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| Number | Title | Issue Date |
| 6433868 | Method for differential spectroscopic measurements The patent relates to a method for spectroscopic and spectrofluorimetric determination of the interaction between materials. The determination takes place using apparatus consisting of several basins.... | 08/13/2002 |
| 6432358 | Diagnostic assay device A diagnostic device adapted to retain a fluid sample to be analyzed until it is desired to initiate the analytical test is described. The device includes a deformable material layer, a well for holding a fluid sample, a porous material and a diagnostic as... | 08/13/2002 |
| 6426230 | Disposable diagnostic device and method Disclosed is a disposable diagnostic device for conducting a diagnostic test on a sample. The device includes a substantially planar, flexible article, a channel formed within the article, at least one fluid-receiving compartment formed within the article... | 07/30/2002 |
| 6410341 | Analytical test device and method for use in medical diagnoses An analytical test device is described for the immunochromatographic determination of the presence of one or more analytes in fluid samples. The device is configured such that the sample is allowed to enter the detection zone simultaneously from many diff... | 06/25/2002 |
| 6410252 | Methods for measuring T cell cytokines The present invention relates to devices and methods for detecting cellular products, and in particular for measuring secreted cellular products, including cytokines. Microwells comprising hydrophobic membranes are described having greater capability to d... | 06/25/2002 |
| 6406672 | Plasma retention structure providing internal flow A capillary hematocrit separation structure is included within a housing having a fluid inlet port, a reaction region, and a capillary pathway connecting the inlet port and the reaction region. The capillary pathway is dimensioned so that the driving forc... | 06/18/2002 |
| 6403298 | Method and apparatus for urine self-test intended for use in a toilet A method and apparatus for urine self testing wherein the apparatus is placed directly into the toilet after urination which avoids the direct placement and retention of an apparatus in the stream of urine as is common with urine testing devices. The appa... | 06/11/2002 |
| 6399295 | Use of wicking agent to eliminate wash steps for optical diffraction-based biosensors The present invention provides an inexpensive and sensitive system and method for detecting analytes present in a medium. The system comprises a diffraction enhancing element, such as functionalized microspheres, which are modified such that they are capa... | 06/04/2002 |
| 6399026 | Sample holder apparatus A sample holder apparatus for a top-loading cryostat insert based on a cage assembly system which is mounted onto a vacuum flange. The vacuum flange has a group of blind bores on the vacuum side of the flange, in which are mounted hollow cage assembly rod... | 06/04/2002 |
| 6399023 | Analytical system and method An analytical system comprised as a base unit, an adapter, and a sample substrate. The adapter is attached to an attachment region on the base unit, and the sample substrate is attached to an attachment region on the adapter. The adapter permits the base ... | 06/04/2002 |
| 6395553 | Method for controlling reactions The invention relates to a method and an apparatus for performing an assay on chemical, biochemical, or biological fluids. The apparatus includes an assay chamber for fluid reactions and a centrifugal force activated-valve for controlling fluid movement t... | 05/28/2002 |
| 6395562 | Diagnostic microarray apparatus A compact assay system having a solid support has at least one capture binding agent on the support surface. By applying a combination of different binding agents on the support surface, the present invention can conduct multiple chemical reactions on the... | 05/28/2002 |
| 6391653 | Acoustic standing-wave enhancement of a fiber-optic salmonella biosensor A fluorescent fiber-optic biosensor system using ultrasonic concentration of particles and cells for the detection of Salmonella typhimurium. A biosensor test chamber serves as an ultrasonic standing-wave cell that allows microspheres or cells to be conce... | 05/21/2002 |
| 6391541 | Apparatus for analyzing a fluid sample A cartridge for separating a desired analyte from a fluid sample has a sample flow path and a lysing chamber in the sample flow path. The lysing chamber contains at least one filter for capturing cells or viruses from the sample as the sample flows throug... | 05/21/2002 |
| 6387327 | Apparatus for the preparation and the performance of sedimentation velocity tests on organic liquids and other substances On a base structure (101, 103), an assembly (104) oscillates about a horizontal axis (X--X) between two limit positions; on said assembly, a rotor (106) is capable of rotating about an axis (Y--Y) of rotation orthogonal to said horizontal axis (X--X) and ... | 05/14/2002 |
| 6383748 | Analytical test device with substrate having oriented through going channels and improved methods and apparatus for using same The present invention is directed to methods for analyzing one or more fluid samples for the presence, amount or identity of one or more analytes optionally present in said samples, which uses a device having one or more round wells with a fixed diameter,... | 05/07/2002 |
| 6372514 | Even fluid front for liquid sample on test strip device Test strip device for accepting a liquid sample and forming an even fluid front across the test strip. When the sample is applied to a contacting surface, it runs down the surface where it collects between the contacting surface and a slope surface. As th... | 04/16/2002 |
| 6372511 | Swabbing means and methods of use Swabbing structures and methods of use are provided that enable a test surface to be swabbed, and subsequently facilitate a quantitative determination of the quantities of analyte collected from the test surface. The swabbing structures include a pre-wett... | 04/16/2002 |
| 6365106 | Sheath flow cell and blood analyzer using the same A sheath flow cell includes a cell having a guide hole with an inlet and an outlet for guiding a sheath liquid. The cell has a rectifying section, an accelerating section and an orifice section having a cylindrical through-hole, a cone-shaped through-hole... | 04/02/2002 |
| 6350412 | Microsample tube with reduced dead volume and barcode capability A micro sample tube is disclosed which is of a standard size on the exterior, but which has a reduced internal volume. A slope of an inner wall of the sample tube is a second order or higher curve, and is preferably a circle. Dead volume is reduced, and s... | 02/26/2002 |
| 6342183 | System for collecting and locally analyzing a fluid specimen A method and apparatus for collecting a fluid specimen, locally analyzing the specimen to qualitatively detect specified chemical components at concentrations above threshold levels, and providing machine readable test results for facilitating data collec... | 01/29/2002 |
| 6338820 | Apparatus for performing assays at reaction sites An apparatus for performing a assays includes an axially rotatable substrate including a plurality of layers of a semiconductor material and numerous radially-arrayed reaction sites. The apparatus further includes a rotary stepper motor which rotates the ... | 01/15/2002 |
| 6333007 | Photometer and cuvette for mixing A photometer for determining the transmission of a liquid sample in a microcuvette (7, 20, 22) has a cavity for a capillary layer of the liquid sample with a free liquid surface extended transversely of the principal plane of the cavity. The cavity is ini... | 12/25/2001 |
| 6328931 | Analyte collection and assaying assembly Swabbing and assaying structures, and selected methods of use, enable a test surface to be swabbed, and subsequently facilitate a quantitative determination of the quantities of analyte collected from the test surface. The swabbing structures include a pr... | 12/11/2001 |
| 6326210 | Method of making and connecting a miniaturized integrated sensor A miniaturized integrated sensor (50) useful for indicating the presence of a sample analyte is disclosed. The sensor (50) has a platform (52) with an upper surface (53) and a detector (62), light source (60), waveguide (58), and reflective fixtures (60,6... | 12/04/2001 |
| 6326612 | System and method for optical sensing utilizing a portable, detachable sensor cartridge Disclosed is a sensing system and method utilizing a sensor cartridge (10) for making analytical measurements regarding one or more samples (50) of interest, the cartridge (10) comprising an opaque housing (12) having an opening (32), the opening (32) all... | 12/04/2001 |
| 6326213 | Acoustic standing-wave enhancement of a fiber-optic Salmonella biosensor A fluorescent fiber-optic biosensor system using ultrasonic concentration of particles and cells for the detection of Salmonella typhimurium. A biosensor test chamber serves as an ultrasonic standing-wave cell that allows microspheres or cells to be conce... | 12/04/2001 |
| 6325980 | Test strip incubation device A test strip incubation device and method for developing a test strip having a reagent test pad disposed thereon, the reagent test pad requiring an incubation time, which allows greater accuracy and reliability of test results as well as a narrower window... | 12/04/2001 |
| 6325978 | Oxygen monitoring and apparatus Apparatus or systems which employ luminescence quenching to produce an oxygen concentration indicative signal. Components of such systems include: (1) an airway adapter, sampling cell, or the like having a sensor which is excited into luminescence with th... | 12/04/2001 |
| 6319719 | Capillary hematocrit separation structure and method A capillary hematocrit separation structure is included within a housing having a fluid inlet port, a reaction region, and a capillary pathway connecting the inlet port and the reaction region. The capillary pathway is dimensioned so that the driving forc... | 11/20/2001 |
| 6316274 | Apparatus and methods for multi-analyte homogeneous fluoro-immunoassays Methods and apparatus for evanescent light fluoroimmunoassays are disclosed. The apparatus employs a planar waveguide with an integral semi-cylindrical lens, and has multi-analyte features and calibration features, along with improved evanescent field int... | 11/13/2001 |
| 6309889 | Nano-grid micro reactor and methods The invention provides exemplary devices and methods to facilitate the performance of assays. In one embodiment, one such device comprises a holding member having a top surface, a bottom surface, and a plurality of holding locations that are adapted to ho... | 10/30/2001 |
| 6306609 | Methods for the detection of nitric oxide in fluid media In accordance with the present invention, there are provided articles for use in non-invasive measurements of nitric oxide levels in a variety of fluid media, e.g., in mammalian body fluids. Articles according to the present invention comprise a nitric ox... | 10/23/2001 |
| 6300082 | Method and apparatus for measurement of the effect of test compounds on signal transduction at the level of biological receptors A method and apparatus for measuring binding between a plurality of molecules of a biological receptor protein and a plurality of molecules of a type which binds to said biological receptor is presented. Apparatus utilizes a sensor possessing a waveguide ... | 10/09/2001 |
| 6287870 | Method and assembly for separating formed constituents from a liquid constituent in a complex biologic fluid sample Formed constituents in an aqueous based fluid biologic material sample are separated from the aqueous constituent of the sample, and are concentrated in an examining instrument's focal plane where they can be examined under magnification. Examples of flui... | 09/11/2001 |
| 6287783 | Optical assay device and method The present invention involves an optical assay device and method of use for the detection of an analyte of interest in a sample that conveniently allows control of the flow characteristics of the sample through the device without significant user interve... | 09/11/2001 |
| 6280960 | Optical detection and analysis of sub-micron particles Method and apparatus for the single particle detection of submicron structures such as biological molecules and viruses utilises and optically transparent substrate coated with a thin film of metal illuminated with an optical beam incident at or close to ... | 08/28/2001 |
| 6277653 | Optical assaying method and system having movable sensor with multiple sensing regions An optical assaying method and system having a movable sensor is described. In one aspect, the present invention is a sensing system having a rotating sensor disk coated with indicator dyes sensitized to a variety of substances. In this configuration the ... | 08/21/2001 |
| 6277647 | Test strip incubation device A test strip incubation device and method for developing a test strip having a reagent test pad disposed thereon, the reagent test pad requiring an incubation time, which allows greater accuracy and reliability of test results as well as a narrower window... | 08/21/2001 |
| 6277646 | Fluid specimen collecting and testing apparatus A device is provided for both collecting and testing a fluid specimen. The device includes a specimen container having a collection chamber, an isolation chamber and a test chamber. The collection chamber is in fluid communication with the isolation chamb... | 08/21/2001 |
