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| Number | Title | Issue Date |
| 6649403 | Method of preparing a sensor array A system for the rapid characterization of multi-analyte fluids, in one embodiment, includes a light source, a sensor array, and a detector. The sensor array is formed from a supporting member into which a plurality of cavities may be formed. A series of ... | 11/18/2003 |
| 6649361 | Surface plasmon resonance enzyme sensor A surface plasmon resonance enzyme sensor including a sensing part 6 having an optically transparent base 1, a thin metal film 2 made of gold or silver, and a film 4 provided on the metal thin film 2 causing electron transfer reaction with both the thin m... | 11/18/2003 |
| 6649357 | Apparatus and method for detecting and identifying infectious agents Solid phase methods for the identification of an analyte in a biological medium, such as a body fluid, using bioluminescence are provided. A chip designed for performing the method and detecting the bioluminescence is also provided. Methods employing biom... | 11/18/2003 |
| 6649356 | Apparatus and method for detecting and identifying infectious agents Solid phase methods for the identification of an analyte in a biological medium, such as a body fluid, using bioluminescence are provided. A chip designed for performing the method and detecting the bioluminescence is also provided. Methods employing biom... | 11/18/2003 |
| 6649354 | Catalytically generated mass labels The present invention involves a method for assaying a substance. The method of the present invention comprises contacting the substance with an assay agent comprising a catalytic agent to associate the substance with the catalytic agent, contacting the r... | 11/18/2003 |
| 6642007 | Assays for measurement of type II collagen fragments in urine This invention provides novel methods for monitoring urine for type II collagen fragment using a combination of a capture antibody and a detection antibody, such that type II collagen is distinguished from other collagen fragments.... | 11/04/2003 |
| 6635493 | Device for performing an assay, a method for manufacturing said device, and use of a membrane in the manufacture of said device The present invention relates to a device for performing an assay, which device comprises a substrate having oriented through-going channels, said channels opening out on a surface for sample application, the channels in at least one area of the surface f... | 10/21/2003 |
| 6635420 | Purification of substances from a biological sample The invention concerns a method for the purification of a target substance from a biological sample by immobilizing the target substance on a solid phase by means of a high affinity binding pair and subsequently eluting it by adding a partner of the bindi... | 10/21/2003 |
| 6632603 | Non-captive substrate liquid phase immunoassay An immunoassay of a liquid biological specimen for a specific analyte is conducted by forming a test sample by contacting the specimen with: (1) a binding substance of a ligand, antiligand or receptor capable of binding the analyte and (2) a detector subs... | 10/14/2003 |
| 6630358 | Arrays of proteins and methods of use thereof Protein arrays for the parallel, in vitro screening of biomolecular activity are provided. Methods of using the protein arrays are also disclosed. On the arrays, a plurality of different proteins, such as different members of a single protein family, are ... | 10/07/2003 |
| 6627461 | Method and apparatus for detection of molecular events using temperature control of detection environment The present invention provides a method for detecting a molecular event, comprising (1) applying an electromagnetic test signal to a sample in which a molecular event is being detected, whereby the sample interacts with and modulates the test signal to pr... | 09/30/2003 |
| 6627396 | Influenza sensor A sensor for the detection of tetrameric multivalent neuraminidase within a sample is disclosed, where a positive detection indicates the presence of a target virus within the sample. Also disclosed is a trifunctional composition of matter including a tri... | 09/30/2003 |
| 6617142 | Method for attachment of biomolecules to medical device surfaces Methods are provided for forming a coating of an immobilized biomolecule on a surface of a medical device to impart improved biocompatibility for contacting tissue and bodily fluids. A biomolecule such as a glycoprotein having an unsubstituted amide moiet... | 09/09/2003 |
| 6617116 | Assay devices and methods of analyte detection Assay devices, kits, and methods for detection of one or more analytes in a sample are provided. The assay device features the controlled release of reagents and hence is particularly suitable for binding assays such as immunoassays. The assay device achi... | 09/09/2003 |
| 6613895 | System and methods for the rapid isolation of nucleic acids The present invention contemplates a system for rapidly isolating nucleic acids. The system comprises an insoluble silica matrix and a buffered aqueous salt solution containing salt at a concentration of at least 3 molar and a buffering agent at a concent... | 09/02/2003 |
| 6613582 | Methods for rapid and efficient protein cross-linking The present application describes novel uses of ruthenium bipyridyls or palladium porphyrins as photo-activatable crosslinking agents. Crosslinking can be between any two molecules including peptides, proteins, or compounds. Crosslinking occurs in the pre... | 09/02/2003 |
| 6607922 | Immunochromatographic assay method and apparatus An immunochromatographic assay employing superparamagnetic particles to lable the target analytes. An opaque cover prevents misinterpretive readings in field situations and provides a protective surface on the porous membrane. Additional features include ... | 08/19/2003 |
| 6607667 | Method for adsorbing substances using silica adsorbent on magnetic substrate Method for Absorbing substances wherein adsorbent particles comprising superparamagnetic and/or low Curie Temperature transition metal-containing cores surrounded by a hydrous siliceous oxide coating can be formed by an aqueous process wherein the core is... | 08/19/2003 |
| 6602716 | Method and device for referencing fluorescence intensity signals A method and device for fluorimetric determination of a biological, chemical or physical parameter of a sample utilize at least two different luminescent materials, the first of which is sensitive to the parameter, at least with respect to luminescence in... | 08/05/2003 |
| 6602692 | Method for immobilizing biomolecules and affinity ligands on polymer carriers In a method for immobilizing biomolecules and affinity ligands water insoluble matrices, having amino groups and selected from test tubes, microtiter plates, microscope slides, beads, membranes, resins, and filters, are reacted with a cyclobutene carboxyl... | 08/05/2003 |
| 6602661 | Methods and arrays for detecting biomolecules The present invention is directed to a device and a method for detecting biomolecules in a tissue section or other two-dimensional sample by creating "carbon copies" of the biomolecules eluted from the sample and visualizing the biomolecules on the copies... | 08/05/2003 |
| 6599756 | Detection of antibodies to glycosphingolipids using solid-phase reactants coated with carbonyl groups Methods of detecting antibodies to one or more glycosphingolipid(s) of interest in a sample are disclosed which comprise using a solid-phase reactant having carbonyl groups attached thereon, and the glycosphingolipid(s) of interest linked to the solid-pha... | 07/29/2003 |
| 6589731 | Method for detecting biological agents A sensor element is provided including a polymer exhibiting a measurable property from the group of luminescence and electrical conductivity, the polymer being complexed with a unit including a recognition element, a tethering element and a property-alter... | 07/08/2003 |
| 6589726 | Method and apparatus for in situ synthesis on a solid support The present invention relates to methods for fabricating solid supports. More specifically, the present invention features methods for fabricating solid supports for in situ synthesis and for carrying out large numbers of reactions. The present invention ... | 07/08/2003 |
| 6589438 | Method for making microsensor arrays for detecting analytes A device for detection of one or more analytes in a sample is disclosed. The device can simultaneously detect and quantitate multiple analytes in a sample. The device comprises an eletromagnetic radiation generator having one or more chemical sensors ther... | 07/08/2003 |
| 6586259 | Platelet/leukocyte interaction assay and reagent therefor A platelet/leukocyte interaction assay method and reagent therefor are provided using the presence of a solid-phase stimulus, such as magnetic or non-magnetic particles or mixtures thereof, having bound to the surface thereof one or more ligands that inte... | 07/01/2003 |
| 6583191 | Molecularly-imprinted material made by template-directed synthesis A method of making a molecularly imprinted porous structure makes use of a surfactant analog of the molecule to be imprinted that has the imprint molecule portion serving as the surfactant headgroup. The surfactant analog is allowed to self-assemble in a ... | 06/24/2003 |
| 6582971 | Imprinting large molecular weight compounds in polymer composites A method for molecular imprinting polymers with large biomolecules. The imprinted polymer composite is made by the interfacial polymerization of a monomer in the presence of the print molecule and host polymer. Since polymerization occurs at the interface... | 06/24/2003 |
| 6582969 | Microdevices for high-throughput screening of biomolecules Methods for the parallel, in vitro screening of biomolecular activity using miniaturized microfabricated devices are provided. The biomolecules that can be immobilized on the surface of the devices of the present invention include proteins, polypeptides, ... | 06/24/2003 |
| 6582912 | Device, method and apparatus for implementing the method, for dosing at least a particular constituent in a product sample A device for dosing at least a particular constituent in a product sample has a receptacle and a cover assembled to form a closed container having a vertical axis. The receptacle and cover bear coaxial cylindrical walls defining concentric annular chamber... | 06/24/2003 |
| 6579726 | Instruments, methods and reagents for surface plasmon resonance The invention provides methods and reagents for the enhancement of surface plasmon resonance (SPR)-based detection assays. The methods and reagents can be used in any molecular recognition assay that uses a solid support. The invention also provides an SP... | 06/17/2003 |
| 6576429 | Apparatus for intestinal sampling and use thereof An apparatus for taking an intestinal sample of a human or animal patient comprises a holder part (1) and an expandable part (2) supported by the holder part and having one or more sampling areas (8) on the surface thereof. The expandable part (2) is in a... | 06/10/2003 |
| 6573107 | Immunochemical detection of an explosive substance in the gas phase through surface plasmon resonance spectroscopy The biosensor involves a specially designed surface which can be optically coupled to a Surface Plasmon Resonance spectrometer. The key components of the biosensor are a bimetallic layer, a self assembled monolayer of chemicals and a layer of biomolecules... | 06/03/2003 |
| 6569688 | Intravascular apparatus method Intravascular apparatus and method for locally treating a patient's blood vessel, are provided. The apparatus includes an implanted carrier (2) for insertion into the vessel; and a biologically active agent (8) immobilized to the carrier (2), said biologi... | 05/27/2003 |
| 6558944 | High throughput screening assay systems in microscale fluidic devices The present invention provides novel microfluidic devices and methods that are useful for performing high-throughput screening assays. In particular, the devices and methods of the invention are useful in screening large numbers of different compounds for... | 05/06/2003 |
| 6555391 | Methods of conditioning an affinity resin after storage This invention relates methods for conditioning affinity chromatography resins to decrease leaching of the ligand during purification. The methods involve incubating the resin in a buffered solution of a hydroxyalkylamine compound (e.g., ethanolamine) pri... | 04/29/2003 |
| 6555390 | Chromatographic assay or test device A chromatographic assay or test device for detection and/or determination of an analyte in a test sample, comprises a base member, and a chromatographic medium located in or on said base member, the base member being provided with a receptacle to receive ... | 04/29/2003 |
| 6555388 | Binding protein capture assay This invention relates to binding protein assays. In particular, this invention relates to binding protein assays for B12 and folate in serum or plasma. More specifically, this invention provides a sequential assay that uses a combination of specific bind... | 04/29/2003 |
| 6551841 | Device and method for the detection of an analyte utilizing mesoscale flow systems Disclosed are devices for detecting the presence of a preselected analyte in a fluid sample. The devices comprise a substrate microfabricated to define a sample inlet port, and a mesoscale flow system that includes a sample flow channel extending from the... | 04/22/2003 |
| 6548311 | Device and method for detecting analytes The invention relates to a method for detecting analytes and to a device for carrying out the method, for use for analysis or diagnosis in the fields of chemistry, biochemistry, molecular genetics, food chemistry, biotechnology, the environment and medici... | 04/15/2003 |
