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| Number | Title | Issue Date |
| 8158442 | Antagonists of bitter taste receptors and uses thereof The present invention relates to antagonists of the human bitter-taste receptors hTAS2R38. The invention also relates to methods for identifying further molecules that suppress hTAS2R38 mediated bitter taste transduction or bitter... | 04/17/2012 |
| 8158441 | Method for detecting aggregate-forming circulating protein forms using an agent for aggregating said forms and an agent for capturing formed aggregates The present invention concerns a method for detecting aggregate-forming circulating protein forms in a biological sample of human origin that may contain said aggregate-forming circulating protein forms, characterized in that it uses a non-protein agent I producing ... | 04/17/2012 |
| 8124424 | Single molecule-format bioluminescent probe The claimed invention comprises a single molecule-format bioluminescent probe for detecting a target-specific ligand in a living cell, which comprises, a ligand-binding molecule of which conformation is changed upon binding to the ligand, wherein the ligand-binding ... | 02/28/2012 |
| 8119420 | Absorption pad for immunoassay, strip for immunoassay, and immunoassay apparatus Providing an absorption pad which shows remarkable water absorptivity and can shorten a detection time when employed for an immunoassay apparatus. A water absorption pad for the immunoassay apparatus, containing 50% by weight or more of silicon-containing particles ... | 02/21/2012 |
| 8119421 | Methods to identify compounds useful for the treatment of proliferative and differentiative disorders The present invention relates to the discovery, identification and characterization of nucleotide sequences that encode novel substrate-targeting subunits of ubiquitin ligases. The invention encompasses nucleotides encoding novel substrate-targeting subunits of ubiq... | 02/21/2012 |
| 8105842 | Interleukin-13 as a cardiovascular disease marker The present invention relates to use of interleukin-13 as a cardiovascular disease marker. The therapeutic composition and diagnostic composition of the invention for cardiovascular diseases are characterized by comprising an antibody to an interleukin-13 receptor a... | 01/31/2012 |
| 8076159 | Ligand-regulable transactivation systems, methods of use thereof, methods of detecting estrogen receptor ligands, and methods of differentiating estrogen receptor ligand agonists and antagonists Briefly described, embodiments of this disclosure include ligand-regulable transactivation systems, methods of producing ligand-regulable transactivation systems, methods of using ligand-regulable transactivation systems, reporter polynucleotides, method of producin... | 12/13/2011 |
| 8076160 | Drug monitoring assay A method for obtaining at least one binding agent which binds a pharmaceutically active form of the compound with a higher specificity than a pharmaceutically inactive form of the compound is described by using special derivatives of said parent compound. The invent... | 12/13/2011 |
| 8062906 | B-lymphocyte stimulator binding polypeptides and methods based thereon Binding polypeptides that specifically bind B lymphocyte stimulator protein or B lymphocyte stimulator-like polypeptides can be used in methods of the invention for detecting, diagnosing, or prognosing a disease or disorder associated with aberrant B lymphocyte stim... | 11/22/2011 |
| 8048683 | Insect repellent and process for identifying other insect repellent molecules This invention is based on the identification of the role played by the receptor mX on certain insects through the behavior evinced in the taste sensory reactions of these insects. The invention addresses the use of the modulators on the mX receptor, such as L-canav... | 11/01/2011 |
| 8026107 | Agglutination inhibition assay method and reagent Provided are an agglutination-inhibition assay and a reagent for agglutination-inhibition assay, which can be used for measuring a ligand in a sample at high sensitivity in a wide range from the low-concentration range to the high-concentration range and have good r... | 09/27/2011 |
| 8021893 | Molecular recognition polymer enabling reconstruction of recognition field for target molecule and method of producing the same A molecular recognition polymer enabling the reconstruction of the recognition field for a target molecule which is produced by applying the molecular imprinting method is disclosed. A molecular recognition polymer enabling the reconstruction of the recognition fiel... | 09/20/2011 |
| 8008092 | CCR3 inhibition for ocular angiogenesis and macular degeneration Provided are methods and compositions for the treatment or prevention of ocular angiogenesis and neovascularization. Administration of inhibitors of the CCR3 receptor or its ligands eotaxin (CCL11), eotaxin-2 (CCL24) or eotaxin-3 (CCL26) inhibits ocular angiogenesis... | 08/30/2011 |
| 7989216 | Two helix binders An isolated polypeptide, Z domain, derived from B domain of Staphylococcal protein A, comprising a pair of anti-parallel alpha helices that are capable of binding a target, is provided herein. Introduction of different natural amino acid mutations in the polypeptide... | 08/02/2011 |
| 7981692 | Immunoassays to detect diseases or disease susceptibility traits Disclosed are immunoassay methods for the diagnosis/prognosis of diseases and disease susceptibility traits associated with gene mutations that cause protein truncation or allelic loss. The levels of one or more targeted wild-type proteins expressed by a subject gen... | 07/19/2011 |
| 7981690 | Method of assaying antigen and kit to be used therein By using an antibody which is covalently bonded to a water soluble polymer as an antibody to be used in a competitive immunoagglutination assay in a homogeneous system, a protein antigen at a high concentration can be accurately assayed in an undiluted system withou... | 07/19/2011 |
| 7981691 | Two helix binders An isolated polypeptide, Z domain, derived from B domain of Staphylococcal protein A, comprising a pair of anti-parallel alpha helices that are capable of binding a target, is provided herein. Introduction of a covalent bridge between two modified amino acids... | 07/19/2011 |
| 7977118 | Two helix binders An isolated polypeptide, Z domain, derived from B domain of Staphylococcal protein A, comprising a pair of anti-parallel alpha helices that are capable of binding a target, is provided herein. Introduction of an un-natural amino acid in the polypeptide is pro... | 07/12/2011 |
| 7951613 | Chaperonin 10 modulation of toll-like receptor-inducible cytokine and chemokine secretion Methods of use of Chaperonin 10 (Cpn10) are provided for regulating Toll-like receptor signaling and/or Toll-like receptor inducible immunomodulator secretion. Cpn10 negatively regulates Toll-like receptor agonist-induced pro-inflammatory cytokine and chemokine secr... | 05/31/2011 |
| 7951612 | In situ heat induced antigen recovery and staining apparatus and method Contemplated herein is an automated microscope slide antigen recovery and staining apparatus and method that features a plurality of individually operable miniaturized pressurizable reaction compartments for individually and independently processing a plurality of i... | 05/31/2011 |
| 7943394 | Method and device for high sensitivity detection of the presence of DNA and other probes The present invention provides a method for capacitive detection of the presence of target sample on a substrate, which comprises the steps of: binding a target sample to selective binding sites on the substrate, the target sample being directly or indirectly labele... | 05/17/2011 |
| 7939341 | Membrane arrays and methods of manufacture The invention relates to G protein-coupled receptor (GPCR) microarrays on porous substrates for structural or functional analyses of GPCRs, and methods of preparing porous substrate surfaces for receiving membranes that comprise GPCRs. In one embodiment, a GPCR micr... | 05/10/2011 |
| 7932213 | Small molecule printing The present invention provides compositions and methods to facilitate the identification of compounds that are capable of interacting with a biological macromolecule of interest. A composition is provided that comprises an array of chemical compounds attached to a s... | 04/26/2011 |
| 7919329 | Method for screening for agents that affect food intake Screening methods of use in identifying agents that affect caloric intake, food intake, appetite, and energy expenditure are disclosed herein. These methods are used to identify agents of use in treating obesity, or that can be used to decrease the weight of a subje... | 04/05/2011 |
| 7879622 | Barrier-permeable proxy reporter analysis Analysis of complex media (e.g.—blood and seawater) is difficult because the media are composed of particles of different sizes and chemical profiles. Disclosed is a method for the detection of a constituent in a medium that enhances the molecular selectivity of a... | 02/01/2011 |
| 7875465 | Target substance capturing molecule A capturing molecule having not less than two domains specifically binding to different sites of a target substance, wherein the not less than two domains comprise (1) a first domain having a hypervariable loop structure at a binding site to the target substance, an... | 01/25/2011 |
| 7858395 | Antibodies for use in identifying and/or scoring prostate cancer and androgen receptor-dependent gene expression control The invention relates to antibodies for use for modulating the activity of the lysine-specific demethylase (LSD1) in a mammal and to pharmaceutical and diagnostical compositions comprising such antibodies. The invention also relates to a method for identifying and/o... | 12/28/2010 |
| 7858394 | Test methods for determining the intracellular concentration of cyclic nucleotides The invention relates to methods for the quantitative optical analysis of the intracellular concentration of the cyclic nucleotides cGMP and cAMP, said methods using cell lines which express a combination of certain CNG channels, a calcium-sensitive photoprotein, an... | 12/28/2010 |
| 7851228 | Methods for screening agents that modulate presenilin activity and A-β production The disclosure relates generally to neurodegenerative disorders and more specifically to a group of presenilin/G-protein/c-src binding polypeptides and methods of use for modulating signaling and progression of Alzheimer's disease. ... | 12/14/2010 |
| 7846744 | Methods of identifying anti-inflammatory compounds A mammalian C-type lectin receptor type is identified which is shown to bind IgG antibodies or Fc fragments, thus inducing IVIG-related reversal of inflammation associated with various immune disorders. The identification of a DC-SIGN receptor type which interacts w... | 12/07/2010 |
| 7811828 | Method for identifying and quantifying of tumuor-associated Described is a method for identifying and quantifying of tumour-associated peptides, wherein first at least two different sources for obtaining the peptide are provided (tumourous and healthy tissue), and, separately of one another, the peptides from the different s... | 10/12/2010 |
| 7759133 | Method of detecting and/or quantifying a specific IgE antibody in a liquid sample Methods of detecting and/or quantifying an IgE antibody present in a liquid sample. The IgE antibody is specific to a ligand in the form of an antigen, an antibody, or a hapten. These methods can be used for monitoring and evaluating the immunological status of a su... | 07/20/2010 |
| 7754495 | Methods for early diagnosing of an increased risk of preeclampsia Methods are provided for the diagnosis and treatment of patients with increased risk of preeclampsia. The methods involve measuring levels of TGF-β3, receptors of cytokines of the TGβ family, or HIF-1α. ... | 07/13/2010 |
| 7741128 | Cooperative reporter systems, components, and methods for analyte detection The present invention relates to methods and compositions to detect analytes in a sample using antibody molecules that are transformed into nanoscale “self-signaling” biosensors. It relates in particular to those methods and compositions that provide for single-... | 06/22/2010 |
| 7687280 | Device and method for multiple analyte detection The invention is directed to a method and device for simultaneously testing a sample for the presence, absence, and/or amounts of one or more of a plurality of selected analytes. The invention includes, in one aspect, a device for detecting or quantitating a plurali... | 03/30/2010 |
| 7678581 | Correlating chemical and spatial data within pathology samples A tissue sample to be analyzed is tested. Multiple different samples of multiple areas of said tissue sample, each of said multiple areas is a smaller area than an entire tissue sample to be analyzed. After analysis, the tissue sample is processed in a way that faci... | 03/16/2010 |
| 7670849 | Method for diagnosing insulin resistance from nasal secretions The invention is directed to a method of detecting a biological substance in the nasal secretion and diagnosing a disease following the detection of the biological substance wherein the biological substance is not related to a respiratory disease. The invention also... | 03/02/2010 |
| 7662641 | Method of using Zven antibodies The present invention provides novel uses two members of a new family of human proteins, designated as “Zven,” as agents that stimulate gastrointestinal contractility, gastric emptying, intestinal transit, and treating gastroparesis The Zven1 gene, which resides... | 02/16/2010 |
| 7615380 | Methods for modulating an immune response by modulating KRC activity This invention demonstrates that KRC molecules have multiple important functions as modulating agents in regulating a wide variety of cellular processes including: inhibiting NFkB transactivation, increasing TNF-alpha induced apoptosis, inhibiting JNK activation, in... | 11/10/2009 |
| 7615379 | Nucleic acid and corresponding protein entitled 193P1E1B useful in treatment and detection of cancer A novel gene 0193P1E1B (also designated 193P1E1B) and its encoded protein, and variants thereof, are described wherein 193P1E1B exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 19... | 11/10/2009 |
