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| Number | Title | Issue Date |
| RE43097 | Massively parallel signature sequencing by ligation of encoded adaptors The invention provides a method of nucleic acid sequence analysis based on the ligation of one or more sets of encoded adaptors to the terminus of a target polynucleotide. Encoded adaptors whose protruding strands form perfectly matched duplexes with the complementa... | 01/10/2012 |
| 7790421 | Peptide acceptor ligation methods Described herein are methods and reagents for the ligation of a peptide acceptor to an RNA, as well as the RNA-peptide acceptor products. ... | 09/07/2010 |
| 7427483 | Utilization of nucleotide probes in ELISA procedure for the quantitative determination of DNA in malaria The present invention is the development of a simple and specific quantitative method for the determination of P. falciparum DNA in malaria that involves the direct detection of the highly 42-kDa conserved C-terminal region of P. falciparum merozoite s... | 09/23/2008 |
| 7364855 | Methods and kits for methylation detection Ligation-based methods and kits are disclosed for determining the degree of methylation of one or more target nucleotides. In certain embodiments, the methylation status of one or more target nucleotides is determined by generating misligation products. In certain e... | 04/29/2008 |
| 7361821 | Controlled alignment of nanobarcodes encoding specific information for scanning probe microscopy (SPM) reading The methods, apparatus and compositions disclosed herein concern the detection, identification and/or sequencing of biomolecules, such as nucleic acids or proteins. In certain embodiments of the invention, coded probes comprising a probe molecule attached to one or ... | 04/22/2008 |
| 7354708 | Invasion assays The present invention relates to means for the detection and characterization of nucleic acid sequences, as well as variations in nucleic acid sequences. The present invention also relates to methods for forming a nucleic acid cleavage structure on a target sequence... | 04/08/2008 |
| 7351528 | Probing of specific nucleic acids The present invention relates to improved methods for probing of specific nucleic acids using circularizable probes designed such that they report the presence of a target sequence by allowing a detectable moiety to remain bound if an only if the probe has been cycl... | 04/01/2008 |
| 7341831 | Method for immuno-detection of epitopes Methods, systems and kits are provided for detecting, molecules expressing a selected epitope in a sample through use of an epitope detector containing a single chain Fv for the selected epitope or a constrained epitope specific CDR attached to an oligonucleotide. | 03/11/2008 |
| 7323305 | Methods of amplifying and sequencing nucleic acids An apparatus and method for performing rapid DNA sequencing, such as genomic sequencing, is provided herein. The method includes the steps of preparing a sample DNA for genomic sequencing, amplifying the prepared DNA in a representative manner, and performing multip... | 01/29/2008 |
| 7303901 | Thermostable RNA ligase from thermus phage An RNA ligase derived from bacteriophage TS2126 which infects Thermus scotoductus, nucleic acids comprising nucleotide sequences of open reading frame (ORF) and polypeptides encoded by the nucleic acids, are described. ... | 12/04/2007 |
| 7262032 | Allele-specific mutation detection assay using an enzyme-disabling agent The present invention relates to a method of detecting a base at a pre-determined position in a nucleic acid molecule by performing enzymatic detection reactions using base-specific detection oligomers, where each oligomer is specific for a particular base at the pr... | 08/28/2007 |
| 7223544 | Nucleic acid-engineered materials The present invention relates to the design and use of nucleic acid molecules to create novel materials. The present invention further relates to the use of DNA as a bulding block for DNA-materials that are of high yield and purity and that can be incorporated into ... | 05/29/2007 |
| 7214490 | Method of target enrichment and amplification The presently claimed invention provides methods and kits for amplifying a target sequence from within a nucleic acid population. The presently claimed invention provides selection probes which are complementary to at least a portion of said target sequence and mech... | 05/08/2007 |
| 7205130 | Bi-directionally cloned random cDNA expression vector libraries, compositions and methods of use The present invention provides random cDNA expression vector libraries, comprising expression vectors which comprise random cDNAs positioned in sense and antisense orientation, which are useful for the delivery and expression of a combination of genetic effector typ... | 04/17/2007 |
| 7198894 | Detection of nucleic acid differences using combined endonuclease cleavage and ligation reactions The present invention is a method for detecting DNA sequence differences including single nucleotide mutations or polymorphisms, one or more nucleotide insertions, and one or more nucleotide deletions. Labeled heteroduplex PCR fragments containing base mismatches ar... | 04/03/2007 |
| 7198900 | Multiplex detection compositions, methods, and kits The present invention generally relates to the detection of analytes, particularly biomolecules in samples. The invention also relates to compositions, methods, and kits for detecting the presence of analytes, typically in multiplex detection formats. The invention ... | 04/03/2007 |
| 7195871 | Methods and compositions for detecting target sequences The present invention relates to compositions and methods for the detection and characterization of nucleic acid sequences and variations in nucleic acid sequences. The present invention relates to methods for forming a nucleic acid cleavage structure on a target se... | 03/27/2007 |
| 7192558 | Multi-well rotary synthesizer An apparatus for synthesizing polymer chains includes a controller, a plurality of precision fit vials circularly arranged in multiple banks on a cartridge, a drain corresponding to each bank of vials, a chamber bowl, a plurality of valves for delivering reagents to... | 03/20/2007 |
| 7175982 | Method for the characterization of nucleic acid molecules involving generation of extendible upstream DNA fragments resulting from the cleavage of nucleic acid at an abasic site The present invention is drawn to a method for characterising nucleic acid molecules, which comprises the steps of: i) introducing a modified base which is a substrate for a DNA glycosylase into a DNA molecule; ii) excising the modified base with the DNA glycosylase... | 02/13/2007 |
| 7169561 | Methods, compositions, and kits for forming self-complementary polynucleotides The present teachings generally relate to methods, kits, and compositions for detecting target polynucleotide sequences. The teachings also relate to ligation and amplification reactions that generate self-complementary polynucleotide products. In some embodiments, ... | 01/30/2007 |
| 7160702 | Methods and nucleic acid vectors for rapid expression and screening of CDNA clones Recombinant DNA vectors and methods for cloning and expressing nucleic acid molecules by using a combination of site-specific recombination and end-to-end joining or linking of nucleic acid molecules, such as endonuclease restriction digestion and ligation. The DNAs... | 01/09/2007 |
| 7150998 | Multi-well rotary synthesizer An apparatus for synthesizing polymer chains includes a controller, a plurality of precision fit vials circularly arranged in multiple banks on a cartridge, a drain corresponding to each bank of vials, a chamber bowl, a plurality of valves for delivering reagents to... | 12/19/2006 |
| 7122364 | FEN endonucleases The present invention provides novel cleavage agents and polymerases for the cleavage and modification of nucleic acid. The cleavage agents and polymerases find use, for example, for the detection and characterization of nucleic acid sequences and variations in nucl... | 10/17/2006 |
| 7115402 | Polynucleotides encoding a novel testis-specific tubulin tyrosine-ligase-like protein, BGS42 The present invention provides novel polynucleotides encoding BGS-42 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relat... | 10/03/2006 |
| 7105343 | Methods and compositions for transposition using minimal segments of the eukaryotic transformation vector Piggybac The present invention provides efficient transfer of genes into host cells or embryos to transform the cells or embryos by transposition vectors using the minimal amount of nucleotide sequences in the transposon piggyBac required for gene transfer. The transformed c... | 09/12/2006 |
| 7101672 | Target-dependent reactions using structure-bridging oligonucleotides The present invention relates to methods and compositions for analyzing nucleic acids. In particular, the present invention provides methods and compositions for the detection and characterization of nucleic acids and sequence changes. The methods of the present inv... | 09/05/2006 |
| 7090804 | Amplification of nucleic acids with electronic detection The invention relates to compositions and methods useful in the detection of nucleic acids using a variety of amplification techniques, including both signal amplification and target amplification. Detection proceeds through the use of an electron transfer moiety (E... | 08/15/2006 |
| 7090975 | Pyrophosphorolysis and incorporation of nucleotide method for nucleic acid detection Processes are disclosed using the depolymerization of a nucleic acid hybrid and incorporation of a suitable nucleotide to qualitatively and quantitatively analyze for the presence of predetermined nucleic acid target sequences. Applications of those processes includ... | 08/15/2006 |
| 7090979 | Derivatized versions of ligase enzymes for constructing DNA sequences A method of making very long, double-stranded synthetic poly-nucleotides. A multiplicity of short oligonucleotides is provided. The short oligonucleotides are sequentially hybridized to each other. Enzymatic ligation of the oligonucleotides provides a contiguous pie... | 08/15/2006 |
| 7087732 | Nucleotides and analogs having photoremovable protecting groups A synthetic strategy for the creation of large scale chemical diversity. Solid-phase chemistry, photolabile protecting groups, and photolithography are used to achieve light-directed spatially-addressable parallel chemical synthesis. Binary masking techniques are ut... | 08/08/2006 |
| 7083917 | Detection of nucleic acid sequence differences using the ligase detection reaction with addressable arrays The present invention describes a method for identifying one or more of a plurality of sequences differing by one or more single base changes, insertions, deletions, or translocations in a plurality of target nucleotide sequences. The method includes a ligation phas... | 08/01/2006 |
| 7078197 | Peptide acceptor ligation methods Described herein are methods and reagents for the ligation of a peptide acceptor to an RNA, as well as the RNA-peptide acceptor products. ... | 07/18/2006 |
| 7067127 | GIcNAc phosphotransferase of the lysosomal targeting pathway The present invention provides nucleotide and amino sequences of the lysosomal targeting pathway enzyme GlcNAc-phosphotransferase, methods of producing and methods of purifying this enzyme. ... | 06/27/2006 |
| 7060436 | Nucleic acid accessible hybridization sites The present invention relates to methods and compositions for analyzing nucleic acids, and in particular, methods and compositions for detection and characterization of nucleic acid sequences and sequence changes. The present invention also provides methods and comp... | 06/13/2006 |
| 7011944 | Invasive cleavage of nucleic acids The present invention relates to means for the detection and characterization of nucleic acid sequences, as well as variations in nucleic acid sequences. The present invention also relates to methods for forming a nucleic acid cleavage structure on a target sequence... | 03/14/2006 |
| 6986991 | Method of analyzing intestinal flora and analytical apparatus A method of analyzing intestinal bacteria flora which comprises: extracting a sample from a subject; extracting bacteria to prepare a bacteria suspension; extracting DNAs of bacteria from the bacteria suspension to prepare a DNA extract liquid; amplifying a specific... | 01/17/2006 |
| 6974666 | Methods of enzymatic discrimination enhancement and surface-bound double-stranded DNA Methods for discriminating between fully complementary hybrids and those that differ by one or more base pairs and libraries of unimolecular, double-stranded oligonucleotides on a solid support. In one embodiment, the present invention provides methods of using nucl... | 12/13/2005 |
| 6942972 | Efficient synthesis of protein-oligonucleotide conjugates The present invention relates to an improved method for forming a protein-oligonucleotide conjugate. The method is particularly amenable for forming antibody-oligonucleotide conjugates. The invention further concerns the conjugate molecules produced using such impro... | 09/13/2005 |
| 6919211 | Polypeptide arrays The present invention provides methods and apparatus for sequencing, fingerprinting and mapping biological macromolecules, typically biological polymers. The methods make use of a plurality of sequence specific recognition reagents which can also be used for classif... | 07/19/2005 |
| 6908751 | Methods for enhancing the expression of a protein of interest by recombinant host cells The increased use of nucleotide sequence data mining techniques has amplified the demand for efficient methods of producing recombinant proteins in eukaryotic cells. A strategy is provided for enhancing the synthesis of recombinant amino acid sequences by polymerizi... | 06/21/2005 |
