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A self defense weapon formed as a memo pad and which is easily held by a person's fingers, therefore making it possible to provide protection from a mugger and also to quickly and easily write a record or a message without failure of missing or forgetting significant information under a stressful situation.
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| Number | Title | Issue Date |
| 8114637 | Packaging cells for recombinant adenovirus In the absence of substantial sequence overlap between a recombinant adenoviral vector and the genome of a packaging cell, helper-dependent E1-containing particles (HDEP) can be formed at low frequency. Provided are means and methods for reducing or preventing the g... | 02/14/2012 |
| 8093021 | Defective sindbis viral vectors Disclosed herein are new defective Sindbis viral vectors made from a novel Helper plasmid, with differences in envelope proteins between JT vectors and consensus Sindbis virus sequences, and also between JT and Ar-339 vectors. Also disclosed are vectors produced usi... | 01/10/2012 |
| 8067377 | Peptide compositions for targeting adipose tissue The present invention concerns methods and compositions for in vivo and in vitro targeting. A large number of targeting peptides directed towards human organs, tissues or cell types are disclosed. The peptides are of use for targeted delivery of therapeutic agents, ... | 11/29/2011 |
| 8034589 | Method of preparing a proliferation-regulated recombinant adenoviral vector efficiently and kit for preparing the same Provided is a method of preparing a proliferation-regulated recombinant adenoviral vector effectively, comprising preparing a proliferation-regulated vector plasmid by preparing a restriction enzyme-recognizing sequence in a vector plasmid having a proliferation-reg... | 10/11/2011 |
| 7935505 | Plasmid DNA preparations and methods for producing same The various embodiments of the present invention relate generally to plasmid DNA preparations and to methods for producing and using such preparations. ... | 05/03/2011 |
| 7888076 | Collagen-like protein CLAC, precursor thereof and genes encoding the same A novel human collagen-like protein CLAC occurring in brain amyloid and its precursor CLAC-P; genes encoding the same; cDNA of mouse CLAC-P and its deduced amino acid sequence; antibodies specific to these proteins; and methods of diagnosing treating and preventing ... | 02/15/2011 |
| 7879582 | Method for the recombination of genetic elements A method for the recombination of a gene is disclosed. The method involves the design of unpaired forward and reverse primers having homology to the 5′ end of one template and to the 3′ end of another template. Short primer extension periods results in a recombi... | 02/01/2011 |
| 7816104 | Packaging cells for recombinant adenovirus In the absence of substantial sequence overlap between a recombinant adenoviral vector and the genome of a packaging cell, helper-dependent E1-containing particles (HDEP) can be formed at low frequency. The invention provides means and methods reducing or preventing... | 10/19/2010 |
| 7803582 | Recombinant vector and use in gene therapy A recombinant vector for delivering A3G genes into human cells comprising (i) a gene expression block including an A3G gene selected from a wild type A3G gene represented by SEQ ID NO: 1 and a mutant A3G gene and (ii) a group of elements from a modified lentiviral v... | 09/28/2010 |
| 7790419 | Antiviral vectors A viral vector production system is provided which system comprises: (i) a viral genome comprising at least one first nucleotide sequence encoding a gene product capable of binding to and effecting the cleavage, directly or indirectly, of a second nucle... | 09/07/2010 |
| 7781190 | Method for constructing and modifying large DNA molecules This invention provides a method for combining overlapping DNA molecules comprising: (a) providing first and second DNA fragments, the first having a region homologous to a region in the second; (b) tagging the first DNA fragment with a selectable marker; (c) clonin... | 08/24/2010 |
| 7745179 | Lentiviral vectors featuring liver specific transcriptional enhancer and methods of using same Recombinant lentiviruses and transfer vectors for transgene delivery as well as methods for gene therapy using such vectors are disclosed. The invention provides a third generation lentiviral packaging system and a set of vectors for producing recombinant lentivirus... | 06/29/2010 |
| 7629153 | Methods and compositions relating to improved lentiviral vector production systems The present invention provides HIV-derived lentivectors which are multiply modified to create highly safe, efficient, and potent vectors for expressing transgenes for gene therapy. The lentiviral vectors comprise various combinations of an inactive central polypurin... | 12/08/2009 |
| 7510856 | Method for plasmid preparation by conversion of open circular plasmid to supercoiled plasmid In one embodiment of the invention, a method is provided for preparing plasmid from host cells which contain the plasmid, comprising: (a) providing a plasmid solution comprised of unligatable open circular plasmid; (b) reacting the unligatable open circular plasmid ... | 03/31/2009 |
| 7413855 | Method for bisulfite treatment The present application is directed to a method for performing a bisulfite reaction to determine methylation positions in a nucleic acid, i.e. methylated and non-methylated cytosines, whereby the nucleic acid is incubated in a solution comprising the nucleic acid fo... | 08/19/2008 |
| 7413732 | Baculovirus expression system The application relates for method for cloning the gene comprising the steps of: 1. Providing a replication-deficient baculovirus vector, 2. Providing a rescue vector comprising (a) nucleic acid sequence which is capable of restoring replication in the replication-d... | 08/19/2008 |
| 7407758 | HCV variants HCV variants are described. The variants include polynucleotides comprising non-naturally occurring HCV sequences and HCV variants that have a transfection efficiency and ability to survive subpassage greater than HCV that have wild-type polyprotein coding regions. ... | 08/05/2008 |
| 7371568 | Method for modifying chromosomes The present invention relates to a method for producing a modified foreign chromosome(s) or a fragment(s) thereof, which comprises the steps of: (a) preparing a microcell comprising a foreign chromosome(s) or a fragment(s) thereof, and transferring said forei... | 05/13/2008 |
| 7368275 | In vivo incorporation of unnatural amino acids The invention provides methods and compositions for in vivo incorporation of unnatural amino acids. Also provided are compositions including proteins with unnatural amino acids. ... | 05/06/2008 |
| 7361357 | Safe mutant viral vaccines The present invention provides safe vaccines and methods of preparing such vaccines. The vaccines of the present invention contain at least two live mutant viruses of the same family or nucleic acid molecules encoding such viruses, wherein each of the two viruses or... | 04/22/2008 |
| 7354761 | Methods and composition for the production of orthogonal tRNA-aminoacyltRNA synthetase pairs This invention provides compositions and methods for generating components of protein biosynthetic machinery including orthogonal tRNAs, orthogonal aminoacyl-tRNA synthetases, and orthogonal pairs of tRNAs/synthetases. Methods for identifying orthogonal pairs are al... | 04/08/2008 |
| 7339050 | Stress-induced promoter and method of using the same This invention provides a stress-inducible promoter that effectively functions in monocotyledonous plants such as rice, and environmental stress-tolerant plants using the promoter. Such promoter is derived from rice and consists of the following DNA (a) or (b): (a) ... | 03/04/2008 |
| 7332588 | Genome of the HIV-1 inter-subtype (C/B) and use thereof The present invention refers to a polynucleotide comprising the nucleic acid sequence as depicted in SEQ ID NO:1, 2 or 3 or the fragment or derivative thereof, or a polynucleotide hybridizing with the nucleic acid sequence as depicted in SEQ ID NO:1, 2 or 3. The pre... | 02/19/2008 |
| 7332307 | Antibacterial therapy with bacteriophage physico-chemically altered by pegylation to delay inactivation by the host defense system The present invention is directed to bacteriophage therapy, using methods which enable the bacteriophage to delay inactivation by any and all parts of the host defense system (HDS) against foreign objects. The HDS normally reduces the number of bacteriophage in an a... | 02/19/2008 |
| 7323557 | Genome of the HIV-1 inter-subtype (C/B') and use thereof The present invention refers to a polynucleotide comprising the nucleic acid sequence as depicted in SEQ ID NO:1, 2 or 3 or the fragment or derivative thereof, or a polynucleotide hybridizing with the nucleic acid sequence as depicted in SEQ ID NO:1, 2 or 3. The pre... | 01/29/2008 |
| 7323303 | Modified β-lactamases and uses thereof A tool that can screen bacteria for β-lactamases against a panel of various antibiotics is desirable. A biosensor incorporating an indicator molecule into β-lactamases may achieve this purpose, but it requires that the attached indicator molecule must not impair t... | 01/29/2008 |
| 7319001 | High throughput system for producing recombinant viruses using site-specific recombination Disclosed are the methods for producing recombinant viruses using site-specific recombination in vitro. In the present invention, circular viral genomic DNAs are digested with restriction enzymes to generate a linear form viral genomic DNAs flanked by site-specific ... | 01/15/2008 |
| 7314912 | AAv scleroprotein, production and use thereof The invention relates to a structural protein of adeno-associated virus (AAV) which comprises at least one mutation which brings about an increase in the infectivity of the virus. ... | 01/01/2008 |
| 7314710 | Method for replicating the hepatitis C virus The invention concerns the use of cells capable of carrying out a process of prenylation of proteins coded by the hepatitis C virus (HCV) genome, such as prenylation of the NS5A protein, for replicating and, if required, the production of HCV or derivative viable mu... | 01/01/2008 |
| 7312075 | Trap vectors and gene trapping by using the same A trap vector containing a loxP sequence composed of inverted repeat sequence 1, a spacer sequence and inverted repeat sequence 2 in this order, the loxP sequence being a mutant loxP wherein a part of the inverted repeat sequence 1 or 2 is mutated. ... | 12/25/2007 |
| 7303898 | Defective sindbis viral vectors Disclosed herein are new defective Sindbis viral vectors made from wild type Ar-339 Sindbis virus, with differences in replicase and envelope proteins between JT vectors and consensus Sindbis virus sequences, and also between JT and Ar-339 vectors. Also disclosed ar... | 12/04/2007 |
| 7297533 | Recombinant feline herpesvirus type 1 and polyvalent vaccine using the same An attenuated feline recombinant herpesvirus 1 (FHV-1), which is prepared by identifying gene regions in the genome wherein inserted foreign genes can be expressed without affecting the replication of FHV-1 and has least two types of foreign nucleic acid sequences i... | 11/20/2007 |
| 7297542 | Adenovirus vector containing a heterologous peptide epitope in the hi loop of the fiber knob The present invention provides means to modify the tropism of recombinant adenoviral vectors using genetic methods to alter the adenoviral fiber cell-binding protein. The present invention generates an adenovirus with modified fiber gene such that novel tropism is a... | 11/20/2007 |
| 7297520 | Large circular sense molecule array Large circular (LC)-sense molecules in an array is disclosed. The LC-sense molecules array is combined with cDNA hybridization to detect differences in expression profile between different cells. LC-sense molecules were purified from nonredundant clones with recombi... | 11/20/2007 |
| 7291498 | Methods of generating chimeric adenoviruses and uses for such chimeric adenoviruses A method for providing an adenovirus from a serotype which does not grow efficiently in a desired cell line with the ability to grow in that cell line is described. The method involves replacing the left and right termini of the adenovirus with the corresponding ter... | 11/06/2007 |
| 7292944 | Establishment of biological cut-off values for predicting resistance to therapy The present invention concerns methods and systems for improving the accuracy of predicting resistance of a disease to a therapy. In one embodiment of the invention, mean and standard deviation (SD) values of fold change in normalized sensitivity, relative to a labo... | 11/06/2007 |
| 7285399 | Compositions and methods using the yeast YMR107W promoter The invention provides novel yeast promoters useful for controlling the expression of homologous and heterologous nucleic acid molecules in yeast cells. The yeast promoters are induced by a fermentable carbon source, such as glucose, or a non-fermentable carbon sour... | 10/23/2007 |
| 7285414 | Viruses targeted to hypoxic cells and tissues The present invention relates to compositions comprising a novel recombinant virus which replicates selectively in cells or tissues that are hypoxic or have an activated HIF pathway. The novel compositions of the invention comprise a recombinant virus genetically en... | 10/23/2007 |
| 7285657 | Rubisco small subunit promotes from and uses thereof The present invention is related to a family of novel spatiotemporally active Rubisco promoters (SEQ ID NO: 1, 2, 3) obtainable from light grown Brassica seedlings. Furthermore the invention is related to transgene expression in specific plant organs or at sp... | 10/23/2007 |
| 7282326 | Recombinational cloning using engineered recombination sites Recombinational cloning is provided by the use of nucleic acids, vectors and methods, in vitro and in vivo, for moving or exchanging segments of DNA molecules using engineered recombination sites and recombination proteins to provide chimeric DNA molecules that have... | 10/16/2007 |
