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| Number | Title | Issue Date |
| 4434227 | Immunoassay for class specific immunoglobulin antibodies A method for determining an immunoglobulin of the IgX class in a sample where X is either M, A, D or E. Anti-IgG is added to IgG to prevent binding of rheumatoid factor before the sample containing IgX is added to insolubilized IgG.... | 02/28/1984 |
| 4427781 | Particle agglutination immunoassay with agglutinator for determining haptens; PACIA A particle counting assay for haptens (small non-protein monovalent substances having a molecular weight below 1500) comprises mixing a liquid sample (e.g. of human origin) containing the hapten, with finely divided inert particles bearing the same hapten... | 01/24/1984 |
| 4420461 | Agglutination-inhibition test kit for detecting immune complexes Kit for detecting circulating immune complexes containing endogenously bound Clq. Capillary tubes are filled with a mixture of Clq coated GPO reagent cells, rabbit anti-Clq antibodies, and precipitate from the biological fluid sample containing immune com... | 12/13/1983 |
| 4402934 | Diagnostic technique for rheumatoid arthritis A method for diagnosis of rheumatoid arthritis and related diseases comprises determination of polyclonal lymphocyte activation in B-cells cultured in the presence of patient serum. A diagnostic kit is also provided.... | 09/06/1983 |
| 4398894 | Method for quantitatively determining the degree of agglutination of particles A method and apparatus for quantitatively determining a degree of agglutination of a suspension of particles or the presence of the agglutination thereof is disclosed, wherein a liquid which contains agglutinated clots, otherwise a substance or substances... | 08/16/1983 |
| 4397960 | Immunoassays using F(AB')2 fragments Immunoassays for antigens or haptens are effected using, instead of an immunoglobulin antibody, the F(ab')2 fragments thereof. In this way, interference from endogenous RF and Clq in the fluid under assay is avoided without the necessity of pre... | 08/09/1983 |
| 4397959 | Forced precipitation method for preparing antigen/antibody particles Process for the preparation of test reagents comprising antigens or antibodies adsorbed on a surface, for example, the surface of synthetic or natural polymer particles in which the test material to be adsorbed is dissolved in a solvent in contact with th... | 08/09/1983 |
| 4360358 | Immunoassay with solid phase having coating containing blood platelet substitute A method for preparing an immunologically active coated solid phase, suitably in the form of a coated tube or a polymer latex, for solid phase immuno assays, in particular radio immuno assays, is disclosed. The method comprises coating a solid support whi... | 11/23/1982 |
| 4351824 | Polystyrene latex reagents, methods of preparation, and use in immunological procedures Methods of making and using a stable diagnostic reagent for use in serological testing procedures, and in particular, non-auto-agglutinating polystyrene latex particles with surfaces containing a protein, substantially methylated serum albumin, and a boun... | 09/28/1982 |
| 4332783 | Process for immunologic determination tests What is disclosed is a method for the immunological determination of an immuno-complex, comprising an antigen and an antibody, in a liquid containing said immuno-complex, which method comprises (a) incubating said liquid containing said immumo-complex with a f... | 06/01/1982 |
| 4314987 | Method for diagnosing rheumatological diseases A process for differential diagnosis of various rheumatological and arthritic diseases, all of which may yield similar antinuclear antibody test results. The process comprises a continuous sequence of tests on a single serum specimen to minimize and elimi... | 02/09/1982 |
| 4307190 | Immunoassay using ascitic fluid A liquid, particularly but not exclusively a liquid of human origin such as blood serum or urine, is immunoassayed for antibodies, antigens or antibody: antigen complexes, using as a reagent in the analysis an active fraction from mouse ascitic fluid. Thi... | 12/22/1981 |
| 4305925 | Latex reagent What is disclosed is an improved nephelometric method for detecting an antigen or antibody by contact thereof in a liquid medium with particles of a latex reagent comprising latex particles of different sizes loaded with different amounts of a correspondi... | 12/15/1981 |
| 4292403 | Detection and/or determination of IgM, IgA, IgD and IgE immunoglobulins The present invention relates to (1) a method for the detection and/or determination of an antigen specific immunoglobulin of a peculiar IgX class, in which X means M, A, D or E, comprising: (a) contacting and reacting the test-medium with either insolubi... | 09/29/1981 |
| 4290997 | Apparatus for automatic measurement of the results of agglutination tests A method and an apparatus for automatic measurement of the results of agglutination tests, e.g., in a spectrophotometer, adsorption photometer, fluorometer, or nephelometer. Samples of agglutination tests are incubated in reaction vessels, such as cuvette... | 09/22/1981 |
| 4283383 | Analysis of biological fluids Biological fluids, such as serum, are analyzed for the presence, nature and/or amount of antibodies, antigens and antibody:antigen complexes therein using as a reagent, insolubilized rheumatoid factor or insolubilized Clq. These reagents are themselves no... | 08/11/1981 |
| 4282002 | Sensitized sheep stroma immunoassay for rheumatoid factor A new and immunochemically useful reagent is disclosed for the detection of rheumatoid factors (RF) in human blood, plasma, serum or synovial fluid in agglutination reactions, together with a new clinical diagnostic test and test slide using said reagent.... | 08/04/1981 |
| 4279617 | Iummunoassay involving agglutination A particle agglutination assay for antigens, antibodies and other binding proteins such as rheumatoid factor, uses two different, microscopic or submicroscopic particulate reagents. The first particulate reagent binds with the antigen or antibody under as... | 07/21/1981 |
| 4254097 | Method of detecting antibodies to human thyroglobulin A method of detecting antibodies to native deoxyribonucleic acid (n-DNA), anti-nuclear antibodies, antibodies to non-histone containing protein, rheumatoid factors, antibodies to thyroglobulin, and an immunofluorescent assay for such detection is describe... | 03/03/1981 |
| 4250394 | Apparatus for determining immunochemical substances A novel method and a novel apparatus therefor are described for detecting and measuring a predetermined immunochemical substance, for example, an antigen, an antibody, a hapten, or certain low molecular weight substance. The detection and measurement of a... | 02/10/1981 |
| 4213764 | Method for determining immunochemical substances An immunoassay based on the agglutination or the agglutination inhibition of a suspension of immunologically coated particles by the sample. Measurements are made with an apparatus having means for providing electromagnetic radiation at wavelengths equal ... | 07/22/1980 |
| 4189466 | Detection of rheumatoid factor by antibody sensitized microbial particles Detection of antigens in a biological specimen of animal origin by means of antibody-sensitized microbial particles, which particles may be sensitized from a whole immunoglobulin fraction, an immunoglobulin fraction derived therefrom (IgG), a purified ant... | 02/19/1980 |
| 4184847 | Method of indicating rheumatoid factors A method of indicating rheumatoid factors, primarily such rheumatoid factors which belong to immunoglobulin classes other than the immunoglobulin class IgM, in an aqueous sample. The sample is reacted in the presence of the complement factor C1q in non-bo... | 01/22/1980 |
| 4153417 | Method of indicating rheumatoid factors A method of indicating rheumatoid factors belonging to at least one of the immunoglobulin classes IgM, IgG and IgA in an aqueous sample is disclosed. According to this method any complement factor C1q present in the sample is pacified in a manner known pe... | 05/08/1979 |
| 4143124 | Antigen-antibody analysis with solid phase RF and C1q Biological fluids, such as serum, are analyzed for the presence, nature and/or amount of antibodies, antigens and antibody:antigen complexes therein using as a reagent, insolubilized rheumatoid factor or insolubilized C1q. These reagents are themselves no... | 03/06/1979 |
| 4138213 | Agglutination immunoassay of immune complex with RF or Clq A method of determining Ab:Ag complex in a biological fluid sample comprising adding to the sample a solution of RF or Clq and a known quantity of a material, such as immunoglobulin-coated polystyrene particles, which is caused to agglutinate on contact w... | 02/06/1979 |
| 4062935 | Immunoassay involving the binding of RF to the antigen-antibody complex A method for analyzing a biological fluid sample for Ab, Ag, or Ab:Ag complexes therein which includes the step of adding to the sample a solution of RF or Clq to bind with Ab:Ag complexes present or formed therein, and thereafter analyzing the mixture so... | 12/13/1977 |
| 4060597 | Serological reagent and preparation thereof A latex reagent is prepared by allowing latex particles to adsorb a nonionic surfactant of ethylene oxide type, sensitizing the latex particles thus having the surfactant adsorbed with a serologically active substance such as antigen or antibody and suspe... | 11/29/1977 |
| 3992517 | Detection of hepatitis B surface antigen by latex agglutination A diagnostic composition for the detection of hepatitis B surface antigen in blood serum which comprises an aqueous suspension of finely divided synthetic resin particles of substantially uniform size coated with purified antibody specific to hepatitis B ... | 11/16/1976 |
