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| Number | Title | Issue Date |
| 7208631 | 2-alkylcysteinamide or salt thereof, process for producing these, and use of these A process for producing a 2-alkylcysteinamide, which comprises hydrolysis of a 4-alkylthiazolidine-4-carboxamide represented by the general formula (2) or a salt thereof: wherein R represents a lower alkyl group ... | 04/24/2007 |
| 7166457 | Method for treating bacterial effluents containing at least a CIP I-2194 ether A process for the treatment of aqueous effluents containing at least one of the following ethers is described: ethyl tert-butyl ether (ETBE) and/or methyl tert-butyl ether (MTBE) and/or tert-amyl methyl ether (TAME) in order to reduce the concentration of these ethe... | 01/23/2007 |
| 7094403 | superoxide dismutase The invention relates to Mycobacterium tuberculosis superoxide dismutase antibodies, methods of using them for detection of M. tuberculosis, methods of testing for an inhibitor of an M. tuberculosis superoxide dismutase, and methods of detecting... | 08/22/2006 |
| 7022320 | immunization Recombinant nucleic acid molecules are described. The molecules have a sequence or sequences encoding at least two M. tuberculosis antigens. Vectors and compositions containing these molecules are also described. In addition, compositions containing a cocktai... | 04/04/2006 |
| 6977075 | Photosensitizer conjugates for targeting intracellular pathogens The methods of the invention can be used to treat mycobacterial infections, or any disease or disorder that is caused by (or aggravated by) an intracellular pathogen. Accordingly, the invention features methods for treating a subject who has a disorder that is assoc... | 12/20/2005 |
| 6878377 | Mycobacterium vaccae for down-regulation of the Th2 activity of the immune system Antigenic and/or immunogenic material derived from Mycobacterium vaccae is used to down-regulate Th2 activity of the immune system without up-regulation of Th1 activity. Disorders such as Chronic Fatigue Syndrome, Gulf War Syndrome and Total Allergy Syndrome ... | 04/12/2005 |
| 6849445 | Process for treatment of aqueous effluents that contain methyl-tert-butyl ether and/or methyl-tert-amyl ether by mycobacterium austroafricanum I-2562 A process for treatment of aqueous effluents, for example, an aquifer, that contains at least methyl-tert-butyl ether (MTBE) or methyl-tert-amyl ether (TAME) so as to reduce the concentration of said ether is described, characterized in that a Mycobacterium austr... | 02/01/2005 |
| 6821769 | IniB, iniA and iniC genes of mycobacteria and methods of use This invention relates to the identification, cloning, sequencing and characterization of the iniB, iniA and iniC genes of mycobacteria which are induced by a broad class of antibiotics that act by inhibiting cell wall biosynthesis, including the first line antitube... | 11/23/2004 |
| 6752994 | Insertional mutations in mycobacteria A mutated mycobacterium selected from the class consisting of mutated M. bovis-BCG, mutated M. tuberculosis, and mutated M. leprae. The mutation of M. bovis-BCG, M. tuberculosis, or M. leprae is preferably effected through a... | 06/22/2004 |
| 6664096 | Methods for improved diagnosis and treatment of mycobacterial infections Media for growth enhancement and resuscitation of mycobacteria (such as Mycobacterium tuberculosis, Mycobacterium paratuberculosis, and Mycobacterium leprae) are provided. The media comprise isolated cell extract, early-stationary-phase or stationary phas... | 12/16/2003 |
| 6559295 | Mycobacterium fol A gene that encodes for the enzyme dihydrofolate reductase The invention relates to the nucleic acid sequence and amino acid sequence of dihydrofolate reductase (DHFR) from mycobacteria and to expression of recombinant DHFR protein. Utilizing the recombinant protein, novel therapies and diagnostic strategies can ... | 05/06/2003 |
| 6537552 | Vaccine adjuvant The invention features fusion agents such as fusion proteins that are useful for the treatment of and prevention from diseases that are susceptible to the effects of cellular (Th1 type) immune responses. Also encompassed by the invention are nucleic acids... | 03/25/2003 |
| 6524842 | Biodegradation of gasoline oxygenates A method for degrading an undesirable ether-based environmental contaminant by contacting the ether with a hydrogen-oxidizing microorganism to convert the ether to innocuous compounds which are environmentally acceptable, including treating the ether-base... | 02/25/2003 |
| 6517845 | Mycobacterium tuberculosis superoxide dismutase The invention relates to Mycobacterium tuberculosis superoxide dismutase antibodies, methods of using them for detection of M. tuberculosis, methods of testing for an inhibitor of an M. tuberculosis superoxide dismutase, and methods of detecting tuberculo... | 02/11/2003 |
| 6436409 | Polynucleotide functionally coding for the LHP protein from Mycobacterium tuberculosis, its biologically active derivative fragments, as well as methods using the same The present invention is directed to a polynucleotide carrying an open reading frame coding for an antigenic polypeptide from Mycobacterium tuberculosis, named lhp, which is placed under the control of its own regulation signals which are functional in my... | 08/20/2002 |
| 6410720 | Compounds and methods for treatment and diagnosis of mycobacterial infections The present invention provides polypeptides comprising an immunogenic portion of a M. vaccae soluble protein and DNA molecules encoding such polypeptides, together with methods for their use in the diagnosis and treatment of mycobacterial infection. Metho... | 06/25/2002 |
| 6403100 | Method of attenuating pathogenic mycobacteria and strains of mycobacteria so attenuated This invention provides for novel attenuated strains of Mycobacterium tuberculosis and M. bovis. Attenuation is achieved by eliminating or by downregulating the expression of the -crystallin heat shock protein gene ("acr gene"). The invention provi... | 06/11/2002 |
| 6303366 | Biodegradation of the gasoline oxygenates Disclosed is a method for monitoring the degradation of methyl tert-butyl ether in a contaminated media which contains methyl tert-butyl ether and/or which is treated under conditions which cause the degradation of methyl tert-butyl ether into 2-hydroxy i... | 10/16/2001 |
| 6297015 | Crohn's disease diagnostic and treatment methods and compositions A composition and method for detecting Crohn's disease include the use of serological testing as a rapid and simple way to diagnose Crohn's disease. The serological tests were based on the use of the two recombinant clones isolated from an M. paratubercul... | 10/02/2001 |
| 6284523 | Process for biodegradation of a xenobiotic A process for biodegradation of a xenobiotic. A process for biodegradation of a xenobiotic comprising the steps of: contacting an organic phase comprising the xenobiotic and at least one substantially water-immiscible organic solvent with an aqueous phase... | 09/04/2001 |
| 6284255 | Compounds and methods for treatment and diagnosis of mycobacterial infections The present invention provides polypeptides comprising an immunogenic portion of a M. vaccae soluble protein and DNA molecules encoding such polypeptides, together with methods for their use in the diagnosis and treatment of mycobacterial infection. Metho... | 09/04/2001 |
| 6274356 | Carbohydrate complex extracted from Mycobacterium tuberculosis and process for the preparation thereof A carbohydrate complex, which is a mixture of low molecular-weight polysaccharides of an arabinomannan structure extracted from Mycobacterium tuberculosis, is highly effective in treating various cancer patients without incurring any adverse side effects.... | 08/14/2001 |
| 6268201 | IniB, iniA and iniC genes of mycobacteria and methods of use This invention relates to the identification, cloning, sequencing and characterization of the iniB, iniA and iniC genes of mycobacteria which are induced by a broad class of antibiotics that act by inhibiting cell wall biosynthesis, including the first li... | 07/31/2001 |
| 6254777 | Process for bacterial treatment of effluents that contain at least one ether A process for treating aqueous effluents that contain at least one ether, preferably ethyl tert-butyl ether (ETBE) and/or methyl tert-butyl ether (MTBE) and/or tert-amylmethylether (TAME) to reduce the concentration of said ether is described, characteriz... | 07/03/2001 |
| 6229001 | Mycobacterium fol a gene that encodes for the enzyme dihydrofolate reductase The invention relates to the nucleic acid sequence and amino acid sequence of dihydrofolate reductase (DHFR) from mycobacteria and to expression of recombinant DHFR protein. Utilizing the recombinant protein, novel therapies and diagnostic strategies can ... | 05/08/2001 |
| 6106822 | Hormone and growth factor phosphoglycokine mimetics from mycobacterium A hormone or growth factor mimetic second messenger is derived from a microorganism of the genus Mycobacterium, suitably M. vaccae. The mimetic second messenger may mimic the action of insulin, ACTH, NGF, EGF, FGF, TGFଲ or HGF. Further, methods of t... | 08/22/2000 |
| 6040154 | Process for bacterial treatment of effluents that contain ethyl-tert-butyl ether A process for treating aqueous effluents that contain ethyl-tert-butyl ether (ETBE) to reduce the ETBE concentration is described, characterized in that in the presence of effluents, at least one bacterium that is selected from the group that is formed by... | 03/21/2000 |
| 6015890 | EmbCAB operon of mycobacteria and mutants thereof This invention relates to the identification, cloning, sequencing and characterization of the embCAB operon which determines mycobacterial resistance to the antimycobacterial drug ethambutol. The embCAB operon encodes the proteins which are the target of ... | 01/18/2000 |
| 6008201 | DNA molecule encoding for cellular uptake of mycobacterium tuberculosis and uses thereof The present invention relates to a DNA molecule conferring on Mycobacterium tuberculosis an ability to enter mammalian cells and to survive within macrophages. The protein encoded by this gene fragment is useful in vaccines to prevent infection by Mycobac... | 12/28/1999 |
| 6004771 | Method for processing mycrobacteria A method for the preparation of Mycobacteria from any liquid, semi solid or exotic source is described. The extracted Mycobacterial sample is suitable for detection by culture and amplification.... | 12/21/1999 |
| 5994346 | Use of exochelins in the preservation of organs for transplant Exochelins can be used to prevent damage to organs for transplant from the formation or presence of the .circle-solid.OH radical. In particular, the invention is directed to the administration of exochelins to the organ prior to or coincidental with remov... | 11/30/1999 |
| 5981210 | Method for determining a presence or absence of a nonparaffinophilic hydrophobic microorganism in a body specimen by using a DNA extraction procedure and a novel DNA extraction procedure The method of the invention involves providing a first receptacle and a second receptacle. The first receptacle contains a sterile aqueous broth and the second receptacle contains an aqueous broth including a carbon source. The method then includes placin... | 11/09/1999 |
| 5922575 | Mutations in the katG gene useful for detection of M. tuberculosis A method for selectively detecting M. tuberculosis is provided employing restriction fragment length polymorphism analysis of an enzymatic digest of the M. tuberculosis katG gene.... | 07/13/1999 |
| 5876993 | Epicholesterol dehydrogenase The present invention relates to a process for producing a cholesterol-reduced substance obtained by converting cholesterol in a substance to epicholesterol, as well as to a novel cholesterol oxidase and a novel epicholesterol dehydrogenase which are used... | 03/02/1999 |
| 5837480 | Method and compounds for inhibiting lipid biosynthesis of bacteria and plants This invention relates to InhA enzyme crystals and to methods of growing said crystals. This invention is further directed to the utilization of said crystals to determine the three dimensional structure of InhA enzyme utilizing heavy atom derivatives of ... | 11/17/1998 |
| 5837677 | Method for the treatment of cancer with Exochelins of Mycobacterium tuberculosis The invention is directed toward the use of desferri-Exochelins to destroy cancer cells or retard or eliminate the growth of those cancer cells.... | 11/17/1998 |
| 5830475 | Recombinant mycobacterial vaccines The present invention relates to recombinant mycobacteria, particularly recombinant M. bovis BCG, which express heterologous DNA encoding a product (protein or polypeptide) of interest, such a protein or polypeptide (e.g., an antigen) against which an imm... | 11/03/1998 |
| 5814514 | Biodegradation of the gasoline oxygenates The present invention is directed to a method for degrading an undesirable ether-based environmental contaminant by contacting the ether with a propane-oxidizing microorganism or with an isopropanol-oxidizing microorganism to convert the ether to innocuou... | 09/29/1998 |
| 5804406 | Determining sensitivity of paraffinophilic microorganisms to antimicrobials A method of determining the sensitivity of at least one paraffinophilic microorganism from a specimen obtained from a patient to different antimicrobial agents and predetermined quantities thereof includes providing at least one receptacle containing an a... | 09/08/1998 |
| 5801009 | Method for determining the antimicrobial agent sensitivity of a paraffinophilic microorganism using various milieus and an associated apparatus An apparatus for determining sensitivity of at least one paraffinophilic microorganism from a specimen obtained from a patient to different antimicrobial agents and predetermined quantities thereof. The apparatus includes a receptacle adapted to contain a... | 09/01/1998 |