults resulting in interrupted cranial blood flow. The method involves ... | 07/31/2001 |
| 6265229 | Method and device for detection of specific target cells in specialized or mixed cell populations and solutions containing mixed cell populations The invention relates to a method and apparatus for detecting specific target cells in a simple and time-saving way, using paramagnetic particles, antibodies recognizing the Fc portions of target-cell associating antibodies and target-cell associating ant... | 07/24/2001 |
| 6258607 | Indirect agglutination immunoassay and apparatus therefor An indirect agglutination immunoassay includes the steps of providing, in a container, an immunoassay system comprising a test sample containing a desired analyte, and a reagent composed of magnetic particles or magnetic-material containing particles cont... | 07/10/2001 |
| 6258551 | Method for carrying out an immunoassay in a multiphase system The present invention relates to a method of carrying out an immunoassay in a multiphase system. A sample containing an analyte is brought into contact with a receptor A and a tracer. The analyte can either form a complex with the tracer, or counteract th... | 07/10/2001 |
| 6255477 | Particles having a magnetic core and outer glass layer for separating biological material Magnetic glass particles are prepared containing a magnetic core coated with a glass layer having a substantially pore-free glass surface. The particles are used for separating biological material such as nucleic acids. A preferred process of preparing th... | 07/03/2001 |
| 6254830 | Magnetic focusing immunosensor for the detection of pathogens A magnetic focusing immunosensor for the detection of pathogens comprising a laser, an exciting fiber and a collecting fiber, a fiber optic magnetic probe in communication with the collecting and exciting fibers and means for detecting, collecting and mea... | 07/03/2001 |
| 6251691 | Light-controlled electrokinetic assembly of particles near surfaces A method and apparatus for the manipulation of colloidal particles and biomolecules at the interface between an insulating electrode such as silicon oxide and an electrolyte solution. Light-controlled electrokinetic assembly of particles near surfaces rel... | 06/26/2001 |
| 6245579 | Polymeric metal coating The invention relates to water-soluble polymeric thiosulfates, to a method for their preparation by polymer-analogous addition of tetrathionate to unsaturated polymers and to their application in surface coating.... | 06/12/2001 |
| 6242262 | Method and apparatus for screening catalyst libraries A method for isolating an active catalyst from a library of compounds that are potential catalysts is disclosed. The method involves providing a library which comprises a plurality of discrete solid supports, each solid support having a different organic ... | 06/05/2001 |
| 6232080 | Monoclonal antibodies immunoreactive with lipopolysaccharide binding protein (LBP) and methods of their use The present invention concerns a method of treating LBP-mediated LPS-induced myeloid cell activation comprising administering a therapeutically effective amount of an anti-LBP monoclonal antibody molecule. A therapeutic composition comprising anti-LBP ant... | 05/15/2001 |
| 6228268 | Method for mixing and separation employing magnetic particles A method for carrying out the affinity separation of a target substance from a liquid test medium by mixing magnetic particles having surface immobilized ligand or receptor within the test medium to promote an affinity binding reaction between the ligand ... | 05/08/2001 |
| 6221315 | Apparatus for separation of biologic components from heterogeneous cell populations Apparatus for separating a biological component from a biological fluid are disclosed. The apparatus includes a chamber for receiving a biological fluid including a biological component, and a rotor for creating a centrifugal field within the chamber. A s... | 04/24/2001 |
| 6210906 | Specific antibodies to kringle 5 of apo(a) and methods of use therefor The present invention provides monoclonal antibodies specific for kringle 5 of apo(a) and hybridomas secreting such antibodies. The invention also relates to assay methods for directly measuring concentrations of lipoprotein(a) [Lp(a)] in a plasma sample.... | 04/03/2001 |
| 6207463 | Separation device for microparticles involving a magnetic rod The invention relates to a means for separating magnetic particles from a composition. The means comprises an elongated protective cover (1) that comprises a recess (2) extending from the upper end towards the lower end thereof, the recess comprising a mo... | 03/27/2001 |
| 6207398 | Cyclosporine derivatives and uses thereof The present invention provides novel cyclosporine C (CsC) derivatives having improved protein conjugatibility and hydrolytic stability. The present invention further provides a CsC derivative conjugated to a carrier, e.g., a solid support. Preferably, the... | 03/27/2001 |
| 6203983 | Method for detecting chemical interactions between naturally occurring bio-polymers which are non-identical binding partners A method of using micromechanical devices as sensors for detecting chemical interactions between naturally occurring bio-polymers which are non-identical binding partners is provided. The method is useful whether the reactions occur through electrostatic ... | 03/20/2001 |
| 6190921 | Ouabain immunoassay and kit and ouabain labeled with 125I or fluorescent label The invention deals with the use of a reactive compound in immunological analyses. The compound is ouabain or its analog to which another compound, labeled by radioiodine or by a fluorogen, is coupled. The invention covers also the method to measure ouaba... | 02/20/2001 |
| 6190870 | Efficient enrichment and detection of disseminated tumor cells Tumor cells, particularly carcinoma cells, are separated from peripheral blood by magnetic sorting. The tumor cells are magnetically labeled with antibodies directed to tissue specific antigens, preferably cytoplasmic proteins. Labeling for cytoplasmic an... | 02/20/2001 |
| 6184043 | Method for detection of specific target cells in specialized or mixed cell population and solutions containing mixed cell populations The invention relates to a method for detecting specific target-cells in a simple and time saving way, using paramagnetic particles, antibodies recognizing the Fc portions of target-cell associating antibodies and target-cell associating antibodies direct... | 02/06/2001 |
| 6180418 | Force discrimination assay A sensor for a selected target species has (a) a substrate which has been chemically modified by attachment of substrate modifiers; (b) one or more magnetically active beads which have been chemically modified by attachment of bead modifiers, where these ... | 01/30/2001 |
| 6165800 | Chemiluminescent energy transfer conjugates and their uses as labels in binding assays A new class of chemiluminescent acridinium or benzacridinium compounds is disclosed by virtue of forming an intramolecular energy transfer conjugate (ETC) between the acridinium or benzacridinium compound and a luminophore. A method of extending the emiss... | 12/26/2000 |
| 6159689 | Methods of capture and assay procedures Methods of capturing and labeling a species, include attracting magnetically attractable particles to a solid support by magnetic forces, which particles have an affinity for the species, contacting the particles on the support with a sample containing th... | 12/12/2000 |
| 6159378 | Apparatus and method for handling magnetic particles in a fluid The present invention is an apparatus and method for handling magnetic particles suspended in a fluid, relying upon the known features of a magnetic flux conductor that is permeable thereby permitting the magnetic particles and fluid to flow therethrough;... | 12/12/2000 |
| 6159742 | Nanometer-scale microscopy probes A carbon-based tip for scanning probe microscopy. The tip used in microscopy to reveal chemical characteristics of a sample includes a structure of the formula: X--(L--M)n in which n is 1 to 100, X is a carbon-based nanotube, L is a linking group ... | 12/12/2000 |
| 6156524 | Reagent for the detection of Staphylococcus aureus by agglutination Reagents and methods for the detection of Staphylococcus aureus are provided. The reagents contain an antibody that binds to a capsular polysaccharide of type 5 of Staphylococcus aureus, and can be used in methods for detection of oxacillin resistant Stap... | 12/05/2000 |
| 6153440 | Simultaneous measurement of free triiodothyronine and free thyroxine by equilibrium dialysis and immunoassay The present invention provides methods for the simultaneous measurement of triiodothyronine (T3) and thyroxine (T4) in biological fluids such as serum by direct equilibrium dialysis and immunoassay. Specifically, the method comprises... | 11/28/2000 |
| 6150123 | Affinity biotinylation The present invention relates to a method for biotinylating a desired subset of a larger population of proteins, wherein the subset of proteins is first selectively bound to a solid phase, thereby separating it from undesired proteins of the population, a... | 11/21/2000 |
| 6150182 | Method for separation of components in a biochemical reaction utilizing a combination of magnetic and centrifugal processes A method for combining magnetic and centrifugal extraction techniques in a manner that improves wash efficiency and reduces the relative disadvantages of stand alone magnetic or centrifugal systems is provided. Centrifugation occurs about the rotational a... | 11/21/2000 |
| 6150181 | Magnetic nanoparticles coupled to annexine, and utilization thereof The invention relates to a process for producing ferrofluid-forming magnetic particles substituted by DMSA (FFSH) that can be covalently coupled, directly or through a difunctional reactant, to an effector, which process comprises combining DMSA with ferr... | 11/21/2000 |
| 6146838 | Detecting water-borne parasites using electrochemiluminescence A method for the detection or quantitation of a water-borne parasite, such as Cryptosporidia. The detection or quantitation is accomplished by an electrochemiluminescence assay comprising the steps of filtering water to obtain a sludge thought to contain ... | 11/14/2000 |
| 6143578 | Method and apparatus for wash, resuspension, recollection and localization of magnetizable particles in assays using magnetic separation technology Method and apparatus for enabling resuspension wash and magnetic localization of sample components bound to particles with magnetic properties in reaction vessels during separation and wash for enhanced chemiluminescent signal generation in biomedical ass... | 11/07/2000 |
| 6143577 | Process and installations for separation of magnetic particles in a fluid for biological analysis, and application of said process A process for magnetic immunoseparation of cells, in particular bacteria, fetal cells, stock cells of bone marrow and circulating cancerous cells, of the type consisting in affixing the target cells on paramagnetic balls and in causing a magnetic field to... | 11/07/2000 |
| 6143510 | Measuring method using whole blood sample A method for quantitatively measuring analyte in an undiluted whole blood sample is disclosed which involves contacting an undiluted whole blood sample comprising the analyte with magnetically-responsive particles which comprise a first partner which is c... | 11/07/2000 |
| 6136549 | systems and methods for performing magnetic chromatography assays Novel magnetic assay methods and systems, as well as systems for conducting spectrophotometric analysis therewith. According to a preferred embodiment, the magnetic assay methods and systems incorporate a chromatographic medium, such as an assay test stri... | 10/24/2000 |
