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| Number | Title | Issue Date |
| 8080421 | Method for determining crystallization parameters and apparatus for use with the same The present disclosure provides a method to allow a user to pre-screen numerous crystallization conditions in the crystallization space to identify those conditions with the highest probability of yielding crystals and high quality diffracting crystals. In one embod... | 12/20/2011 |
| 8030077 | Non-linear optical imaging of protein crystals Methods for detecting and evaluating the quality of protein crystals are provided comprising subjecting a sample to second order non-linear optical imaging and detecting the second harmonic generation signal. ... | 10/04/2011 |
| 7943380 | Leak detection materials and methods A leak detection material and method of introducing the leak detection material into a fluid system such as a climate control system, an engine oil system, or a fuel system is described. The leak detection material can be a dye delivery composition including a mixtu... | 05/17/2011 |
| 7901939 | Method for performing crystallization and reactions in pressure-driven fluid plugs The present invention provides microfabricated substrates and methods of conducting reactions within these substrates. The reactions occur in plugs transported in the flow of a carrier-fluid. ... | 03/08/2011 |
| 7745220 | Devices and methods for analyte detection using distorted liquid crystals The present invention provides devices and methods for detection of analytes based on measuring the anchoring strength of liquid crystals having distorted geometries. Methods for detecting an analyte in a sample include the steps of: (a) capturing an analyte on a su... | 06/29/2010 |
| 7569391 | Method for making β-secretase co-crystals complexed with a ligand The present application relates to methods for growing crystals of both the uncomplexed and complexed forms of β-secretase (BACE) polypeptide. The present application also relates to crystalline forms of uncomplexed BACE and the three-dimensional structure of BACE,... | 08/04/2009 |
| 7444273 | Crystallization of aurora/LPL1P-related kinase Provided are crystals relating to Aurora/LPL1P-related kinase and its various uses. ... | 10/28/2008 |
| 7442537 | Crystals of unliganded beta secretase and/or beta secretase-like proteins and the use thereof The x-ray crystal structure of BACE or BACE-like proteins is useful for solving the structure of other molecules or molecular complexes, and identifying and/or designing potential modifiers of BACE activity. ... | 10/28/2008 |
| 7433788 | Crystallization of IGF-1 Crystalline IGF-1 is provided along with a method for production thereof. Crystallizing IGF-1 comprises the steps of mixing an aqueous solution comprising IGF-1 with a reservoir solution comprising a precipitant to form a mixture; and crystallizing the mixture, opti... | 10/07/2008 |
| 7422885 | Crystalline form of the catalytic domain of Aurora 2 kinase and methods of use thereof The present invention discloses nucleic acids that encode an active human Aurora 2 kinase catalytic domain. The present invention also discloses methods of growing X-ray diffractable crystals of polypeptides comprising the active human Aurora 2 kinase catalytic doma... | 09/09/2008 |
| 7384773 | Crystal of HIV protease-cleaved human beta secretase and method for crystallization thereof The x-ray crystal structure of human BACE or BACE-like proteins is useful for solving the structure of other molecules or molecular complexes, and identifying and/or designing potential modifiers of human BACE activity. ... | 06/10/2008 |
| 7368288 | Detection and recognition of analytes based on their crystallization patterns The invention contemplates a method for recognition of proteins and other biological molecules by imaging morphology, size and distribution of crystalline and amorphous dry residues in droplets (further referred to as “crystallization pattern”) containing predet... | 05/06/2008 |
| 7368269 | Crystallization of MAPK/ERK Kinase 2 Provided are crystals relating to human mitogen-activated protein kinase kinase2 (MAPKK2), also known as MAPK/ERK Kinase2 (MEK2) and its various uses. ... | 05/06/2008 |
| 7361492 | Crystal structure of aurora-2 protein and binding pockets thereof The present invention provides crystalline molecules or molecular complexes which comprise binding pockets of Aurora-2 or its homologues. The invention also provides crystals comprising Aurora-2. The present invention also relates to a computer comprising a data sto... | 04/22/2008 |
| 7326552 | Wild-type kinase domain of human Ephrin receptor A2 (EPHA2) and crystallization thereof Provided are crystals relating to human Ephrin Receptor A2 and its various uses. ... | 02/05/2008 |
| 7326385 | Plate and method for high throughput screening A multiple well plate and method for media exchange, including a body defining a plurality of cell wells each connected via a channel to one of a plurality of aspiration holes, is provided. The cell wells contain a porous, hydrophilic frit which is suspended on a le... | 02/05/2008 |
| 7312082 | Crystal structure of G-quadruplex containing a potassium ion The present invention relates to a crystal structure of G-quadruplexes and its use. The invention provides a crystal of an intramolecular G-quadruplex structure having a hexagonal space group P6, and unit cell dimensions a=b=56.7 and c=42.1; α=β=90°, γ=120° and... | 12/25/2007 |
| 7303991 | Atomic layer deposition methods The invention includes an atomic layer deposition method of forming a layer of a deposited composition on a substrate. The method includes positioning a semiconductor substrate within an atomic layer deposition chamber. On the substrate, an intermediate composition ... | 12/04/2007 |
| 7303725 | Automated high volume slide staining system An automated slide processing apparatus includes a plurality of work stations arranged in a stack, and a transport/elevator for transporting slides between the various work stations. ... | 12/04/2007 |
| 7300750 | Analyte assay device with preabsorbing zone The present invention provides an assay device for detection of an analyte which is a member of a specific binding partner in a sample, the assay device comprising a sample application zone, a preabsorbing zone and a specific binding zone. The device can provide a H... | 11/27/2007 |
| 7285408 | Crystalline form of an n231 mutant catalytic domain of ADAM33 and methods of use thereof The present invention discloses purified polypeptides that comprise an active human ADAM33 catalytic domain. In addition, the present invention discloses nucleic acids that encode the polypeptides of the present invention. The present invention also discloses method... | 10/23/2007 |
| 7276477 | Crystals of etanercept and methods of making thereof The present invention relates to crystalline etanercept and to methods of making crystalline etanercept; to pharmaceutical compositions comprising crystalline etanercept; and to therapeutic uses of such compositions. ... | 10/02/2007 |
| 7270987 | Crystallization of FMS-like tyrosine kinase 3 Provided are crystals and structure coordinates relating to FMS-like tyrosine kinase 3 and its various uses. ... | 09/18/2007 |
| 7267957 | Detection and amplification of ligands A system for the detection of ligands comprising at least one receptor and an amplification mechanism coupled to the receptor wherein an amplified signal is produced as a result of receptor binding a ligand. Examples of suitable amplification mechanisms include anti... | 09/11/2007 |
| 7148066 | Dye solutions for use in methods to detect the prior evaporation of anhydrous ammonia and the production of illict drugs Systems and methods providing for the introduction of a dye, particularly a xanthene dye, and more particularly a rhodamine dye, to liquid anhydrous ammonia to discourage theft of the anhydrous ammonia and provide for leak detection in storage vessels. The dye will ... | 12/12/2006 |
| 7135143 | Detecting compounds with liquid crystals A device for detecting a compound in a sample includes a substrate and a self-assembled monolayer. The substrate includes a support with a metallized top surface, and the self-assembled monolayer includes an alkanethiol attached to the metallized top surface of the ... | 11/14/2006 |
| 7101714 | Molecules of the card-related protein family and uses thereof Novel CARD-3, CARD-4L, CARD-4S, CARD-4Y, CARD-4Z, and murine CARD-4L polypeptides, proteins, and nucleic acid molecules are disclosed. In addition to isolated CARD-3, CARD-4L, CARD-4S, CARD-4Y, CARD-4Z, and murine CARD-4L proteins, and the invention further provides... | 09/05/2006 |
| 7081364 | Substrate for packaging perishable goods or for application onto same and method for determining the quality of said goods The invention relates to a substrate for packaging of or for attachment to products which are sensitive to aging and temperature, having a planar time-temperature integrator comprising a matrix and at least one reversible indicator embedded therein, which has photoc... | 07/25/2006 |
| 7058249 | Waveplate and optical circuit formed using mesogen-containing polymer Waveplate, planar lightwave circuit incorporating the waveplate, and method of making an optical device. The waveplate is formed of a mesogen-containing polymer film having a backbone and sidechains containing mesogen groups. The waveplate may be formed by producing... | 06/06/2006 |
| 7015041 | Automated method for setting up multiple crystallization experiments in submicroliter volumes A method is provided for performing array microcrystallizations to determine suitable crystallization conditions for a molecule, the method comprising: forming an array of microcrystallizations, each microcrystallization comprising a drop comprising a mother liquor ... | 03/21/2006 |
| 7010468 | Method and apparatus for slope to threshold conversion for process state monitoring and endpoint detection A method for converting a slope based detection task to a threshold based detection task is provided. The method initiates with defining an approximation equation for a set of points corresponding to values of a process being monitored. Then, an expected value at a ... | 03/07/2006 |
| 7001438 | Method for performing submicroliter crystallization experiments with high experiment to experiment precision A method is provided for forming crystallization experiments for a molecule, the method comprising forming a plurality of crystallization experiments that comprise a molecule to be crystallized and a composition that varies among the plurality of crystallization exp... | 02/21/2006 |
| 6951575 | Method for performing high density submicroliter crystallization experiments A method is provided for performing array microcrystallizations to determine suitable crystallization conditions for a molecule, the method comprising: forming an array of microcrystallizations, each microcrystallization comprising a drop comprising a mother liquor ... | 10/04/2005 |
| 6939515 | Apparatuses and methods for creating and testing pre-formulations and systems for same The invention provides methods, apparatus, and systems for performing high-throughput preparation and screening of salts and polymorphs of drug candidates. The invention is directed towards enhancing the pre-formulation discovery process used for drug development. I... | 09/06/2005 |
| 6932845 | Method for performing submicroliter crystallization experiments A method is provided for performing crystallization experiments for a molecule, the method comprising performing a plurality of crystallization experiments where the crystallization experiments have volumes of less than 1 microliter, the crystallization experiments ... | 08/23/2005 |
| 6916657 | Evaluation method for polycrystalline silicon An evaluation method for polycrystalline silicon including the steps of immersing the polycrystalline silicon in an agent which is capable of dissolving the polycrystalline silicon, and counting the number of foreign particles in the agent. The polycrystalline silic... | 07/12/2005 |
| 6911056 | Method for diffracting crystals formed by submicroliter crystallization experiments A method is provided for characterizing a crystal structure of a molecule, the method comprising performing a plurality of crystallization experiments where the crystallization experiments have volumes of less than 1 microliter, the crystallization experiments compr... | 06/28/2005 |
| 6890764 | Encoding and decoding of array sensors utilizing nanocrystals Described herein are assays and components for encoding and decoding microspheres. Each assay or component described utilizes at least one nanocrystal. ... | 05/10/2005 |
| 6867858 | Raman spectroscopy crystallization analysis method A method of monitoring sample crystallization from a solution. The method includes the collection of multiple Raman spectra from a sample dissolved in a solvent as a function of time and under conditions promoting crystallization. Within each of the multiple Raman s... | 03/15/2005 |
| 6858423 | Optical Amplification of molecular interactions using liquid crystals Interactions between molecules which are components of self-assembled monolayers and other molecules can be amplified and transduced into an optical signal through the use of a mesogenic layer. The invention provides a device and methods for detecting analytes. The ... | 02/22/2005 |
