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| Number | Title | Issue Date |
| 6099740 | Apparatus and methods for preparing blood or plasma component solutions of known concentration An apparatus for separating a blood component, e.g., fibrin monomer, from blood or plasma comprises a container (110) with a reaction chamber for receiving the plasma, where said reaction chamber is defined by an outer wall and comprises means for supplyi... | 08/08/2000 |
| 6096268 | Chromogenic and turbidimetric assay device The present invention relates to a diagnostic assay device comprising a fluorophore element comprising a fluorophore imbedded therein, and a reagent element. The fluorophore element and reagent element have opposed surfaces which are spaced apart througho... | 08/01/2000 |
| 6096552 | Method for determining the concentration of colored compounds in meat juice A method is provided for monitoring the cooking temperature of meat patties. More specifically, a method is provided for monitoring the cooking temperature of meat patties by determining the concentration of colored compounds, such as myoglobin, in meat j... | 08/01/2000 |
| 6077711 | Frangible ampule specimen test card A method and apparatus for testing tissue samples is provided which includes an integrated specimen test card. The test card is especially useful in testing for the presence of blood in stool samples and includes a frangible ampule contained within a chan... | 06/20/2000 |
| 6071478 | Analytical system and method An analytical or preparatory system comprised as a base unit, an adapter, and a substrate. The adapter is attached to an attachment region on the base unit, and the substrate is attached to an attachment region on the adapter. The adapter permits the base... | 06/06/2000 |
| 6046056 | High throughput screening assay systems in microscale fluidic devices The present invention provides novel microfluidic devices and methods that are useful for performing high-throughput screening assays. In particular, the devices and methods of the invention are useful in screening large numbers of different compounds for... | 04/04/2000 |
| 6042543 | Test device and method for quantitative measurement of an analyte in a liquid A device and method for determining the concentration of an analyte, particularly a chloride ion, in a liquid sample are particularly useful to screen for cystic fibrosis in an individual. In a preferred embodiment, the device takes the form of a patch co... | 03/28/2000 |
| 6033914 | Electrochemical analytical cartridge An electro-analytical cartridge adapted for use in analyzing fluids. The cartridge includes an electrochemical device that measures ionic activity using ion-specific electrodes. The cartridge further includes a plumbing system composed of the electrochemi... | 03/07/2000 |
| 6030845 | Immunoassay method for lysed whole blood An immunoassay method in which blood can be measured even without pretreatment by a centrifuge etc. In the present invention, antibodies or antigens in a sample are subjected to agglutination reaction with insoluble carriers onto which antigens or antibod... | 02/29/2000 |
| 6024923 | Integrated fluorescence-based biochemical sensor An integrated biochemical sensor (200) for detecting the presence of one or more specific samples (240) having a device platform (355) with a light absorbing upper surface and input/output pins (375) is disclosed. An encapsulating housing (357) provides a... | 02/15/2000 |
| 6019944 | Diagnostic devices and apparatus for the controlled movement of reagents without membranes The assay devices, assay systems and device components of this invention comprise at least two opposing surfaces disposed a capillary distance apart, at least one of which is capable of immobilizing at least one target ligand or a conjugate in an amount r... | 02/01/2000 |
| 6017696 | Methods for electronic stringency control for molecular biological analysis and diagnostics A self-addressable, self-assembling microelectronic device is designed and fabricated to actively carry out and control multi-step and multiplex molecular biological reactions in microscopic formats. These reactions include nucleic acid hybridizations, an... | 01/25/2000 |
| 6013528 | Analyzer throughput featuring through-the-tip analysis Apparatus and method for detecting patient sample quality, and/or analytes, in the tip used to aspirate the patient sample liquid and then dispense it onto a slide test element. Spectrophotometric analysis is done on the liquid while still in the tip, by ... | 01/11/2000 |
| 6007999 | Reversible flow chromatographic binding assay Disclosed are devices and methods for performing an assay which determines the presence or quantity of an analyte in a fluid sample by detecting binding of the analyte to at least one immobilized analyte capture reagent and washing unbound material from t... | 12/28/1999 |
| 6004820 | Method of using a water testing capsule using water soluble film membranes A capsule package and a touch-free method for water analysis. It allows for addition of dry ingredients and aqueous test reagent without any human intervention, and therefore substantially decreases the possibility for analysis error. Furthermore, it elim... | 12/21/1999 |
| 6002475 | Spectrophotometric analytical cartridge An analytical cartridge adapted for use in analyzing fluids for spectrophotometry. The cartridge includes a plumbing system composed of the cuvette and various wells or chambers which are interconnected by passageways. After introduction into the cartridg... | 12/14/1999 |
| 5998214 | Environmental sample collection and membrane testing device An apparatus for collecting fluids and holding samples taken from the fluid for qualitative and quantitative testing. The apparatus comprises a tubular container open at both ends with a quantitative test storage unit removably secured to one of said tubu... | 12/07/1999 |
| 5994150 | Optical assaying method and system having rotatable sensor disk with multiple sensing regions An optical assaying method and system having a movable sensor is described. In one aspect, the present invention is a sensing system having a rotating sensor disk coated with indicator dyes sensitized to a variety of substances. In this configuration the ... | 11/30/1999 |
| 5993746 | Plate holder A holder for sample-holding plates has a retainer for pressing a plate placed in the holder both against the back wall and against a side wall. Thus a plate of a certain type will always settle in the same position in the holder. It is also possible to us... | 11/30/1999 |
| 5989923 | Hologram containing sensor The invention relates to a sensor (9) comprising a hologram (17) supported on or within a holographic support medium (10). A species to be detected is reactive with a substance disposed throughout, the sensor (9). Optionally, a chemical reactive with a species... | 11/23/1999 |
| 5972715 | Use of thermochromic liquid crystals in reflectometry based diagnostic methods A method for improving the accuracy of temperature sensitive diagnostic assays which are carried out using reflectance spectrometers to detect color changes in a solid test system which has been contacted with a fluid test system suspected of containing a... | 10/26/1999 |
| 5965453 | Test apparatus, system and method for the detection of test samples The invention concerns a test apparatus for the testing of a test sample on or in a material, such as body fluids or food, particularly adapted to a bioluminescent test, such as for the detection of ATP or phosphatase or other materials. The test apparatu... | 10/12/1999 |
| 5961923 | Matrices with memories and uses thereof Combinations, called matrices with memories, of matrix materials that are encoded with an optically readable code are provided. The matrix materials are those that are used in as supports in solid phase chemical and biochemical syntheses, immunoassays and... | 10/05/1999 |
| 5955026 | Detecting the thickness of fibrin polymer using an optical device An apparatus for separating a blood component, e.g., fibrin monomer, from blood or plasma comprises! includes a container (110)! with a reaction chamber for receiving the plasma, where said! the reaction chamber is defined by an outer wall and com... | 09/21/1999 |
| 5948686 | Method for performing blood cell counts A method for evaluating constituents of a sample of substantially undiluted anti-coagulated whole blood is provided which includes the steps of a) providing a sample chamber; b) admixing a sensible colorant with the sample of whole blood; c) inserting the... | 09/07/1999 |
| 5939329 | Test strip incubation device and method A test strip incubation device and method for developing a test strip having a reagent test pad disposed thereon, the reagent test pad requiring an incubation time, which allows greater accuracy and reliability of test results as well as a narrower window... | 08/17/1999 |
| 5940178 | Nephelometer and turbidimeter combination A nephelometer and nephelometer/turbidimeter combination of the type useful in automated chemical analyzers is provided. The combination includes a laser for generating a polarized laser beam having an S-wave component and a P-wave component. The beam is ... | 08/17/1999 |
| 5922285 | Integrated fluorescence-based biochemical sensor An integrated biochemical sensor (200) for detecting the presence of one or more specific samples (240) having a device platform (355) with a light absorbing upper surface and input/output pins (375) is disclosed. An encapsulating housing (357) provides a... | 07/13/1999 |
| 5922593 | Microbiological test panel and method therefor A microbiological test panel assembly used in microorganism identification (ID) and antimicrobial susceptibility determinations (AST) testing is provided. The microbiological test panel assembly includes a plurality of test wells segregated into two secti... | 07/13/1999 |
| 5919712 | Apparatus and methods for multi-analyte homogeneous fluoro-immunoassays Methods and apparatus for evanescent light fluoroimmunoassays are disclosed. The apparatus employs a planar waveguide with an integral semi-cylindrical lens, and has multi-analyte features and calibration features, along with improved evanescent field int... | 07/06/1999 |
| 5919711 | Analytical cartridge An analytical cartridge adapted for use in analyzing fluids which contain liquid and solid components. The cartridge includes a plumbing system composed of various wells or chambers which are interconnected by passageways. After introduction into the cart... | 07/06/1999 |
| 5916814 | Presealed integral hematocrit test assembly and method A presealed integral hematocrit test assembly includes a holder, a bore molded into the holder, and a blood sample tube mounted on the holder adapted to receive a sample of blood by capillary action, whereby the blood sample tube is filled with blood from... | 06/29/1999 |
| 5912134 | Disposable cartridge and method for an assay of a biological sample A cartridge is provided to present a biological sample for analysis by an imaging instrument. The cartridge of the invention utilizes a series of channels, capillaries, reservoirs and stop junctions to precisely move a sample, reagent and diluent through ... | 06/15/1999 |
| 5910449 | Assessment of characteristics of fluids The invention relates to an apparatus for measuring the ability of a fluid to transmit radiation therethrough, the apparatus comprises a chamber for receiving the fluid and associated means for examining the transmission of radiation through the fluid at ... | 06/08/1999 |
| 5908786 | Blood coagulation monitoring device with liquid crystal and gradient heater A device and method are disclosed for determining whether or not an individual's blood coagulation time is in a normal or abnormal range, and is particularly suitable for measuring prothrombin time and activated partial thromboplastin time coagulation val... | 06/01/1999 |
| 5895762 | Apparatus and method for handling fluid samples of body materials A system for handling a body specimen is described for particular use in the handling of fecal specimen which are to be treated with a stain for enhancing its visibility. The system includes dual optical viewing chambers mounted alongside of each other on... | 04/20/1999 |
| 5894061 | Diffusion through a membrane assaying apparatus and method The diffusion through a membrane assaying apparatus and method facilitates rapid detection of small or larger molecular weight substances such as hazardous wastes, toxic chemicals or the like by using a semipermeable membrane having a predetermined molecu... | 04/13/1999 |
| 5891658 | Single-step, solid-state competitive immunoassay Simplicity, sensitivity and versatility of optical sensors based on competitive immunoassays using antibody-antigen reactions are achieved by solid-state, single-step reactions which permit accurate sensitive qualitative and quantitative information to be... | 04/06/1999 |
| 5885529 | Automated immunoassay analyzer An improved automated immunoassay analyzer including a high throughput automated immunoassay system which can perform high volume testing on a broad range of analytes while selecting from among a diverse set of immunoassays for any given sample. The immun... | 03/23/1999 |
| 5885842 | Methods for the detection of nitric oxide in fluid media Non-invasive methods have been developed for the measurement of NO levels in a variety of fluid media, e.g., body fluids. The present invention embraces the use of a semi-permeable vessel wherein said vessel contains an NO reacting substance to trap NO di... | 03/23/1999 |
