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| Number | Title | Issue Date |
| 7422902 | Lipid-nucleic acid particles prepared via a hydrophobic lipid-nucleic acid complex intermediate and use for gene transfer Novel lipid-nucleic acid particulate complexes which are useful for in vitro or in vivo gene transfer are described. The particles can be formed using either detergent dialysis methods or methods which utilize organic solvents. Upon removal of a solubilizing compone... | 09/09/2008 |
| 7422849 | Method for determining expression of a PI3 kinase gene This invention relates to new polypeptides which exhibit kinase activity or, more specifically, which show phosphoinositide (PI) 3-kinase activity. Such polypeptides are involved in pathways responsible for cellular growth and differentiation. An isolated polypeptid... | 09/09/2008 |
| 7405205 | Antitumor antisense sequences directed against R1 and R2 components of ribonucleotide reductase Compounds and methods for modulating cell proliferation, preferably inhibiting the proliferation of tumor cells are described. Compounds that may be used to modulate cell proliferation include antisense oligonucleotides complementary to regions of the mammalian ribo... | 07/29/2008 |
| 7399586 | Modulation of biological signal transduction by RNA interference Compositions and methods relating to small interfering RNA (siRNA) polynucleotides are provided as pertains to modulation of biological signal transduction. Shown are siRNA polynucleotides that interfere with expression of members of the protein tyrosine phosphatase... | 07/15/2008 |
| 7381708 | Suppression of eIF5A1 expression by the use of antisense oligonucleotides for the prevention of retinal cell death in the glaucomatous eye The present invention provides methods for preventing retinal ganglion cell death in the glaucomatous eye and methods for suppressing apoptosis-specific eIF5A1 expression through the use of antisense oligonucleotides targeted to human apoptosis-specific eIF5A1. ... | 06/03/2008 |
| 7345025 | Methods for genetic modification of hematopoietic progenitor cells and uses of the modified cells Described are compositions and methods relating to gene therapy, particularly as applied to hematopoietic progenitor (HP) cells, to transduced cells and methods of obtaining them, and to methods of using them to provide prolonged engraftment of modified hematopoieti... | 03/18/2008 |
| 7335760 | Nucleic acid sequences encoding zinc finger proteins Isolated polynucleotides and polypeptides encoded thereby are described, together with the use of those products for making transgenic plants. ... | 02/26/2008 |
| 7332335 | Decreasing cell proliferation by decreasing levels of PP5 The invention provides a method of increasing expression of p21WAF1/Cip 1 in cells to decrease proliferation of the cells, the method comprising decreasing levels of PP5 protein in the cells. The invention further provides a method of treating or preventi... | 02/19/2008 |
| 7309786 | Oligonucleotide antagonist for human tumor necrosis factor α (TNF-α) The present invention relates to a group of new oligonucleotides sequences with human tumor necrosis factor α (TNF-α) inhibiting activity, which includes DNA sequences and RNA sequences. These oligonucleotides or aptamer can specifically be bound to TNF-α and inh... | 12/18/2007 |
| 7309588 | Nucleic acid assays The present invention relates to the detection of specific nucleic acid sequences after an amplification process, or directly without amplification. In particular, the invention provides for the automation of the amplification and detection process, the amplificatio... | 12/18/2007 |
| 7297488 | Identifying and testing antisense oligonucleotides that inhibit telomerase reverse transcriptase This disclosure provides TRT antisense oligonucleotides, methods of detecting TRT, methods of diagnosing telomerase-related conditions, methods of diagnosing and providing a prognosis for cancer, and methods of treating telomerase-related conditions, including cance... | 11/20/2007 |
| 7294713 | Antisense IAP oligonucleotides and uses thereof The present invention feature antisense IAP oligonucleotides and other negative regulators of the IAP anti-apoptotic pathway, and methods for using them to enhance apoptosis. ... | 11/13/2007 |
| 7262008 | Nucleic acid assays The present invention relates to the detection of specific nucleic acid sequences, either by a process of amplification of specific nucleic acid sequences or not. More particularly the invention provides for improved compositions and methods for reducing the chance ... | 08/28/2007 |
| 7217572 | Modulation of HIF1α and HIF2α expression Compounds, compositions and methods are provided for modulating the expression of HIF1α and/or HIF2α. The compositions comprise oligonucleotides, targeted to nucleic acid encoding HIF1α and HIF2α. Methods of using these compounds for modulation of HIF1α and/or ... | 05/15/2007 |
| 7186530 | Protein associated with cell stress response A stress-phosphorylated endoplasmic reticulum protein, Nogo B, is provided. The protein is hyperphosphorylated as a result of exposure of cells to stress. Two transcripts of Nogo B are identified in human tissues, and the longer transcript is predominant in human br... | 03/06/2007 |
| 7179593 | Estrogen receptor site-specific ribozymes and uses thereof for estrogen dependent tumors Highly specific hammerhead ribozymes are provided that human target estrogen receptor mRNA. These ribozymes, designated RZ1 through RZ7 provide predictable mRNA cleavage products. Methods for inhibiting estrogen-dependent tumor growth, such as that characteristic of... | 02/20/2007 |
| 7179796 | Antisense modulation of PTP1B expression Compounds, compositions and methods are provided for modulating the expression of PTP1B. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding PTP1B. Methods of using these compounds for modulation... | 02/20/2007 |
| 7176304 | RNA interference mediated inhibition of vascular endothelial growth factor and vascular endothelial growth factor receptor gene expression using short interfering nucleic acid (siNA) The present invention concerns methods and reagents useful in modulating vascular endothelial growth factor (VEGF, VEGF-A, VEGF-B, VEGF-C, VEGF-D) and/or vascular endothelial growth factor receptor (e.g., VEGFR1, VEGFR2 and/or VEGFr3) gene expression in a variety of... | 02/13/2007 |
| 7148044 | Nucleic acid enzyme for RNA cleavage A method is described for cleaving a nucleic acid substrate with a nucleic acid enzyme at a cleavage site comprising mixing the substrate with the enzyme, wherein the substrate includes a 7 nucleotide sequence with at least 6 nucleotides 3′ to the cleavage site an... | 12/12/2006 |
| 7144999 | Modulation of hypoxia-inducible factor 1 alpha expression Compounds, compositions and methods are provided for modulating the expression of hypoxia-inducible factor 1 alpha. The compositions comprise oligonucleotides, targeted to nucleic acid encoding hypoxia-inducible factor 1 alpha. Methods of using these compounds for m... | 12/05/2006 |
| 7141665 | Enzymatic DNA molecules The present invention discloses deoxyribonucleic acid enzymes—catalytic or enzymatic DNA molecules—capable of cleaving nucleic acid sequences or molecules, particularly RNA, in a site-specific manner, as well as compositions including same. Methods of making and... | 11/28/2006 |
| 7138378 | Genetic suppression and replacement A strategy for suppressing specifically or partially specifically an endogenous gene and introducing a replacement gene, said strategy comprising the steps of: 1. providing suppressing nucleic acids or other suppression effectors able to bind to an endo... | 11/21/2006 |
| 7138517 | Sugar modified oligonucleotides Compositions and methods are provided for the treatment and diagnosis of diseases amenable to modulation of the production of selected proteins. In accordance with preferred embodiments, oligonucleotides and oligonucleotide analogs are provided which are specificall... | 11/21/2006 |
| 7135312 | Circular DNA vectors for synthesis of RNA and DNA The present invention provides methods for synthesis and therapeutic use of DNA and RNA oligonucleotides and analogs. RNA oligonucleotides are synthesized using a small, circular DNA template which lacks an RNA polymerase promoter sequence. The RNA synthesis is perf... | 11/14/2006 |
| 7125660 | Nucleic acid sensor molecules and methods of using same Methods for engineering a nucleic acid sensor molecule are provided. Biosensors comprise a plurality of nucleic acid sensor molecules labeled with a first signaling moiety and a second signaling moiety. The nucleic acid sensor molecules recognizes target molecules w... | 10/24/2006 |
| 7102024 | Functional biopolymer modification reagents and uses thereof Hydrazino, oxyamino and carbonyl-based reagents and methods for incorporation into oligonucleotides during their solid phase synthesis are provided. Modified oligonucleotides are provided that incorporate the reagents provided here in. Immobilized oligonucleotides a... | 09/05/2006 |
| 7074601 | Nucleozymes Nucleozymes containing ribonucleotides and deoxyribonucleotides or nucleic acid analogues are described herein. The nucleozymes have catalytic activity and are significantly more resistant to degradation than their all-RNA ribozyme counterparts. Also described are m... | 07/11/2006 |
| 7041817 | Synthesis, deprotection, analysis and purification of RNA and ribozymes Method for purification and synthesis of RNA molecules and enzymatic RNA molecules in enzymatically active form. ... | 05/09/2006 |
| 7022828 | siRNA treatment of diseases or conditions related to levels of IKK-gamma The present invention relates to nucleic acid molecules, including antisense and enzymatic nucleic acid molecules, such as hammerhead ribozymes, DNAzymes, allozymes, aptamers, decoys and siRNA (RNAi), which modulate the expression or function of IKK genes, such as I... | 04/04/2006 |
| 6995259 | Method for the chemical synthesis of oligonucleotides The present invention features novel compositions, linkers, derivatized solid supports, and methods for the efficient solid phase synthesis of oligonucleotides, including RNA, DNA, RNA-DNA chimeras, and analogs thereof. ... | 02/07/2006 |
| 6924096 | Delivery construct for antisense nucleic acids and methods of use A novel nucleic acid construct for delivery of antisense targeting sequences is provided. The construct includes intact stem loop structures and an antisense nucleic acid. Optionally, a ribozyme nucleic acid is included in the construct. The construct is useful for ... | 08/02/2005 |
| 6916653 | Ribozymal nucleic acid A vector system which can be incorporated in liposomes, comprising at least one DNA vector, the vector or vectors containing a target-cleaving hammerhead ribozymal DNA sequence under control of a promoter effective in human cells and which, upon transcription to RNA... | 07/12/2005 |
| 6869780 | Nodavirus-like DNA expression vector and uses therefor The present invention describes the production of a nodavirus-based DNA vector that drives abundant expression of foreign genes in a wide variety of cell types. The DNA plasmid is initially transcribed by a host-cell RNA polymerase to produce primary transcripts fro... | 03/22/2005 |
| 6867039 | Antisense modulation of dual specific phosphatase 5 expression Antisense compounds, compositions and methods are provided for modulating the expression of dual specific phosphatase 5. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding dual specific phosphat... | 03/15/2005 |
| 6858590 | Vaccines containing ribavirin and methods of use thereof Compositions and methods for enhancing the effect of vaccines in animals, such as domestic, sport, or pet species, and humans are disclosed. More particularly, vaccine compositions comprising ribavirin and an antigen, preferably an antigen that has an epitope presen... | 02/22/2005 |
| 6849612 | Oligonucleotide modulation of cell adhesion Compositions and methods for the treatment of ophthalmic disorders, particularly preservation of corneal explants and prevention of corneal allograft rejection. These compositions comprise oligonucleotides which are specifically hybridizable with nucleic acids encod... | 02/01/2005 |
| 6841541 | Regulation of BCL-2-gene expression The present invention provides novel anticode oligomers and methods of using them for controlling growth of cancer cells expressing the bcl-2 gene. ... | 01/11/2005 |
| 6828151 | Antisense modulation of hematopoietic cell protein tyrosine kinase expression Antisense compounds, compositions and methods are provided for modulating the expression of hematopoietic cell protein tyrosine kinase. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding hematop... | 12/07/2004 |
| 6828139 | Production of replicative hepatitis C virus A nucleic acid having a first nucleotide sequence encoding an infectious hepatitis C virus, a second nucleotide sequence encoding a ribozyme, and an inducible promoter operably linked to the first and second nucleotide sequences, the ribozyme being configured to rem... | 12/07/2004 |
| 6828148 | Miniribozymes active at low magnesium ion concentrations This invention is directed to a class of miniribozymes, capable of hybridizing with a target RNA to be cleaved and exhibiting very high cleavage rates at low Mg2+ concentration. The miniribozymes may be used in vitro or in vivo. They may be used as diagno... | 12/07/2004 |
