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| Number | Title | Issue Date |
| 7435539 | Typing of human enteroviruses The present invention discloses a method for detecting the presence of an enterovirus in a clinical sample. The invention additionally discloses a method for typing an enterovirus in a clinical sample. Both methods employ a set of primer oligonucleotides for reverse... | 10/14/2008 |
| 7332588 | Genome of the HIV-1 inter-subtype (C/B) and use thereof The present invention refers to a polynucleotide comprising the nucleic acid sequence as depicted in SEQ ID NO:1, 2 or 3 or the fragment or derivative thereof, or a polynucleotide hybridizing with the nucleic acid sequence as depicted in SEQ ID NO:1, 2 or 3. The pre... | 02/19/2008 |
| 7323557 | Genome of the HIV-1 inter-subtype (C/B') and use thereof The present invention refers to a polynucleotide comprising the nucleic acid sequence as depicted in SEQ ID NO:1, 2 or 3 or the fragment or derivative thereof, or a polynucleotide hybridizing with the nucleic acid sequence as depicted in SEQ ID NO:1, 2 or 3. The pre... | 01/29/2008 |
| 7264932 | Nuclease inhibitor cocktail Methods and compositions for inhibiting and/or inactivating nucleases by using nuclease inhibitors are provided. The nuclease inhibitors comprise anti-nuclease antibodies and non-antibody nuclease inhibitors. ... | 09/04/2007 |
| 7179457 | Modified nodavirus RNA for gene delivery The invention provides a nodavirus RNA1 molecule modified to include a heterologous insertion which is downstream of its replicase ORF and, preferably, its B2 ORF. The insertion preferably comprises one or more protein-coding regions. The modified RNA1 may be packag... | 02/20/2007 |
| 7166287 | Viral agent The invention relates to post-transfusional non-A non-B hepatitis viral polypeptide, DNA sequences encoding such viral polypeptide, expression vectors containing such DNA sequences, and hosts transformed by such expression vectors. The invention also relates to the ... | 01/23/2007 |
| RE39282 | Nucleic acid derivatives This invention relates to a methodology for assessing the sensitivity of an HIV-1 sample to zidovudine and to diagnostic assays for use in such assessment. ... | 09/12/2006 |
| 7064248 | Method of preparing fertile transgenic corn plants by microprojectile bombardment A method of preparing fertile transgenic Zea mays (corn) plants which stably express DNA encoding a Bacillus thuringiensis endotoxin, so as to impart insect resistance to the fertile transgenic plants is taught. The method comprises bombarding regenera... | 06/20/2006 |
| 7033749 | Ribonuclease resistant RNA preparation and utilization The present invention relates to nuclease resistant nucleic acids in general and ribonuclease resistant RNAs in particular. Methods of making and using such nucleic acids are disclosed. ... | 04/25/2006 |
| 6960709 | Method for altering the nutritional content of plant seed The invention provides preselected DNA sequences and methods of using them to alter the nutritional content of plant seed. Methods of the invention are directed to increasing the weight percent of an amino acid essential to the diet of animals, or increasing the sta... | 11/01/2005 |
| 6958211 | Methods of assessing HIV integrase inhibitor therapy Methods and products for the evaluation of HIV treatment are provided. The methods are based on evaluating molecular events at the HIV integrase resulting in altered therapeutic efficacy of tho investigated compounds. The methods rely on providing an integrase gene ... | 10/25/2005 |
| 6956117 | Self-replicating RNA molecule from hepatitis C virus A unique HCV RNA molecule is provided having an enhanced efficiency of establishing cell culture replication. Novel adaptive mutations have been identified within the HCV non-structural region that improves the efficiency of establishing persistently replicating HCV... | 10/18/2005 |
| 6908762 | Method of preparing a eukaryotic viral vector The inventive method of producing a eukaryotic viral vector comprises contacting a eukaryotic cell, which comprises a unique enzyme that nicks or cleaves a DNA molecule, with a recombinant phage vector, or contacting a eukaryotic cell, which does not comprise a uniq... | 06/21/2005 |
| 6887707 | Induction of viral mutation by incorporation of miscoding ribonucleoside analogs into viral RNA The present invention is directed to the identification and use of ribonucleoside analogs to induce the mutation of an RNA virus, including BVDV, HIV and HCV, or a virus which otherwise replicates through an RNA intermediate. The increase in the mutation rate of the... | 05/03/2005 |
| 6869780 | Nodavirus-like DNA expression vector and uses therefor The present invention describes the production of a nodavirus-based DNA vector that drives abundant expression of foreign genes in a wide variety of cell types. The DNA plasmid is initially transcribed by a host-cell RNA polymerase to produce primary transcripts fro... | 03/22/2005 |
| 6866853 | Interferon inducing genetically engineered attenuated viruses The present invention relates to genetically engineered attenuated viruses and methods for their production. In particular, the present invention relates to engineering live attenuated viruses which contain a modified NS gene segment. Recombinant DNA techniques can ... | 03/15/2005 |
| 6849431 | Non-B, non-C, non-G hepatitis virus gene, polynucleotide, polypeptide, virus particle, method for isolating virus particle, and method for detecting virus By isolating a so far unknown novel hepatitis virus and determining the gene sequence thereof, genes, polynucleotides, polypeptides, methods for isolating virus particles, virus particles, and antiviral antibodies, which can be used for diagnosis and treatment, as w... | 02/01/2005 |
| 6846621 | Typing of human enteroviruses The present invention discloses a method for detecting the presence of an enterovirus in a clinical sample. The invention additionally discloses a method for typing an enterovirus in a clinical sample. Both methods employ a set of primer oligonucleotides for reverse... | 01/25/2005 |
| 6818209 | Retroviral delivery system A retroviral delivery system capable of transducing a target site is described. The retroviral delivery system comprises a first nucleotide sequence coding for at least a part of an envelope protein; and one or more other nucleotide sequences derivable from a retrov... | 11/16/2004 |
| 6803194 | Use of ribozymes for functionating genes Double stranded DNAs, expression vectors and methods for their use are provided in which the intracellular expression of the double stranded DNAs is used to alter the phenotype of a target cell so that the function of a target nucleic acid that includes a nucleotide... | 10/12/2004 |
| 6723321 | Autoinducer synthase modulating compounds and uses thereof Provided are compositions and methods useful for modulating the activity of autoinducer synthase catalysts. A method for identifing modulators of the autoinducer synthesis reaction is also provided. Such modulators are useful for controlling bacterial growth and can... | 04/20/2004 |
| 6706874 | Self-replicating RNA molecule from hepatitis C virus A unique HCV RNA molecule is provided having an enhanced efficiency of establishing cell culture replication. Novel adaptive mutations have been identified within the HCV non-structural region that improves the efficiency of establishing persistently replicating HCV... | 03/16/2004 |
| 6699987 | Formulations and method for isolating nucleic acids from optional complex starting material and subsequent complex gene analytics The subject of the invention are formulations not containing chaotropic components for isolating nucleic acids with binding to a solid phase, in particular of DNA, from optional complex starting materials and quantities containing a lysis/binding buffer s... | 03/02/2004 |
| 6660264 | Treatment of intracellular infection An agent for combating an intracellular microbial infection comprises a phage component and, associated therewith, a targeting moiety which directs the agent to a target cell and initiates delivery of the phage into the target cell. Once inside the target... | 12/09/2003 |
| 6630300 | Oligonucleotides and method for characterizing and detecting Genogroup II type small round structured virus Nucleic acid sequences, oligonucleotides and a method for detection of SRSV, in particular, a virus which belongs to Genotype II (GII), in clinical examinations, public health examinations, food evaluations and food poisoning examinations are provided.... | 10/07/2003 |
| 6613516 | Preparation of nucleic acid samples The presently claimed invention provides methods, compositions, and apparatus for studying nucleic acids. Specifically, the present invention provides a novel enrichment and labeling strategy for ribonucleic acids. In one embodiment, the invention provide... | 09/02/2003 |
| 6596268 | Viruses for the treatment of cellular proliferative disorders Methods for treating cell proliferative disorders by administering virus to proliferating cells having an activated Ras-pathway are disclosed. The virus is administered so that it ultimately directly contacts proliferating cells having an activated Ras-pa... | 07/22/2003 |
| 6573092 | Method of preparing a eukaryotic viral vector The inventive method of producing a eukaryotic viral vector comprises contacting a eukaryotic cell, which comprises a unique enzyme that nicks or cleaves a DNA molecule, with a recombinant phage vector, or contacting a eukaryotic cell, which does not comp... | 06/03/2003 |
| 6514694 | Methods for the detection of encysted parasites The present invention relates to immunogenic Toxoplasma gondii proteins, to T. gondii nucleic acid molecules, including those that encode such proteins and to antibodies raised against such proteins. The present invention also includes methods to obtain s... | 02/04/2003 |
| 6392124 | Infectious vectors and clones of plants derived from the turnip mosaic virus (TUMV) The infectious clone comprises: a) a complete copy of the complementary DNA (cDNA) to the genomic RNA of the turnip mosaic virus (TuMV), in the form of double stranded DNA, b) a transcription promoter sequence, c) a replicon and, optionally, d) a transcri... | 05/21/2002 |
| 6331417 | Detection and quantification of human herpes virus 7 by enzymic amplification The present invention relates to an isolated nucleic acid molecule comprising: (i) a primer protion consisting of a contiguous sequence of from 10 to 50 nucleotides capable of hybridizing to (a) the target nucleic acid molecule represented by SEQ ID NO:1,... | 12/18/2001 |
| 6284249 | Fusion polypeptide having the C protein and E1 protein of hepatitis C virus The invention concerns a pharmaceutical composition for treating or preventing C hepatitis (HCV), induced infections, which in a preferred embodiment, comprises a main active principle, (i) a fusion polypeptide, including the HCV capsid polypeptide (C191)... | 09/04/2001 |
| 6280974 | Recombinant feline coronavirus S proteins The present invention provides polynucleotide molecules encoding portions of the S protein from feline infectious peritonitis virus (FIPV). The present invention further provides polynucleotide molecules encoding the entire S protein or portions thereof f... | 08/28/2001 |
| 6245528 | Latent baculovirus expression system The invention relates to a baculovirus including a disruption in its endogenous p35 gene and its use in establishing latent baculovirus infections. In some embodiments, the baculovirus can also include a sequence encoding a non-baculovirus RNA and a bacul... | 06/12/2001 |
| 6218105 | High throughput papilloma virus in vitro infectivity assay A high throughput virus in vitro infectivity assay method comprising growing cells in a multi-well format, infecting the cells with intact virion incubated with a test agent, and measuring expression of at least one viral nucleic acid sequence in the cell... | 04/17/2001 |
| 6197944 | DNA molecules stabilized by modifications of the 3'-terminal phosphodiester linkage The use of oligodeoxynucleotides modified at the 3'-terminal internucleotide link as therapeutic agents by a method of hybridizing the modified oligonucleotide to a complementary sequence within a targeted mRNA and cleaving the mRNA within the RNA-DNA hel... | 03/06/2001 |
| 6063628 | Induction of viral mutation by incorporation of miscoding ribonucleoside analogs into viral RNA The present invention is directed to the identification and use of ribonucleoside analogs to induce the mutation of an RNA virus, including HIV and HCV, or a virus which otherwise replicates through an RNA intermediate. The increase in the mutation rate o... | 05/16/2000 |
| 6037126 | Compositions, methods, kits and apparatus for determining the presence or absence of protein component of telomerase enzyme The present invention is directed to methods, compositions, kits and apparatus to identify and detect the presence or absence of target analytes. The embodiments of the present invention have utility in identification of protein component of human telomer... | 03/14/2000 |
| 5973137 | Low pH RNA isolation reagents, method, and kit The present invention describes an RNA isolation process which utilizes low pH reagents. In addition, the reagents are less hazardous and are more stable than those used in prior art methods. This rapid method may be used to obtain purified RNA from a var... | 10/26/1999 |
| 5962274 | Viral vector directed to predetermined target cells Disclosed are compositions comprising viral vectors derived from the paramyxovirus, simian virus 5 (SV5). The SV5 vectors of the present invention are designed so that the HN protein that binds to sialic acid is not expressed, and in certain embodiments a... | 10/05/1999 |
