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| Number | Title | Issue Date |
| 7413892 | Systems and methods for molecular recognition Acoustic wave devices coated with a biolayer are described for the detection target bio-molecules. The acoustic wave device is connected in an oscillator circuit, and the frequency shift Δf resulting from a biomolecular event is recorded. Further described are the ... | 08/19/2008 |
| 7407764 | Plasma C5A levels as an indicator of asthma severity This invention provides the first blood test which characterizes asthma severity. More specifically, the present invention provides methods of determining the severity of acute asthma in a patient by determining the levels of C5a or C5a-desArg in the patient's blood... | 08/05/2008 |
| 7399470 | Sandwich immunoassay kits for detecting ciguatoxin CTX3C A sandwich immunoassay kit for detecting ciguatoxins based on a combination of two anti-ciguatoxin CTX3C monoclonal antibodies produced by hybridomas, 3D11 (deposited at IPOD, AIST under accession number FMRM PB-8293) and 10C9 (FMRM PB-8292). In particular, one of t... | 07/15/2008 |
| 7393697 | Diagnostic test for analytes in a sample Diagnostic devices and methods are provided. The diagnostic devices preferably comprise a test strip with a test area. The sample to be analyzed contacts the test area, which comprises a specific binding partner for the analyte of interest. Analyte, if present in th... | 07/01/2008 |
| 7361480 | Method and means for detecting gluten-induced diseases The invention is directed to a method of detecting gluten-induced diseases such as e.g. celiac disease and dermatitis herpetiformis. Said diseases are indicated by the presence of autoantibodies against tissue transglutaminase tTG in the blood The test is carried ou... | 04/22/2008 |
| 7361479 | Assay The present invention provides a method of determining the presence or amount of newly synthesized antibody in a sample in response to an immunogen by detecting the released antibodies or parts thereof in a sample containing lymphocytes which have been disrupted whe... | 04/22/2008 |
| 7358058 | Method and agents for the diagnosis and therapy of chronic inflammatory intestinal disease Methods for diagnosis, early diagnosis, differential diagnosis, assessment of the severity and therapy-accompanying monitoring and prognosis of chronically inflammatory intestinal diseases (Crohn's disease, Colitis ulcerosa), in which the presence and/or the ... | 04/15/2008 |
| 7341839 | Diagnostic methods for age related macular degeneration Diagnostic methods for identifying a test subject who has or is at risk of developing age-related macular degeneration (AMD) or an analogous disease associated with oxidation of DHA-containing lipids are provided. In one aspect, the methods comprise: assaying for th... | 03/11/2008 |
| 7329536 | Piezoimmunosensor An apparatus comprising one or more piezoelectric mass sensors for use in diagnostic and analytic processes, in particular for immunochemical detection of diagnostically relevant analytes in real time, is described. Each piezoelectric mass sensor comprises a piezoel... | 02/12/2008 |
| 7315378 | Optical arrangement for assay reading device Disclosed, in one aspect, is an assay result reading device for reading the result of an assay performed using a test strip, the device comprising: a light source or sources, said light source/s emitting light incident upon at least two, spatially separated zones of... | 01/01/2008 |
| 7306919 | Antigen-antibody cancer recognition system A method for the isolation and purification of a cancer recognition (CARE) antigen about 66,000 Dalton molecular weight with a pH between 4.5 and 6.5, and detection of antibodies to this CARE antigen (CARE antibody). The CARE antigen and CARE antibody are cancer mar... | 12/11/2007 |
| 7300633 | Specimen collection container The present invention recognizes that sample handling devices, particularly those used for testing for substances of abuse, do not allow for a separation of the bulk sample from a sample thereof to be tested. The present invention provides such a device and methods ... | 11/27/2007 |
| 7285424 | Membrane-based assay devices A membrane-based assay device for detecting the presence or quantity of an analyte residing in a test sample is provided. The device utilizes a self-calibrated magnetic binding assay format (e.g., sandwich, competitive, etc.) that includes detection probes capable o... | 10/23/2007 |
| 7270959 | Specimen collection container The present invention recognizes that sample handling devices, particularly those used for testing for substances of abuse, do not allow for a separation of the bulk sample from a sample thereof to be tested. The present invention provides such a device and methods ... | 09/18/2007 |
| 7258994 | Saliva immunoassay for detection of antibodies for cardiovascular disease A method for diagnosing the likelihood and severity of cardiovascular disease in a patient is disclosed. The method determines the levels of antibodies against autoantigens, including myosin, oxidized LDL, β-2-glycoprotein, heat shock protein-60, platelet glycoprot... | 08/21/2007 |
| 7256263 | Dermatophagoides proteins and uses thereof The present invention relates to high molecular weight Dermatophagoides proteins, nucleic acid molecules encoding such proteins, and therapeutic and diagnostic reagents derived from such proteins. ... | 08/14/2007 |
| 7244580 | Epsilon immunoglobulin chain derived peptides for induction of anti-IgE antibodies The present invention relates to identification of polypeptides useful for generating antibodies specific for non-human IgE, particularly equine IgE. The invention, therefore, also relates to antibodies that specifically bind to IgE and methods to detect IgE using t... | 07/17/2007 |
| 7223534 | Diffraction-based diagnostic devices A biosensor includes a substrate with a layer of receptive material disposed thereon. The receptive material is specific for an analyte of interest. A pattern of active and deactivated areas of the receptive material are defined in the receptive material layer by a ... | 05/29/2007 |
| 7214493 | Polynucleotides encoding humanized antibodies against human 4-1BB A humanized antibody that binds to human 4-1BB and that allows binding of human 4-1BB to a human 4-1BB ligand. In one aspect, the antibody is an IgG4 antibody. Also provided is a method for treating cancer in a subject comprising administering a therapeutically effe... | 05/08/2007 |
| 7205382 | Peptides, the production and use thereof for binding immunoglobulins Peptides having the following amino acid sequence as well as peptides or proteins which contain this amino acid sequence: R1-X01-X02-X03-X04-X05-X06-X07-X08-X09-X10-X11-X12-X13-R2. These peptides have a high affinity for imm... | 04/17/2007 |
| 7195881 | Method and kit for following neurodegenerative diseases The invention relates to a method for detecting and supervising neurodegenerative diseases, which consists in detecting the presence of antibodies of the A-isotype and/or M-isotype which are directed against the antigens which are associated with these diseases.... | 03/27/2007 |
| 7195922 | Allergen detection A method of determining allergen activity in dust comprises: providing a dust sample; extracting from the dust sample at least one breakdown component or proteins or peptides; reacting the extracted at least one breakdown component with a colorimetric amine detectio... | 03/27/2007 |
| 7195909 | Measurement and use of molecular interactions The subject invention pertains to a method for determining the affinity between binding partners, or a property of one of the binding partners dependent on the affinity, comprising the steps of: (i) contacting the binding partners,... | 03/27/2007 |
| 7186566 | Combining transmittance detection and chromatographic strip techniques for quantification of analyte in biological fluids Chromatographic strip is used in combination with a transmittance detecting system in a test to quantitate analytes in biological fluid. Chemical reagents or conjugate labels are simply absorbed on the passages' materials of the strip. The substrates, affinity reage... | 03/06/2007 |
| 7172874 | Diagnostic methods for age related macular degeneration Diagnostic methods for identifying a test subject who has or is at risk of developing age-related macular degeneration (AMD) or an analogous disease associated with oxidation of DHA-containing lipids are provided. In one aspect, the methods comprise: assaying for th... | 02/06/2007 |
| 7169550 | Diffraction-based diagnostic devices A biosensor includes a substrate with a receptive material layer of radiation-absorbing member (RAM)-tagged biomolecules disposed thereon. The receptive material is specific for an analyte of interest. A pattern of active and deactivated areas of the receptive mater... | 01/30/2007 |
| 7157551 | Compositions and methods for the detection and treatment of methylthioadenosine phosphorylase deficient cancers Compositions and methods involving agents that specifically bind to methylthioadenosine phosphorylase (MTAP) protein are disclosed. Illustrative compositions comprise binding agents that bind to human MTAP protein in biological samples, including embedded samples. T... | 01/02/2007 |
| 7153682 | Microarrays on mirrored substrates for performing proteomic analyses Provided are peptidomimetic protein-binding arrays, their manufacture, use, and application. The protein-binding array elements of the invention include a peptidomimetic segment linked to a solid support via a stable anchor. The invention contemplates peptidomimetic... | 12/26/2006 |
| 7148058 | Protein microarrays on mirrored surfaces for performing proteomic analyses Provided are protein microarrays, their manufacture, use, and application. Protein microarrays in accordance with the present invention are useful in a variety preoteomic analyses. Various protein arrays in accordance with the present invention may immobilize large ... | 12/12/2006 |
| 7144742 | Quantitative lateral flow assays and devices This invention provides solid phase specific binding lateral flow assay methods, devices and kits for quantitating high and low molecular weight analytes. The methods and devices of the invention employ labelled reagents which are either analyte analogs or complemen... | 12/05/2006 |
| 7138237 | Diagnosis, prevention and treatment of Crohn's disease using the OmpC antigen The present invention provides a method of diagnosing Crohn's disease in a subject by determining the presence or absence of IgA anti-OmpC antibodies in the subject, where the presence of the IgA anti-OmpC antibodies indicates that the subject has Crohn's disease. | 11/21/2006 |
| 7122380 | Pharmaceutical compositions containing antigen-antibody complexes and uses therefor A pharmaceutical composition suitable for administration to human beings in the prevention or treatment of immunologic disorders includes: an immune complex of an antigen and a purified antibody specific thereto, the antigen being ... | 10/17/2006 |
| 7115710 | Diagnosis and treatment of PTP related disorders The present invention relates to PTP05 polypeptides and PTP10 polypeptides, nucleic acids encoding such polypeptides, cells, tissues and animals containing such nucleic acids, antibodies to such polypeptides, assays utilizing such polypeptides, and methods relating ... | 10/03/2006 |
| 7101851 | IgE receptor antagonists The invention provides novel compounds which bind to the high affinity receptor for immunoglobulin E (IgE) designated FcεRI and methods for identifying and preparing such compounds. In particular aspects, the invention provides to the treatment of disorders mediate... | 09/05/2006 |
| 7091324 | Prevention and treatment of HCV infection employing antibodies directed against conformational epitopes Conformational epitopes of the envelope protein E2 of the Hepatitis C virus (HCV) have been identified and characterized using a panel of monoclonal antibodies derived from patients infected with HCV. These conformational epitopes have been determined to be importan... | 08/15/2006 |
| 7090984 | Device and method for detecting substance A method for detecting a substance, comprising developing a developing liquid through a test region up to a reference region, and a detection device for use therein, wherein the reference region comprises a metal compound other than an alkali metal salt, and the dev... | 08/15/2006 |
| 7091049 | Enhanced diffraction-based biosensor devices An enhanced diffraction based biosensor system and method are provided for detecting an analyte of interest in a test medium. The system incorporates at least one additional detection tag substance with the analyte of interest, the tag emitting a measurable paramete... | 08/15/2006 |
| 7078176 | Detection and quantification of Cripto-1 The present invention provides methods and compositions for the detection and quantification of Cripto-1. In particular, the present invention provides methods and compositions for the detection and quantification of Cripto-1 in samples such as milk, plasma, serum, ... | 07/18/2006 |
| 7074519 | Molehole embedded 3-D crossbar architecture used in electrochemical molecular memory device This invention provides a new design and fabrication for a three-dimensional crossbar architecture embedding a sub-micron or nanometer sized hole (called a molehole) in each cross-region. Each molehole is an electrochemical cell consisting of two or more sectional s... | 07/11/2006 |
| 7074621 | Surface plasmon resonance biosensor for measurement of anti-glycolipid antibody levels in neuropathy The present invention provides a method of detecting human antibodies in a sera solution. The invention also provides a method of quantitating anti-glycolipid antibody levels in solutions. The invention provides a method of diagnosing disease states, including neuro... | 07/11/2006 |
