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| Number | Title | Issue Date |
| 6642007 | Assays for measurement of type II collagen fragments in urine This invention provides novel methods for monitoring urine for type II collagen fragment using a combination of a capture antibody and a detection antibody, such that type II collagen is distinguished from other collagen fragments.... | 11/04/2003 |
| 6632603 | Non-captive substrate liquid phase immunoassay An immunoassay of a liquid biological specimen for a specific analyte is conducted by forming a test sample by contacting the specimen with: (1) a binding substance of a ligand, antiligand or receptor capable of binding the analyte and (2) a detector subs... | 10/14/2003 |
| 6630358 | Arrays of proteins and methods of use thereof Protein arrays for the parallel, in vitro screening of biomolecular activity are provided. Methods of using the protein arrays are also disclosed. On the arrays, a plurality of different proteins, such as different members of a single protein family, are ... | 10/07/2003 |
| 6623983 | Apparatus and methods for capture and analysis of particulate entities Apparatus and methods are disclosed which facilitate immobilization of magnetically labelled particulate entities, e.g., cells, preferably in a defined pattern, on a collection surface via binding between specific binding pair members, as an aid to partic... | 09/23/2003 |
| 6620626 | Antigen detection device and method A monitor having a hollow semipermeable casing with a test strip is agitated in a sample volume of suspect liquid. The monitor is partially filled with tiny colored beads confined to its interior by the size of the openings in the semipermeable structure.... | 09/16/2003 |
| 6620628 | Analytical elements having a surface charge An assay element for analyzing a charged analyte employs an immobilized receptor and a material having a net charge which is the same as that of the analyte. In a preferred embodiment, the analyte is an aminoglycoside and the material is a polymer having ... | 09/16/2003 |
| 6613582 | Methods for rapid and efficient protein cross-linking The present application describes novel uses of ruthenium bipyridyls or palladium porphyrins as photo-activatable crosslinking agents. Crosslinking can be between any two molecules including peptides, proteins, or compounds. Crosslinking occurs in the pre... | 09/02/2003 |
| 6589799 | Supported aldehydic silanes and method of manufacture A method for producing a derivatized aldehydic support matrix material includes activating surface hydroxyl groups on the support matrix material and reacting the activated hydroxyl groups with an aldehydic alkoxy silane. The derivatized aldehydic support... | 07/08/2003 |
| 6589798 | Method and system for analyte determination The invention relates to methods, kits and systems for determining an analyte in a liquid sample as well as the use thereof for concentration analysis and screening purposes. In one method, a specific binding partner to the analyte is permitted to compete... | 07/08/2003 |
| 6586259 | Platelet/leukocyte interaction assay and reagent therefor A platelet/leukocyte interaction assay method and reagent therefor are provided using the presence of a solid-phase stimulus, such as magnetic or non-magnetic particles or mixtures thereof, having bound to the surface thereof one or more ligands that inte... | 07/01/2003 |
| 6586193 | Analyte assay using particulate labels Method for specific detection of one or more analytes in a sample. The method includes specifically associating any one or more analytes in the sample with a scattered-light detectable particle, illuminating any particle associated with the analytes with ... | 07/01/2003 |
| 6582970 | Simple immunochemical semi-quantitative assay method and apparatus The present invention relates to a simple immunochemical semi-quantitative assay method according to chromatography, which comprises trapping a certain amount of an analyte in a sample with a predetermined amount of a fixed antibody for the analyte before... | 06/24/2003 |
| 6582969 | Microdevices for high-throughput screening of biomolecules Methods for the parallel, in vitro screening of biomolecular activity using miniaturized microfabricated devices are provided. The biomolecules that can be immobilized on the surface of the devices of the present invention include proteins, polypeptides, ... | 06/24/2003 |
| 6579726 | Instruments, methods and reagents for surface plasmon resonance The invention provides methods and reagents for the enhancement of surface plasmon resonance (SPR)-based detection assays. The methods and reagents can be used in any molecular recognition assay that uses a solid support. The invention also provides an SP... | 06/17/2003 |
| 6579721 | Biosensing using surface plasmon resonance The invention provides methods and reagents for the enhancement of surface plasmon resonance (SPR)-based detection assays. The methods and reagents can be used in any molecular recognition assay that uses a solid support. The invention also provides an SP... | 06/17/2003 |
| 6579684 | Assay of YKL-40 as a marker for cancer This invention is a method of identifying the presence of, and monitoring, a disease state in a mammal which is associated with degradation of connective tissue in the mammal. The method detects and determines whether diagnostically or prognostically sign... | 06/17/2003 |
| 6579673 | Patterned deposition of antibody binding protein for optical diffraction-based biosensors The present invention provides an inexpensive and sensitive device and method for detecting and quantifying analytes present in a medium. The device comprises a metalized film upon which is printed a specific, predetermined pattern of an antibody-binding ... | 06/17/2003 |
| 6573107 | Immunochemical detection of an explosive substance in the gas phase through surface plasmon resonance spectroscopy The biosensor involves a specially designed surface which can be optically coupled to a Surface Plasmon Resonance spectrometer. The key components of the biosensor are a bimetallic layer, a self assembled monolayer of chemicals and a layer of biomolecules... | 06/03/2003 |
| 6558961 | Immunodiagnostics using particle delivery methods Methods for assessing immunocompetence, cellular or humoral immunity, antigen exposure, or allergic conditions in an individual by accelerating diagnostic particles into a target skin site in the individual are provided.... | 05/06/2003 |
| 6548645 | Immunoassay for 2-oxo-3-hydroxy LSD To improve the detection of LSD, and LSD metabolites in biological samples, antibodies are raised to 2-oxo-3-hydroxy-LSD conjugated to a protein carrier. Selected antibodies are matched with an immunoassay reagent in which the 2-oxo-3-hydroxy-LSD is conju... | 04/15/2003 |
| 6548311 | Device and method for detecting analytes The invention relates to a method for detecting analytes and to a device for carrying out the method, for use for analysis or diagnosis in the fields of chemistry, biochemistry, molecular genetics, food chemistry, biotechnology, the environment and medici... | 04/15/2003 |
| 6548264 | Coated nanoparticles Disclosed are silica-coated nanoparticles and a process for producing silica-coated nanoparticles. Silica-coated nanoparticles are prepared by precipitating nano-sized cores from reagents dissolved in the aqueous compartment of a water-in-oil microemulsio... | 04/15/2003 |
| 6548263 | Miniaturized cell array methods and apparatus for cell-based screening The present invention describes novel methods for making a substrate for selective cell patterning, and the substrates themselves, wherein the method comprises contacting reactive hydroxyl groups on the surface of a substrate with a hydroxyl-reactive bifu... | 04/15/2003 |
| 6537441 | Biosensor involving the use of optically sensitive moieties The present invention provides biosensors which include or are fabricated using optically sensitive moieties. The use of optically sensitive moieties provides advantages in the synthesis of the biosensors. Further the inclusion of optically sensitive moie... | 03/25/2003 |
| 6534320 | Process for immunochromatography with colloidal particles The present invention relates to improved specific binding assay methods, kits and devices utilizing chromatographically mobile specific binding reagents labelled with colloidal particles. Specific binding reagents labelled with colloidal particles such a... | 03/18/2003 |
| 6531323 | Agglutination assay method and element in a dry system An agglutination assay method for quantitatively determination of an analyte in a liquid sample using particles bearing an anti-analyte. A non-fluid substance which retains the particles while suppressing the diffusion of the particles therein is used as ... | 03/11/2003 |
| 6531278 | Ligand-DNA composition for capture and detection of contaminants on a solid surface Compositions and methods of use thereof for capture and detection of selected molecules are described. In one embodiment, a first composition includes a ligand component, such as an antibody coupled to a nucleic acid component. An a preferred embodiment, ... | 03/11/2003 |
| 6528321 | Opposable-element chromatographic assay device for detection of analytes in whole blood samples A chromatographic assay device according to the present invention provides a unidirectional immunoassay for an analyte in a whole blood sample with improved sensitivity and freedom from interference. Such a device comprises: (1) a first opposable componen... | 03/04/2003 |
| 6514773 | Method of detecting surface contamination by an analyte Subject matter of the invention is a method for detecting surface contamination by an analyte by wiping the analyte off the surface with the aid of a wiping surface, eluting the analyte from the wiping surface with an eluant, and detecting the analyte in ... | 02/04/2003 |
| 6514772 | Semiconductor nanoparticles for analysis of blood cell populations and methods of making same A semiconductor nanoparticle for use in analysis of biological samples is described. This semiconductor nanoparticle is composed of an aminodextran which is bound to at least one nanoparticle of the formula (X Y)n wherein X is selected from the... | 02/04/2003 |
| 6514767 | Surface enhanced spectroscopy-active composite nanoparticles Metal nanoparticles associated with a spectroscopy-active analyte and surrounded by an encapsulant are useful as sensitive optical tags detectable by surface-enhanced spectroscopy.... | 02/04/2003 |
| 6511854 | Regenerable biosensor using total internal reflection fluorescence with electrochemical control An improved electrochemical method for disassociating a biological binding partner from a corresponding second biological binding partner associated with a waveguide surface, the electrochemical method involving the application of an electrical potential ... | 01/28/2003 |
| 6506612 | Immunoassay devices and materials An immunochemical label comprising finely particulate carbon black on which is adsorptively immobilized a component which terminates distally from a point of adsorption with an immunologically active ligand or ligand binding molecule wherein said componen... | 01/14/2003 |
| 6485984 | CALIXCROWN DERIVATIVES, A PROCESS FOR THE PREPARATION THEREOF, A SELF-ASSEMBLED MONO-LAYER OF THE CALIXCROWN DERIVATIVES PREPARED BY USING THE SAME AND A PROCESS FOR IMMOBILIZING A PROTEIN MONO-LAYER BY USING THE SELF-ASSEMBLED MONO-LAYER OF THE CALIXCROWN DERIVATIVES The present invention is to provide calixcrown derivatives of formulae 1 to 3 requisite for the preparation of a self-assembled monolayer as well as a process for the preparation thereof. Further the present invention is to provide a self-assembled monola... | 11/26/2002 |
| 6485982 | Test device and method for colored particle immunoassay Disclosed is a test cell and a method for detection of a preselected ligand in a liquid sample such as a body fluid. The test cell includes an elongate outer casing which houses an interior permeable material capable of transporting an aqueous solution an... | 11/26/2002 |
| 6479301 | Methods for fabricating an array for use in multiplexed biochemical analysis The invention provides devices for preparing a reaction substrate for use as an assay device, and methods of using these devices. The devices prepare reaction substrates comprising arrays of biosites bound to reaction substrates. The devices have a plural... | 11/12/2002 |
| 6475808 | Arrays of proteins and methods of use thereof Protein arrays for the parallel, in vitro screening of biomolecular activity are provided. Methods of using the protein arrays are also disclosed. On the arrays, a plurality of different proteins, such as different members of a single protein family, are ... | 11/05/2002 |
| 6472228 | Composition and methods for synthesis of novel tracers for detecting amphetamine and methamphetamine in samples This invention relates to novel tracers and their synthesis and use in an immunoassay for the detection of controlled drugs such as amphetamine (APM), methamphetamine (MAPM) and their derivatives, in a biological or aqueous sample. In particular, this inv... | 10/29/2002 |
| 6468808 | Water-soluble luminescent quantum dots and biomolecular conjugates thereof and related compositions and method of use The present invention provides a water-soluble luminescent quantum dot, a biomolecular conjugate thereof and a composition comprising such a quantum dot or conjugate. Additionally, the present invention provides a method of obtaining a luminescent quantum... | 10/22/2002 |
| 6465183 | Multidentate arrays A method of evaluating for the presence of a target polynucleotide in a sample, using an addressable array of multiple polynucleotide probes linked to a substrate. The sample is exposed to the array and a set of polynucleotide target probes, such that tar... | 10/15/2002 |
