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| Number | Title | Issue Date |
| 4371514 | Radioimmunoassay of pterins and novel pterin derivatives useful therefor Pterin derivatives are described having the formula (I) ##STR1## wherein R represents a hydroxyphenyl group, a radioiodinated hydroxyphenyl group, a tyraminocarbonyl group, a radioiodinated tyraminocarbonyl group, a proteinocarbonyl group or a carbox... | 02/01/1983 |
| 4355018 | Assay for vitamin B12 A highly specific assay for plasma vitamin B12 levels in humans is disclosed. The assay employs intrinsic factor preparations obtained from mouse or rat stomachs, which intrinsic factors are free of R-protein and thus react specifically with vi... | 10/19/1982 |
| 4351822 | Quantitative testing for vitamin B12 The vitamin B12 (cobalamin) level of human blood and mammalian tissue is routinely assayed utilizing radioisotope dilution assay (RIDA) techniques. The presence of vitamin "B12 analogues" in most such samples, which analogues are err... | 09/28/1982 |
| 4336185 | Folic acid derivatives Novel protein conjugates and radioiodinated derivatives of folic acid and salts, esters and amides useful in the radioimmunoassay (RIA) of body fluids to determine folic acid are disclosed.... | 06/22/1982 |
| 4333918 | Radioassay for vitamin B12 The amount of vitamin B12 in solution in a liquid is determined by mixing a sample of the solution with vitamin B12 -binding proteins from chicken serum in a pH of about 12.8 to 13.2, and then analyzing a component of the mixture. In... | 06/08/1982 |
| 4332786 | Method and composition for vitamin B-12 Assay The binding of vitamin B-12 by natural substances in samples assayed for vitamin B-12 is reduced by heating the test sample in an alkaline buffer comprising thioglycerol and denaturing agent having the formula (R)2 NC(A)N(R)2, wherei... | 06/01/1982 |
| 4314988 | Folic acid derivatives and process for preparation Folic acid derivatives, such as radiolabeled pteroyltyrosine, are conveniently synthesized from either pteroic acid or by the direct condensation of 6-formylpterin with p-aminobenzoyltyrosine methyl ester. The radioiodinated derivatives are particularly u... | 02/09/1982 |
| 4300907 | Serum vitamin B12 assay and kit therefor In a vitamin B12 assay, serum, containing vitamin B12 bound to endogenous binders therefor, is released from such endogenous binders by a releasing agent comprised of a water miscible organic liquid, such as, acetone, reducing agent ... | 11/17/1981 |
| 4298735 | Folic acid derivatives Folic acid derivatives, such as radiolabeled pteroyltyrosine, are conveniently synthesized from either pteroic acid or by the direct condensation of 6-formylpterin with p-aminobenzoyltyrosine methyl ester. The radioiodinated derivatives are particularly u... | 11/03/1981 |
| 4279859 | Simultaneous radioassay of folate and vitamin B12 A serum sample is heated at an alkaline pH to release folate and vitamin B12 from endogenous binders. A simultaneous radioassay for folate and vitamin B12 is effected by contacting the sample with binder for folate, binder for vitami... | 07/21/1981 |
| 4276280 | Radiolabeled derivatives of folic acid Derivatives of folic acid wherein the -carboxyl group of the glutamyl moiety is substituted with a radical which is capable of being radioiodinated, such as, substituted and unsubstituted tyrosyl and histidyl. The radioiodinated derivatives can be ... | 06/30/1981 |
| 4273757 | Determination of transcobalamins A process and test kit for the quantitative determination of the individual and total unsaturated Vitamin B-12 binding capacities of the three transcobalamins TC-I, TC-II, and TC-III in serum. The process comprises incubating a serum sample with a solutio... | 06/16/1981 |
| 4271140 | Method and composition for double receptor, specific binding assays The performance of double receptor, specific binding assays is improved by use of a receptor complex having the structure wherein BL is a binding ligand, ABL is a receptor specific for binding ligand, A1 is a receptor, BL is covalently bo... | 06/02/1981 |
| 4235867 | Acrylamide copolymer matrix for radioimmune assay techniques Disclosed is a polymer matrix based on a copolymer of acrylamide to immobilize antibodies in the radioimmunological determination of hormones and the pharmaceuticals. The specific copolymers are formed by polymerization of acrylamide and one or more copol... | 11/25/1980 |
| 4225784 | Covalently bound biological substances to plastic materials and use in radioassay Covalently bound biological substances to plastic materials whose inside surfaces have been coated with glutaraldehyde, with or without prior treatment with an aliphatic amine or diamine, useful in radioimmunoassay procedures.... | 09/30/1980 |
| 4209614 | Vitamin B12 derivative suitable for radiolabeling Radiolabeled vitamin B12 derivatives having the formula ##STR1## wherein R is hydrogen or alkyl of 1 to 3 carbon atoms; n is 0, 1, 2, 3 or 4; and the asterisk (*) indicates tagging with a radioisotope, are useful as tracers in radioassays.... | 06/24/1980 |
| 4188189 | Quantitative testing for vitamin B12 Errors in the radioisotope dilution assay (RIDA) of the vitamin B12 level of human blood have been traced to the presence of vitamin B12 analogues. These previously unrecognized analogues bind with proteins normally included with bin... | 02/12/1980 |
| 4167556 | Determination of transcobalamins A process for the quantitative determination of the transcobalamins TC-I, TC-II, and TC-III in serum. The process comprises incubating the serum with radiolabeled vitamin B-12, passing the resulting mixture through adsorption means, such as a charged cell... | 09/11/1979 |
| 4166104 | Specific binding assay method and test kit employing polystyrene as separating agent A specific binding assay method and test kit for determining a ligand, particularly an antigen or hapten, in, or the ligand binding capacity of, a liquid medium, particularly a body fluid such as serum, wherein the liquid medium is combined with assay rea... | 08/28/1979 |
| 4166103 | Specific binding assay method and test kit employing polyvinyl alcohol as separating agent A specific binding assay method and test kit for determining a ligand, particularly an antigen or hapten, in, or the ligand binding capacity of, a liquid medium, particularly a body fluid such as serum, wherein the liquid medium is combined with assay rea... | 08/28/1979 |
| 4146602 | Simultaneous radioassay of folate and vitamin B12 A serum sample is heated at an alkaline pH to release folate and vitamin B12 from endogenous binders. A simultaneous radioassay for folate and vitamin B12 is effected by contacting the sample with binder for folate, binder for vitami... | 03/27/1979 |
| 4136159 | Radioassay of folates Novel folic acid derivatives useful in processes for analysis of biological fluids for folic acid or its metabolites comprising components of the formula: ##STR1## wherein R is hydrogen or radioactive iodine.... | 01/23/1979 |
| 4135880 | Folate assay with ion exchange resin bound-free separation Improved competitive binding serum folate assay in which serum folate bound by folate-selective protein is separated from free serum folate by removal with an anion exchanger, preferably intermediate base anion exchange resin. Preferable are resins charac... | 01/23/1979 |
| 4119709 | Diagnostic test A diagnostic test is provided based on competitive binding in which a partition coefficient is established for the substance whose concentration is to be determined and for the radioactive labeled form of the substance between liquid and solid phases.... | 10/10/1978 |
| 4115534 | In vitro diagnostic test A method for determining the concentration of substances in biological fluids (e.g., drugs, hormones, vitamins and enzymes) is disclosed wherein magnetically responsive, permeable, solid, water-insoluble microparticles are employed.... | 09/19/1978 |
| 4115065 | Saturation analysis of folate compound with selenium-75 labeled folate Folic acid and related compounds are assayed by competitive radio-assay using a selenium - 75 labelled version of folic acid as the competing compound.... | 09/19/1978 |
| 4039652 | Column method of immunoassay employing an immobilized binding partner An improved method is disclosed for determining substances in a fluid sample having a mutual specific binding affinity, such as antigens and antibodies, said method utilizing a device comprising a column containing an insoluble porous matrix with which sp... | 08/02/1977 |
| 4028465 | Assay method for serum folate Serum folate assay procedure by competitive binding in which serum folate is stabilized while being freed from serum folate proteins in the presence of a dithiopolyol, preferably a 1,4-dithiotetritol such as dithiothreitol. Subsequently in the procedure, ... | 06/07/1977 |
| 4001583 | Covalently bound biological substances to plastic materials and use in radioassay Covalently bound biological substances to plastic materials whose inside surfaces have been coated with glutaraldehyde, with or without prior treatment with an aliphatic amine or diamine, useful in radioimmunoassay procedures.... | 01/04/1977 |
| 3992152 | Gold plating test procedure A process is described for making devices with gold plated surfaces in which a procedure is carried out to determine if visual defects in the gold plated surface have exposed base metal. This procedure is advantageous because defects with exposed base met... | 11/16/1976 |
| 3989812 | Folic acid derivatives and use in radio-assay Novel folic acid derivatives useful for radio-assaying folic acid and its metabolites in biological liquids are prepared from pteroyl-γ-glutamyl-tyrosines by iodination with I125 or I131.... | 11/02/1976 |
| 3988431 | Radioassay of folates In the radioassay of folates, the standard is prepared by using folic acid (pteroyl glutamic acid; PGA) as the standard folate at a pH of 9.2 to 9.4. At such pH values, folic acid and 5-methyltetrahydrofolic acid (the predominant folate in human serum) ha... | 10/26/1976 |
| 3981863 | Cyanocobalamin derivatives The present invention is concerned with novel derivatives of cyanocobalamin (vitamin B12), especially of the monocarboxylic acid hydrolysates thereof, by which (1) an antigenic conjugate thereof with a protein is obtainable and (2) a readily io... | 09/21/1976 |
| 3981983 | Rapid, radiochemical-ligand binding assay for methotrexate A radiochemical ligand binding assay for methotrexate is provided. A binder factor comprising a partially purified dihydrofolic acid reductase preparation is employed. The binder factor is conveniently prepared by homogenizing a factor containing animal o... | 09/21/1976 |
| 3980764 | Polymeric competitive protein binding adsorbents for radioassey Serum protein comprising specific binding proteins such as antibodies, B12 intrinsic factor, thyroxin binding globulin and the like may be copolymerized with globulin constituents of serum by the action of ethylchloroformate to form readily pac... | 09/14/1976 |
| 3972991 | Radioisotopic assay and binder therefor There is provided a rapid and less costly radioisotopic assay for measuring the concentration of folate in blood serum. This procedure utilizes 3 H-pteroylmonoglutamate, unlabeled 5-methyl-tetrahydrofolic acid, and a partially purified folate b... | 08/03/1976 |
| 3937799 | Radioassay of vitamin B-12 employing bentonite Radioassay for vitamin B-12 using the unknown quantity of non-radioactive vitamin B-12 released from serum mixed with the radioactivity of a known quantity of radioactive vitamin B-12 tracer. A solution of intrinsic factor having a binding capacity less t... | 02/10/1976 |
