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| Number | Title | Issue Date |
| 8183055 | Peptide aptamer for neutralizing the binding of platelet antigen specific antibodies and diagnostic and therapeutic applications containing the same The present invention relates to a peptide aptamer which mimics particularly the human platelet antigene HPA-Ia epitope present on the platelet GPIIb/IIIa molecules and which is capable of neutralizing the binding of HPA-I a specific antibodies (anti-HPA-1 a). This ... | 05/22/2012 |
| 8178358 | Serpine2 as a biomarker for IgA nephropathy The present invention provides a method for diagnosis or prognosis of IgA nephropathy in a subject based on detection of the expression level of one or more biomarker genes selected from the group consisting of thymosin β4 (Tmsb4), serine or cysteine proteinase inh... | 05/15/2012 |
| 8153443 | Characterization of the CBir1 antigenic response for diagnosis and treatment of Crohn's disease This invention provides methods of diagnosing or predicting susceptibility to Crohn's Disease by determining the presence or absence of genetic variants. In one embodiment, the present invention provides methods to diagnose and/or predict susceptibility to Crohn's D... | 04/10/2012 |
| 8062907 | Method to assess the severity of rheumatoid arthritis by measuring anti-CCP and serum amyloid A Disclosed is a method for assessing a severity of rheumatoid arthritis. The method involves measuring in a patient sample a concentration of anti-cyclic citrullinated peptides (anti-CCP) and serum amyloid A, combining the concentrations determined to obtain a combin... | 11/22/2011 |
| 8008093 | Inhibition of Hsp27 phosphorylation for the treatment of blistering disorders A method of treating a blistering disorder, which includes administering to a target tissue in a subject in need thereof an effective amount of a composition that inhibits activation of the HSP27 phosphorylation pathway. ... | 08/30/2011 |
| 7981693 | Combined measurement of anti-CCP and serum amyloid A to assess rheumatoid arthritis The present invention relates to a method aiding in the assessment of rheumatoid arthritis. The method especially is used in assessing the absence or presence of rheumatoid arthritis in vitro. It can be best practiced by analyzing biochemical markers, comprising mea... | 07/19/2011 |
| 7785898 | Maternal antibodies as fetal cell markers to identify and enrich fetal cells from maternal blood The present invention provides methods for identifying and/or enriching fetal cells from maternal blood, using as fetal cell markers the antibodies that the mother produces against paternally inherited fetal antigens. The fetal cell-maternal antibody complexes are i... | 08/31/2010 |
| 7772011 | Method and kit for detection of autoimmune chronic urticaria Disclosed is a rapid, non-invasive and highly specific and sensitive diagnostic assay for the identification of individuals with autoimmune chronic urticaria, which makes use of CD203c, and in some embodiments, additional proteins, as a marker for the disease. Test ... | 08/10/2010 |
| 7462495 | Methods and compositions for use in diagnosing and characterizing chronic immune disease Methods are provided for diagnosing and/or characterizing chronic immune disease activity in a subject. In the subject methods, a sample is obtained from a subject suspected of having or known to have a chronic immune disease. The sample is then assayed for the pres... | 12/09/2008 |
| 7410802 | Methods for simultaneously detecting both members of a binding pair Methods and kits for simultaneously measuring both members of a binding pair are described. ... | 08/12/2008 |
| 7402403 | Tumour markers A method of determining the immune response of a mammal to circulating tumour marker proteins is described in which a sample of bodily fluid, for example plasma or serum, is contacted with a panel of two or more distinct tumour marker antigens. The presence of compl... | 07/22/2008 |
| 7368542 | Method of altering the binding specificity of plasma proteins by oxidation-reduction reactions The binding specificity of at least one plasma protein suspended or dissolved in a liquid medium is altered by exposing the protein to an oxidizing agent or an electric current sufficient to alter its binding specificity. A masked protein such as an autoantibody can... | 05/06/2008 |
| 7361157 | Syringe-pump driving apparatus It is an object of the present invention to provide a multiple-syringe-pump driving apparatus having superior liquid discharging and drawing-up precision. A syringe-pump driving apparatus of the present invention is used for controlling discharge from and drawing-up... | 04/22/2008 |
| 7361480 | Method and means for detecting gluten-induced diseases The invention is directed to a method of detecting gluten-induced diseases such as e.g. celiac disease and dermatitis herpetiformis. Said diseases are indicated by the presence of autoantibodies against tissue transglutaminase tTG in the blood The test is carried ou... | 04/22/2008 |
| 7358058 | Method and agents for the diagnosis and therapy of chronic inflammatory intestinal disease Methods for diagnosis, early diagnosis, differential diagnosis, assessment of the severity and therapy-accompanying monitoring and prognosis of chronically inflammatory intestinal diseases (Crohn's disease, Colitis ulcerosa), in which the presence and/or the ... | 04/15/2008 |
| 7356925 | Method for producing a cooled ring carrier The invention relates to a method for producing a cooled ring carrier (1) for an aluminium piston pertaining to an internal combustion engine and produced according to a casting method, comprising a cooling channel (6) which is embodied on the rear ( | 04/15/2008 |
| 7354614 | Diagnostic device A diagnostic device 1 for performing an immunochromatographic analysis of a sample is disclosed. The diagnostic device 1 comprises a porous substrate 10 for performing the analysis and a pre-filter 30 to remove solid components, such as s... | 04/08/2008 |
| 7344846 | Diagnostics and therapeutics for macular degeneration-related disorders The invention relates to methods for diagnosing and treating macular degeneration-related disorders. The invention also related to methods for identifying genes that cause macular degeneration-related disorders. ... | 03/18/2008 |
| 7335724 | Peptides immunoreactive with autoantibodies from patients suffering from rheumatoid arthritis The invention relates to a peptide derived from an antigen recognized by autoantibodies, which peptide is reactive with autoimmune antibodies from a patient suffering from rheumatoid arthritis. The peptide according to the invention possesses a modified arginine res... | 02/26/2008 |
| 7291473 | Screening process for atopic dermatitis The present invention provides a process of screening patients for atopic dermatitis. The process includes the step of determining, in sera of the patient, the presence of antibodies against nuclear antigens such as transcription co-activator p75, wherein the presen... | 11/06/2007 |
| 7285242 | Biochemical analysis unit and biochemical analyzing method using the same A biochemical analysis unit includes a substrate made of a material capable of attenuating radiation energy and/or light energy and formed with a plurality of holes, and a plurality of absorptive regions formed by forming an absorptive region in every hole. Accordin... | 10/23/2007 |
| 7267963 | Modified plant viruses and methods of use thereof The present invention relates to modulating the nature and/or level of an immune response to a molecule. In particular, the invention relates to effecting an increase in the TH1 immune response to molecules such as, but not limited to, antigens or immunogens. The in... | 09/11/2007 |
| 7262062 | Diagnostic for scleroderma As anti-RNA polymerase (RNAP) antibodies are detected with high frequency in patients suffering from cutaneous scleroderma where skin sclerosis progresses rapidly, supervenes scleroderma renal crisis at a high rate, and associates with clinical entities whose progno... | 08/28/2007 |
| 7258994 | Saliva immunoassay for detection of antibodies for cardiovascular disease A method for diagnosing the likelihood and severity of cardiovascular disease in a patient is disclosed. The method determines the levels of antibodies against autoantigens, including myosin, oxidized LDL, β-2-glycoprotein, heat shock protein-60, platelet glycoprot... | 08/21/2007 |
| 7247703 | Immune reactivity to HER-2/neu protein for diagnosis and treatment of malignancies in which the HER-2/neu oncogene is associated Methods for the detection, monitoring and treatment of malignancies in which the HER-2/neu oncogene is associated are disclosed. Detection of specific T cell activation (e.g., by measuring the proliferation of T cells) in response to in vitro exposure to the HER-2/n... | 07/24/2007 |
| 7220739 | Therapeutic application of pro-apoptotic benzodiazepines Benzodiazepine compounds, and methods for using those compounds are provided. Some of the benzodiazepine compounds include 1,4-benzodiazepine-2-one and 1,4-benzodiazepine-2,5-dione compounds of the following structures: | 05/22/2007 |
| 7205382 | Peptides, the production and use thereof for binding immunoglobulins Peptides having the following amino acid sequence as well as peptides or proteins which contain this amino acid sequence: R1-X01-X02-X03-X04-X05-X06-X07-X08-X09-X10-X11-X12-X13-R2. These peptides have a high affinity for imm... | 04/17/2007 |
| 7199216 | Peptide constructs for treating autoimmune and related diseases Conjugated peptides include a first peptide component which is an antigen associated with autoimmune disease, allergy, asthma or transplantation rejection and binds to an antigen-specific receptor on a T cell, and a second peptide component which corresponds to an â... | 04/03/2007 |
| 7189516 | Method for characterizing autoimmune disorders The invention relates to methods of characterizing autoimmune diseases by detecting and measuring at least one analyte using multiplexed assay systems. According to one embodiment, a target is detected and measured by different bead sets having different reactants. ... | 03/13/2007 |
| 7183065 | Diagnosis, prevention and treatment of ulcerative colitis, and clinical subtypes thereof, using microbial UC pANCA antigens The present invention relates to microbial UC pANCA antigens. The invention provides methods of diagnosing ulcerative colitis (UC) and methods of inducing tolerance in a pANCA-positive patient with UC using a histone H1-like antigen. The invention further provides m... | 02/27/2007 |
| 7175989 | Antibodies to trisulfated heparin disaccharide in painful sensory axonal neuropathy Methods aiding in the diagnosis of certain painful, predominantly sensory, polyneuropathies are disclosed, in which the amount of antibodies to trisulfated disaccharide is assessed in a test sample. Also disclosed are kits that can be used in the methods of the inve... | 02/13/2007 |
| 7160686 | Method for producing a specific antiserum against the universal tumorous antigen and method for diagnosing malignant tumours using said antiserum The present invention pertains to the field of medicine and may be used for producing a specific antiserum as well as for carrying out immunological diagnoses of malignant tumours. This method for producing an antiserum involves sampling an embryo at the foetal stag... | 01/09/2007 |
| 7157234 | Detection of very low quantities of analyte bound to a solid phase A microscale binding assay, analyte binding array, and kits are disclosed, which exploit the mass action law to harvest analyte from a liquid sample. This is achieved by fabrication of sorbent zones having up to ten times the binding capacity per unit area generally... | 01/02/2007 |
| 7138237 | Diagnosis, prevention and treatment of Crohn's disease using the OmpC antigen The present invention provides a method of diagnosing Crohn's disease in a subject by determining the presence or absence of IgA anti-OmpC antibodies in the subject, where the presence of the IgA anti-OmpC antibodies indicates that the subject has Crohn's disease. | 11/21/2006 |
| 7105336 | Selection and use of lactic acid bacteria for reducing inflammation caused by Strains of Lactobacillus which have been selected for their capability of reducing gastrointestinal inflammation, such as that due to Helicobacter pylori, and products derived from these strains, including agents for treatment or prophylaxis of inflamm... | 09/12/2006 |
| 7067127 | GIcNAc phosphotransferase of the lysosomal targeting pathway The present invention provides nucleotide and amino sequences of the lysosomal targeting pathway enzyme GlcNAc-phosphotransferase, methods of producing and methods of purifying this enzyme. ... | 06/27/2006 |
| 7056686 | Method of diagnosing fibromyalgia caused by small intestinal bacterial overgrowth Disclosed is a method of diagnosing irritable bowel syndrome, fibromyalgia, chronic fatigue syndrome, depression, attention deficit/hyperactivity disorder, autoimmune diseases, such as multiple sclerosis and systemic lupus erythematosus, or Crohn's disease, which in... | 06/06/2006 |
| 7029676 | Methods and compositions for modulating heterotypic E-cadherin interactions with T lymphocytes The present invention relates to methods and compositions for modulating the heterotypic adhesion between E-cadherin expressing cells and T lymphocytes. Monoclonal antibodies which specifically bind to E-cadherin and isolated peptides which mimic the binding functio... | 04/18/2006 |
| 7026132 | Method of monitoring the effect of Cathepsin S inhibitors The present invention relates to a method for monitoring the effect of in vivo administration of Cathepsin S inhibitors by measuring accumulation of an intermediate degradation product of invariant chain (Ii), in particular the p10 Ii fragment, in blood of dosed sub... | 04/11/2006 |
| 7011952 | Diagnostics and therapeutics for macular degeneration-related disorders The invention relates to methods for diagnosing and treating macular degeneration-related disorders. The invention also related to methods for identifying genes that cause macular degeneration-related disorders. ... | 03/14/2006 |
