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| Number | Title | Issue Date |
| 7655442 | Method for stabilizing macrolide compounds The present invention provides a method for stabilizing a macrolide compound, and an efficient method for producing the compound. Specifically, it provides a method for stabilizing a macrolide compound, in which a 12-membered ring macrolide compound, such as a compo... | 02/02/2010 |
| 7638306 | Process of increasing cellular production of biologically active compounds A process of increasing the cellular production of biologically active compounds is provided. The process is particularly useful for increasing antibiotic production by bacterial cells. The process includes the step of inhibiting the activity of methylmalonyl-CoA mu... | 12/29/2009 |
| 7560252 | Borrelidin-producing polyketide synthase and its use The present invention relates to the biosynthesis of polyketides and derives from the cloning of nucleic acids encoding a polyketide synthase and other associated proteins involved in the synthesis of the polyketide borrelidin. Materials and methods including enzyme... | 07/14/2009 |
| 7413878 | Recombinant host cells expressing atoAD and capable of making a polyketide using a starter unit Host cells, such as E. coli, are provided with an expression system for making starter units required for biosynthesis of polyketides using the ato pathway. ... | 08/19/2008 |
| 7388085 | gene directing the ratio of B2:B1 avermectins The present invention relates to polynucleotide molecules comprising nucleotide sequences encoding an aveC gene product, which polynucleotide molecules can be used to alter the ratio or amount of class 2:1 avermectins produced in fermentation cultures of S. averm... | 06/17/2008 |
| 7381546 | Polyketides and their synthesis and use The rapamycin gene cluster is an example of a gene cluster which includes a gene (rapL) leading to the formation of a precursor compound (pipecolic acid, in this case) which is required for inclusion in the larger product (rapamycin) produced by the enzymes encoded ... | 06/03/2008 |
| 7309711 | Fungicidal agent combinations The invention relates to novel fungicidallly active compound combinations of 2′-cyano-3,4-dichloroisothiazole-5-carboxanilide of the formula and the active compounds listed in the disclosure. ... | 12/18/2007 |
| 7291486 | Genetically modified cells and methods for converting (R)-methylmalonyl CoA to (S)-methylmalonyl CoA Recombinant Escherichia coli host cells that comprise recombinant DNA expression vectors that drive expression of methylmalonyl CoA mutase from Propionibacterium shermanii or Streptomyces cinnamonensis as well as Propionibacterium shermanii | 11/06/2007 |
| 7288572 | Active substance combinations having insecticidal and acaricidal properties The present invention relates to novel insecticidally and acaricidally active compound combinations of N2-[1,1-dimethyl-2-(methylsulphonyl)ethyl]-3-iodo-N1-{2-methyl-4-[1,2,2,2-tetrafluoro-1-(trifluoromethyl)ethyl]phenyl}phthalamide of the form... | 10/30/2007 |
| 7285653 | Nucleic acids which code for the enzyme activities of the spinosyn biosynthesis The present invention relates to nucleic acid coding for enzyme activities of spinosyn biosynthesis and to the relevant enzymes per se. Furthermore, the invention relates to methods for preparing spinsoyn derivatives and spinosyn precursors. ... | 10/23/2007 |
| 7259241 | gene directing the ratio of B2:B1 avermectins The present invention relates to polynucleotide molecules comprising nucleotide sequences encoding an aveC gene product, which polynucleotide molecules can be used to alter the ratio or amount of class 2:1 avermectins produced in fermentation cultures of S. averm... | 08/21/2007 |
| 7247461 | Nucleic acid molecule encoding ORFA of a PUFA polyketide synthase system and uses thereof The invention generally relates to polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) systems isolated from or derived from Schizochytrium sp., to homologues thereof, to isolated nucleic acid molecules and recombinant nucleic acid molecules encoding ... | 07/24/2007 |
| 7220560 | Secondary metabolite congener distribution modulation The present invention provides a generalized oxygen-limited cultivation method for myxobacterial strains engineered to heterologously express polyketides synthase (PKS) gene clusters under various oxygen tension conditions, modulating the polyketide congener distrib... | 05/22/2007 |
| 7217856 | PUFA polyketide synthase systems and uses thereof Disclosed are the complete polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) systems from the bacterial microorganisms Shewanella japonica and Shewanella olleyana, and biologically active fragments and homologues thereof. More particularly, t... | 05/15/2007 |
| 7211418 | PUFA polyketide synthase systems and uses thereof The invention generally relates to polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) systems, to homologues thereof, to isolated nucleic acid molecules and recombinant nucleic acid molecules encoding biologically active domains of such a PUFA PKS system, t... | 05/01/2007 |
| 7208294 | Display device and display panel driving method A display device and a display panel driving method, in which a matrix panel includes pixel portions each have a series circuit of a bistable element and a light emitting element, every time one scan line is specified in order in accordance with an input image signa... | 04/24/2007 |
| 7205289 | Combinations of active ingredients with insecticidal and acaricidal properties The invention relates to novel active compound combinations of certain cyclic ketoenols and certain insecticidally active compounds that together have very good insecticidal and acaricidal properties. ... | 04/17/2007 |
| 7198922 | Polyketides and their synthesis A polyketide synthase (“PKS”) of Type I is a complex multienzyme including a loading domain linked to a multiplicity of extension domains. The first extension module receives an acyl starter unit from the loading domain and each extension module adds a further k... | 04/03/2007 |
| 7172884 | Methods for the preparation, isolation and purification of epothilone B, and x-ray crystal structures of epothilone B The present invention relates to improved methods for the production, isolation and purification of epothilone B. These methods include, for example, a fermentation process for the production of epothilone B, isolation via adsorption onto a resin, and subsequent pur... | 02/06/2007 |
| 7135499 | Active substance combinations having insecticidal and acaricidal properties The present invention relates to novel insecticidally and acaricidally active compound combinations of N2-[1,1-dimethyl-2-(methylsulphonyl)ethyl]-3-iodo-N1-{2-methyl-4-[1,2,2,2-tetrafluoro-1-(trifluoromethyl)ethyl]phenyl}phthalamide of the form... | 11/14/2006 |
| 7129071 | Recombinant methods and materials for producing epothilone and epothilone derivatives Recombinant nucleic acids that encode all or a portion of the epothilone polyketide synthase (PKS) are used to express recombinant PKS genes in host cells for the production of epothilones, epothilone derivatives, and polyketides that are useful as cancer chemothera... | 10/31/2006 |
| 7122341 | Engineering of metabolic control The invention features a method of producing heterologous molecules in cells under the regulatory control of a metabolite and metabolic flux. The method can enhance the synthesis of heterologous polypeptides and metabolites. ... | 10/17/2006 |
| 7101684 | Modified modular polyketide synthase Modular polyketide synthases modified so as not to incorporate natural starter units can be used for clean synthesis of novel polyketides. ... | 09/05/2006 |
| 7070964 | Epothilone compounds and methods for making the same The present invention provides bioconversion methods for making epothilone analogs. These analogs differ from the starting material by the addition of one or more hydroxyl groups or by the addition of an epoxide. These compounds, in turn, can be further modified by ... | 07/04/2006 |
| 7067290 | Method for production of polyketides A method for the production of a polyketide by fermentation comprising the steps of growing a culture of a polyketide-producing organism at a pH value conducive to cell growth for a time sufficient to generate the producing culture, lowering the pH of the culture to... | 06/27/2006 |
| 7067286 | host cells containing heterologous PKS genes for the synthesis of polykedtides Recombinant host cells of the suborder Cystobacterineae, genus Stizmatella, containing recombinant expression vectors that encode heterologous epothilone polyketide synthase (PKS) genes and can produce epothilones at high levels are provided. ... | 06/27/2006 |
| 7064248 | Method of preparing fertile transgenic corn plants by microprojectile bombardment A method of preparing fertile transgenic Zea mays (corn) plants which stably express DNA encoding a Bacillus thuringiensis endotoxin, so as to impart insect resistance to the fertile transgenic plants is taught. The method comprises bombarding regenera... | 06/20/2006 |
| 7049100 | Multi-plasmid method for preparing large libraries of polyketides and non-ribosomal peptides A multiple-plasmid system for heterologous expression of polyketides facilitates combinatorial biosynthesis. The method can be extended to any modular polyketide synthase (PKS) or non-ribosomal peptide synthase (NRPS) and has the potential to produce thousands of no... | 05/23/2006 |
| 7033621 | Isoflavone compositions produced from legumes Processes for the production of isoflavones are described wherein plant material from plants of the genus leguminosae are contacted with water, an enzyme which cleaves isoflavone glycosides to the aglucone form and a C2-C10 organic solve... | 04/25/2006 |
| 7034130 | Method for producing novel spinosyn derivatives The present invention relates to methods for producing novel spinosyn derivatives which are substituted with a 1-hydroxy-ethyl radical in the C-21 position and to novel spinosyn derivatives of this type per se and to their use for producing novel spinosyns. ... | 04/25/2006 |
| 7033818 | Recombinant polyketide synthase genes Regions of sequence identity are recurrent in some modular polyketide synthase (PKS) gene clusters. Such sequences are potentially detrimental to the stability of PKS gene clusters and expression plasmids for the genes in the gene cluster. PKS gene and gene cluster ... | 04/25/2006 |
| 7029887 | Methods related to gene directing the ratio of B2:B1 avermectins The present invention relates to polynucleotide molecules comprising sequences encoding avec gene products, which polynucleotide molecules can be used to alter the ratio or amount of class 2:1 avermectins produced in fermentation cultures of Streptomyces avermiti... | 04/18/2006 |
| 7018814 | Process of purifying vancomycin hydrochloride Provided is a method of purifying a vancomycin from a fermentation broth of a microorganism containing vancomycin, including passing the fermentation broth of a microorganism containing vancomycin through a strong acid cation exchange resin, a weak base anion exchan... | 03/28/2006 |
| 7015001 | DNA encoding SPNF of the spinosyn cluster Spinosyn biosynthetic genes from Saccharopolyspora spinosa, spinosyn producing microorganisms transformed with the biosynthetic genes, methods using the biosynthetic genes to increase production of spinosyn insecticidal macrolides, and methods using the genes... | 03/21/2006 |
| 7015203 | Macrolides The invention relates to novel erythromycin analogs and azalides, particularly ones with novel C-13 substituents, and to pharmaceutically acceptable salts thereof. The compounds of this invention are antibacterial agents that may be used to treat various bacterial a... | 03/21/2006 |
| 7011959 | Heterologous production of polyketides Recombinant E. coli host cells that comprise recombinant DNA expression vectors that drive expression of methylmalonyl CoA mutase from Propionibacterium shermanii or Streptomyces cinnamonensis as well as Propionibacterium shermanii epimer... | 03/14/2006 |
| 7010937 | Natural gas liquefaction A process for liquefying natural gas in conjunction with producing a liquid stream containing predominantly hydrocarbons heavier than methane is disclosed. In the process, the natural gas stream to be liquefied is partially cooled, expanded to an intermediate pressu... | 03/14/2006 |
| 7001903 | Synergistic insecticidal mixtures The invention relates to insecticidal mixtures of spinosyns and agonists or antagonists of nicotinic acetylcholine receptors for protecting plants against attack by pests. ... | 02/21/2006 |
| 7001747 | Nucleic acid molecules encoding modified polyketide synthases containing polylinkers and uses thereof Nucleic acid molecules encoding at least part of a Type I polyketide synthase, and having a polylinker with multiple restriction enzyme sites in place of one or more PKS genes encoding enzymes associated with reduction, optionally further including nucleic acid inco... | 02/21/2006 |
| 7001748 | Methods of making polyketides using hybrid polyketide synthases Linking sequences which modulate cross-talk between modules of Type I polyketide synthases have been identified. Thus, arbitrarily chosen modules can be mixed and matched by supplying the appropriate linkers to obtain desired polyketide synthases and new polyketides... | 02/21/2006 |
