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| Number | Title | Issue Date |
| 8178474 | Functionalised solid support for alpha-oxoaldehyde synthesis The invention relates to a functionalised solid support for the synthesis of compounds comprising at least one α-oxoaldehyde function, to a process for preparing it and to its applications, in particular for the preparation of a library of organic compounds, of a d... | 05/15/2012 |
| 8003353 | Cyanocobalamin low viscosity aqueous formulations for intranasal delivery A stable pharmaceutical mercury-free aqueous solution of cyanocobalamin comprised of cyanocobalamin and water wherein said solution of cyanocobalamin is suitable for intranasal administration, has a viscosity less than about 1000 cPs, and wherein said solution of cy... | 08/23/2011 |
| 7977072 | Sandwich immunoassay for identifying partial proANP peptides Disclosed is an improved sandwich immunoassay for identifying partial proANP peptides in cardiac and sepsis diagnosis by using two antibodies which specifically bond to partial sequences in the mid-regional area of NT-proANP, extending from amino acid 53 to amino ac... | 07/12/2011 |
| 7553642 | Branched neutral amino acid transporters acting as single molecule It is intended to provide amino acid transporters which act as a single molecule and transport neutral amino acids typified by branched amino acids, and genes thereof. A protein consisting of an amino acid sequence represented by SEQ ID NO:2, 4, 6 or 8 or an amino a... | 06/30/2009 |
| 7404489 | Cyanocobalamin low viscosity aqueous formulations for intranasal delivery A stable pharmaceutical mercury-free aqueous solution of cyanocobalamin comprised of cyanocobalamin and water wherein said solution of cyanocobalamin is suitable for intranasal administration, has a viscosity less than about 1000 cPs, and wherein said solution of cy... | 07/29/2008 |
| 7332356 | Fluorescent dye binding peptides The present invention is directed to novel polypeptides, termed fluorettes, that bind with high avidity to fluorophore dyes. The peptides find use in a variety of methods and approaches involving fluorophore dyes. ... | 02/19/2008 |
| 7314732 | Drug and manufacturing method of same The drug of the present invention, and a method of manufacturing the drug are so arranged that a photosynthetic bacterium is incubated together with a lactic acid bacterium so as to cause the photosynthetic bacterium to produce a viscous material in a liquid medium,... | 01/01/2008 |
| 7229636 | Cyanocobalamin low viscosity aqueous formulations for intranasal delivery A stable pharmaceutical mercury-free aqueous solution of cyanocobalamin comprised of cyanocobalamin and water wherein said solution of cyanocobalamin is suitable for intranasal administration, has a viscosity less than about 1000 cPs, and wherein said solution of cy... | 06/12/2007 |
| 7167819 | Method of determining the three-dimensional shape of a macromolecule The present invention provides a fast and efficient method for determining the three-dimensional conformation of a protein. The steps of the method of the invention include: 1) formation of physical distance constraints, e.g., forming intramolecular chemical crossli... | 01/23/2007 |
| 7041793 | Detergent compositions comprising benefit agents Detergent composition comprising fusion protein comprising a cellulose binding domain and a domain having a high binding affinity for another ligand. Preferably, the domain having a high binding affinity is directed at a Benefit Agent. ... | 05/09/2006 |
| 7018815 | Method for producing vitamin B12 from hydrogen-metabolizing methane bacterium Mesophilic methane bacteria obtained from digested sludge are acclimatized in an H2/CO2 medium and the acclimatized methane bacteria are grown on a support inclusive of inorganic nutritional salts of trace metal elements by using an immobilized... | 03/28/2006 |
| 6972188 | Process for producing vitamin Bfrom hydrogen-metabolizing methane bacterium Mesophilic methane bacteria obtained from digested sludge are acclimatized in an H2/CO2 medium and the acclimatized methane bacteria are grown on a support inclusive of inorganic nutritional salts of trace metal elements by using an immobilized... | 12/06/2005 |
| 6887979 | Method of preventing decrease in the activity of protein due to freezing and use of polypeptide in the production of protein activity decrease preventing agent An objective of the present invention is to provide a means to prevent freeze-induced decrease in protein activity. The present invention relates to a method for preventing freeze-induced decrease in protein activity comprising adding a polypeptide comprising the fo... | 05/03/2005 |
| 6830901 | Propionibacteruim vector An endogenous plasmid of Propionibacterium is described, isolated from Propionibacteria freudenreichii LMG 16545 (deposited as CBS 101022), and its sequence provided. This plasmid can be used to transform Propionibacteria to express homologous or heter... | 12/14/2004 |
| 6670152 | Enzymatic reduction of cobalt in cobalamin It is disclosed that the enzymes ATP:corrinoid adenosyltransferase (CobA) from Salmonella typhimurium and reduced flavodoxin (FldA) from E. coli are both necessary and sufficient, in the presence of ATP, to reduce the oxidation state of the cobalt atom in... | 12/30/2003 |
| 6656709 | Methods of increasing the production of cobalamins using cob gene expression Novel polypeptides involved in the biosynthesis of cobalamines and/or cobamides, in particular coenzyme B12, genetic material responsible for expressing these polypeptides, and a method for preparing them, are described. A method for amplifying... | 12/02/2003 |
| 6506570 | Method of sorting birds in ovo A method of determining the gender of a bird in ovo comprises detecting the presence or absence of an elevated level of a sex-related hormone in the extra-embryonic fluid of the bird egg, and then determining the gender of the bird within the egg from the... | 01/14/2003 |
| 6492141 | Process for the production of vitamin b12 The present invention relates to a process for producing vitamin B12, wherein said process comprises the steps of (a) culturing a strain of the genus Propionibacterium in a first fermenter under anaerobic conditions to obtain a culture of Propionibacteriu... | 12/10/2002 |
| 6492113 | Detection of Mycoplasma genus and species in patients with chronic fatigue syndrome and fibromyalgia Methods for detecting chronic fatigue syndrome and/or fibromyalgia in an individual, comprising isolating peripheral blood mononuclear cells (PBMC) and: 1) determining the amounts of Mycoplasma genus or Mycoplasma species; 2) determining the Mycoplasma ge... | 12/10/2002 |
| 6287818 | Method for synthesis of N-homocysteine thiolactonyl retinamido cobalamin and uses thereof The present invention describes methods for the synthesis of N-homocysteine thiolactonyl retinamido cobalamin (thioretinaco), a compound that has potential anticancer, antineoplastic, antiviral, and antiatherogenic properties.... | 09/11/2001 |
| 6194224 | Diagnostic membrane containing fatty acid sarcosinate surfactant for testing oral fluid A diagnostic test strip for determining the presence of a specified analyte in a fluid sample is described. The test strip has a test membrane sandwiched between two layers of a plastic sheath. The upper layer of the sheath has a sample well into which a ... | 02/27/2001 |
| 6187761 | Production and use of compositions comprising high concentrations of vitamin B12 activity The present invention provides a process for the preparation of a composition comprising natural vitamin B12, wherein said process comprises the steps of: a) obtaining microbial cells containing natural vitamin B12, b) causing opening of the microbial cells su... | 02/13/2001 |
| 6156545 | Biosynthesis method enabling the preparation of cobalamins The present invention relates to a biosynthetic process for preparing cobalamines. More precisely, it relates to a process for amplifying the production of cobalamines and, more specifically, of coenzyme B12 by means of recombinant DNA techniqu... | 12/05/2000 |
| 6150341 | Vitamin B12 derivatives and methods for their preparation This invention relates to methods for preparing vitamin B12 (VB12) derivatives suitable for linking to a polymer, nanoparticle or therapeutic agent, protein or peptide. The methods involve reacting the 5'OH group of VB12 o... | 11/21/2000 |
| 5985574 | Modulators of actin The invention provides methods and compositions which find use, inter alia, for modulating the stabilization of actin filaments. The compositions may comprise one or more polypeptide moieties derived from a novel human diaphanous polypeptide and/or one or... | 11/16/1999 |
| 5955321 | Production and use of compositions comprising high concentrations of vitamin B12 activity The present invention provides a process for the preparation of a composition comprising natural vitamin B12, wherein said process comprises the steps of: a) obtaining microbial cells containing natural vitamin B12, b) causing opening of the microbial cells su... | 09/21/1999 |
| 5830668 | Detection of chronic fatigue syndrome A method for diagnosing chronic fatigue syndrome in an individual. Peripheral blood monocytes are isolated and p68 kinase activity, mRNA levels, protein levels, apoptosis and cell cycle analysis are measured. Significantly increased levels of any of these... | 11/03/1998 |
| 5773228 | Activation-dependent protein expressed on the surface of activated platelets and antibodies thereto The present invention provides a thrombin-activated platelet protein (TAPP). The protein is selectively expressed on the surface of thrombin-activated platelets. Antibodies which selectively bind to the thrombin-activated platelet protein are also provide... | 06/30/1998 |
| 5691163 | Cells with altered betaine catabolism and their use in producing metabolites or enzymes Cells with an alteration at least in the gene involved in betaine catabolism, their preparation and their use, in particular for producing metabolites and/or enzymes, are disclosed.... | 11/25/1997 |
| 5545538 | Method of producing vitamin B12 using rhizobium cobalaminogenum ferm BP-4429 There is provided an economical, efficient and industrially useful method of producing vitamin B12 which comprises cultivating a microorganism belonging to Rhizobium cobalaminogenum FERM BP-4429 which is capable of producing vitamin B12 | 08/13/1996 |
| 5210023 | Method of purifying ferment-produced riboflavin A method of purifying ferment-produced riboflavin, wherein the impure riboflavin is suspended in water or dilute aqueous acid, and the suspension is heated at a temperature of from 75° to 130° C. for from 0.3 to 3 hours with stirring, during which time ... | 05/11/1993 |
| 5130241 | Clavam derivatives and its enzymatic preparation A compound having the formula (I): ##STR1## is described, together with salts thereof and an enzymatic process for converting such compounds into clavulanic acid. A process for the preparation of the compound of formula (I) and its salts is disclosed... | 07/14/1992 |
| 5026640 | Process for the conversion of corrinoids produced by microorganisms into cyanocorrinoids The invention relates to a process for the conversion of corrinoids produced by microorganisms into cyanocorrinoids by reaction with cyanides. According to the invention a fermentation broth obtained by disruption of microorganism cells in a known manner,... | 06/25/1991 |
| 4925931 | N-homocysteine thiolactonyl retinamido cobalamin and methods of use thereof N-Homocysteine thiolactonyl retinamido cobalamin is useful for decreasing the induction of chemically-induced tumors in animals. It is also useful for inhibiting weight gain.... | 05/15/1990 |
| 4752584 | Process for the production of inoculum for anaerobic fermentation of coenzyme B12 A fermentation process is disclosed for the preparation of an inoculum, suitable for batchwise, semicontinuous, or continuous production of coenzyme B12 under septic conditions. The fermentation process begins with a broth consisting of methano... | 06/21/1988 |
| 4659661 | Process for the preparation of fermentation broth for coenzyme B12 and other corrinoid production The invention relates to a process for the preparation of a fermentation broth containing coenzyme B12, with a new, anaerobic, mesophilic, methane-producing mixed micropopulation, under anaerobic, septic conditions, using a new broth containing... | 04/21/1987 |
| 4657859 | Process for the treatment of fermentation broth containing vitamin B12 and other corrinoids and for the preparation of vitamin B12 concentrates A process is disclosed for the treatment of fermentation broths containing vitamin B12 and other corrinoids, and for the preparation of vitamin B12 concentrates or crystalline vitamin B12 wherein the fermentation broth is ... | 04/14/1987 |
| 4544633 | Process for producing vitamin B12 by the fermentation technique, and vitamin B12 -producing microorganism A process for producing vitamin B12 by the fermentation technique which comprises cultivating a vitamin B12 -producing microorganism belonging to the genus Propionibacterium in a culture medium containing a carbon source and a nitrog... | 10/01/1985 |
| 4430429 | Production of vitamin B12 -activity substances Vitamin B12 -active substances are produced by the fermentation of an aqueous medium consisting essentially of methanol as the main source of assimilable carbon, a source of assimilable nitrogen, cobalt ions and essential growth factors and min... | 02/07/1984 |
| 4407947 | Process for obtaining metal-free corrinoids A process for obtaining metal-free corrinoids consisting of inoculating a culture media free of added compounds of metals of the VIIIth group of the Periodic Table with a parent strain of Rhodopseudomonas, cultivating under illumination, repeating the ste... | 10/04/1983 |
