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| Number | Title | Issue Date |
| 6855263 | Rapid process for purification and concentration of plasmin A method for rapid purification of a blood component from blood is described in which the blood plasma is first separated from the cellular blood elements by any conventional means, such as centrifugation. An affinity cartridge is then activated with a molecule, suc... | 02/15/2005 |
| 6852547 | Dynamically formed rotors for lock-in amplifier detection A method for measuring low levels of a substance in a sample includes the formation of a rotor from paramagnetic particles in a substantially uniform magnetic field. The rotor is rotated by rotating the substantially uniform magnetic field. A portion of the substanc... | 02/08/2005 |
| 6852285 | Optical amplification of molecular interactions using liquid crystals Interactions between molecules which are components of self-assembled monolayers and other molecules can be amplified and transduced into an optical signal through the use of a mesogenic layer. The invention provides a device and methods for detecting analytes. The ... | 02/08/2005 |
| 6849463 | Microfabricated devices for the storage and selective exposure of chemicals and devices Microchip devices and methods of use are provided for the controlled exposure of a secondary device. In one embodiment, the microchip device include a substrate, a plurality of reservoirs in the substrate, a secondary device in one or more of the reservoirs, at leas... | 02/01/2005 |
| 6846639 | Method for detecting pathogens attached to specific antibodies The use of impedance measurements to detect the presence of pathogens attached to antibody-coated beads. In a fluidic device antibodies are immobilized on a surface of a patterned interdigitated electrode. Pathogens in a sample fluid streaming past the electrode att... | 01/25/2005 |
| 6844164 | Antibody against rat postacrosome reaction sperm and utilization thereof An antibody biding specifically to rat's acrosome reacted sperm is produced and hybridomas (FARS-91 and FARS-92 strains) capable of stably proliferating are obtained by fusing mouse spleen cells having a high antibody titer against rat's acrosome reacted sperm with ... | 01/18/2005 |
| 6844165 | Retentate chromatography and protein chip arrays with applications in biology and medicine This invention provides methods of retentate chromatography for resolving analytes in a sample. The methods involve adsorbing the analytes to a substrate under a plurality of different selectivity conditions, and detecting the analytes retained on the substrate by d... | 01/18/2005 |
| 6844184 | Device for arraying biomolecules and for monitoring cell motility in real-time The invention relates to devices, devices for arraying biomolecules, including cells, methods for arraying biomolecules, assays for monitoring cellular movement, and systems for monitoring cellular movement. The devices include a support; a first layer configured to... | 01/18/2005 |
| 6844201 | Method for capturing analytes eluted from surface-bound ligands Methods for capturing analytes associated with surface-bound ligands are disclosed. The methods involve eluting analytes from surface-bound ligands with a first liquid to generate free analytes, and capturing the free analytes with a solid capturing material within ... | 01/18/2005 |
| 6838089 | Antigen delivery system and method of production The present invention concerns polymer particle vaccine delivery systems in which a water insoluble protein antigen, e.g. a lipidated HpaA protein, is incorporated with particles comprising a polymer matrix. The present invention also concerns a method for incorpora... | 01/04/2005 |
| 6835552 | Impedance measurements for detecting pathogens attached to antibodies The use of impedance measurements to detect the presence of pathogens attached to antibody-coated beads. In a fluidic device antibodies are immobilized on a surface of a patterned interdigitated electrode. Pathogens in a sample fluid streaming past the electrode att... | 12/28/2004 |
| 6835543 | Step agglutination immunoassay An immunoassay for detecting an antigen in a sample, by: (a) sequentially contacting the sample with (i) a first antibody which is capable of specifically binding to a first binding site on the antigen,... | 12/28/2004 |
| 6833275 | Gold conjugates containing detergent A composition which contains stabilized conjugates composed of colloidal particles and biomolecules is obtained by adding a detergent to a solution containing biomolecules before or/and during treatment of colloidal particles with this solution. ... | 12/21/2004 |
| 6830895 | Method and kit for typing feline blood The present invention relates to a kit for determining feline blood type, wherein the kit includes a mixture comprised of a first monoclonal antibody and a second monoclonal antibody, wherein both antibodies recognize feline blood group specific A antigens. The pres... | 12/14/2004 |
| 6828158 | Microparticle enhanced light scattering agglutination assay Reagents and the use of the reagents in a microparticle light scattering agglutination assay are disclosed. The reagents comprise a mixture of particles having relatively stronger light scattering properties and particles having relatively weak light scattering prop... | 12/07/2004 |
| 6828157 | Products and methods for single parameter and multiparameter phenotyping of cells A method of single parameter and multiparameter characterizing of cells, particularly immunophenotyping of cells, is provided. The method preferably uses antibody coated microspheres which are adapted to bind to specific types of cells. One or more sets of coated mi... | 12/07/2004 |
| 6815217 | Use of check surfaces for identifying disturbing samples in a detection procedure A solid phase with at least one test area is described which contains reagents for the detection of at least one analyte in a sample, wherein the solid phase additionally comprises at least one control area for the detection of interfering reactions. ... | 11/09/2004 |
| 6815162 | Passivation of porous semiconductors A method is disclosed for stabilizing porous silicon. A porous silicon structure having a surface terminated with hydrogen atoms is subjected to organic thermal processing to substitute the hydrogen atoms with a protective organic layer. The resulting structure are ... | 11/09/2004 |
| 6808938 | Method and apparatus for assaying a drug candidate to estimate a pharmacokinetic parameter associated therewith A method and apparatus for assaying a drug candidate with a biosensor having one or more sensing surface-bound biomolecules associated therewith are disclosed. The method comprises the steps of measuring the binding interaction between the drug candidate and the one... | 10/26/2004 |
| 6808908 | Functionalized porous substrate for binding chemical and biological moieties The invention relates to porous polymeric materials, methods of making them, and applications in medical devices. A specific embodiment of the invention encompasses a material comprising a porous polyolefin substrate containing inclusions of a material to which chem... | 10/26/2004 |
| 6800439 | Methods for improved array preparation Improved nucleic acid arrays are provided which have been prepared in a non-oxidizing atmosphere. ... | 10/05/2004 |
| 6794052 | Polymer arrays from the combinatorial synthesis of novel materials Methods and apparatus for the preparation and use of a substrate having an array of diverse materials in predefined regions thereon. A substrate having an array of diverse materials thereon is generally prepared by delivering components of materials to predefined re... | 09/21/2004 |
| 6790965 | Combinatorial dihydrobenzopyran library Combinatorial libraries are disclosed which are represented by Formula I: (T′—L)q—Ŝ—C(O)—L′—II′ I wherein: Ŝ is a solid support; T′—L— is an identifier residue; and —L′—II′ is a l... | 09/14/2004 |
| 6787368 | Biosensor method for detecting analytes in a liquid A diagnostic method and device for use in detecting or quantitating an analyte present in a liquid sample. The method includes reacting an analyte-containing sample with reagents capable of generating a first coil-forming peptide in solution form. This peptide is th... | 09/07/2004 |
| 6783962 | Particulate material for purification of bio-macromolecules The present invention relates to particulate material having a density of at least 2.5 g/ml, where the particles of the particulate material have an average diameter of 5-75 μm, and the particles of the particulate material are essentially constructed of a polymeri... | 08/31/2004 |
| 6783929 | Biological sample component purification and differential display Provided are affinity support materials having intermediate binding affinity for biological samples. Among the materials provided by the present invention are hydrophilic solid supports composed of hydrophilic ligands coupled to hydrophilic matrixes which are compat... | 08/31/2004 |
| 6780582 | Arrays of protein-capture agents and methods of use thereof Arrays of protein-capture agents useful for the simultaneous detection of a plurality of proteins which are the expression products, or fragments thereof, of a cell or population of cells in an organism are provided. A variety of antibody arrays, in particular, are ... | 08/24/2004 |
| 6780606 | Method for diagnosing and distinguishing stroke and diagnostic devices for use therein A method for determining whether a subject has had a stroke and, if so, the type of stroke which includes analyzing the subject's body fluid for at least four selected markers of stroke, namely, myelin basic protein, S100 protein, neuronal specific enolase and a bra... | 08/24/2004 |
| 6777193 | Methods for diagnostic and/or treatment of antiphospholipids antibodies-related diseases, and devices Methods for detecting anti-lipidic particles antibodies and lipidic particles in cellular membranes for the diagnosis of diseases associated to the antiphospholipid syndrome are disclosed. Kits or sets to put these methods of diagnosis into practice are also disclos... | 08/17/2004 |
| 6777198 | Assay method and kit therefor The invention relates to a method of determining an analyte in a sample, especially a high concentration analyte, comprises the steps of: a) contacting the sample with a specified amount of a receptor which binds specifically to the analyte to form an analyte... | 08/17/2004 |
| 6770488 | Practical method and apparatus for analyte detection with colloidal particles A colloidal system for detection of a variety of analytes involves techniques which permit reconstitution of a desiccated substance such as for surface enhanced Raman spectroscopic analysis and multiple sensors at once, each having different spectra through the use ... | 08/03/2004 |
| 6767714 | Diagnostic detection device and method The invention provides an improved test cell for detecting the presence of an analyte in a liquid sample. The device has an elongate casing defining a liquid sample inlet, a reservoir volume, a test volume, and a window through the casing at the test volume. Dispose... | 07/27/2004 |
| 6767709 | Immunoassay of human medullasin and diagnosis of multiple sclerosis using the same There is provided an immunoassay by which the amount of human medullasin present inside granulocytes, which are one leukocyte component in blood, can be determined with high accuracy and with good reproducibility. Also provided is an immunoassay of medullasin, where... | 07/27/2004 |
| 6767635 | Magnetic nanoparticles having biochemical activity, method for the production thereof and their use The invention relates to magnetic nanoparticles, their production, and their use. The object of the invention is to provide nanoparticles capable of specifically forming bonds to intracellular biomacromolecules even in the intracellular region of cells, so th... | 07/27/2004 |
| 6764825 | Methods and device for detecting prostate specific antigen (PSA) An immunoassay device and assay to detect an antigen, such as PSA, in a biological sample. The device comprises a solid support having multiple reaction zones containing capture antibodies directed to the antigen. Exposure of a test sample to a mixture of incubation... | 07/20/2004 |
| 6766071 | Device and method for the measurement of the heat of a reaction Disclosed is an apparatus for use in the measurement of the heat generated in a chemical or biochemical reaction, by detecting and measuring a change in the conformation of a polymer transducer responsive to a heat change, the transducer being bound to the surface o... | 07/20/2004 |
| 6762062 | Method of determining cholesterol and sensor applicable to the same The present disclosure relates to a method for determining cholesterol in low density lipoprotein comprising the steps of (a) measuring total cholesterol level in a sample containing at least high density lipoprotein, low density lipoprotein, very low density lipopr... | 07/13/2004 |
| 6743638 | Detection system using liposomes and signal modification A process for detecting an analyte which process comprises (a) contacting a sample suspected of containing said analyte with a containment means comprising a barrier which separates signal generating reagents from said sample, in the presence of an element which int... | 06/01/2004 |
| 6737277 | Immunoassay devices and materials An immunochemical assay device comprising a base member, an array disposed on the base member, and at least one assay indicia zone. The array comprises (i) a reservoir pad to receive sample liquid, (ii) a wicking membrane, and (iii) at least one filter zone interpos... | 05/18/2004 |
| 6730487 | Surface plasmon resonance biosensor for measurement of anti-glycolipid antibody levels in neuropathy The present invention provides a method of detecting human antibodies in a sera solution. The invention also provides a method of quantitating anti-glycolipid antibody levels in solutions. The invention provides a method of diagnosing disease states, including neuro... | 05/04/2004 |
