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| Number | Title | Issue Date |
| 7736874 | Methods for cloning amplified nucleic acid molecules The present invention is directed generally to methods facilitating the cloning of nucleic acid molecules. In particular, the invention relates to the use of polymerase inhibitors, including but not limited to anti-polymerase antibodies (such as anti-Taq antibodies)... | 06/15/2010 |
| 7608434 | Mutated Tn5 transposase proteins and the use thereof Transposase proteins that are modified relative to and have higher transposase activities than the wild-type Tn5 transposase are disclosed. A transposase protein of the present invention differs from the wild-type Tn5 transposase at amino acid position 41, 42, 450, ... | 10/27/2009 |
| 7524653 | Small interfering RNA libraries and methods of synthesis and use In one aspect, the invention provides a random or semirandom siRNA (encoding) library. Another aspect of the invention pertains to methods for construction of random or semirandom siRNA (encoding) libraries. Another aspect of the invention is vector systems for use ... | 04/28/2009 |
| 7393632 | Use of multiple recombination sites with unique specificity in recombinational cloning The present invention provides compositions and methods for recombinational cloning. The compositions include vectors having multiple recombination sites with unique specificity. The methods permit the simultaneous cloning of two or more different nucleic acid molec... | 07/01/2008 |
| 7371542 | Gene expression system The present invention relates to nucleic acid molecules and in particular to vectors, comprising at least one gene of interest, at least one scaffold/matrix attached region (S/MAR), at least one origin of replication, and at least one replication initiation factor, ... | 05/13/2008 |
| 7371537 | Modulators of B-lymphocyte activation, myosin-1F compositions and methods of use The present invention provides compositions and methods for modulating B-lymphocyte activation. Nucleic acids encoding proteins and proteins so encoded which are capable of modulating B-lymphocyte activation are provided. Compositions and methods for the treatment o... | 05/13/2008 |
| 7368235 | Method for identifying reading frame mutations The invention relates to a simple and rapid method for identifying mutations in a gene of interest indicating an alteration in the reading frame of the proteins derived therefrom. The inventive method more particularly relates to the use of said method for scanning ... | 05/06/2008 |
| 7351578 | Use of multiple recombination sites with unique specificity in recombinational cloning The present invention provides compositions and methods for recombinational cloning. The compositions include vectors having multiple recombination sites with unique specificity. The methods permit the simultaneous cloning of two or more different nucleic acid molec... | 04/01/2008 |
| 7335502 | Chlorohydrin and hydroxycarboxylic ester asymmetric hydrolase gene The present invention is to provide a gene having asymmetric hydrolase activity which is useful for synthesis of an optically active carboxylic acid, its antipode ester, and lactone, and a hydroxycarboxylic ester asymmetric hydrolase enzyme (EnHCH) derived from E... | 02/26/2008 |
| 7332333 | Host cells containing multiple integrating vectors The present invention relates to the production of proteins in host cells, and more particularly to host cells containing multiple integrated copies of an integrating vector. Suitable integrating vectors for use in the present invention include retrovirus vec... | 02/19/2008 |
| 7329486 | High-throughput assay for virus entry and drug screening The present invention provides a rapid virus entry/binding detection assay. An enzyme such as luciferase was incorporated at the C-terminal end of viral envelope proteins that would deliver the enzyme into the viral particles upon viral assembly. Virus entry/binding... | 02/12/2008 |
| 7316923 | Compositions and methods for non-targeted activation of endogenous genes The present invention is directed generally to activating gene expression or causing over-expression of a gene by recombination methods in situ. The invention also is directed generally to methods for expressing an endogenous gene in a cell at levels higher than tho... | 01/08/2008 |
| 7297520 | Large circular sense molecule array Large circular (LC)-sense molecules in an array is disclosed. The LC-sense molecules array is combined with cDNA hybridization to detect differences in expression profile between different cells. LC-sense molecules were purified from nonredundant clones with recombi... | 11/20/2007 |
| 7297533 | Recombinant feline herpesvirus type 1 and polyvalent vaccine using the same An attenuated feline recombinant herpesvirus 1 (FHV-1), which is prepared by identifying gene regions in the genome wherein inserted foreign genes can be expressed without affecting the replication of FHV-1 and has least two types of foreign nucleic acid sequences i... | 11/20/2007 |
| 7291498 | Methods of generating chimeric adenoviruses and uses for such chimeric adenoviruses A method for providing an adenovirus from a serotype which does not grow efficiently in a desired cell line with the ability to grow in that cell line is described. The method involves replacing the left and right termini of the adenovirus with the corresponding ter... | 11/06/2007 |
| 7285399 | Compositions and methods using the yeast YMR107W promoter The invention provides novel yeast promoters useful for controlling the expression of homologous and heterologous nucleic acid molecules in yeast cells. The yeast promoters are induced by a fermentable carbon source, such as glucose, or a non-fermentable carbon sour... | 10/23/2007 |
| 7285414 | Viruses targeted to hypoxic cells and tissues The present invention relates to compositions comprising a novel recombinant virus which replicates selectively in cells or tissues that are hypoxic or have an activated HIF pathway. The novel compositions of the invention comprise a recombinant virus genetically en... | 10/23/2007 |
| 7282355 | Nucleic acid detection method Disclosed are methods for detecting a target nucleic acid molecule having a known sequence among a plurality of nucleic acid molecules. The method includes hybridizing two oligonucleotides to adjacent nucleotide sequences on the target nucleic acid molecule, ligatin... | 10/16/2007 |
| 7262032 | Allele-specific mutation detection assay using an enzyme-disabling agent The present invention relates to a method of detecting a base at a pre-determined position in a nucleic acid molecule by performing enzymatic detection reactions using base-specific detection oligomers, where each oligomer is specific for a particular base at the pr... | 08/28/2007 |
| 7262056 | Enhancing intermolecular integration of nucleic acids using integrator complexes We disclose compositions and processes for enhancing transposon mediated integration of a nucleic acid molecule into another target nucleic acid molecule. Integration by an integrator complex is enhanced by cationic reagents. ... | 08/28/2007 |
| 7256324 | Plant regulatory sequences for selective control of gene expression Promoters from male reproductive tissues were isolated from corn (Zea mays). These promoters can be used in plants to regulate transcription of target genes including genes for control of fertility, insect or pathogen tolerance, herbicide tolerance or any gen... | 08/14/2007 |
| 7247297 | Use of DF3/MUC1 regulated expression in gene therapy The present invention provides for improved vectors for use in gene therapy. Utilizing the cancer specific DF3/MUC1 promoter to drive a replication essential gene, vectors are made conditionally replication-competent, permitting wider infection and expression of tum... | 07/24/2007 |
| 7241600 | Process for the preparation of L-amino acids using strains of the enterobacteriaceae family The invention relates to a process for the preparation of L-amino acids, in particular L-threonine. ... | 07/10/2007 |
| 7238489 | Identification of sortase gene The present invention is a substantially purified sortase-transamidase enzyme from Gram-positive bacteria, such as Staphylococcus aureus. The enzyme having a molecular weight of about 23,539 daltons and catalyzing a reaction that covalently cross-links the ca... | 07/03/2007 |
| 7220578 | Single LTR lentivirus vector The present invention provides an isolated nucleic acid comprising a single retroviral LTR, a polypurine tract, a packaging signal, a primer binding site and a rev responsive element. Further provided is an isolated nucleic acid comprising a heterologous nucleotide ... | 05/22/2007 |
| 7214515 | Viral delivery system for infectious transfer of large genomic DNA inserts The present invention relates to HSV-based amplicon vectors carrying a genomic DNA fragment, and methods of constructing and using the same. Included within the present invention is a method of converting any large capacity DNA cloning vector, such as a BAC or PAC, ... | 05/08/2007 |
| 7214368 | Therapeutic regimen for treating cancer comprising the administration of adenoviral vectors comprising a TNF-α transgene The invention provides a method for treating a tumor in a human comprising administering to the tumor a dose of a pharmaceutical composition comprising (i) a pharmaceutically acceptable carrier and (ii) an adenoviral vector comprising a nucleic acid sequence encodin... | 05/08/2007 |
| 7205130 | Bi-directionally cloned random cDNA expression vector libraries, compositions and methods of use The present invention provides random cDNA expression vector libraries, comprising expression vectors which comprise random cDNAs positioned in sense and antisense orientation, which are useful for the delivery and expression of a combination of genetic effector typ... | 04/17/2007 |
| 7202022 | Method for identification, separation and quantitative measurement of nucleic acid fragments The invention relates to a new method for sequence-specific identification, separation and quantitative measurement of nucleic acid fragments. The invention is based on the use of restriction endonucleases that have degenerate bases in their recognition or cleavage ... | 04/10/2007 |
| 7192772 | Recombinant cells that highly express chromosomally-integrated heterologous gene Recombinant host cells are obtained that comprise (A) a heterologous, polypeptide-encoding polynucleotide segment, stably integrated into a chromosome, which is under transcriptional control of an endogenous promoter and (B) a mutation that effects increased express... | 03/20/2007 |
| 7169585 | Papillomavirus vaccine A method of providing papillomavirus like particles which may be used for diagnostic purposes or for incorporation in a vaccine for use in relation to infections causd by papillomavirus. The method includes an initial step of constructing one or more recombinant DNA... | 01/30/2007 |
| 7160702 | Methods and nucleic acid vectors for rapid expression and screening of CDNA clones Recombinant DNA vectors and methods for cloning and expressing nucleic acid molecules by using a combination of site-specific recombination and end-to-end joining or linking of nucleic acid molecules, such as endonuclease restriction digestion and ligation. The DNAs... | 01/09/2007 |
| 7150874 | Vector for integration of heterologous sequences into poxviral genomes A new DNA vector is disclosed comprising a nucleic acid sequence useful for inserting heterologous sequences into the genome of poxviruses by homologous recombination. Also disclosed are recombinant poxviruses carrying heterologous coding sequences transferred by th... | 12/19/2006 |
| 7148054 | Evolution of whole cells and organisms by recursive sequence recombination The invention provides methods employing iterative cycles of recombination and selection/screening for evolution of whole cells and organisms toward acquisition of desired properties Examples of such properties include enhanced recombinogenicity, genome copy number,... | 12/12/2006 |
| 7144579 | Paramyxoviruses comprising modified transcription start sequence The present invention provides virus vectors of the family Paramyxoviridae in which the transcription start (S) sequence has been modified so as to modify the expression of genes located downstream thereof, a method for producing the vectors, and uses thereof. By me... | 12/05/2006 |
| 7144712 | Human hepatitis B virus core proteins as vaccine platforms and methods of use thereof The present invention relates to hepatitis virus core proteins and nucleic acids. In particular, the present invention provides compositions and methods comprising recombinant hepatitis virus core proteins or nucleic acids for use in vaccine formulations. ... | 12/05/2006 |
| 7115391 | Production of recombinant AAV using adenovirus comprising AAV rep/cap genes This invention relates to novel adenoviruses useful in the production of high titers of recombinant adeno-associated virus (rAAV) comprising a foreign DNA insert and methods of making these adenoviruses. The adenovirus comprises the AAV rep gene in which the p5 prom... | 10/03/2006 |
| 7112434 | Vector system for selection of genes encoding secreted proteins and membrane-bound proteins The subject invention concerns novel vectors for the rapid and robust selection for cDNA sequences that encode secreted or membrane-bound proteins. The invention also pertains to methods for cloning secreted or membrane-bound proteins, including proteins encoded by ... | 09/26/2006 |
| 7112428 | Chlorohydrin and hydroxycarboxylic ester asymmetric hydrolase gene The present invention is to provide a gene having asymmetric hydrolase activity which is useful for synthesis of an optically active carboxylic acid, its antipode ester, and lactone, and a hydroxycarboxylic ester asymmetric hydrolase enzyme (EnHCH) derived from E... | 09/26/2006 |
| 7109178 | Method for ligating nucleic acids and molecular cloning The invention provides methods of covalently joining nucleic acid molecules and methods of molecular cloning. The methods provide either sequential or simultaneous ligation of flanking or vector nucleic acid molecules to nucleic acid insert molecules by topoisomeras... | 09/19/2006 |
