Did You Know...
...that the Slinky toy was the result of a failed attempt by engineer Richard James to produce an antivibration device for ship instruments? His goal was to develop a spring that would instantaneously counterbalance the wave motion that rocks a ship at sea. Instead, he developed the Slinky.
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| Number | Title | Issue Date |
| 8114594 | Crude biological derivatives competent for nucleic acid detection The invention relates generally to the fields of making biological unit lysates or admixtures of body fluids and of RNA analysis. More specifically, it relates to direct methods for the detection of a specific sequence of RNA in a biological unit, for example a viru... | 02/14/2012 |
| 8076105 | Device and method for high-throughput quantification of MRNA from whole blood Disclosed are a method, device kit, and automated system for simple, reproducible, and high-throughput quantification of mRNA from whole blood. More particularly, the method, device, kit and automated system involve combinations of leukocyte filters attached to olig... | 12/13/2011 |
| 7939300 | Device and method for high-throughput quantification of mRNA from whole blood Disclosed are a method, device kit, and automated system for simple, reproducible, and high-throughput quantification of mRNA from whole blood. More particularly, the method, device, kit and automated system involve combinations of leukocyte filters attached to olig... | 05/10/2011 |
| 7915016 | cDNA production from cells after laser microdissection The present invention provides a new procedure for the synthesis of cDNA from single cells after microdissection. It has the advantage that it is cost-efficient and can be carried out quickly with only few steps, even by less skilled laboratory employees. For the fi... | 03/29/2011 |
| 7785844 | Compositions and methods for detecting hepatitis B virus Compositions, methods and kits for detecting viral nucleic acids. Targets that can be detected in accordance with the invention include HBV and/or HIV-1 and/or HCV nucleic acids. Particularly described are oligonucleotides that are useful as hybridization probes and... | 08/31/2010 |
| 7776569 | Virally-encoded RNAs as substrates, inhibitors and delivery vehicles for RNAi The present invention provides methods for identifying druggable targets in assays that feature compositions, cells and/or organisms having structured viral non-coding RNAs (svRNAs) and an RNA interference (RNAi) pathway. Methods for identifying antiviral agents and... | 08/17/2010 |
| 7745180 | Device and method for high-throughput quantification of mRNA from whole blood Disclosed are a method, device kit, and automated system for simple, reproducible, and high-throughput quantification of mRNA from whole blood. More particularly, the method, device, kit and automated system involve combinations of leukocyte filters attached to olig... | 06/29/2010 |
| 7422849 | Method for determining expression of a PI3 kinase gene This invention relates to new polypeptides which exhibit kinase activity or, more specifically, which show phosphoinositide (PI) 3-kinase activity. Such polypeptides are involved in pathways responsible for cellular growth and differentiation. An isolated polypeptid... | 09/09/2008 |
| 7402388 | Expression analysis of FKBP54 in assessing prostate cancer therapy The invention relates to compositions, kits, and methods for detecting, characterizing, preventing, and treating prostate cancer. FKBP markers are provided, wherein changes in the levels of expression of one or more of the FKBP markers is correlated with the presenc... | 07/22/2008 |
| 7385038 | Non-natural labeled amino acid and method of constructing amino acid/tRNA complex This invention relates to: a labeled amino acid that can be introduced into a protein with the aid of a protein synthesis system; a functional protein having functions derived from a label compound; a labeled amino acid comprising an aromatic ring bound to an amino ... | 06/10/2008 |
| 7361488 | Nucleic acid detection methods using universal priming The present invention is directed to providing sensitive and accurate assays for gene detection, genome-wide gene expression profiling and alternative splice monitoring with a minimum or absence of target-specific amplification. ... | 04/22/2008 |
| 7323310 | Methods and compositions for RNA amplification and detection using an RNA-dependent RNA-polymerase Methods and compositions are provided for amplifying RNA from an RNA template. Methods and compositions are further provided for detecting an RNA in an RNA containing sample. Compositions used for the amplification of RNA from RNA include a RNA-dependent RNA-polymer... | 01/29/2008 |
| 7291455 | Assessment of human papilloma virus-related disease This invention provides novel methods for assessing HPV infection. Gene expression levels are used to assess the progression of HPV infection from benign to malignant growth. Also provided are kits for carrying out the methods of this invention. ... | 11/06/2007 |
| 7270980 | Compounds for immunodiagnosis of prostate cancer and methods for their use Compounds and methods for diagnosing prostate cancer are provided. The inventive compounds include polypeptides containing at least a portion of a prostate tumor protein. The inventive polypeptides may be used to generate antibodies useful for the diagnosis and moni... | 09/18/2007 |
| 7252941 | Expression profiling based on histocultures Methods of obtaining faithful expression libraries from tissue samples comprise extraction of RNA from intact tissue cultured in three-dimensional sponge-gel based histocultures. ... | 08/07/2007 |
| 7247457 | Detection and identification of enteroviruses by semi-nested amplification of the enterovirus VP1 protein Disclosed are methods of using enterovirus-specific primers for the detection and identification of enterovirus infection. Also provided are isolated nucleic acid molecules and kits useful for detection and diagnostic testing of enterovirus infection in a subject. | 07/24/2007 |
| 7214490 | Method of target enrichment and amplification The presently claimed invention provides methods and kits for amplifying a target sequence from within a nucleic acid population. The presently claimed invention provides selection probes which are complementary to at least a portion of said target sequence and mech... | 05/08/2007 |
| 7205130 | Bi-directionally cloned random cDNA expression vector libraries, compositions and methods of use The present invention provides random cDNA expression vector libraries, comprising expression vectors which comprise random cDNAs positioned in sense and antisense orientation, which are useful for the delivery and expression of a combination of genetic effector typ... | 04/17/2007 |
| 7202028 | Methods for the electrochemical detection of multiple target compounds A method of detecting two different target molecules through a single electrode is carried out by (a) providing a conductive oxidation-reduction reaction detection electrode; (b) contacting a sample suspected of containing a first and second target molecule to the e... | 04/10/2007 |
| 7183399 | Nucleic acids encoding linked chromo/fluorescent domains and methods for using the same Nucleic acid compositions encoding polypeptide products having at least two linked chromo/fluorescent domains, as well as the proteins encoded by the same, are provided. Also provided are the polypeptides encoded by the subject nucleic acids, as well as antibodies t... | 02/27/2007 |
| 7163789 | Cancer diagnosis method The invention concerns a method for the diagnosis and/or the follow up of the evolution of cancer comprising the analysis of the RNA components of the telomerase enzyme present in the plasma or serum of the blood. ... | 01/16/2007 |
| 7153672 | Method of performing reverse transcription reaction using reverse transcriptase encoded by non-LTR retrotransposable element The present invention relates to a method of preparing a cDNA molecule which includes: contacting an RNA molecule, in the presence of dNTPs, with a non-LTR retrotransposon protein or polypeptide having reverse transcriptase activity under conditions effective for pr... | 12/26/2006 |
| 7129045 | Methods of detecting polynucleotide kinase and its use as a label Methods of detecting or measuring the activity of polynucleotide kinase are disclosed as well as methods of detecting an analyte in an assay using polynucleotide kinase as a label on a member of a specific binding pair. The methods rely on the phosphorylation of an ... | 10/31/2006 |
| 7122304 | Methods for the storage and synthesis of nucleic acids using a solid support The invention relates to storage of nucleic acid (particularly mRNA) on a solid support and to using such nucleic acid in nucleic acid synthesis or amplification reactions. In a preferred aspect, the invention provides synthesis of cDNA and cDNA libraries. ... | 10/17/2006 |
| 7115406 | Recombinant method for making RSV reverse transcriptases and mutants thereof A method of producing a Rous Sarcoma Virus reverse transcriptase (RSV RT) by expressing one orniore nucleic acid sequences encoding one or more subunits of RSV RT in a eukaryotic host cell and culturing the host cell under conditions sufficient to produce the recomb... | 10/03/2006 |
| 7094539 | reverse transcription compositions and kits The present invention relates to reverse transcription of RNA, and in particular to reverse transcription by thermostable DNA polymerases. Thermoactinomyces vulgaris and Bacillus stearothermophilus possess reverse transcriptase activity in the presence... | 08/22/2006 |
| 7074556 | cDNA synthesis improvements The present invention generally relates to methods of making cDNA molecules and cDNA libraries. The invention also relates to cDNA molecules and cDNA libraries produced according to these methods, as well as to vectors and host cells containing such cDNA molecules a... | 07/11/2006 |
| 7074596 | Synthesis and use of anti-reverse mRNA cap analogues The ability to synthesize capped RNA transcripts in vitro has been of considerable value in a variety of applications. However, one-third to one-half of the caps have, until now, been incorporated in the reverse orientation. Such reverse caps impair the translation ... | 07/11/2006 |
| 7074558 | Nucleic acid amplification using an RNA polymerase and DNA/RNA mixed polymer intermediate products This invention provides for a novel amplification procedure for nucleic acid. The method uses a wild type or mutant RNA polymerase designed to transcribe both deoxyribonucleotides and ribonucleotides. ... | 07/11/2006 |
| 7037692 | Plant desaturases compositions and uses By this invention, compositions and methods of use of plant desaturase enzymes, especially Δ-9 desaturases, are provided. Of special interest are methods and compositions of amino acids and nucleic acid sequences related to biologically active plant desaturases as ... | 05/02/2006 |
| 7029881 | Methods for constructing DNA library and support carrying DNA library immobilized thereon Method and apparatus for constructing a cDNA library by hybridizing mRNA with oligo (dT) on a support and treating with a reverse transcriptase to immobilized complementary DNA, or for constructing a gDNA library by ligating a double-stranded chromosomal DNA library... | 04/18/2006 |
| 7005278 | Method of determining dihydropyrimidine dehydrogenase gene expression The present invention relates to prognostic methods which are useful in medicine, particularly cancer chemotherapy. The object of the invention to provide a method for assessing Dihydropyrimidine dehydrogenase (DPD) expression levels in tissues and prognosticate the... | 02/28/2006 |
| 6998232 | Methods of diagnosing bladder cancer There is provided a method of diagnosing the presence of bladder cancer in a patient by analyzing a tissue sample from the patient for the presence of a least one expressed gene wherein the presence of the expressed gene is indicative of bladder cancer. Also provide... | 02/14/2006 |
| 6994963 | Methods for recombinatorial nucleic acid synthesis This invention pertains to a method for generating a pool of nucleic acid fragments useful for in vitro recombination and the creation of novel DNA sequences that encode desirable proteins or enzymes. The invention provides a defined mixture of nucleic acids and met... | 02/07/2006 |
| 6994969 | Diagnostic sequencing by a combination of specific cleavage and mass spectrometry The present invention is in the field of nucleic acid-based diagnostic assays. More particularly, it relates to methods useful for the “diagnostic sequencing” of regions of sample nucleic acids for which a prototypic or reference sequence is already available (a... | 02/07/2006 |
| 6986988 | Method for enrichment of natural antisense messenger RNA A method for enrichment of natural antisense mRNA which involves hybridization of cDNA obtained from sense RNA with cDNA obtained from antisense RNA, followed by DNA polymerase treatment of the sense-antisense hybrid DNA molecule. A natural antisense library can be ... | 01/17/2006 |
| 6967016 | Method of determining therapeutic activity and/or possible side-effects of a medicament The invention relates to the diagnosis of disease or the determination of functioning of cellular organisms, being of multi-cellular or unicellular nature, being visible by the naked eye or being a microorganism. The invention provides a method for determining funct... | 11/22/2005 |
| 6958245 | Array cytometry A method and apparatus for the manipulation of colloidal particulates and biomolecules at the interface between an insulating electrode such as silicon oxide and an electrolyte solution. Light-controlled elektrokinetic assembly of particles near surfaces relies on t... | 10/25/2005 |
| 6939671 | Method enabling use of extracellular RNA extracted from plasma or serum to detect, monitor or evaluate cancer This invention relates to the use of tumor-derived or associated extracellular ribonucleic acid (RNA) found circulating in the plasma or serum fraction of blood for the detection, monitoring, or evaluation of cancer or premalignant conditions. Extracellular RNA may ... | 09/06/2005 |
| 6916634 | Method enabling use of extracellular RNA extracted from plasma or serum to detect, monitor or evaluate cancer This invention relates to the use of tumor-derived or associated extracellular ribonucleic acid (RNA) found circulating in the plasma or serum fraction of blood for the detection, monitoring, or evaluation of cancer or premalignant conditions. Extracellular RNA may ... | 07/12/2005 |
