U.S. patents available from 1976 to present.
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Class 435/839 - Bacillus subtilis


Subclass of Class 435 - Chemistry: molecular biology and microbiology
No. of patents: 199
Last issue date: 09/30/2008


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NumberTitleIssue Date
4119493Process for producing a peptide
A peptide having the formula wherein A and B are the same or different and represent an amino acid residue or a peptide residue; X represents an amino protective group and Y represents a carboxyl protective group, is prepared by reacting an amino acid or ...
10/10/1978
4113856Antibiotic mm 13902
It has been found that a novel antibiotic can be obtained by the fermentation of certain strains of Streptomyces olivaceus and related organisms. In addition to being a potent antibiotic this new material which we have designated MM 13902 acts synergistic...
09/12/1978
4105804Method for separation of bacteria cells from culture broth
Bacterial cells are separated from a culture broth by adding thereto a solution of casein or alkali-soluble soybean proteins, said culture broth being maintained at a pH less than 6. Bacteria cells are flocculated to form a protein-bacteria co-precipitate...
08/08/1978
4104379Substituted 1-alkylthiophenyl-2,3,4,5-tetrahydro-1H-3-benzazepine compounds
A group of 1-phenyl-1H-3-benzazepines whose structures are characterized by having a functional thio containing group on the 1-phenyl moiety and which have pronounced peripheral and diminished central dopaminergic activity. This activity is manifested in ...
08/01/1978
4101379Enzyme complex hydrolyzing bacterial mucus
A process for preparing complex enzymes capable of hydrolyzing bacterial mucus. A fermentation medium is inoculated with an appropriate bacterial species, fermentation of said medium is promoted while monitoring the development of complex enzymes in the f...
07/18/1978
4100151Enzymatic modification of corn gluten
Modification of corn gluten by proteolytic hydrolysis, preferably by a microbial proteinase, of an aqueous corn gluten suspension substrate concentration above about 6% w/w based on protein dry matter with an enzyme concentration of 0.05 - 0.5 Anson units...
07/11/1978
4086137Process for the production of L-arginine by fermentation
L-arginine is produced by fermentation of a microorganism belonging to the genus Bacillus capable of producing L-arginine and having a nutritional requirement for at least one compound of the group consisting of methionine, histidine, threonine, proline, ...
04/25/1978
4086139Differential inactivation of amylase in amylase-protease mixtures
Use of hypochlorite and chlorite ions to differentially inactivate amylase in protease-amylase mixtures, and product produced thereby....
04/25/1978
4075062Throw-in type colorimeter
The present invention relates to a throw-in type colorimeter having a defoaming mechanism comprising a double-cylinder whereby it is possible to very easily detect the optical density of the solution to be examined, and more particularly to a thrown-in ty...
02/21/1978
4071411Antitumor antibiotics aclacinomycins A and B [RD-9187A]
New antitumor agents named aclacinomycins A and B, which are anthracycline glycosides and inhibit the growth of various microorganisms e.g., Staphylococcus aureus, Micrococcus flavus, Corynebacterium bovis and inhibit the growth of animal tumors such as l...
01/31/1978
4066509Detection of hydrolyzing enzymes
The activity, or concentration, of a hydrolyzing enzyme, e.g., an endo-enzyme, is determined by providing a detection layer comprising a carrier matrix and a water-insoluble substrate dispersed in said carrier matrix which substrate is detectably marked, ...
01/03/1978
4065557Amino sugars and their use in improving the meat:fat ratio in animals
Glucopyranosyl and oligoglucosidyl derivatives of 4,6-bisdesoxy-4-(4,5,6-trihydroxy-3-hydroxymethylcyclohex-2-en-1-ylamino)- ଱-D-glucopyranose, which are inhibitors of glycoside hydrolases of the digestive tract, favorably improve the meat:fat ratio ...
12/27/1977
40557189-(2-O-Acyl-ଲ-D-arabinofuranosyl)-adenine compounds and method for their production
9-(2-O-Acyl-ଲ-D-arabinofuranosyl)adenine compounds and their production by enzymatic removal of the 3-O-acyl and 5-O-acyl groups of a 9-(2,3-di-O-acyl-ଲ-D-arabinofuranosyl)adenine compound or a 9-(2,3,5-tri-O-acyl-ଲ-D-arabinofuranosyl)ad...
10/25/1977
4055468Processes for producing physiologically active peptide and its N-acyl derivatives
A novel physiologically active peptide Val--X--Ala--X, in which X is 4-amino-3-hydroxy-6-methylheptanoic acid, which is prepared from R--Val--Val--X--Ala--X by the action of a microbial enzyme, N-acyl derivatives thereof which are produced by acylating sa...
10/25/1977
4049499Microbial medium having fluorescent growth indicator
Solidified, polar, micorbial growth medium containing 8-anilino-1-naphthalenesulfonic acid or a salt thereof. Microbial colonies grown on the medium can be detected fluorimetrically....
09/20/1977
4039386Method for determining the viable bacteria count of food and a medium for accomplishing the method
A method of determining the viable bacterial count of food which comprises incubating said food in a liquified agar medium which contains from 0.005 to 0.1 gram per liter of said liquified agar medium 2, 3, 5-triphenyl tetrazolium chloride as an inhibitor...
08/02/1977
4038144Method of increasing fermentation yields
A method of increasing the yield of a fermentation process comprises adding a water-soluble carotenoid to the nutrient medium....
07/26/1977
4032663Process for using cell wall-lysing enzymes
Complex enzymes which can lyse the cell wall of a variety of microorganisms such as bacteria, fungi, yeast, Basidiomycetes and chlorella are produced and recovered from cultivation of Pellicularia sasakii or Pellicularia filamentosa....
06/28/1977
4032403Process for the production of saccharified starch products wherein maltose is the predominant constituent
A process for the production of saccharified starch products in which maltose is the predominant constituent characterized by subjecting a starch hydrolysate simultaneously or successively to the action of an enzyme(s) with a maltotriose-decomposing activ...
06/28/1977
4022666Alpha-amylases from Bacillus subtilis
Alpha-amylases which have optimum activity between pH 6.5 to 8 and between pH 9.0 to 11.5 at 40° C are produced by culturing strains of Bacillus subtilis on a nutrient medium under aerobic conditions. Some of the alpha amylases are effective in hot and a...
05/10/1977
4021303Method for treatment of microorganisms
Microorganisms are chemically treated with alkali at a pH of 10.5 - 12.9 and a temperature of 0° - 30° C., washed with water and mechanically ruptured at a pH of 7 - 10.2....
05/03/1977
4013514Preparing a reactor containing enzymes attached to dialdehyde cellulose
Water-insoluble, biologically active conjugates for use in a reactor core of a flow-through reactor are prepared by covalently bonding an enzyme directly to a fibrous dialdehyde cellulose such as cotton. Preferably the fibrous cellulose is placed in the r...
03/22/1977
4011137Process for producing dextrose using mixed immobilized enzymes
Process for converting starch to dextrose wherein a partially hydrolyzed starch solution containing at least 10 percent hydrolyzed starch is contacted with an enzyme system under conditions whereby substantially complete conversion of the starch to dextro...
03/08/1977
4010071Clarification of xanthan gum
Fermentation broths and other aqueous suspensions containing a dissolved xanthan gum and suspended solids resulting from the fermentation producing the xanthan gum are clarified by treatment with a minor amount of a protease enzyme. The injectivity of aqu...
03/01/1977
4009078Detecting the presence of microorganisms
The presence of microorganisms in a sample is determined by culturing microorganisms in a growth medium which is in contact with a measuring electrode and a reference electrode and detecting a change in potential between the electrodes caused by the prese...
02/22/1977
3986926Method for preparing tannable pelts from animal skins and hides
A method for preparing tannable pelts from animal skins or hides, said method effecting concurrent softening, dehairing, opening of the hide structure, and bating in a single procedural step, which method comprises treating said skins or hides, free of pr...
10/19/1976
3985686Detergent compositions containing enzymes
This invention relates to enzymatic detergent compositions containing a combination of anionic and cationic surface-active agents. In more detail, these compositions contain as essential ingredients enzymes, preferably proteases, in combination with an es...
10/12/1976
3983005Integral element for the analysis of cholesterol
An integral analytical element for analysis of liquids for their cholesterol content is disclosed. The element is of the type which comprises at least two superposed layers including a spreading layer and a reagent layer in fluid contact and, optionally, ...
09/28/1976
3981803Method and apparatus for anaerobic fermentation
A method for the anaerobic fermentation of organic waste materials in a digestion zone, which method comprises introducing into the zone algae produced externally of the zone, and/or at least part of the liquid substrate in which such algae have been grow...
09/21/1976
3972774Enzymatic de-esterification of cephalosporin para-nitrobenzyl esters
Cephalosporin p-nitrobenzyl esters are de-esterified via an esterase enzyme derived from the genus Bacillus....
08/03/1976
3970522Method for the production of D-ribose
D-Ribose is produced by cultivating a strain belonging to the genus Bacillus, which lacks sporulation ability or has high 2-deoxy-D-glucose-oxidizing activity or has both of these two properties and also lacks at least one of transketolase and D-ribulose ...
07/20/1976
3969188Method of producing guanosine by fermentation
Method for producing guanosine by culturing a guanosine-producing mutant of the genus Bacillus which requires adenine for growth, and is resistant to at least one sulfa drug....
07/13/1976
3968009Process for reducing nucleic acid content of yeasts and bacteria
Process for reducing nucleic acid content of yeasts and bacteria comprising heat shocking for a period of time and at a temperature selected to increase effectiveness of enzymes which break down nucleic acids without allowing proteins to break down or lea...
07/06/1976
3963573Process for producing N-acyl-L-methionine
A process for producing optically pure N-acyl-L-methionine comprising (1) subjecting an N-acyl-D,L-methionine ester to the action of a proteolytic enzyme selected from the group consisting of sulfhydryl proteinases and microbially derived serine proteinas...
06/15/1976
3962466Method for treatment of microorganisms
A method for treating a microorganism which comprises chemically treating the microorganism with at least one agent selected from the group consisting of an acid, an alkali and a hydrophilic solvent and mechanically rupturing the cell membrane of the resu...
06/08/1976
3960660Method of producing guanosine by fermentation
Production of guanosine by fermentation with a Bacillus mutant requiring adenine for growth and resistant to psicofuranine or decoyinine....
06/01/1976
3960661Method for producing inosine by fermentation
Mutant strains of Bacillus subtilis which require adenine for growth and are resistant to at least one sulfa drug produce inosine in culture medium....
06/01/1976
3950221Process for improving the quality of microbial rennet
A process for improving the quality of microbial rennet by inactivating cellulase impurities in microbial rennet which comprises heat-treating microbial rennet in an aqueous medium in the presence of sodium chloride....
04/13/1976
3948731Method and apparatus for measuring reactant concentrations and quantities
A method and apparatus is provided for determining the concentration or quantity of substrate molecules by monitoring directly the concentration and/or the quantity of vaporous byproduct produced from the selective reaction of the molecule catalyzed with ...
04/06/1976
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