Celebrity Inventors
Mark Twain (Samuel L. Clemens) received Patent No. 121,992 for "An Improvement in Adjustable and Detachable Straps for Garments." He later received two more patents: one for a self-pasting scrapbook and one for a game to help players remember important historical dates.
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| Number | Title | Issue Date |
| 7435563 | Method for the production of (s)-3-methylamino-1-(thien-2-yl)propan-1-ol The present invention relates to a process for the preparation of enantiomerically pure (S)-3-methyl-amino-1-(thien-2-yl)propan-1-ol of the formula II-S by obtainment of (S)-3-hydroxy-3-thien-2-ylpropionitrile from its enan... | 10/14/2008 |
| 7361467 | Methods for detection of a target nucleic acid by capture The invention relates to a method of generating a signal indicative of the presence of a target nucleic acid in a sample, where the method includes forming a cleavage structure by incubating a sample comprising a target nucleic acid with a probe having a secondary s... | 04/22/2008 |
| 7354708 | Invasion assays The present invention relates to means for the detection and characterization of nucleic acid sequences, as well as variations in nucleic acid sequences. The present invention also relates to methods for forming a nucleic acid cleavage structure on a target sequence... | 04/08/2008 |
| 7354715 | High-throughput methods of screening DNA for deletions and other mutations The subject invention relates to high-throughput methods of screening DNA for mutations. These methods offer various unexpected advantages over current methods. In a preferred embodiment, the subject invention includes pooling DNA samples from many plants that were ... | 04/08/2008 |
| 7309573 | Methods for detection of a nucleic acid by sequential amplification The invention relates to methods and compositions for detecting a target nucleic acid. The methods include subjecting a target, template, cleavage agent, polymerase and first, second and third oligonucleotide to reaction conditions that permit: (1) formation of a du... | 12/18/2007 |
| 7276597 | Compositions and kits for detection of a nucleic acid by sequential amplification The invention relates to nucleic acid compositions for use in sequential amplification detection assays which permit the detection of a nucleic acid target in a sample. ... | 10/02/2007 |
| 7273696 | Kits for the detection of target sequences The present invention relates to means for cleaving a nucleic acid cleavage structure in a site-specific manner. Enzymes, including 5′ nucleases and 3′ exonucleases, are used to detect and identify nucleic acids derived from microorganisms. Methods are provided ... | 09/25/2007 |
| 7195871 | Methods and compositions for detecting target sequences The present invention relates to compositions and methods for the detection and characterization of nucleic acid sequences and variations in nucleic acid sequences. The present invention relates to methods for forming a nucleic acid cleavage structure on a target se... | 03/27/2007 |
| 7183052 | Methods for detection of a target nucleic acid using multi-subunit probes The invention relates to a method of generating a signal indicative of the presence of a target nucleic acid sequence in a sample, comprising forming a complex by incubating a sample comprising a target nucleic acid sequence with a probe comprising a first and secon... | 02/27/2007 |
| 7148054 | Evolution of whole cells and organisms by recursive sequence recombination The invention provides methods employing iterative cycles of recombination and selection/screening for evolution of whole cells and organisms toward acquisition of desired properties Examples of such properties include enhanced recombinogenicity, genome copy number,... | 12/12/2006 |
| 7122364 | FEN endonucleases The present invention provides novel cleavage agents and polymerases for the cleavage and modification of nucleic acid. The cleavage agents and polymerases find use, for example, for the detection and characterization of nucleic acid sequences and variations in nucl... | 10/17/2006 |
| 7122314 | Methods for detecting vancomycin-resistant microorganisms and compositions therefor A method for detecting the presence of a vancomycin-resistant microorganism in a biological sample using a single chimeric probe in a cycling probe reaction. ... | 10/17/2006 |
| 7118860 | Methods for detection of a target nucleic acid by capture The invention relates to a method of generating a signal indicative of the presence of a target nucleic acid in a sample, as well as a method of detecting or measuring a target nucleic acid in a sample. The invention comprises forming a cleavage structure by incubat... | 10/10/2006 |
| 7112423 | Nucleic acid amplification using nicking agents The present invention provides methods and kits for amplifying target nucleic acids (including whole genomes) using nicking agents. In certain aspects, the amplification does not require the use of any external oligonucleotide primers that are capable of annealing t... | 09/26/2006 |
| 7101672 | Target-dependent reactions using structure-bridging oligonucleotides The present invention relates to methods and compositions for analyzing nucleic acids. In particular, the present invention provides methods and compositions for the detection and characterization of nucleic acids and sequence changes. The methods of the present inv... | 09/05/2006 |
| 7074563 | Mass spectrometric methods for detecting mutations in a target nucleic acid Provided herein are mass spectrometric methods for detecting a mutation in a target nucleic acid. In an embodiment, provided is a method which comprises digesting a target nucleic acid molecule; capturing digested fragments on a solid support that comprises oligonuc... | 07/11/2006 |
| 7067643 | Systems for the detection of target sequences The present invention relates to means for cleaving a nucleic acid cleavage structure in a site-specific manner. Enzymes, including 5′ nucleases and 3′ exonucleases, are used to detect and identify nucleic acids derived from microorganisms. Methods are provided ... | 06/27/2006 |
| 7060436 | Nucleic acid accessible hybridization sites The present invention relates to methods and compositions for analyzing nucleic acids, and in particular, methods and compositions for detection and characterization of nucleic acid sequences and sequence changes. The present invention also provides methods and comp... | 06/13/2006 |
| 7011944 | Invasive cleavage of nucleic acids The present invention relates to means for the detection and characterization of nucleic acid sequences, as well as variations in nucleic acid sequences. The present invention also relates to methods for forming a nucleic acid cleavage structure on a target sequence... | 03/14/2006 |
| 6964848 | Invasion assay The invention relates to improved methods of detecting and characterizing polynucleotide sequences and variations in polynucleotide sequences. The invention further relates to a device that can be used to detect and characterize polynucleotide sequences and variatio... | 11/15/2005 |
| 6964847 | Derivative nucleic acids and uses thereof The invention features a method for multiplexed analysis of a plurality of target nucleic acid sequences in a sample. The method provides a derivative nucleic acid for each target sequence analyzed and present in the sample. ... | 11/15/2005 |
| 6872816 | Nucleic acid detection kits The present invention relates to means for the detection and characterization of nucleic acid sequences, as well as variations in nucleic acid sequences. The present invention also relates to methods for forming a nucleic acid cleavage structure on a target sequence... | 03/29/2005 |
| 6833260 | Lactose hydrolysis The invention features methods and compositions for rapidly and effectively hydrolyzing lactose using recombinant lactic acid bacteria. ... | 12/21/2004 |
| 6669963 | Stable particle in liquid formulations A stable particle in liquid formulation comprising a discontinuous phase of microparticles is suspended in a continuous phase which is a non-aqueous liquid, preferably biocompatible in which the microparticles are insoluble. The microparticles comprise fi... | 12/30/2003 |
| 6607901 | Alkaline alpha-galactosidase An enzyme isolated from an organism that metabolizes alpha-galactosyl containing saccharides, comprising an alpha-galactosidase (E.C. 3.2.1.22, alpha-D-galactoside galatohydrolase) with optimal activity in the neutral to alkaline pH range, and which hydro... | 08/19/2003 |
| 6548250 | Methods for detection of a target nucleic acid sequence The invention relates to a method of generating a signal indicative of the presence of a target nucleic acid sequence in a sample, where the method includes forming a cleavage structure by incubating a sample containing a target nucleic acid sequence with... | 04/15/2003 |
| 6541226 | Method for specifically cleaving double-stranded DNA and kit for the method A method for specifically cleaving a double-stranded DNA. The method comprises forming a three-stranded portion comprising the double-stranded DNA portion including the position to be cleaved or its vicinity and an oligonucleotide and treating the three-s... | 04/01/2003 |
| 6531294 | Preparation of pancreatic procarboxypeptidase B, isoforms and muteins thereof and their use Pancreatic carboxypeptidase B or an isoform or a mutein of carboxypeptidase B may be prepared by (a) expressing a natural or unnatural enzymatically inactive precursor form of carboxypeptidase B in a microorganism by secretion, (b) purifying the precursor... | 03/11/2003 |
| 6504024 | Propargylethoxyamino nucleotide primer extensions Propargylethoxyamino nucleosides are disclosed having the structure ##STR1## wherein R1 and R2 are --H, lower alkyl, or label; B is a 7-deazapurine, purine, or pyrimidine nucleoside base; W1 is --H or --OH; W2 i... | 01/07/2003 |
| 6458535 | Detection of nucleic acids by multiple sequential invasive cleavages 02 The present invention relates to means for the detection and characterization of nucleic acid sequences, as well as variations in nucleic acid sequences. The present invention also relates to methods for forming a nucleic acid cleavage structure on a targ... | 10/01/2002 |
| 6451563 | Method for making linear, covalently closed DNA constructs A process to obtain linear double-stranded covalently closed DNA "dumbbell" constructs from plasmids by restriction digest, subsequent ligation with hairpin oligodesoxyribonucleotides, optionally in the presence of restriction enzyme, and a final digestio... | 09/17/2002 |
| 6416950 | DNA-protein fusions and uses thereof Disclosed herein are molecules that include a deoxyribonucleic acid (DNA) covalently bonded to a protein and uses thereof.... | 07/09/2002 |
| 6391595 | Transferase and amylase, process for producing the enzymes, use thereof, and gene coding for the same The invention provides a novel transferase that acts on a saccharide, as a substrate, composed of at least three sugar units wherein at least three glucose residues on the reducing end are linked -1,4 so as to transfer the -1,4 lingages to a... | 05/21/2002 |
| 6368803 | Detection of nucleic acids by target-catalyzed formation A method is disclosed for modifying an oligonucleotide, which method has application to the detection of a polynucleotide analyte. An oligonucleotide is reversibly hybridized with a polynucleotide, for example, a polynucleotide analyte, in the presence of... | 04/09/2002 |
| 6326166 | Chimeric DNA-binding proteins Chineric proteins containing composite DNA-binding regions are disclosed together with DNA constructs encoding them, compositions containing them and applications in which they are useful.... | 12/04/2001 |
| 6121001 | Detection of nucleic acids by target-catalyzed product formation A method is disclosed for modifying an oligonucleotide, which method has application to the detection of a polynucleotide analyte. An oligonucleotide is reversibly hybridized with a polynucleotide, for example, a polynucleotide analyte, in the presence of... | 09/19/2000 |
| 6110462 | Enzymatic DNA molecules that contain modified nucleotides The present invention discloses catalytic or enzymatic DNA molecules that contain a modified nucleotide and that are capable of cleaving nucleic acid sequences or molecules, particularly RNA, in a site-specific manner, as well as compositions including sa... | 08/29/2000 |
| 6110677 | Oligonucleotide modification, signal amplification, and nucleic acid detection by target-catalyzed product formation A method is disclosed for modifying an oligonucleotide, which method has application to the detection of a polynucleotide analyte. An oligonucleotide is reversibly hybridized with a polynucleotide, for example, a polynucleotide analyte, in the presence of... | 08/29/2000 |
| 5994069 | Detection of nucleic acids by multiple sequential invasive cleavages The present invention relates to means for the detection and characterization of nucleic acid sequences, as well as variations in nucleic acid sequences. The present invention also relates to methods for forming a nucleic acid cleavage structure on a targ... | 11/30/1999 |
| 5968786 | Method for producing labeled single-stranded nucleic acid probes Disclosed is a method for the introduction of unidirectional deletions in a cloned DNA segment. More specifically, the method comprises providing a recombinant DNA construct comprising a DNA segment of interest inserted in a cloning vector, the cloning ve... | 10/19/1999 |
