Did You Know...
...that the x-ray was discovered purely by accident? When German physicist Wilhelm Konrad von Roentgen was experimenting with cathode rays in 1895, he put an activated Crookes tube in a book and went out to lunch. When he returned, he discovered that a key that had also been placed in the book showed up as an image on the developed film!
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| Number | Title | Issue Date |
| 6720152 | Diagnosis of histoplasmosis using antigens specific for H. capsulatum A method for identifying a protein antigen to a target fungus is disclosed. The method comprises screening expressed proteins from a cDNA gene expression library with antisera to the target fungus and cross-screening with antisera to a nontarget fungus. Antibodies t... | 04/13/2004 |
| 6716641 | Dipstick for carbohydrate-free transferrin assay The invention relates to a new dipstick assay for detecting and quantifying the content of an target analyte in a sample. The assay is particularly useful for example in the diagnosis and monitoring of alcoholism by the detection of asialo transferrin or carbohydrat... | 04/06/2004 |
| 6716640 | Stabilization and amplification of electrochemiluminescence signals The invention concerns the stabilization and amplification of electrochemiluminescence signals in detection methods. ... | 04/06/2004 |
| 6716639 | Immunoassay apparatus for detecting nicotine or continine The invention relates to an immunoassay apparatus, comprising a dry, porous substrate having at least two sections (1, 2), communicating with one another in the moist state by capillary action, wherein the first section (1) has a marked detection reage... | 04/06/2004 |
| 6713308 | System for electrochemical quantitative analysis of analytes within a solid phase The analytical process utilized in the system of this invention comprises three (3) step distinct steps wherein an analyte of interest in a test sample is initially labeled and subsequently isolated within a porous medium of a test device. Once isolated within the m... | 03/30/2004 |
| 6713256 | Fluorescent energy transfer mediated chemical activation (fetma) for the elucidation of the three-dimensional structure of biomacromolecules The present invention relates to a method for the selected chemical activation of photo-activatable cross-linker molecules around ligand binding pockets and fluorescent groups in macromolecules, especially biological macromolecules, by using fluorescent ligands of t... | 03/30/2004 |
| 6706539 | Enzyme substrate delivery and product registration in one step enzyme immunoassays One-step enzyme immunoassays in which enzyme-antibody conjugate or label and enzyme substrate are separated until separation of bound and free enzyme conjugate or label is complete. This separation is accomplished by using variable flow paths, immobilization of subs... | 03/16/2004 |
| 6703205 | Apparatus and methods for correcting for variable velocity in microfluidic systems Electrokinetic devices having a computer for correcting for electrokinetic effects are provided. Methods of correcting for electrokinetic effects by establishing the velocity of reactants and products in a reaction in electrokinetic microfluidic devices a... | 03/09/2004 |
| 6703196 | General purpose structure of an analytical element and its application for analyte determination The invention concerns an analytical element for the determination of an analyte containing in or on material which enables liquid transport between zones, a sample application zone and a detection zone located downstream thereof, wherein the detection zo... | 03/09/2004 |
| 6699722 | Positive detection lateral-flow apparatus and method for small and large analytes Methods and devices for the detection and/or quantification of an analyte in a sample are provided. These are positive detection methods and devices, in that the more analyte is present in the sample, the stronger the signal that is provided. Devices of t... | 03/02/2004 |
| 6696264 | Method and apparatus for detection of multiple biological materials with a heterogeneous antibody mixture The present invention relates to bioassay materials useful for the detection of toxic substances and, more particularly, to packaging materials for food and other products, along with methods for their manufacture and use. The invention provides a unique ... | 02/24/2004 |
| 6692923 | Tapasin-like protein The invention provides a cDNA which encodes tapasin-like protein. It also provides for the use of the cDNA, protein, and antibody in the diagnosis, prognosis, treatment and evaluation of therapies for cancer. The invention further provides vectors and hos... | 02/17/2004 |
| 6686167 | Test device for detecting semen and method of use A test device (20) for detecting semen includes a strip (22) having an introduction station (24), a test station (26), and a control station (28) disposed in spaced apart relationship. The introduction station (24) has labeled p30 antibodies, the test sta... | 02/03/2004 |
| 6682942 | Microdevices for screening biomolecules Methods for the parallel, in vitro screening of biomolecular activity using miniaturized microfabricated devices are provided. The biomolecules immobilized on the surface of the devices employed in the method of the present invention include proteins, pol... | 01/27/2004 |
| 6673628 | Analytical test device and method An analytical test device is described for the immunochromatographic determination of the presence of one or more analytes in fluid samples. The device is configured such that the sample is allowed to enter the detection zone simultaneously from many diff... | 01/06/2004 |
| 6673561 | Diagnostic test for thrombotic or thromboembolic disease Thrombotic or thromboembolic disease is detected or monitored by determining the presence or amount B in a urine sample.... | 01/06/2004 |
| 6667160 | Method for diagnosing immunologic food sensitivity The invention includes novel methodology for diagnosing immunologic food or drug sensitivities. A method for diagnosing food sensitivities includes using diagnoses of other related disorders as indicators in the diagnosis of the food sensitivity. Addition... | 12/23/2003 |
| 6664114 | Solid phase assay for detection of ligands The present invention provides an improved system for detecting the presence or level of an analyte in a sample. In "competition-like" assays of the present invention, a sample including an analyte is mixed with a second ligand to which the analyte binds,... | 12/16/2003 |
| 6660534 | IgG antibody testing method A method of determining the concentration of IgG antibodies in the biological fluids of mammals. The assay may be performed in a lateral flow cassette or dipstick format where dehydrated immobilized reagents are spaced along a membrane. A sample of a mamm... | 12/09/2003 |
| 6660488 | Antibodies for the alpha platelet-derived growth factor receptor Discoveries are disclosed that show particular aspects of recombinant DNA technology can be used successfully to produce a hitherto unknown type of human Platelet-Derived Growth Factor (PDGF) receptor protein free of other PDGF receptors. These proteins c... | 12/09/2003 |
| 6656745 | Devices and methods for a multi-level, semi-quantitative immunodiffusion assay The present invention relates to an immunoassay device featuring a semi-quantitative, multi-level method for determining the presence and an amount of an analyte. The immunoassay involves a device comprising a layer with a porous medium deposited thereon.... | 12/02/2003 |
| 6656744 | One-step lateral flow assays The efficiency and accuracy of one-step lateral flow assays can be improved by employing more efficient binding between participants in labeling and capture. Thus, in addition to analyte/anti-analyte interactions, specific binding is achieved through memb... | 12/02/2003 |
| 6649419 | Method and apparatus for protein manipulation A method and apparatus for extracting, identifying, and manipulating proteins or peptides from a solution uses paramagnetic beads having a coating with an affinity for the target component. In one embodiment, paramagnetic beads coated with C18 are used to... | 11/18/2003 |
| 6649418 | Internally referenced competitive assays The present invention provides internally calibrated competitive assays for use on a solid support. Additionally, the invention provides a method of using such assays.... | 11/18/2003 |
| 6641993 | Aspirating and mixing of liquids within a probe tip Apparatus and a method for mixing a liquid within a disposable aspirating probe tip so that most of the liquid is forced to move past a transition zone between two different inside diameters to cause rotational mixing. The apparatus and method can be used... | 11/04/2003 |
| 6632619 | Microfluidic system and methods of use This invention relates to a novel microfluidic device and methods of using this device to conduct in vitro studies on the reaction and effects of various compounds on cells. More particularly, it relates to a method for using stop flow in a microfluidic s... | 10/14/2003 |
| 6627459 | Immunoassay controls A device and method for performing a rapid immunoassay for a biological analyte containing a positive control analyte which is concurrently tested using the same device and immunochemical reaction as the biological analyte. The positive control analyte is... | 09/30/2003 |
| 6627446 | Robotic microchannel bioanalytical instrument A substrate with a plurality of microchannels is movably deployed with other movable objects that will load sample into the microchannels, stimulate molecular migration, read the results of the migration, remove and replace the substrate, and prepare for ... | 09/30/2003 |
| 6623984 | MEMS-based integrated magnetic particle identification system The present invention provides a MEMS-based integrated particle identification system having a substrate, a magnetic structure, and a bioferrograph. The substrate includes a topside portion, backside portion and a flow system. The flow system includes a f... | 09/23/2003 |
| 6617116 | Assay devices and methods of analyte detection Assay devices, kits, and methods for detection of one or more analytes in a sample are provided. The assay device features the controlled release of reagents and hence is particularly suitable for binding assays such as immunoassays. The assay device achi... | 09/09/2003 |
| 6613581 | Microfluidic analytic detection assays, devices, and integrated systems Methods of detecting a component of interest, such as a protein, in a microfluidic system are provided. The methods include the use of a component-binding moiety specific to the component of interest, such as an antibody, to detect the component of intere... | 09/02/2003 |
| 6613512 | Apparatus and method for correcting for variable velocity in microfluidic systems Electrokinetic devices having a computer for correcting for electrokinetic effects are provided. Methods of correcting for electrokinetic effects by establishing the velocity of reactants and products in a reaction in electrokinetic microfluidic devices a... | 09/02/2003 |
| 6607922 | Immunochromatographic assay method and apparatus An immunochromatographic assay employing superparamagnetic particles to lable the target analytes. An opaque cover prevents misinterpretive readings in field situations and provides a protective surface on the porous membrane. Additional features include ... | 08/19/2003 |
| 6605476 | Immunochromatographic assay device A chromatography immunoassay device is described which can be used more easily, is protected from moisture and/or oxygen more effectively and can be produced at a lower cost than known chromatography immunoassay devices. The chromatography immunoassay dev... | 08/12/2003 |
| 6599754 | Biphasic reaction vessel and methods of use A reaction vessel and method of identifying a ligand having affinity for a target molecule are disclosed. The reaction vessel includes a first member defining a first chamber, the first chamber including an organic solvent and a plurality of reactants whi... | 07/29/2003 |
| 6599708 | Immunologically based strip test utilizing ionophore membranes A testing apparatus 10 having an absorbent matrix 12, including a membrane 14 which contains a plurality of counter-ions 16. Chromionophore (or fluorionophore)s 18 and affinophores 22 compete to carry ions into the membrane 14 and neutralize the charge of... | 07/29/2003 |
| 6596545 | Microdevices for screening biomolecules Devices for the parallel, in vitro screening of biomolecular activity using miniaturized microfabricated devices are provided. The biomolecules immobilized on the surface of the devices of the present invention include proteins, polypeptides, polynucleoti... | 07/22/2003 |
| 6596502 | Kit and method for detecting fecal parasites The invention concerns a home kit and a method for detection of the presence of a fecal parasite in a stool.... | 07/22/2003 |
| 6593085 | Assay method and apparatus A method of assaying for an analyte including the steps of: (i) passing a sample suspected of containing an analyte and reagents comprising a target ligand-analyte receptor conjugate and a detectable tracer containing a label for the analyte through filte... | 07/15/2003 |
| 6589754 | Immunoassay element and process for immunoassay An immunoassay element for quantitatively analyzing a macromolecular antigen by determining the change in enzymatic activity caused by a reaction between the macromolecular polymer antigen and an enzyme-labelled antibody. The immunoassay element comprises... | 07/08/2003 |
