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| Number | Title | Issue Date |
| 4521522 | Optical specific binding assay with reflection of polarized electromagnetic radiation A process, means and devices for the quantitative determination, using electromagnetic radiation, of a component of a group including specifically bonding receptors and substances which can be specifically bonded by these receptors are based on a process ... | 06/04/1985 |
| 4454233 | Method of tagged immunoassay An immunoassay method for measurement of the content of a target antigen or antibody in a fluid or tissue specimen comprises reacting the target with reagent antibody or antigen which forms a complex with the target and is carried by small tagged mobile u... | 06/12/1984 |
| 4442218 | Method of measuring degree of partitioning A method of measuring the degree of partitioning of a labeled species between free and bound states which involves the use of an insoluble porous monolith having a means for binding a portion of the labeled species within the pores thereof, which monolith... | 04/10/1984 |
| 4436826 | Tagged immunoassay An immunoassay method for measurement of the content of a target antigen or antibody in a fluid or tissue specimen comprises reacting the target with reagent antibody or antigen which forms a complex with the target and is tagged with tagging elements whi... | 03/13/1984 |
| 4353886 | Method for detecting organic vapors A method of detecting the vapors of particular organic materials, such as narcotic vapors, in which a test plate is provided having a surface coated with an antibody specific for a particular organic material. The test plate is exposed to atmosphere in a ... | 10/12/1982 |
| 4313734 | Metal sol particle immunoassay A method, test kit and labeled component for the detection and/or determination of one or more components of the reaction between a specific binding protein and the corresponding bindable substance, in which one or more labelled components are used, that ... | 02/02/1982 |
| 4277560 | Enzyme immunoassays using immobilized reagents in a flowing stream This invention relates to a method and apparatus for the rapid quantitative determination of an antigen contained in aqueous biochemical samples, for example, blood. The method comprises a series of sequentially arranged stages through which a buffered st... | 07/07/1981 |
| 4260678 | Determining creatine kinase isoenzmes via immobilized antibody-isoenzyme complexes Creatine kinase isoenzymes in a liquid sample are determined by means of immobilized antibody-isoenzyme complexes in which measureable isoenzyme activity is retained.... | 04/07/1981 |
| 4224304 | Method and apparatus for the measurement of antigens and antibodies A method of the quantitative measurement of antigens and antibodies by reacting antibody- or antigen-sensitized insoluble carrier particles with a corresponding antigen or antibody or a mixture thereof in a sample, irradiating the reaction mixture with li... | 09/23/1980 |
| 4222743 | Method and apparatus for detecting biological particles by fluorescent stain A metal-covered substrate is first adsorbed with a layer of known biological particles. This active substrate is then put into a solution containing an unknown amount of second biological particles that will bind the first kind of particles which are rand... | 09/16/1980 |
| 4210722 | Protein immobilizer Biologically active proteins are immobilized on polar supports by first applying to the support a monolayer of a water-soluble polymer containing a ଲ-hydroxyalkyleneamine moiety wherein the equivalent weight of the polymer based on the ଲ-hydro... | 07/01/1980 |
| 4188371 | Immunological detection of Neisseria bacteria via labelled antibodies This invention is concerned with two closely related assay methods for detecting the presence of Neisseria bacteria in a fluid sample. Both of the methods utilize radiolabelled antibodies specific to the enzyme released upon lysis of the bacteria. In the ... | 02/12/1980 |
| 4181501 | Method and apparatus for measuring antibody levels A diagnostic device is described employing a solid, rigid diagnostic substrate (having as a part thereof an exposed layer of first immunologically reactive biological particles) in combination with means spaced therefrom for containing a solution of secon... | 01/01/1980 |
| 4171956 | Laser immunoassay An immune assay for tracing processes and reactions employs a narrow band laser tuned to the absorption line of a tracer isotope coupled chemically to a carrier molecule of protein. The carrier molecule is reacted with another molecule, the reaction produ... | 10/23/1979 |
| 4169138 | Method for the detection of antibodies A method for the detection of antibodies immunochemically bound to the corresponding antigen fixed to a smooth surface of glass, metal, polymerfilm or the like. The surface with antigen bound antibodies is contacted with a suspension of small water-insolu... | 09/25/1979 |
| 4163779 | Test for quantitation of immunoglobulin and identification of abnormal immunoglobulin A combined test for quantitating immunoglobulin and identifying the presence of abnormal homogeneous immunoglobulin usually of myeloma origin. In a direct test, a first fraction of serum sample is adsorbed to a solid surface and the adsorbed immunoglobuli... | 08/07/1979 |
| 4127385 | Assay of antibodies with antigen-treated aluminum hydroxide gel A specimen of body fluid is applied to an aluminum-hydroxide gel to which a known quantity of antigens is adhered by adsorption. Antibodies in the body fluid may be detected by determining the antigen-antibody complex adsorbed to the aluminum-hydroxide ge... | 11/28/1978 |
| 4118192 | Method and apparatus for the measurement of antigens and antibodies A method of the quantitative measurement of antigens and antibodies by reacting antibody- or antigen-sensitized insoluble carrier particles with a corresponding antigen or antibody or a mixture thereof in a sample and irradiating the reaction mixture with... | 10/03/1978 |
| 4115535 | Diagnostic method employing a mixture of normally separable protein-coated particles A mixture of two different kinds of particles having distinctive, different properties is employed for determining the presence of a select protein in, or the absence of a select protein from, a solution. The first kind of particle provides a property fac... | 09/19/1978 |
| 4092116 | Method for binding antibodies to a surface such that they remain active In carrying out an immunological reaction or diagnostic test, an immunologically inert organic compound of sufficient quantity is added to an aqueous medium containing an immunologically reactive antigen. A substrate is then treated with the aqueous mediu... | 05/30/1978 |
| 4067959 | Indirect solid surface test for antigens or antibodies An indirect method for the quantitation of an antigen or antibody in a liquid sample. In the antigen assay, antigen of the same type as the sample antigen is adsorbed onto a solid support surface. Then, specific labelled antibody is immunologically reacte... | 01/10/1978 |
| 4054646 | Method and apparatus for detection of antibodies and antigens Method and apparatus for the detection of antibodies and antigens based upon the effect that any arbitrary antigen will adsorb onto a substrate in a monomolecular layer only, but that a corresponding specific antibody for such arbitrary antigen will bond ... | 10/18/1977 |
| 4041146 | Method for detection of biological particles A monomolecular layer of first biological particles is absorbed on the surface of a non-reactive substrate. The coated substrate is exposed to a solution suspected of containing second biological particles specific to the first biological particles. Next,... | 08/09/1977 |
| 4020151 | Method for quantitation of antigens or antibodies on a solid surface A method for quantitation of antigens or antibodies from a liquid sample on a solid surface. The sample is first sorbed directly to a nonimmunological surface. Then the surface is exposed to antibody or antigen labelled preferably with a fluorogen, to cau... | 04/26/1977 |
| 4013411 | Method for detecting hepatitis associated antigen A method for testing biological materials, and especially those obtained from the human body, for the presence of the hepatitis associated antigen (HAA), in which Zeise's salt, or another water soluble platinum or palladium salt containing a trans directi... | 03/22/1977 |
| 4011308 | Method for surface immunological detection of biological particles by the use of tagged antibodies The detection of immunologically reactive biological particles such as viruses, bacteria and other cells is obtained by detection of the occurrence of an immunological reaction on a substrate between the particle to be detected and its tagged antibody. A ... | 03/08/1977 |
| 3979184 | Diagnostic device for visually detecting presence of biological particles Devices for the detection of biological particles, particularly proteins. Such devices comprise a non-transparent surface of metal (solid metal or a non-transparent coating of metal on some different substrate) covered with a thin transparent first layer ... | 09/07/1976 |
| 3979509 | Opaque layer method for detecting biological particles A monomolecular layer of first biological particles is adsorbed on the surface of a substrate fabricated of virtually any nonreactive solid material, the coated substrate is then exposed to a solution suspected of containing second biological particles sp... | 09/07/1976 |
| 3960491 | Method and apparatus for detecting immunologically reactive biological particles A metallized solid substrate is covered with a moistened porous paper, and specimens of first and second solutions suspected of respectively containing first and second immunologically reactive biological particles specific to each other are applied to se... | 06/01/1976 |
| 3960489 | Method and apparatus for determination of concentration of immunologically reactive biological particles The area of a bimolecular layer formed on a metallized slide is related to the concentration of second immunologically reactive biological particles forming the second layer. The slide initially has adsorbed thereon a first monomolecular layer of first im... | 06/01/1976 |
| 3960488 | Method and apparatus for quantitative surface inhibition test A metallized slide has adsorbed thereon a first monomolecular layer of particular first immunologically reactive biological particles and is covered with a suitable moisture holding medium. A test solution is then applied along a first edge of the slide, ... | 06/01/1976 |
| 3960490 | Method and apparatus for detecting immunologic reactions by diffusion in gel A thin layer of gel on a metallized solid surface has two or more wells formed through the gel which are subsequently filled with specimens of first and second solutions suspected of respectively containing first and second immunologically reactive biolog... | 06/01/1976 |
