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| Number | Title | Issue Date |
| 8187895 | Small volume in vitro analyte sensor and methods of making A sensor utilizing a non-leachable or diffusible redox mediator is described. The sensor includes a sample chamber to hold a sample in electrolytic contact with a working electrode, and in at least some instances, the sensor also contains a non-leachable or a diffus... | 05/29/2012 |
| 8183058 | Target substance detection element, target substance detection method, and method for producing target substance detection element It is intended to provide a target substance detection element wherein a target substance capturing body for capturing target substances is immobilized with good orientation in a desired region on the surface of the target substance detection element, a method for p... | 05/22/2012 |
| 8183059 | Device for detection of target molecules and uses thereof Devices and methods for the detection of antigens are disclosed. Devices and methods for detecting food-borne pathogens are disclosed. ... | 05/22/2012 |
| 8183057 | Biomaterial construct, its producing method, biomaterial support, target material purifying method, affinity chromatography container, separation chip, analyzing method and analyzing separator for target material, biomaterial complex, and its support, sensor chip, solid support with biomaterial fixed thereon A biomaterial structure containing a larger amount of biomaterial than the conventional art with maintaining the reactivity of the biomaterial is provided by linking particulate lumps in which the biomaterial is bound with a compound capable of binding to the biomat... | 05/22/2012 |
| 8178359 | Masking of the background fluorescence and luminescence in the optical analysis of biomedical assays A process for the quantitative optical analysis of fluorescently labeled biological cells involves contacting a cell layer on a transparent support at the bottom of a reaction vessel with a solution containing the fluorescent dye. This process can also be used for i... | 05/15/2012 |
| 8168446 | Monoclonal and polyclonal antibodies to equine albumin and hemoglobin and apparatus and methods using the antibodies in the identification and localization of ulcers and other digestive tract bleeding in equines A diagnostic and testing apparatus and related methods for the use of the same are disclosed which derive and use antibodies to equine albumin and equine hemoglobin in testing apparatus, kits, and methods for detecting and localizing gastric and colonic ulcers or bl... | 05/01/2012 |
| 8168445 | Use of metal complexes A method of immobilizing a target molecule on a substrate, which comprises exposing the target molecule to the substrate in the presence of a metal complex, wherein the target molecule is an unmodified target molecule, and wherein the metal complex is selected to pr... | 05/01/2012 |
| 8163566 | Microporous materials, methods of making, using, and articles thereof Described herein are methods for separating one or more analytes present in a fluid sample. The methods involve passing the fluid through or into a microporous material, wherein the analytes are localized near the surface of the microporous material. Additional proc... | 04/24/2012 |
| 8163567 | Methods and compositions comprising capture agents The present invention relates to methods and compositions for detecting a substance using mixed or multiple element capture agents (MECA). The affinity of a MECA for a target is produced by the concomitant binding of at least two low to moderate affinity capture age... | 04/24/2012 |
| 8163568 | Recording assay device A method for assaying a sample involves an assessment device having an assay part and a detachable recording part, which are disposed on separable portions of a substrate. The sample to be assayed is received in a sample application well on the assay element, where ... | 04/24/2012 |
| 8158443 | Turbidimetric immunoassay for assessing human Cystatin C There is a demand for improved turbidimetric immunoassays for human Cystatin C in biological samples, especially in human clinical samples of body fluids. The present invention provides a turbidimetric immunoassay method and reagent set enabling measurement of human... | 04/17/2012 |
| 8153444 | Immuno gold lateral flow assay A chromatographic specific binding assay strip device, comprising: a non-permeable platform strip; a permeable membrane testing strip positioned on top of said non-permeable platform strip, with the testing strip comprising at least one capture reagent site containi... | 04/10/2012 |
| 8148171 | Multiplexed analysis of clinical specimens apparatus and methods A method for the multiplexed diagnostic and genetic analysis of enzymes, DNA fragments, antibodies, and other biomolecules comprises the steps of constructing an appropriately labeled beadset, exposing the beadset to a clinical sample, and analyzing the combined sam... | 04/03/2012 |
| 8148172 | Methods for ionophorically screening pore forming bacterial protein toxins and receptors One embodiment of the present invention is directed to methods for ionophorically screening pore forming bacterial protein toxins and receptors. The method includes: a) forming a membrane comprising a lipid and a receptor, b) contacting the membrane with the pore fo... | 04/03/2012 |
| 8143071 | Method and device for extracting an analyte The invention provides columns and methods for the purification and concentration of an analyte (e.g., a biological macromolecule, such as a peptide, protein or nucleic acid) from a sample solution. The columns typically include a bed of extraction medium positioned... | 03/27/2012 |
| 8137986 | Non-liquid phase type chemiluminescent enzyme immunoassay method and assay kit A chemiluminescent enzyme immunoassay method whereby a target substance such as a protein is assayed. This chemiluminescent enzyme immunoassay method comprises: the step of capturing an immune complex containing an enzyme-labeled antibody, which is labeled with an e... | 03/20/2012 |
| 8137987 | Simultaneous assay for determining drugs Bodily fluid is analyzed for the presence of drugs of a selected panel of drugs in a simultaneous assay in which sample of the fluid is incubated with additional amounts of all drugs of the panel, antibodies specific to each of the drugs of the panel, and microparti... | 03/20/2012 |
| 8129198 | Porous substrate plates and the use thereof A substrate plate or device adapted for use with biological or chemical assays is disclosed. The device may take the form of a multi-well plate having a three-dimensional, porous layer as part of a support surface within each well for immobilizing probe species. The... | 03/06/2012 |
| 8110406 | Analytical method and analytical apparatus [PROBLEMS] To reduce the amount of, for example, a capturing antibody to be employed without lowering detection sensitivity. At the same time, to enable the achievement of intense color development or light emission in a determination area even in the case where onl... | 02/07/2012 |
| 8105846 | Methods using pores The invention relates to a method of identifying an individual nucleotide, comprising (a) contacting the nucleotide with a transmembrane protein pore so that the nucleotide interacts with the pore and (b) measuring the current passing through the pore during the int... | 01/31/2012 |
| 8105845 | System and method for carrying out multiple binding reactions in an array format A method for determining one or more kinetic parameters of binding between a first binding member and a second binding member. The method comprises adsorbing the first binding member to a surface at a plurality of microspots. The second binding member is then presen... | 01/31/2012 |
| 8101430 | Fluorescent sensor based on two fluorescent moieties one of which is a semiconductor nanocrystal and methods of using and making Binding an analyte can cause a change in fluorescence emission of a sensor. The change in fluorescence can be related to the amount of analyte present. The sensor can include a semiconductor nanocrystal linked to a fluorescent moiety. Upon excitation, the fluorescen... | 01/24/2012 |
| 8084274 | Programmable illumination pattern for transporting microparticles An apparatus providing programmable illumination pattern generation for the manipulation of colloidal particulates and biomolecules in suspension between electrodes is disclosed. The apparatus implements LEAPS (light-controlled electrokinetic assembly of particles n... | 12/27/2011 |
| 8071394 | Test device for detecting an analyte in a liquid sample The present invention relates to test devices, and in particular devices capable of detecting the presence or absence of an analyte in a sample, such as a liquid sample. Also provided are methods of using such devices for quantitative or qualitative measurement of o... | 12/06/2011 |
| 8071393 | Method of analyzing nucleic acids using an array of encoded beads A method and apparatus for the manipulation of colloidal particulates and biomolecules at the interface between an insulating electrode such as silicon oxide and an electrolyte solution. Light-controlled electrokinetic assembly of particles near surfaces relies on t... | 12/06/2011 |
| 8067246 | Diagnostic testing process A method and apparatus for use in a flow through assay process is disclosed. The method is characterised by a “pre-incubation step” in which the sample which is to be analyzed (typically for the presence of a particular protein), and a detection analyte (typical... | 11/29/2011 |
| 8043868 | Method and apparatus for detecting an analyte A method for determining a concentration of an analyte is provided. The method includes providing a substrate including a conductive region and a recognition layer where the conductive region has a first surface operatively coupled with the recognition layer; The me... | 10/25/2011 |
| 8039269 | Mechanically induced trapping of molecular interactions The invention provides devices and methods for surface patterning the substrate of a microfluidic device, and for detection and analysis of interactions between molecules by mechanically trapping a molecular complex while substantially expelling solvent and unbound ... | 10/18/2011 |
| 8039270 | Apparatus and method for performing ligand binding assays on microarrays in multiwell plates Ellipsometry systems for imaging binding events between analytes in a sample and an array of ligands in an evanescent field generated by a beam of light reflected from the plane of the ligands is adapted to a multiwell plate structure in common use. In one example, ... | 10/18/2011 |
| 8034630 | Protein capable of binding to hyaluronic acid, and method for measurement of hyaluronic acid using the same The present invention relates to a polynucleotide encoding a protein comprising an amino acid sequence shown in SEQ ID NO: 2, wherein the protein encoded by the polynucleotide has a hyaluronic acid binding ability, the protein, a method for measuring hyaluronic acid... | 10/11/2011 |
| 8030092 | Controlled electrophoresis method An electrophoresis apparatus is generally disclosed for sequentially analyzing a single sample or multiple samples having one or more analytes in high or low concentrations. The apparatus comprises a relatively large-bore transport capillary which intersects with a ... | 10/04/2011 |
| 8030093 | Dispensing mechanism, dispensing apparatus and dispensing method for liquid to be dispensed There is provided a dispensing mechanism for a liquid to be dispensed that does not damage microspherical bodies such as an erythrocyte and a liposome in the liquid to be dispensed when the liquid to be dispensed such as a sample and test liquid is sucked/discharged... | 10/04/2011 |
| 8021894 | Retentate chromatography and protein chip arrays with applications in biology and medicine This invention provides methods of retentate chromatography for resolving analytes in a sample. The methods involve adsorbing the analytes to a substrate under a plurality of different selectivity conditions, and detecting the analytes retained on the substrate by d... | 09/20/2011 |
| 8012770 | Device for detection of antigens and uses thereof Devices and methods for the detection of antigens are disclosed. Devices and methods for detecting food-borne pathogens are disclosed. ... | 09/06/2011 |
| 8008094 | Methods for analyzing interactions between proteins and sugar chains As a result of investigating the optimum conditions of methods for immobilizing proteins that interact with sugar chains onto a substrate, it was revealed that coating the surface of a slide glass with GTMS enables immobilization at a higher S/N ratio than conventio... | 08/30/2011 |
| 7998754 | In vitro method for the simultaneous detection and identification of antibiotics of different classes and corresponding diagnostic kit The invention concerns a diagnostic kit for simultaneous assay of antibiotics of different classes. The kit contains a single reaction mixture containing at least one first labelled receptor, specific of recognition of β-lactams, a second labelled receptor, specifi... | 08/16/2011 |
| 7989218 | Protein fragment complementation assays for the detection of biological or drug interactions The present invention describes a method for detecting biomolecular interactions said method comprising: (a) selecting an appropriate reporter molecule selected from the group consisting of a protein, a fluorescent protein, a luminescent protein and a phosphorescent... | 08/02/2011 |
| 7989219 | Bispecific capturing molecule A capturing molecule having an association containing a plurality of polypeptide chains that specifically bind to different sites of a target substance, characterized in that each of the polypeptide chains has a domain having a hypervariable loop structure at a bind... | 08/02/2011 |
| 7981694 | Solid phase isolation of proteins, nucleic acids and other macromolecules The invention is a method for the isolation of molecules of interest using tubes in which at least a portion of the inner walls of the tube are coated with microbeads that are coated with a capture reagent to bind the molecule of interest. The microbeads may be glas... | 07/19/2011 |
| 7977119 | Chemical arrays and methods of using the same Methods and compositions for generating mixtures of product molecules from an initial chemical array are provided. In the subject methods, a chemical array of surface immobilized first moieties is subjected to cleavage conditions such that a composition of solution ... | 07/12/2011 |
