Class 435/87 - Nucleoside

Subclass of Class 435 - Chemistry: molecular biology and microbiology
Definition: Processes wherein the nitrogen is part of a purine or pyrimidine
No. of patents: 100
Last issue date: 08/24/2010

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Number	Title	Issue Date
7781189	Catalyzing transglycosylation using a recombinant host cell overexpressing uridine phosphorylase and purine nucleoside phosphorylase Novel strains of genetically modified prokaryotic micro-organisms capable of expressing polypeptides having the enzyme activity of the enzymes uridine phosphorylase (UdP) and purine nucleoside phosphorylase (PNP) are described; the strains in question can be used, b...	08/24/2010
7608432	Method for producing purine nucleoside by fermentation A microorganism which has a gene encoding an enzyme in which feedback inhibition is desensitized by substitution of one or two amino acids in PRPP amidotransferase encoded by purF of Escherichia coli, a gene encoding a protein which is an inactivated represso...	10/27/2009
7601519	Method for producing purine nucleoside by fermentation A microorganism which has a gene encoding an enzyme in which feedback inhibition is desensitized by substitution of one or two amino acids in PRPP amidotransferase encoded by purF of Escherichia coli, a gene encoding a protein which is an inactivated represso...	10/13/2009
7575901	Method for producing nucleotide by fermentation Nucleoside 5′-phosphate ester is produced by culturing a bacterium belonging to the genus Escherichia having an ability to produce nucleoside 5′-phosphate ester, in which ushA gene and aphA gene do not function normally, in a medium to produce and accumul...	08/18/2009
7435560	Method for producing purine nucleoside by fermentation A microorganism which has a gene encoding an enzyme in which feedback inhibition is desensitized by substitution of one or two amino acids in PRPP amidotransferase encoded by purF of Escherichia coli, a gene encoding a protein which is an inactivated represso...	10/14/2008
7338792	Process for the preparation of D-pantothenic acid and/or salts thereof The invention provides a process for the preparation of D-pantothenic acid and/or salts thereof or feedstuffs additives comprising these by fermentation of microorganisms of the Bacillus group, in particular those which already produce D-pantothenic acid, whi...	03/04/2008
7335502	Chlorohydrin and hydroxycarboxylic ester asymmetric hydrolase gene The present invention is to provide a gene having asymmetric hydrolase activity which is useful for synthesis of an optically active carboxylic acid, its antipode ester, and lactone, and a hydroxycarboxylic ester asymmetric hydrolase enzyme (EnHCH) derived from E...	02/26/2008
7294486	Enzymatic process for the synthesis of organo-fluorine compounds There is described a process for the synthesis of a fluoronucleoside compound, said process comprising mixing a substrate and an enzyme from Streptomyces cattelya as catalyst. The process may be used to produce an 18F labelled fluoronucleoside comp...	11/13/2007
7270980	Compounds for immunodiagnosis of prostate cancer and methods for their use Compounds and methods for diagnosing prostate cancer are provided. The inventive compounds include polypeptides containing at least a portion of a prostate tumor protein. The inventive polypeptides may be used to generate antibodies useful for the diagnosis and moni...	09/18/2007
7250281	Subtilisin variants Novel carbonyl hydrolase variants derived from the DNA sequences of naturally-occurring or recombinant non-human carbonyl hydrolases are disclosed. The variant carbonyl hydrolases, in general, are obtained by in vitro modification of a precursor DNA sequence encodin...	07/31/2007
7238338	System and method for the large scale labeling of compounds with radiohalogens Disclosed are methods for manufacturing radiohalogen-labeled steroids, nucleosides, nucleotides and proteins, for example, pyrimidines and proteins. Methods according to the example embodiments specific to pyrimidines includes dissolving a halogenated pyrimidine to ...	07/03/2007
7235650	Derivatized oligonucleotides having improved uptake and other properties Linked nucleosides having at least one functionalized nucleoside that bears a substituent such as a steroid molecule, a reporter molecule, a non-aromatic lipophilic molecule, a reporter enzyme, a peptide, a protein, a water soluble vitamin, a lipid soluble vitamin, ...	06/26/2007
7229797	Enzymatic synthesis of deoxyribonucleosides The present invention relates to a method for the in vitro enzymatic synthesis of deoxyribonucleosides and enzymes suitable for this method. ...	06/12/2007
7189553	Modified subtilisins and detergent, compositions containing same The present invention relates to enzymes produced by mutating the genes for a number of subtilisin proteases and expressing the mutated genes in suitable hosts are presented. The enzymes exhibit improved wash performance in comparison to their wild type parent enzym...	03/13/2007
7148042	Method of preparing a guanosine-group compound and an intermediate thereof A glyoxal-guanosine-group compound is prepared either by reacting glyoxal-guanine with any one of ribose-1-phosphate and 2-deoxyribose-1-phosphate in the presence of purine nucleoside phosphorylase, or by reacting glyoxal-guanine with any one selected from the group...	12/12/2006
7141396	Method of preparing a guanosine-group compound and an intermediate thereof A glyoxal-guanosine-group compound is prepared either by reacting glyoxal-guanine with any one of ribose-1-phosphate and 2-deoxyribose-1-phosphate in the presence of purine nucleoside phosphorylase, or by reacting glyoxal-guanine with any one selected from the group...	11/28/2006
7141397	Method of preparing a guanosine-group compound and an intermediate thereof A glyoxal-guanosine-group compound is prepared either by reacting glyoxal-guanine with any one of ribose-1-phosphate and 2-deoxyribose-1-phosphate in the presence of purine nucleoside phosphorylase, or by reacting glyoxal-guanine with any one selected from the group...	11/28/2006
7138517	Sugar modified oligonucleotides Compositions and methods are provided for the treatment and diagnosis of diseases amenable to modulation of the production of selected proteins. In accordance with preferred embodiments, oligonucleotides and oligonucleotide analogs are provided which are specificall...	11/21/2006
7119096	Uracil reductase inactivators Uracil reductase inactivators, notably a 5-substituted uracil or 5,6-dihydro-5-substituted uracil, potentiate 5-flourouracil and find use particularly in the treatment of cancer. The 5-substituent is selected from bromo, ido, cyano, halo-substituted C1-4 ...	10/10/2006
7119184	Oligonucleotides having A-DNA form and B-DNA form conformational geometry Modified oligonucleotides containing both A-form conformation geometry and B-from conformation geometry nucleotides are disclosed. The B-form geometry allows the oligonucleotide to serve as substrates for RNase H when bound to a target nucleic acid strand. The A-for...	10/10/2006
7112428	Chlorohydrin and hydroxycarboxylic ester asymmetric hydrolase gene The present invention is to provide a gene having asymmetric hydrolase activity which is useful for synthesis of an optically active carboxylic acid, its antipode ester, and lactone, and a hydroxycarboxylic ester asymmetric hydrolase enzyme (EnHCH) derived from E...	09/26/2006
7038039	Process for selectively producing 1-phosphorylated sugar derivative anomer and process for producing nucleoside A desired isomer is selectively prepared by phosphorolyzing and isomerizing an anomer mixture of a 1-phosphorylated saccharide derivative while crystallizing one of the isomers to displace the equilibrium. Furthermore, using the action of a nucleoside phosphorylase,...	05/02/2006
7037646	Amine-derivatized nucleosides and oligonucleosides Nucleosides and oligonucleosides functionalized to include alkylamino functionality, and derivatives thereof. In certain embodiments, the compounds of the invention further include steroids, reporter molecules, reporter enzymes, lipophilic molecules, peptides or pro...	05/02/2006
6991924	Mutant carbamoylphosphate synthetase and method for producing compounds derived from carbamoylphosphate L-arginine, citrulline and pyrimidine derivatives including orotic acid, uridine, uridine 5′-monophosphate (UMP), cytidine and cytidine 5′-monophosphate (CMP) are produced using a bacterium belonging to the genus Escherichia harboring a mutant carbamoylph...	01/31/2006
6974865	C3′ -methylene hydrogen phosphonate oligomers and related compounds The present invention is directed to nucleoside monomers wherein the 3′-O atom is replaced with a methylene group. The present invention also provides oligomers comprising a plurality of such monomers which are linked by methylene phosphonate linkages. Further, me...	12/13/2005
6960568	Nucleosides and related processes, pharmaceutical compositions and methods The invention provides novel nucleosides and related processes, pharmaceutical compositions, and methods. The novel nucleosides are useful in a wide variety of antiviral, antineoplastic, and antibacterial applications. Preferred embodiments of the instant invention ...	11/01/2005
6951931	Pyrimidine derivatives for labeled binding partners Compounds having structure (1) wherein R1 is —H a protecting group, a linker or a binding partner; and R2 and R34 are as defined in the specification. The invention also provides inte...	10/04/2005
6942771	Microfluidic systems in the electrochemical detection of target analytes The invention relates generally to methods and apparatus for conducting analyses, particularly microfluidic devices for the detection of target analytes. ...	09/13/2005
6929939	Proteins producing an altered immunogenic response and methods of making and using the same The present invention relates to novel protein variants that exhibit reduced allergenicity when compared to the parental proteins. Also included are DNA molecules that encode the novel variants, host cells comprising the DNA and methods of making proteins less aller...	08/16/2005
6919439	Derivatized oligonucleotides having improved uptake and other properties Linked nucleosides having at least one functionalized nucleosid that bears a substituent such as a steroid molecule, a reporter molecule, a non-aromatic lipophilic molecule, a reporter enzyme, a peptide, a protein, a water soluble vitamin, lipid soluble vitamin, an ...	07/19/2005
6911341	Vectors, host cells, and methods for production of uridine phosphorylase and purine nucleoside phosphorylase Strains of genetically modified prokaryotic micro-organisms capable of expressing polypeptides having the enzyme activity of the enzymes uridine posphorylase (UdP) and purine nucleoside phosphorylase (PNP) are described; the strains in question can be used, both in ...	06/28/2005
6900301	Backbone modified oligonucleotide analogues Therapeutic oligonucleotide analogues which have improved nuclease resistance and improved cellular uptake are provided. Replacement of the normal phosphorodiester inter-sugar linkages found in natural oligomers with four atom linking groups forms unique di- and pol...	05/31/2005
6890739	Use of uridine diphosphate glucose 4-epimerase The present invention relates to a new use of uridine diphosphate glucose 4-epimerase (also called uridine diphosphate galactose 4-epimerase), and a method of converting uridine diphosphate N-acetylglucosamine (UDP-GlcNAc) to uridine diphosphate N-acetylgalactosamin...	05/10/2005
6858721	Method for producing cytosine nucleoside compounds The invention provides a method for producing a cytosine nucleoside compound from pentose-1-phosphate and cytosine or a derivative thereof using a nucleoside phosphorylase reactive to cytosine or a bacterium having the enzyme activity. The invention also provides a ...	02/22/2005
6800743	Pyrimidine derivatives for labeled binding partners Compounds having structure (1) wherein R1 is —H a protecting group, a linker or a binding partner; and R2 and R34 are as defined in the specification. The invention also provides interm...	10/05/2004
6777209	Vectors, cells and processes for pyrimidine deoxyribonucleosides production Novel DNA constructs and host cells comprising the same are disclosed. DNA constructs comprise a transcription unit (e.g. operon) comprising DNA sequences encoding for ribonucleotide reductase and thioredoxin or a uridine kinase gene and/or a dCTP deaminase gene. In...	08/17/2004
6777208	Method for producing 2′ -deoxyribonucleoside A 2′-deoxyribonucleoside is produced by culturing a microorganism, which is transformed with a gene encoding a ribonucleotide reductase and in which 2′-deoxyribonucleoside degradation activity is decreased or eliminated by disrupting a gene encoding a purine nuc...	08/17/2004
6743910	Stereoselective synthesis of nucleoside analogues The invention is a process for stereoselectively producing a dioxolane nucleoside analogue from an anomeric mixture of β and α anomers represented by the following formula A or formula B: wherein R is selected from the...	06/01/2004
6649753	Stable salts of S-adenosyl-L-methionine (SAMe) and the process for their preparation This invention relates to the production of new & stable salts of S-adenosyl-L-methionine SAMe). The source of SAMe used in the salt formation is from chemical process wherein stereoselective methylation of S-adenosyl-L-homocysteine is achieved. The proce...	11/18/2003
6620596	Method of preparing a guanosine-group compound A glyoxal-guanosine-group compound is prepared either by reacting glyoxal-guanine with any one of ribose-1-phosphate and 2-deoxyribose-1-phosphate in the presence of purine nucleoside phosphorylase, or by reacting glyoxal-guanine with any one selected fro...	09/16/2003

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Class 435/87 - Nucleoside