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| Number | Title | Issue Date |
| 7297480 | Method for detection of melanoma The present invention provides non-invasive methods for detecting, monitoring, staging, and diagnosing malignant melanoma in a skin sample of a subject. The methods include analyzing expression in skin sample of one or more melanoma skin markers. The melanoma skin m... | 11/20/2007 |
| 7214522 | Thermophilic DNA polymerases from The present invention provides compositions comprising thermostable DNA polymerases derived from hyperthermophilic eubacteria. In particular, the present invention comprises thermostable DNA polymerases from the hyperthermophilic eubacterial species Thermoactinom... | 05/08/2007 |
| 7094539 | reverse transcription compositions and kits The present invention relates to reverse transcription of RNA, and in particular to reverse transcription by thermostable DNA polymerases. Thermoactinomyces vulgaris and Bacillus stearothermophilus possess reverse transcriptase activity in the presence... | 08/22/2006 |
| 7074565 | Preparation of DNA-containing extract for PCR amplification Environmental samples typically include impurities that interfere with PCR amplification and DNA quantitation. Samples of soil, river water, and aerosol were taken from the environment and added to an aqueous buffer (with or without detergent). Cells from the sample... | 07/11/2006 |
| 6951721 | Method for determining the haplotype of a human BRCA1 gene Methods for identifying functional allele profiles of a given gene are disclosed. Functional allele profiles comprise the commonly occurring alleles in a population, and the relative frequencies at which such alleles of a given gene occur. Functional allele profiles... | 10/04/2005 |
| 6569629 | Gene markers for beef marbling and tenderness Methods and compositions are provided for objectively identifying: i) bovine animals having the genetic potential to produce beef that is marbled or tender, and ii) bovine carcasses whose beef is marbled or tender. The methods comprise extracting DNA from... | 05/27/2003 |
| 6533255 | Liquid metal-heating apparatus for biological/chemical sample An apparatus for temperature control of biological/chemical samples employing liquid metal is described. A gallium-indium alloy may be used to provide excellent temperature control. Methods of using liquid metal to provide temperature control for biologic... | 03/18/2003 |
| 6524795 | Diagnostics for cardiovascular disorders The kits and methods of the present invention relate to the diagnosis of cardiovascular disorders. In one aspect, the invention discloses a method and a kit for determining whether a subject has a fragile plaque disorder. In one aspect, the invention disc... | 02/25/2003 |
| 6451980 | Signal enhancement of bispecific antibody-polymer probe for immunoassay use An immunoassay method including reacting a sample from a patient with a bispecific antibody, wherein the bispecific antibody includes one antibody specific for a compound to be detected and a second antibody specific for a compound foreign to said patient... | 09/17/2002 |
| 6423490 | Method for measuring the concentration of polynucleotides A method for measuring the presence of polynucleotide in a sample, comprising the steps of: (1) preparing a sample, an agglutinative agent and an agglutination promoter capable of binding to polynucleotide; (2) mixing said sample, said agent and said prom... | 07/23/2002 |
| 6410235 | DNA detection by means of a strand reassociation complex The discriminating capability of hybridization assays is increased by a combination of labelled primers which produce amplificates of one strand of a nucleic acid with a capture probe which is complementary to the same strand of the nucleic acid.... | 06/25/2002 |
| 6274317 | Automated allele caller An auto allele caller executed in a computer system for identifying alleles from a trace is described. The auto allele caller applies a typical shape of an allele for a marker to the trace to identify potential allele calls that match to the typical shape... | 08/14/2001 |
| 6258542 | Method for supporting DNA-fixation and DNA-fixed support In order to make possible to preserve promptly and efficiently a DNA and to distribute the same without taking much labor and much time, a DNA solution is allowed to adhere to a sheet-like support having a prescribed thickness, and the DNA solution which ... | 07/10/2001 |
| 6251877 | Composition for external application containing a ଲ-1,6-branched-ଲ-1,3-glucan Disclosed herein is a process for liquid cultivating Schizophyllum commune Fr. for isolation of ଲ-1,6-branched-ଲ-1,3-glucan and a composition for external application containing ଲ-1,6-branched-ଲ-1,3-glucan as an active ingredient, ... | 06/26/2001 |
| 6218111 | Tag reagent and assay method This invention provides reagents, libraries and sets of the reagents, and assay methods using the reagents, the reagents comprising an analyte moiety and a tag moiety, wherein the tag moiety contains information defining the identify and location of the a... | 04/17/2001 |
| 6197502 | Expression cloning processes for the discovery characterization, and isolation of genes encoding polypeptides with a predetermined property The present invention is directed to a method for detection, characterization and isolation of nucleic acids encoding proteins of a desired property, such as a particular cellular localization. The invention further provides for rapid expression of such p... | 03/06/2001 |
| 6168918 | Method of detecting foreign DNA integrated in eukaryotic chromosomes Methods of detecting the presence of a plasmid DNA sequence integrated in a chromosomal DNA molecule of a eukaryotic cell in a sample that contains chromosomal DNA molecules of eukaryotic cells and free plasmid DNA molecules are disclosed. According to th... | 01/02/2001 |
| 6153388 | Method of determining melanoma micrometastasis using tyrosinase A highly sensitive method to detect melanoma micrometastasis by examining lymph nodes for the presence of tyrosinase messenger RNA. In a preferred mode, this is accomplished using the combination of reverse transcription and double round polymerase chain ... | 11/28/2000 |
| 6083698 | Cancer susceptibility mutations of BRCA1 New mutations have been found in the BRCA1 gene. The mutations are located at nucleotide numbers 421-2, 815, 903, 926, 1506, 2034, 2428, 3888, 3904, 4164, 4643, 5053, 5150, 5210, or 5396+40 of the gene sequence of BRCA1. A process for identifying a sequen... | 07/04/2000 |
| 6054268 | Method and system for genotyping The present invention pertains to a process which can be fully automated for accurately determining the alleles of genetic markers. More specifically, the present invention is related to performing PCR amplification on locations of DNA to generate a repro... | 04/25/2000 |
| 5929017 | Enzymatic detergent composition A lipolytic enzyme with high activity at alkaline pH in the absence of Ca++ can be obtained from strains of filamentous fungi belonging to the genus Absidia. The lipolytic enzymes are effective for improving the effect of detergents towards fat... | 07/27/1999 |
| 5800980 | Detection of MSRV1 virus and MSRV2 pathogen and/or infective agent associated with multiple sclerosis, by nucleic acid hybridization Composition including two pathogenic and/or infective agents associated with multiple sclerosis, namely a first agent which consists of a human virus possessing reverse transcriptase activity and related to a family of endogenous retroviral elements, or a... | 09/01/1998 |
| 5232842 | Method for preparing chitosan According to the method for preparing chitosan of the present invention, chitosan is prepared by inoculating a filamentous fungi belonging to the family Mucoraceae into a culture medium for pre-cultivation containing yeast extract, malt extract, peptone, ... | 08/03/1993 |
| 5089176 | Optically active monoester compounds and producing An optically active monoester of the formula of ##STR1## where R is C1 -C15 alkyl is disclosed. The monoester is produced by transesterification of cis-endo-bicyclo [2,2,2] oct-5-ene-2,3-dimethanol with a fatty acid alkyl or vin... | 02/18/1992 |
| 4956285 | Process for the preparation of S-2,2-R1,R2 -1,3 -dioxolane-4-methanols A process for the preparation of an enriched S-isomer of a 2,2-R1,R2 -1,3-dioxolane-4-methanol of the formula ##STR1## wherein R1 and R2 are individually selected from the group consisting of hydrogen and a... | 09/11/1990 |
| 4415657 | Process for preparation of an optically active monoalkyl ester of ଲ-(S)-aminoglutaric acid A process is disclosed in which an optically active monoalkyl ester of ଲ-(S)-aminoglutaric acid is prepared by subjecting a dialkyl ester of ଲ-protected aminoglutaric acid to the action of a culture broth, cells, or treated cells of a microorg... | 11/15/1983 |
| 4153509 | Microbial production of hydroxylated biphenyl compounds A process for preparing hydroxylated biphenyl compounds by enzymatically biotransforming the biphenyl compound with a microorganism.... | 05/08/1979 |
| 4138289 | Process for the manufacture of tertiary, optically active aliphatic compounds A process for asymmetrically hydrogenating through the use of microorganisms a double bond connected to tertiary carbon atom in an olefinic aliphatic compound to produce a tertiary, optically active aliphatic compound useful as an intermediate for optical... | 02/06/1979 |
| 4026923 | D-Homosteroids A novel class of D-homosteroids is disclosed. These compounds have potent endocrinal activity, particularly as anti-inflammatory agents.... | 05/31/1977 |
| 4011314 | 7-Hydroxyestradiols 7-Hydroxyestradiols of the formula ##STR1## wherein R1 is hydrogen, acyl, alkyl, cycloalkyl, an oxygenated saturated heterocyclic group or hydrocarbylsulfonyl; R2 and R3 each are hydrogen, acyl, oxygenated saturated h... | 03/08/1977 |
| 3957578 | Method for manufacture of -galactosidase by microorganism When novel mold strains belonging to genus Absidia are cultured in an inducer-containing medium of the type ordinarily used for the culture of -galactosidase producing molds, notably high -galactosidase activity is produced and absolutely no... | 05/18/1976 |