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| Number | Title | Issue Date |
| 7163397 | Apparatus for applying material for selectively modifying the optical properties of metabolically different cells An apparatus for applying a viscous modification material includes a material source of the modification material and a needle connected to the source. A material for selectively modifying the optical properties of cells comprises a basic material and a modification... | 01/16/2007 |
| 7148054 | Evolution of whole cells and organisms by recursive sequence recombination The invention provides methods employing iterative cycles of recombination and selection/screening for evolution of whole cells and organisms toward acquisition of desired properties Examples of such properties include enhanced recombinogenicity, genome copy number,... | 12/12/2006 |
| 6531299 | Cell-free synthesis of polyketides Cell-free systems which effect the production of polyketides employing modular polyketide synthases are described. Libraries of new and/or known polyketides may also be produced in cell-free systems employing aromatic PKS, modular PKS or both.... | 03/11/2003 |
| 4729951 | Process for the improvement of antibiotic production by in vivo genetic recombination A process for the production of aminoglycoside antibiotics using fused protoplasts derived from streptomyces. The cells are precultured in a medium containing sucrose, calcium and magnesium salts. Protoplasts are formed and then fused. The fused protoplas... | 03/08/1988 |
| 4592728 | Periodontal lavage delivery system Collected bacteria in a deep periodontal pocket may be treated without the need for periodontal surgery by introducing a delivery instrument into the pocket through its open end, and then delivering a bactericidal solution to the bottom of the pocket thro... | 06/03/1986 |
| 4515942 | Antibiotics KA-6606 XII, XIII, XV, XVI and XVII A process for producing an antibiotic, which comprises cultivating an antibiotic KA-6606-producing strain of the genus Saccharopolyspora in a nutrient culture medium, isolating an antibiotic KA-6606-containing substance from the culture broth, and separat... | 05/07/1985 |
| 4425430 | Process for production of antibiotics and novel antibiotics produced thereby A process for producing an antibiotic, which comprises cultivating an antibiotic KA-6606-producing strain of an genus Saccharopolyspora in a nutrient culture medium, isolating the antibiotic KA-6606-containing substance from the culture broth, and separat... | 01/10/1984 |
| 4396609 | Aminocyclitol antibiotics, pharmaceutical compositions and method of using same Aminocyclitol analogs of gentamicin C1, C2 and C1a and the corresponding compounds acylated on the 1-, 3- and 2'-amino groups with an ω-amino--hydroxy-lower-alkanoyl group are prepared by culturing a nutrient mediu... | 08/02/1983 |
| 4380581 | Istamycins and streptomyces culture for the production thereof Four new antibiotics which are denominated istamycin A, istamycin B, istamycin Ao and istamycin Bo, and which are useful as antibacterial agents, are produced by fermentation of a new microorganism, Streptomyces tenjimariensis.... | 04/19/1983 |
| 4369251 | Method for the production of sisomicin Sisomicin is produced by culturing Micromonospora danubienis.... | 01/18/1983 |
| 4365020 | Method for the preparation of antibiotic sisomicin A process of producing sisomycin by cultivating a new species of Micromonospora.... | 12/21/1982 |
| 4349667 | Aminoglycoside antibiotic G-367-2 Aminoglycoside antibiotic G-367-2 believed to have the formula ##STR1## is produced by culturing Dactylosporangium thailandense G-367 FERM-P No. 4840 in a nutrient medium and separating the produced antibiotic therefrom. It has strong antibacterial e... | 09/14/1982 |
| 4348516 | Microbiological methylation of aminoglycosyl-aminoglycosides The microorganisms Micromonospora inyoensis 1550F-1G and M. purpurea strain 1124 each microbiologically convert tobramycin, kanamycin A, kanamycin B and dibekacin to their respective 3"-N-methyl and 3"-N-methyl-4"-C-methyl derivatives. The derivatives exh... | 09/07/1982 |
| 4329426 | Process for preparation of antibiotics and biologically pure culture for use therein An antibiotic substance KA-7038 selected from the group consisting of the compounds having formulae I to VII described in claim 1, mixtures thereof and acid addition salts thereof; an antibiotic composition composed of (i) antibiotically effective amount ... | 05/11/1982 |
| 4328307 | Novel antibiotics, process for preparation thereof and biologically pure culture for use therein Novel antibiotics of the following structure ##STR1## wherein R represents a moiety selected from the group consisting of hydrogen, --COCH2 NH2, --COCH2 NHCONH2 and --COCH2 NHCHO; process for pre... | 05/04/1982 |
| 4298690 | Antibiotics XK-62-3 and XK-62-4 and process for production thereof New antibacterial compounds, XK-62-3 and XK-62-4, are produced by fermentation of microorganisms belonging to the genus Micromonospora. The compounds are accumulated in the culture liquor and are isolated therefrom.... | 11/03/1981 |
| 4297486 | Aminoglycoside antibiotic G-367-1 and method for the production thereof Aminoglycoside antibiotic G-367-1 believed to have the formulae ##STR1## is produced by culturing Dactylosporangium thailandense G-367 FERM-P No. 4840 in a nutrient medium and separating the produced antibiotic therefrom. It has strong antibacterial ... | 10/27/1981 |
| 4296106 | Istamycins and production thereof Four new antibiotics which are denominated istamycin A, istamycin B, istamycin Ao and istamycin Bo, and which are useful as antibacterial agents, are produced by fermentation of a new microorganism, Streptomyces tenjimariensis.... | 10/20/1981 |
| 4294927 | Genetic process for the preparation of antibiotic-producer micromonospora strains The invention provides a process for the preparation of antibiotic-producer Micromonospora strains having modified genetic material, wherein a protoplast suspension is prepared with lysozyme, under osmotically buffered conditions ensured by sucose, from e... | 10/13/1981 |
| 4288547 | Fermentative process for preparing antibiotics of the gentamicin class 2-Hydroxygentamicins B, B1 and A3 and 2-hydroxy antibiotics JI-20A and JI-20B are prepared as fermentation products by culturing a nutrient medium containing carbohydrates, a source of assimilable nitrogen, essential salts and D-stre... | 09/08/1981 |
| 4279997 | Process for production of aminoglycoside antibiotics Aminoglycoside antibiotics biochemically transformed from Kanamycin A or Kanamycin B, which are represented by the formula ##STR1## wherein R1 represents a hydrogen atom or a methyl group and R2 represents an amino group or a hy... | 07/21/1981 |
| 4275155 | Manufacture of aminoglycoside antibiotics A process for the production of gentamicins or more specifically a mixture of gentamicins C1, C2 and C1 a by the aerobic fermentation of a new species Micromonospora scalabitana closely related to Micromonospora narashinoe... | 06/23/1981 |
| 4250170 | Antibacterial agents Bu-2349A and B and method of using same A novel water-soluble basic antibiotic complex designated herein as Bu-2349 is produced by fermentation of Bu-2349-producing strains of the genus Bacillus. Complex Bu-2349 and its bioactive components designated as Bu-2349A and B are found to possess mark... | 02/10/1981 |
| 4241182 | Fortimicin factors KG1, KG2 and KG3 and processes for production thereof New antibiotic compounds, Fortimicin factors KG1, KG2 and KG3 are produced by fermentation of microorganisms belonging to the genus Micromonospora. The antibiotic compounds are accumulated in the culture liquor and are iso... | 12/23/1980 |
| 4234685 | Microbiological methylation of aminoglycosyl-aminoglycosides The microorganisms Micromonospora inyoensis 1550F-1G and M. purpurea strain 1124 each microbiologically convert tobramycin, kanamycin A, kanamycin B and dibekacin to their respective 3"-N-methyl and 3"-N-methyl-4"-C-methyl derivatives. The derivatives exh... | 11/18/1980 |
| 4219642 | Fortimicin AO A new fortimicin, fortimicin AO. The compound is coproduced in the fermentation of Micromonospora olivoasterospora ATCC No. 21819, 31009 or 31010 along with fortimicin A, Isofortimicin, Fortimicin E and a number of other minor factors. The compound is use... | 08/26/1980 |
| 4219643 | Fortimicin AN Fortimicin AN is coproduced with fortimicin A, fortimicin B and a number of other minor factors in the fermentation of Micromonospora olivoasterospora ATCC Nos. 21819, 31009 or 31010. Structurally, fortimicin AN is 1-N-glycyl-3-O-demethylfortimicin B. The... | 08/26/1980 |
| 4216308 | Fortimicin factors D and KE compounds New antibiotic compounds, Fortimicin factors D and KE are produced by fermentation of microorganisms belonging to the genus Micromonospora. The antibiotic compounds are accumulated in the culture liquor and are isolated therefrom. A semisynthetic method o... | 08/05/1980 |
| 4214074 | Hydroxyalkyl derivatives of aminoglycoside antibiotics Certain 2-deoxystreptamine aminoglycoside antibiotics, substituted on the 1-amino group by an alkyl group bearing one or more hydroxy groups, are useful antibacterial agents. The 2-deoxystreptamine aminoglycoside compounds which are substituted in this ma... | 07/22/1980 |
| 4209511 | Aminoglycoside antibiotics and process for production thereof Aminoglycoside antibiotics biochemically transformed from Kanamycin A or Kanamycin B, which are represented by the formula ##STR1## wherein R1 represents a hydrogen atom or a methyl group and R2 represents an amino group or a hy... | 06/24/1980 |
| 4209612 | Fortimicin factors KF and KG and process for production thereof New antibiotic compounds, Fortimicin factors KF and KG are produced by fermentation of microorganisms belonging to the genus Micromonospora. The antibiotic compounds are accumulated in the culture liquor and are isolated therefrom.... | 06/24/1980 |
| 4187299 | Fortimicin E A new aminoglycoside antibiotic, Fortimicin E, is produced by fermentation of Micromonospora olivoasterospora ATCC 21819, 31009 and 31010 and isolated from the fermentation broth.... | 02/05/1980 |
| 4075322 | Enzyme composition An enzyme of hydrolytic action, according to the invention, is a neutral protease having the molecular weight of about 37,000, the isoelectric point at pH 8.8, the optimum activity at 40° - 45° C, the stability range in aqueous solutions at pH 6.8 - 8.0... | 02/21/1978 |
| 4066503 | Enzyme of hydrolytic action, enzymatic preparation, method for preparing both and their uses An enzyme of hydrolytic action, according to the invention, is a neutral protease having the molecular weight of about 37,000, the isoelectric point at pH 8.8, the optimum activity at 40° - 45° C, the stability range in aqueous solutions at pH 6.8 - 8.0... | 01/03/1978 |
| 4063015 | Garamine and derivatives thereof This disclosure relates to the preparation of garamine, its use as an antibacterial, and its use as an intermediate in the novel processes for preparing novel pseudotrisaccharides containing a garamine moiety, and to the use of the novel pseudotrisacchari... | 12/13/1977 |
| 4049498 | Methods for the preparation of semi-synthetic aminocyclitol aminoglycoside antibiotics Micromonospora inyoensis strain 155OF-1G NRRL 5742 is incapable of producing antibiotics unless an aminocyclitol is added to the fermentation medium. When such a compound is added, antibiotics are produced, said antibiotics being analogs of known aminogly... | 09/20/1977 |
| 4045298 | Antibiotic XK-62-2 and process for production thereof The antibiotic XK-62-2 is produced by fermentation of microorganisms belonging to the genus Micromonospora. The antibiotic is accumulated in the culture liquor and is isolated therefrom.... | 08/30/1977 |
| 4032404 | Fermentation process for producing apramycin and nebramycin factor V' A fermentation process is disclosed for preparing the known aminoglycoside antibiotics apramycin and nebramycin factor V' by culturing Streptoalloteichus hindustanus A.T.C.C. 31217, 31218 or 31219. The so-produced nebramycin factor V' may subsequently be ... | 06/28/1977 |
| 4011390 | Semi-synthetic aminocyclitol aminoglycoside antibiotics and methods for the preparation thereof Micromonospora inyoensis strain 1550F-1G NRRL 5742 is incapable of producing antibiotics unless an aminocyclitol is added to the fermentation medium. When such a compound is added, mutamicins are produced, said mutamicins being analogs of known aminoglyco... | 03/08/1977 |
| 4009328 | Aminoglycoside 66-40C, method for its manufacture, method for its use as an intermediate in the preparation of known antibiotics and novel antibacterials Aminoglycoside 66-40C, a minor product produced by the fermentation of Micromonospora inyoensis, is separated from said fermentation mixture, and is used as an intermediate in preparing the known antibiotic, sisomicin, as well as 6' -N-alkylsisomicins hav... | 02/22/1977 |
