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| Number | Title | Issue Date |
| 4929700 | Production of purified, biologically active, bacterially produced recombinant human CSF-1 A process for recovering dimeric, biologically active CSF-1 from bacterially expressed recombinant CSF1 genes is described. The process comprises recovery of the solubilized monomeric form, followed by dimerization under refolding conditions and further p... | 05/29/1990 |
| 4882425 | Receptor specific proteins and their use in receptor typing Described is composition of matter and methods useful for the indentification of blood group antigens. Additionally a kit which can be used to identify and quantify a large number of blood group antigens is disclosed. The composition of matter and the met... | 11/21/1989 |
| 4876194 | Protein L and subfragments thereof, with immunoglobulin binding activity, a process for preparing thereof, reagent kit, pharmaceutical composition and a peptococcus magnus strain This invention relates to a new protein L and subfragments thereof with binding activity for all classes of immunoglobulins from different species, a process for preparing the same, a reagent kit, a pharmaceutical composition and strain 312 of P. magnus. ... | 10/24/1989 |
| 4870053 | Novel compositions and processes A novel process for the preparation of water-soluble acyl glycoprotein extracted from Klebsiella Pneumoniae containing 30 to 45% by weight of proteins, 30 to 40% by weight of neutral saccharides, less than 4% of glucuronic acid, 2 to 5% by weight of osami... | 09/26/1989 |
| 4865975 | Process for recuperation of the proteins lost by the dairy industry A process for the recuperation, in a form usable by Man, of the proteins present in the sullage of the dairy industry. This process is effected in a number of devices successively including a biological pre-neutralizing tank, in which the alcaline sullage... | 09/12/1989 |
| 4863856 | Weighted collagen microsponge for immobilizing bioactive materials Weighted collagen microsponges having a highly crosslinked collagen matrix are described suitable for use in culturing organisms in motive reactor systems. The microsponges have an open to the surface pore structure, and pore sizes and volumes suitable fo... | 09/05/1989 |
| 4861714 | Weighted collagen microsponge for immobilizing bioactive material Weighted collagen microsponges having a highly crosslinked collagen matrix are described suitable for use in culturing organisms in motive reactor systems. The microsponges have an open to the surface pore structure, and pore sizes and volumes suitable fo... | 08/29/1989 |
| 4859588 | Production of a single cell protein There is disclosed a method for desulfurizing gases by microbiological techniques which involve the use of chemoautotrophic bacteria of the Thiobacillus genus to convert sulfides to sulfates either as a sulfide removal process or as a process for producin... | 08/22/1989 |
| 4857318 | Bordetella bronchiseptica pilus subunit protein vaccine effective against bordetella pertussis A vaccine derived from Bordetalla bronchiseptica effective against Bordetella pertussis infection is disclosed herein.... | 08/15/1989 |
| 4849358 | Method for culturing bordetella pertussis, a pertussis toxoid and a pertussis vaccine There is disclosed a method for culturing Bordetella pertussis in the prece of a cellulose and/or cellulose derivatives. The present method is useful for obtaining a mixed antigen comprising pertussis toxin and filamentous hemagglutinin in a large amount... | 07/18/1989 |
| 4836855 | Additive of protein nature for hydraulic cements, mortars & concretes, and use thereof in the field construction The present invention relates to a novel additive for hydraulic cements, mortars and concretes, particularly for improving the mechanical strengths and the workability and for reducing sweating and segregation, which is characterized in that it is a prote... | 06/06/1989 |
| 4812441 | Hypocholesterolemically active protein derived from streptococcus A hypocholesterolemically active protein capable of reducing the blood cholesterol in mammals having the following characteristics: (a) Molecular weight by gel filtration: 30,000&#b1;7,000 (b) Isoelectric point: 7.9&#b1;0.2 (c) Amino acid composition (mole %): (d) ... | 03/14/1989 |
| 4788058 | B. pertussis vaccine production using carbodiimides The present invention provides a method of preparing a substantially non-toxic immunogenic preparation of pertussis toxic comprising treatment of pertussis toxin with a carbodiimide. The preparation may be used for vaccination against whooping cough as we... | 11/29/1988 |
| 4772584 | Inhibitor of C5a-mediated chemotaxis Polypeptides are disclosed which inhibit the binding of the C5a chemotaxin to polymorphonuclear leukocytes by cleaving a six amino acid peptide from the carboxy-terminus of the C5a chemotaxin. The polypeptides can be isolated from virulent strains of grou... | 09/20/1988 |
| 4757134 | IgA binding protein Describes IgA binding protein isolatable from Group B streptococci, methods of isolation and use in immunological testing procedures.... | 07/12/1988 |
| 4744983 | Immunogenic protein or peptide complex, method of producing said complex and the use thereof as an immune stimulant and as a vaccine The invention relates to an immunogenic complex containing antigenic membrane proteins or peptides from viruses mycoplasmas, bacteria, parasites or animal cells or prepared synthetically or with hybride DNA technique and glycoside. The invention also rela... | 05/17/1988 |
| 4711846 | Process for the production of L-aspartyl-L-phenylalanine methy ester or L-aspartyl-L-phenylalanine A process for the production of L-aspartyl-L-phenylalanine methyl ester of L-aspartyl-L-phenylalanine by contacting an appropriate microorganism or enzyme-containing fraction of said microorganism with L-aspartic acid and L-phenylalanine methyl ester or L... | 12/08/1987 |
| 4704274 | Method for the purification of LPF-HA A method for producing highly pure LPF-HA (Leucocytosis-promoting Factor agglutinin) from culture media of Bordetella pertussis in a high yield by an affinity chromatography using a denatured ceruloplasmin as a ligand. The LPF-HA obtained by this inventi... | 11/03/1987 |
| 4702910 | Common antigen (PSC-A) to Pseudomonas aeruginosa which acts as an agent for pretecting Pseudomonas aeruginosa infection PSC-A is a new serological common antigen to Pseudomonas aeruginosa having very low toxicity, and highly effective for protecting infection by any of the serotypes of Pseudomonas aeruginosa. PSC-A can be used as the active component in a pharmaceutical ag... | 10/27/1987 |
| 4687738 | Method for the production of HA fraction containing protective antigens of Bordetella pertussis and pertussis vaccine A method for production of HA fraction containing protective antigens of Bordetella pertussis (i.e. a fraction containing F-HA and LPF-HA) in an industrial scale, for instance, with a fermentater, which comprises inoculating a strain of B. pertussis in a ... | 08/18/1987 |
| 4675387 | Method for extracting protein with organic acid A method for extracting protein produced by procaryotic or eucaryotic cells comprising contacting said cells with a solution containing from about 50 to about 100 volume percent of an organic acid having from 1 to 5 carbon atoms and mixtures thereof is di... | 06/23/1987 |
| 4663306 | Pyridine-soluble extract-refined detoxified endotoxin composition and use A pharmaceutical composition comprising a purified pyridine-soluble extract of a microorganism and a refined detoxified endotoxin which is effective in producing an immunological response in warm blooded animals and humans. Methods of using the compositio... | 05/05/1987 |
| 4659568 | Process for solubilization, purification and characterization of protein from insoluble protein aggregates or complexes and compositions of matter therefrom This invention discloses a novel process for the solubilization, purification and characterization of a protein or proteins from insoluble protein aggregates or complexes. The novel process comprises the use of a dissociating step gradient which can be fo... | 04/21/1987 |
| 4649110 | Polymeric substance, and method of separating and culturing bacteria to provide polymeric substance useful in liquid clarification and soil conditioning J-1 which is a strain of cyanobacteria is used to form and excrete a material useful as a floculating agent and as an additive useful in soil conditioning. Method of separating and culturing the cyanobacteria under conditions necessary to achieve maximum ... | 03/10/1987 |
| 4643970 | Production of HCG Method for the production of chorionic gonadotropin (CG) with properties similar to those of human CG (HCG) from a microorganism or mutant thereof isolated by natural or hybridization procedure from the body or body extract carrier of a malignant tumor ca... | 02/17/1987 |
| 4640767 | Hydrocarbon extraction agents and microbiological processes for their production Materials of particular utility in separating hydrocarbon values from mineral deposits, e.g. bitumen from tar sands, are prepared by a microbiological fermentation process using certain selected microorganisms. The fermentation process is conducted under ... | 02/03/1987 |
| 4634671 | Water-soluble cross-linked polymer of lysyl endopeptidase, process for preparing same and use of same A water-soluble cross-linked polymer of the enzyme lysyl endopeptidase produced by Achromobacter lyticus and a process for preparing the polymer as well as a semi-synthesis of human insulin using the polymer.... | 01/06/1987 |
| 4626430 | Processes for growth of modified Pasteurella haemolytica bacteria and preparation of a vaccine therefrom The chemical modification of virulent Pasteurella multocida and Pasteurella haemolytica strains and preparation of live bacteria vaccines from the modified organisms for immunization of bovine, porcine and ovine animal species are disclosed.... | 12/02/1986 |
| 4617274 | Biochemical conversions by yeast fermentation at high cell densities Novel yeasts are disclosed including Pichia pastoris NRRL Y-11430, yeasts having the characteristics of Pichia pastoris NRRL Y-11430, mutants of Pichia pastoris NRRL Y-11430, and strains derived therefrom. Also disclosed are methods of culturing the strai... | 10/14/1986 |
| 4609549 | Biologically active substance from Islets-Activating Protein The present invention relates to biologically active substances obtained by reacting Islets-Activating Protein having an insulin secretion promoting action with a carbonyl compound in the presence of a reducing agent; to anti-diabetic composition in dosag... | 09/02/1986 |
| 4604234 | Protein having cell growth stimulating action, composition thereof and method for producing the same A protein effective in stimulating cell growth activity. The protein has a molecular weight of from 5,000 to about 160,000, is composed predominantly of neutral and acidic amino acids, contains a significant amount of glutamic acid and aspartic acid, and ... | 08/05/1986 |
| 4596778 | Single cell protein from sulfur energy sources Single cell protein is produced in an aqueous fermentation process employing an oxidizable sulfur energy source plus a carbon dioxide source, such as hydrogen sulfide and carbon dioxide, in a controlled oxygen aqueous environment. The process also can emp... | 06/24/1986 |
| 4596709 | Novel immunostimulating glycoproteins Novel water-soluble, immunostimulating glycoproteins extracted from Klebsiella pneumoniae containing 30 to 45% by weight of proteins, 30 to 40% by weight of neutral saccharides, up to 4% by weight of glucuronic acid, 2 to 5% by weight of osamines and havi... | 06/24/1986 |
| 4594244 | Antigenic materials An antigenic material having a molecular weight of 3800-4500, and useful in the preparation of an anticaries vaccine is produced from a known antigenic material, antigen I/II of molecular weight 185,000 daltons obtained from the culture supernatant of Str... | 06/10/1986 |
| 4591558 | Novel substances having antitumor and immunostimulating activity, process for preparing the same and antitumor agent containing the same Novel TF-2 substances having antitumor and immunostimulating activity, which are obtained from a culture or its supernatant fluid prepared by culturing bacteria belonging to Fusobacterium genus. Said substances are useful for the treatment of cancerous di... | 05/27/1986 |
| 4587214 | Process for preparation of aspartylphenylalanine alkyl esters -L-aspartylphenylalanine lower alkyl esters are prepared by a process wherein fumaric acid, ammonia and a lower alkyl ester of L-phenylalanine are contacted with a culture or treated culture of a microorganism belonging to the genus Pseudomonas, an... | 05/06/1986 |
| 4582799 | Process for recovering nonsecreted substances produced by cells Disclosed is a process for recovering nonsecreted substances produced by cells. The process eliminates some of the high molecular weight contaminants thereby simplifying the purification process. The cells are encapsulated within a semipermeable membrane ... | 04/15/1986 |
| 4582798 | Preparation and use of enzyme-detergent extracted Streptococcus equi vaccine Immunogenic protein material obtained from Streptococcus equi bacteria via enzymatic digestion and detergent treatment and useful as a vaccine.... | 04/15/1986 |
| 4575459 | Toxoids of elastase of Pseudomonas aeruginosa origin Provided herein are two kinds of toxoid of elastase of Pseudomonas aeruginosa origin, one of which is obtained by treating a purified elastase produced from Pseudomonas aeruginosa with a synthetic peptide for chloroacetyl-N-hydroxy-L-leucyl-L-alanylglycin... | 03/11/1986 |
| 4554248 | Composition and method for detecting Antistreptolysin O A composition is used as a reagent in a method for measuring Antistreptolysin O (ASO) in a blood sample. The composition contains Streptolysin O (SO) at a pH outside the range of its hemolytic activity, e.g., outside the pH range of 5-9. At that pH the SO... | 11/19/1985 |
