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Patent No. 6650315

Mouse device with a built-in printer

A mouse device for use as an input device of a computer is provided that includes a housing in which recording paper is loadable, and a printer unit provided within the housing for printing on the recording paper print information received from the computer.

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Class 436/525 - Metal or metal coated


Subclass of Class 436 - Chemistry: analytical and immunological testing
Definition: Subject matter in which the carrier is a metal.
No. of patents: 710
Last issue date: 03/09/2010


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NumberTitleIssue Date
7674633Biosensor
It is an object of the present invention to provide a technique of conserving a functional group used for binding a physiologically active substance in the form of an inactive ester, and converting it to an activated ester by simple operations immediately before for...
03/09/2010
7674632Method and composition for homogeneous multiplexed microparticle-based assay
A method and composition for detecting and measuring analytes, such as antibodies, which are capable of binding with certain binding partners such as antigens. A homogenous assay is performed in the presence of free unbound antibodies. Such a homogeneous assay testi...
03/09/2010
7611907Nano-sized optical fluorescence labels and uses thereof
A composition is disclosed which is capable of being used for detection, comprising an encapsulated noble metal nanocluster. Methods for preparing the encapsulated noble metal nanoclusters, and methods of using the encapsulated noble metal nanoclusters are also disc...
11/03/2009
7563624Measurement method using biosensor
It is an object of the present invention to provide a method for carrying out on a same biosensor both of the measurement of the amount of a physiologically active substance immobilized on a biosensor substrate and the measurement of the biological activity of the a...
07/21/2009
7517700Core-shell particles
Colloidal metal particles having a coating comprising non cross-linked, SH-activated dextran or aminodextran. Biomolecules may be linked directly or indirectly to the particles, which are useful as detection reagents in immunological assays. ...
04/14/2009
7485471Detection of enhanced multiplex signals by surface enhanced Raman spectroscopy
Various methods of using Raman-active or SERS-active probe constructs to detect analytes in biological samples, such as the nucleic acid and/or protein-containing analytes in a body fluid are provided. ...
02/03/2009
7470550Method of evaluating cell activity
The invention provides a method for evaluating the physiological activity of an external stimulus on living cells by means of a surface plasma resonance analyzer, which comprises evaluating the physiological activity of the external stimulus on the cells with an ind...
12/30/2008
7465588Apparatus and method of assay in utilizing attenuated total reflection
An assay apparatus is loaded with a sensor unit as surface plasmon resonance (SPR) biosensor, which includes a transparent dielectric medium and thin film. A first surface of the thin film is a thin film/dielectric interface. Its sensing surface causes reaction of s...
12/16/2008
7442498Method of examining specimen and specimen container to be used in the examination method
A method of immunologically examining a specimen which comprises attaching a cap having a filter impregnated with a labeled antibody enclosed therein to a container body containing a diluted liquid specimen, pouring the diluted liquid specimen from the container int...
10/28/2008
7439078Method for measuring dissociation rate coefficient by surface plasmon resonance analysis
An object of the present invention is to provide a method for measuring the dissociation rate coefficient (Kd) by surface plasmon resonance analysis without measuring the theoretical maximum amount of binding (Rmax). The present invention provides a method for measu...
10/21/2008
7435384Diagnostic instrument with movable electrode mounting member and methods for detecting analytes
An instrument (A) detects in a sample the presence of an analyte. The sample includes electrically readable particles (126) with an agent attached thereto that binds with the analyte or is an analog of the analyte. The instrument includes a port for the sampl...
10/14/2008
7432113Surface modification of metals for biomolecule detection using surface enhanced Raman scattering (SERS)
The present invention is based on the discovery that the methods described herein for the production of metallic colloids result in colloids exhibiting increased signal enhancement and reproducibility for the SERS detection of biomolecules. Thus, using the methods o...
10/07/2008
7432112Surface modification of metals for biomolecule detection using surface enhanced Raman scattering (SERS)
The present invention is based on the discovery that the methods described herein for the production of metallic colloids result in colloids exhibiting increased signal enhancement and reproducibility for the SERS detection of biomolecules. Thus, using the methods o...
10/07/2008
7429492Multiwell plates with integrated biosensors and membranes
The invention provides compositions and methods of detecting binding of molecules to a biosensor. Compositions of the invention comprise a multiwell plate with an integrated biosensor and a membrane. ...
09/30/2008
7427512Light-controlled electrokinetic assembly of particles near surfaces
A method and apparatus for the manipulation of colloidal particulates and biomolecules at the interface between an insulating electrode such as silicon oxide and an electrolyte solution. Light-controlled electrokinetic assembly of particles near surfaces relics on t...
09/23/2008
7427513Surface modification of metals for biomolecule detection using surface enhanced Raman scattering (SERS)
The present invention is based on the discovery that the methods described herein for the production of metallic colloids result in colloids exhibiting increased signal enhancement and reproducibility for the SERS detection of biomolecules. Thus, using the methods o...
09/23/2008
7425454Biosensor
It is an object of the present invention to provide a detection surface used for biosensors, in which non-specific adsorption is suppressed and the generation of pinholes is also suppressed. The present invention provides a biosensor, which comprises a substrate coa...
09/16/2008
7423155N-sulfonyldicarboximide containing tethering compounds
Compounds having two reactive functional groups are described that can be used as a tethering compound to immobilize an amine-containing material to a substrate. The first reactive functional group can be used to provide attachment to a surface of a substrate. The s...
09/09/2008
7413607Templated semiconductor particles and methods of making
Composite particles of a semiconductor particle such as a metal chalcogenide within a crosslinked, cored dendrimer are described. Additionally, methods of making the composite particles and compositions that contain the composite particles are described. ...
08/19/2008
7413911Method for measuring reaction rate coefficient by surface plasmon resonance analysis
An object of the present invention is to provide a method for measuring a rate coefficient by surface plasmon resonance analysis with excellent accuracy, reliability, and cost performance that can improve the assay accuracy and simplify the apparatus. The present in...
08/19/2008
7410808Method and assay for detection of residues
Embodiments described herein include methods and assays for detecting an analyte in a sample using a plurality of control zone capture agents. Some embodiments include detection of multiple analytes in a sample utilizing a plurality of analyte binders and a control ...
08/12/2008
7410811Analytical method and device utilizing magnetic materials
The present invention relates to an analytical method and device utilizing magnetic materials and acoustics sensor. The invention employs a magnetic material modified with specific recognizable molecules to capture a substance in a sample and provides an external ma...
08/12/2008
7407817Surface plasmon resonance sensors and method for detecting samples using the same
Disclosed is an optical sensing device including a source unit providing a beam of light with continuously modulated phase retardation between p- and s-polarization components of the light by employing a LCM; a reference unit receiving a first part of the light to p...
08/05/2008
7405054Signal amplification method for surface plasmon resonance-based chemical detection
The present invention provides methods and compositions for amplifying the detection signal in surface plasmon resonance (SPR)-based flow systems. The signal amplification methods comprise the use of well established marker systems that provide a precipitate. The ma...
07/29/2008
7404928Thiol terminated monodisperse ethylene oxide oligomer capped gold nanoclusters
A thiol terminated ethylene oxide oligomer and the method of substituting the oligomer onto a gold nanocluster surface using a thiol-exchange reaction to form a charge-neutral, non-ionizable, water soluble, ethylene oxide protected gold nanocluster. The thiol termin...
07/29/2008
7402381Method of immobilizing molecules onto a solid phase substrate and method of fabricating a biosensor using the method
Aspects of the invention can provide a method capable of easily realizing immobilization with the optimum density derived from a concentration control and without phase separation in coadsorption of a number of molecules. The immobilization method can include the st...
07/22/2008
7396676Evanescent wave sensor with attached ligand
The invention in particular embodiments provides an evanescent wave sensor which includes a ligand bound to a sensor substrate via a NCYX linker moiety, as defined herein. Methods of making the subject evanescent wave sensors are also provided which include contacti...
07/08/2008
7396675Kit and method for determining a plurality of analytes
The invention is related to different embodiments of a kit for the simultaneous qualitative and/or quantitative determination of a multitude of analytes comprising a sensor platform comprising an optical thin-film waveguide with a ...
07/08/2008
7390676System and method for programmable illumination pattern generation
A method and apparatus for the manipulation of colloidal particulates and biomolecules at the interface between an insulating electrode such as silicon oxide and an electrolyte solution. Light-controlled electrokinetic assembly of particles near surfaces relies on t...
06/24/2008
7387900Colloidal metal compositions and methods
The present invention comprises compositions and methods for delivery systems of agents, including therapeutic compounds, pharmaceutical agents, drugs, detection agents, nucleic acid sequences and biological factors. In general, these vector compositions comprise a ...
06/17/2008
7387901Target substance detecting element, target substance detection apparatus and target substance detection method
Magnetic particles with a metal coat holding target substance captors are made to react with a target substance contained in a specimen in a solution where the magnetic particles are dispersed in a liquid medium. Subsequently, the dispersion of the magnetic particle...
06/17/2008
7374950Immunoassay device for diagnosing congestive heart failure and predicting mortality in congestive heart failure patients
An immunochemical assay device for determining the presence of NT-proBNP alone or conjunctively with Cardiac Troponin I comprising a base member, an array disposed on the base member, and at least one assay indicia zone. The array comprises (i) a reservoir pad to re...
05/20/2008
7374873Analysis method for substance
A method for analyzing a substance, comprising: a step of obtaining a dispersion complex by co-existing fine particles having a dispersion property higher than that of lyophobic fine particles in a dispersion phase of the lyophobic fine particles at a concentration ...
05/20/2008
7371457Nanoparticle comprising nanoshell of thickness less than the bulk electron mean free path of the shell material
The present invention is for particulate compositions and methods for producing them that can absorb or scatter electromagnetic radiation. The particles are homogeneous in size and are comprised of a nonconducting inner layer that is surrounded by an electrically co...
05/13/2008
7371562Guided mode resonant filter biosensor using a linear grating surface structure
Methods and compositions are provided for detecting biomolecular interactions. The use of labels is not required and the methods can be performed in a high-throughput manner. The invention also provides optical devices useful as narrow band filters. ...
05/13/2008
7368086Functionalized fluorescent nanocrystals, and methods for their preparation and use
Functionalized fluorescent nanocrystal compositions and methods for making and using these compositions are disclosed. The compositions are fluorescent nanocrystals coated with at least one material. The coating material has chemical compounds or ligands with functi...
05/06/2008
7368280Detection of biospecific interactions using amplified differential time domain spectroscopy signal
A method for detecting specific associations between a tethered molecule and an untethered target molecule. The method comprises (1) selecting a tethered molecule; (2) alternately impinging THz radiation onto the tethered molecule and onto a sample including the tet...
05/06/2008
7368281Label-free evanescent-field detection of biological and chemical agents
An evanescent-field sensor system and method of using the system to detect either liquid- or airborne biological pathogens, chemical agents, and other harmful or toxic species is provided. The sensor system involves 1) an evanescent-field sensor having a substrate s...
05/06/2008
7368294Method for optical detection of an adjoining of a material component to a sensor material with the aid of biological, chemical or physical interaction and device for carrying out said method (variants)
Method for detecting biological or chemical components in liquid or gas is based on measuring changes of the sensor layer thickness due to binding reactions. A plate or a gap with two surfaces of a solid optical material is used as the sensor layer. The surfaces are...
05/06/2008
7364919Nanoparticles
Materials and methods for studying and modulating the interaction of carbohydrate-containing moieties with other species are described, in particular, small particles, e.g. clusters of metal or semiconductor atoms, which can be employed as a substrate for immobilizi...
04/29/2008
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