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| Number | Title | Issue Date |
| 7018849 | Process for (A) separating biological/ligands from dilute solutions and (B) conducting an immunochromatographic assay thereof employing superparamagnetic particles throughtout Superparamagnetic (“SPM”) subunits of 1–30 nm average mean diameter (e.g. ferro fluid) subparticles are treated with a magnetically noninterfering substance capable of coating and covering them (e.g, BSA) and they spontaneously form agglomerates of about 100 n... | 03/28/2006 |
| 7018847 | Assay device with timer function An assay device for determining an analyte in an aqueous sample comprises: (i) an elongate flow matrix (6) allowing lateral transport of fluid therethrough by capillary action, wherein the matrix comprises a liquid application zone (3) and downstream t... | 03/28/2006 |
| 7015030 | Microfluidic devices and uses thereof in biochemical processes Provided is a microfluidic device comprising a microfluidic substrate comprising at least one pathway for sample flow; and at least one thermal transfer member which is capable of cycling between at least two temperatures. The thermal transfer member is adapted to h... | 03/21/2006 |
| 7015471 | Surface plasmon resonance systems and methods having a variable charge density layer A device for detecting the presence of a member of a specific binding pair in a sample includes a substrate and a variable charge density layer having a surface adjacent to the substrate and a surface remote from the substrate. A first member of a specific binding p... | 03/21/2006 |
| 7011955 | Quantitative determination of analytes in a heterogeneous system The invention concerns a method for quantitative or qualitative determination of an analyte or its interaction or reaction kinetics in a system with at least two different phases, comprising the step of taking at least one measurement signal from at least one of the... | 03/14/2006 |
| 7011954 | Diagnostics based on tetrazolium compounds A reagent is suitable for measuring the concentration of an analyte in a hemoglobin-containing biological fluid, such as whole blood. The reagent comprises a flavin-dependent enzyme that has specificity for the analyte, a flavin cofactor if, and only if, a flavin is... | 03/14/2006 |
| 7011940 | Quality control for cytochemical assays The invention describes quality control devices for assays that measure analytes in cells and tissue samples, and methods of use thereof. In particular, the quality control device comprises a matrix affixed with synthetic controls in different concentrations, or dif... | 03/14/2006 |
| 7008799 | Analytical test element with a capillary channel The invention concerns an analytical test element for the determination of an analyte in a liquid containing an inert carrier, a detection element and a channel capable of capillary liquid transport which has a sample application opening at one end and a vent openin... | 03/07/2006 |
| 7005292 | Device and method for the detection of an analyte utilizing mesoscale flow systems Disclosed are devices for detecting the presence of a preselected analyte in a fluid sample. The devices comprise a substrate microfabricated to define a sample inlet port, and a mesoscale flow system that includes a sample flow channel extending from the inlet port... | 02/28/2006 |
| 7001775 | Assays for autoantibodies A method and kit for screening a sample of body fluid for at least one autoantibody to at least one antigen. A source of at least one antigen to the autoantibody is provided. A substrate having immobilized thereto at least one antibody to the antigen is also provide... | 02/21/2006 |
| 6998246 | Method for immobilizing conjugates in diagnostic tests The invention concerns a method for the detection of an analyte in a sample using analyte-specific conjugates which have at least one heterologous group for an analyte-independent binding to a control zone. The present invention additionally provides new conjugates ... | 02/14/2006 |
| 6998273 | Collection device for lateral flow chromatography A device for collecting oral liquids includes a lateral flow chromatography strip having a collection pad for insertion into the mouth. The collection pad is separated from the remainder of the chromatography strip by a liquid impermeable removable barrier which pre... | 02/14/2006 |
| 6991909 | Enkurin and uses thereof A novel protein, enkurin, that is preferentially expressed in sperm has been discovered. Enkurin binds to TRPCs including TRPC2-S, a protein encoded by TRPC2 that is not predicted to be a calcium channel subunit. The invention includes methods of identifying compoun... | 01/31/2006 |
| 6991912 | Systems and methods for performing magnetic chromatography assays Novel magnetic assay methods and systems. According to a preferred embodiment, a chromatographic medium, which preferably comprises a test strip, is provided that is designed to be contacted with a test solution having activated magnetic particles such that the solu... | 01/31/2006 |
| 6991940 | Diagnostic sanitary test strip An improved multi-layered diagnostic sanitary test strip for receiving a heterogenous fluid, such as whole blood, to test for presence and/or amount of a suspected analyte in the fluid by facilitating a color change in the strip corresponding to the amount of the an... | 01/31/2006 |
| 6989237 | Capillary array and related methods The invention provides methods and devices for detecting the presence of one or more target analytes in a sample employing a channel having affixed therein one or more binding partners for each target analyte. Assays are carried out by transporting the sample throug... | 01/24/2006 |
| 6986994 | INGAP displacement assays An antibody is provided which specifically recognizes and binds to INGAP protein. The antibody is used in competitive binding assays for quantitation of INGAP in biological samples. The assay can be performed on a solid support or in a suspension. ... | 01/17/2006 |
| 6979576 | Methods of use of one step immunochromatographic device for Streptococcus A antigen A method to determine the presence or absence of Streptococcus Group A antigen in a sample, comprising the following steps: extracting the antigen from the sample in an assay chamber with two or less extraction reagents, wherein the two reagents may be added to the ... | 12/27/2005 |
| 6979567 | Apparatus and methods for multi-analyte homogeneous fluoro-immunoassays Methods and apparatus for evanescent light fluoroimmunoassays are disclosed. The apparatus employs a planar waveguide with an integral semicylindrical lens, and has multi-analyte features and calibration features, along with improved evanescent field intensity. A pr... | 12/27/2005 |
| 6977173 | Apparatus and method for analyte detection Disclosed is a testing device and methods for the identification of an analyte of interest in a sample. In a preferred embodiment, the testing device includes a front panel having at least one sample application aperture; a rear panel having at least one solvent app... | 12/20/2005 |
| 6977163 | Methods and systems for performing multiple reactions by interfacial mixing Methods and systems of performing multiple reactions in a high throughput format by utilizing interfacial mixing of adjacently positioned reagent slugs in a fluid conduit. Preferred applications of the methods and systems are in performing biochemical analyses, incl... | 12/20/2005 |
| 6967081 | Method for prediction of bone fractures by osteocalcin measurements This invention concerns a method for the assessment of bone fragility and fracture risk, or osteoporosis, in a person. In said method, the concentration of gamma-carboxylated osteocalcin (COC) and optionally also the concentration of intact or total osteocalcin (IOC... | 11/22/2005 |
| 6967082 | Monoclonal antibody The present invention relates to a monoclonal antibody suitable for monitoring the activity of systems involving protein C inhibitor, a method for preparation of the monoclonal antibody, a method for monitoring the activity of systems involving protein C inhibitor a... | 11/22/2005 |
| 6967489 | Method and apparatus for controllably effecting samples using two signals Methods and systems for effecting a parameter and detecting a parameter using two electric signal in a conductive path are described. ... | 11/22/2005 |
| 6964747 | Production of dyed polymer microparticles A dye, such as a fluorescent dye, is incorporated into polymer microparticles using a solvent system composed of a first solvent in which the dye and the microparticle polymer are soluble, a second solvent in which the dye and the microparticle polymer are not or on... | 11/15/2005 |
| 6960467 | Biochannel assay for hybridization with biomaterial The invention relates to a microfluidic device with microchannels that have separated regions which have a member of a specific binding pair member such as DNA or RNA bound to porous polymer, beads or structures fabricated into the microchannel. The microchannels of... | 11/01/2005 |
| 6958119 | Mobile phase gradient generation microfluidic device The present invention relates to a microfluidic device for separating the components of a fluid sample. A cover plate is arranged over the first surface of a substrate, which, in combination with a microchannel formed in the first surface, defines a separation condu... | 10/25/2005 |
| 6955924 | Laminin chains: diagnostic uses The instant invention provides for the identification, diagnosis, monitoring, and treatment of invasive cells using the laminin 5 gamma-2 chain protein or nucleic acid sequence, or antibodies thereto. ... | 10/18/2005 |
| 6951715 | Optical detection of label-free biomolecular interactions using microreplicated plastic sensor elements Methods and compositions are provided for detecting biomolecular interactions. The use of labels is not required and the methods can be performed in a high-throughput manner. The invention also provides optical devices useful as narrow band filters. ... | 10/04/2005 |
| 6951631 | Test kits and devices A test kit for determining qualitatively or quantitatively the presence of one or more analytes in a fluid sample, comprising an assay device together with a reading device which engages with the assay device and wherein precisely located engagement of the assay dev... | 10/04/2005 |
| 6949221 | Method of making a test strip for determining analyte concentration over a broad range of sample volumes A test strip for determining the concentration of an analyte in a body fluid includes a membrane in fluid communication with a porous layer. The membrane and the porous layer are divided into compressed portions, which restrict the capillary flow of the body fluid, ... | 09/27/2005 |
| 6949347 | Multiplex analysis using membrane-bound sensitizers The present invention is directed to methods and compositions for determining the presence, absence, and/or amounts of one or more membrane-associated analytes in a sample. In accordance with the invention, binding compounds derivatized with releasable molecular tag... | 09/27/2005 |
| 6942778 | Microstructure apparatus and method for separating differently charged molecules using an applied electric field The field of the present invention relates generally to a microstructure apparatus which may be used in a high-throughput screening context to monitor the rate of reaction of an enzyme with its substrate in cases where the product of the reaction has an altered net ... | 09/13/2005 |
| 6936763 | Magnetic shielding for electronic circuits which include magnetic materials Shielded electronic integrated circuit apparatus (5) includes a substrate (10), with an eletronic integrated circuit (15) formed thereon, and a dielectric region (12) positioned on the electronic integrated circuit. The dielectric region ... | 08/30/2005 |
| 6936476 | Point of care diagnostic systems Systems and methods for medical diagnosis or risk assessment for a patient are provided. These systems and methods are designed to be employed at the point of care, such as in emergency rooms and operating rooms, or in any situation in which a rapid and accurate res... | 08/30/2005 |
| 6927068 | Rapid and non-invasive method to evaluate immunization status of a patient An assay method and kit for detecting the presence of a predesignated, target IgG antibody in a sample selected from one or more patient bodily fluids. The method comprises the following steps: (a) contacting the sample of one or more patient bodily fluids with a me... | 08/09/2005 |
| 6927064 | Fertility computing method A fertility determining system employing hormone level measuring apparatus on selected days in a menstrual cycle to determine the levels of analytes, i.e., estrone-3-glucuronide (“E3G”) and luteinizing hormone (“LH”), in early morning urine. The fertility/in... | 08/09/2005 |
| 6924153 | Quantitative lateral flow assays and devices This invention provides solid phase specific binding lateral flow assay methods, devices and kits for quantitating high and low molecular weight analytes. The methods and devices of the invention employ labelled reagents which are either analyte analogs or complemen... | 08/02/2005 |
| 6925392 | Method for measuring fluid chemistry in drilling and production operations A method for chemical analysis of fluids utilized in hydrocarbon exploration and production in which microfluidic systems designed to react to specific characteristics of a fluid are introduced into fluid samples or during operations. The microfluidic systems are th... | 08/02/2005 |
| 6923939 | Heat activated membrane introduction apparatus and method for screening materials A process and apparatus for rapidly screening materials using, for example, mass spectrometry has been developed. More specifically, an array of materials on a fluid permeable support contained within a reaction cell having a semipermeable membrane can be rapidly sc... | 08/02/2005 |
