Did You Know...
...that Robert Adler has the dubious distinction of being the Father of the Couch Potato? Back in 1955 Adler was employed by what was then Zenith Radio Corp., where he was charged to invent something that would allow viewers to turn down the TV volume without leaving their chairs. After a series of flops (such as a wired contraption that people tripped over), Adler hit on the idea of using sound waves. Thus the Remote Control was born...
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| Number | Title | Issue Date |
| 8173398 | Humanized anti-IL-6 antibodies The present invention relates to novel chimeric, humanized or CDR-grafted anti-IL-6 antibodies, including isolated nucleic acids that encode at least one such anti-IL-6 antibody, vectors, host cells, transgenic animals or plants, and methods of making and using ther... | 05/08/2012 |
| 8148111 | Cell culture carrier comprising poly(meth)acrylic (salt) particle and artificial polypeptide A carrier for cell culture is provided which improves the cell proliferativity in serum-free culture and which is free from risk from infection factor contamination. The gist of the features of the present invention is to be formed of a crosslinked poly(meth)acrylic... | 04/03/2012 |
| 8137933 | Mammalian expression vector pUHAB The present invention relates to the construction and utilization of a new mammalian expression vector that contains a unique multiple cloning site (MCS), designated pUHAB. The pUHAB vector comprises a high copy replication origin (ColE1), a drug resistance gene (TK... | 03/20/2012 |
| 8110379 | Targeted integration into the PPP1R12C locus Disclosed herein are methods and compositions for targeted integration of an exogenous sequence into the human PPP1R12C locus, for example, for expression of a polypeptide of interest. ... | 02/07/2012 |
| 8008043 | Cultures of E1-immortalized cells and processes for culturing the same to increase product yields therefrom Provided are processes for culturing cells derived from embryonic retinoblast cells immortalized by adenovirus E1 sequences, such as PER.C6® cells, to improve product yields from such cells. Feed strategies for such cells and cultures with very high cell densities ... | 08/30/2011 |
| 7972813 | Tetrodotoxin-resistant sodium channel alpha subunit The present invention is directed to a chimp sodium channel alpha subunit and methods and compositions for making and using the same. ... | 07/05/2011 |
| 7867735 | L-glutamic acid producing bacterium and a method for production of L-glutamic acid A method for producing L-glutamic acid by culturing a coryneform bacterium which has L-glutamic acid producing ability and which has been modified so that expression of the fasR gene is enhanced in a medium to produce and accumulate L-glutamic acid in the medium or ... | 01/11/2011 |
| 7727744 | Methods for obtaining directionally truncated polypeptides Methods, compositions and kits are disclosed for obtaining directionally truncated polypeptides by inserting a transposon. Preferably the transposon comprises a selectable marker and an ori, and optionally a promoter, a ribosome binding site and a translation start ... | 06/01/2010 |
| 7723075 | Methods of screening for TRPM5 modulators The invention relates to methods useful in identifying molecules that bind TRPM5, which modulate TRPM5 ion channel activity, and/or which alter expression of TRPM5 within cells. The TRPM5 channels as described herein contain TRPM5 polypeptides, which are in turn enc... | 05/25/2010 |
| 7695939 | Method for the cultivation of primary cells and for the amplification of viruses under serum free conditions The present invention relates to a method for the cultivation of primary cells. The primary cells are cultivated in a serum free medium comprising a factor selected from the group consisting of growth factors and attachment factors. The method for the cultivation of... | 04/13/2010 |
| 7691611 | Production of recombinant IL-18 binding protein The invention relates to a process for the production of IL-18 binding protein (IL-18BP), and to a composition comprising IL-18BP characterized by a specific glycosylation pattern. ... | 04/06/2010 |
| 7632662 | Compounds, compositions and methods for producing antioxidants from carnitine Carnitines are nutraceuticals with indications in treating a variety of mental health disorders. A metabolomics-guided bioprocess method is presented to produce longer chain fatty acid esters of carnitines such as polyunsaturated fatty acid esters including eicosape... | 12/15/2009 |
| 7601518 | Secretion of neublastin The present invention concerns improved methods and compositions for producing a Neublastin polypeptide as well as local delivery of Neublastin to specific regions of the nervous system including the central nervous system and the eye for example by gene therapy. Th... | 10/13/2009 |
| 7556942 | Tumor suppressor designated Hippo Tumor suppressor genes (TSGs) play a major role in the pathogenesis of human cancers. Here, a new TSG designated hippo (hpo) is described, and the human homolog mst2 is identified as an additional TSG. hpo as a gene that regulates both cell proliferation and cell de... | 07/07/2009 |
| 7541164 | Mammalian cell culture processes for protein production The present invention describes methods and processes for the production of proteins, particularly glycoproteins, by animal cell or mammalian cell culture, preferably, but not limited to, fed-batch cell cultures. In one aspect, the methods comprise at least two temp... | 06/02/2009 |
| 7531327 | Methods and compositions for increasing longevity and protein yield from a cell culture Disclosed herein are compositions and methods for increasing the longevity of a cell culture and permitting the increased production of proteins, preferably recombinant proteins, such as antibodies, peptides, enzymes, growth factors, interleukins, interferons, hormo... | 05/12/2009 |
| 7514240 | EGR-EGFR complex The present invention relates to a crystal of a complex of an epidermal growth factor (EGF) and an epidermal growth factor receptor (EGFR), a crystal of a complex of EGFR and a substance regulating EGFR activity, structure coordinates of these crystals, a method for... | 04/07/2009 |
| 7452696 | Recombinant plasmid and method for expressing hepatitis B viral antigens and virions in vivo Disclosed is a recombinant plasmid for expressing hepatitis B viral antigens in vivo, comprising an adeno-associated virus (AVV) vector and a replication-competent hepatitis B virus genome fragment. Mice hydrodynamically injected with the recombinant plasmid of the ... | 11/18/2008 |
| 7442863 | Soybean cultivar 6434385 A soybean cultivar designated 6434385 is disclosed. The invention relates to the seeds of soybean cultivar 6434385, to the plants of soybean 6434385, to plant parts of soybean cultivar 6434385 and to methods for producing a soybean plant produced by crossing soybean... | 10/28/2008 |
| 7442550 | Method for detecting the expression of an envelope protein of a human endogenous retrovirus and uses of a gene coding for said protein A method for detecting the expression of a polypeptide in cells and for detecting the interaction between a polypeptide and cells, ex vivo or in vitro, wherein the polypeptide is selected from the group consisting of: a peptide comprising the cyt domain of the envel... | 10/28/2008 |
| 7442860 | Soybean cultivar 6421326 A soybean cultivar designated 6421326 is disclosed. The invention relates to the seeds of soybean cultivar 6421326, to the plants of soybean 6421326, to plant parts of soybean cultivar 6421326 and to methods for producing a soybean plant produced by crossing soybean... | 10/28/2008 |
| 7442862 | Soybean cultivar S060295 A soybean cultivar designated S060295 is disclosed. The invention relates to the seeds of soybean cultivar S060295, to the plants of soybean S060295, to plant parts of soybean cultivar S060295 and to methods for producing a soybean plant produced by crossing soybean... | 10/28/2008 |
| 7442527 | Screening methods for identifying viral proteins with interferon antagonizing functions and potential antiviral agents The present invention relates, in general, to a screening method for identifying novel viral proteins with interferon antagonizing function using a transfection-based assay, and the use of such proteins in isolating various types of attenuated viruses for the develo... | 10/28/2008 |
| 7442864 | Soybean cultivar 6326393 A soybean cultivar designated 6326393 is disclosed. The invention relates to the seeds of soybean cultivar 6326393, to the plants of soybean 6326393, to plant parts of soybean cultivar 6326393 and to methods for producing a soybean plant produced by crossing soybean... | 10/28/2008 |
| 7439422 | Soybean cultivar 6600375 A soybean cultivar designated 6600375 is disclosed. The invention relates to the seeds of soybean cultivar 6600375, to the plants of soybean 6600375, to plant parts of soybean cultivar 6600375 and to methods for producing a soybean plant produced by crossing soybean... | 10/21/2008 |
| 7435553 | Isolating cells expressing secreted proteins A method of detecting and isolating cells that produce any secreted protein of interest (POI), comprising: a) constructing a cell line transiently or stably expressing a cell surface capture molecule, which binds the POI, by transfecting the cell line with a nucleic... | 10/14/2008 |
| 7435808 | Polynucleotides encoding novel adiponectin receptor variant, AdipoR2v2 The present invention provides novel polynucleotides encoding human AdipoR2v1 polypeptides, mouse AdipoR2v1 polypeptides, human AdipoR3 polypeptides, human AdipoR2v2 polypeptides, human AdipoR3v1 polypeptides, rat AdipoR1 polypeptides, rat AdipoR2 polypeptides, frag... | 10/14/2008 |
| 7432364 | Human TIMP-1 antibodies Human antibodies that bind to TIMP-1 can be used as reagents to diagnose and treat disorders in which TIMP-1 is elevated, such as liver fibrosis, alcoholic liver disease, cardiac fibrosis, acute coronary syndrome, lupus nephritis, glomerulosclerotic renal disease, b... | 10/07/2008 |
| 7427669 | ULBP antibodies The invention is directed to purified and isolated novel ULBP polypeptides, the nucleic acids encoding such polypeptides, processes for production of recombinant forms of such polypeptides, antibodies generated against these polypeptides, fragmented peptides derived... | 09/23/2008 |
| 7427671 | Compositions of alpha platelet derived growth factor receptor nucleic acid and protein and method of making A DNA sequence which encodes a human type α platelet derived growth factor receptor protein which preferentially binds to the AA homodimer and AB heterodimer forms of platelet derived growth factor and also binds the BB homodimer at high affinity, is described. Sub... | 09/23/2008 |
| 7419808 | Methods and compositions for the production of adenoviral vectors The present invention addresses the need to improve the yield of adenovirus when grown in cell culture systems. In particular, it has been demonstrated that for adenovirus, the use of infection temperatures lower than 37° C. in a cell culture system results in impr... | 09/02/2008 |
| 7414175 | Soybean cultivar S06-BA046119 The present invention is in the field of soybean variety S06-BA046119 breeding and development. The present invention particularly relates to the soybean variety S06-BA046119 and its progeny, and methods of making S06-BA046119. ... | 08/19/2008 |
| 7410778 | Estrogen receptor genes and utilization thereof A gene coding for any of the following estrogen receptors (a) to (c): (a) an estrogen receptor comprising the amino acid sequence represented by amino acid numbers 153 to 602 in the amino acid sequence of SEQ ID NO: 1, (b) an estrogen receptor comprising the amino a... | 08/12/2008 |
| 7408097 | Soybean cultivar 6701475 A soybean cultivar designated 6701475 is disclosed. The invention relates to the seeds of soybean cultivar 6701475, to the plants of soybean 6701475, to plant parts of soybean cultivar 6701475 and to methods for producing a soybean plant produced by crossing soybean... | 08/05/2008 |
| 7408047 | Fibroblast growth factor-like polypeptides The present invention provides novel Fibroblast Growth Factor-like (FGF-like) polypeptides and nucleic acid molecules encoding the same. The invention also provides vectors, host cells, antibodies and methods for producing FGF-like polypeptides. Also provided for ar... | 08/05/2008 |
| 7407778 | Compounds, compositions and methods for treating neuropsychiatric disorders Acetyl-L-carnitine (ALCAR) and L-carntine (LCAR) are nutraceuticals with indications in treating a variety of mental health disorders. A metabolomics-guided bioprocess method is presented to enhance ALCAR and LCAR format... | 08/05/2008 |
| 7405060 | Gene amplification methods The present invention provides multivalent vaccines for the treatment of B-cell malignancies (e.g., lymphomas and leukemias). The present invention also provides methods for the production of custom vaccines, including multivalent vaccines for the treatment of immun... | 07/29/2008 |
| 7399908 | Soybean variety XB37J07 According to the invention, there is provided a novel soybean variety designated XB37J07. This invention thus relates to the seeds of soybean variety XB37J07, to the plants of soybean XB37J07 to plant parts of soybean variety XB37J07 and to methods for producing a s... | 07/15/2008 |
| 7396911 | Chimeric polypeptides containing chemokine domains This invention provides a chimeric DNA molecule comprising a sequence encoding a chemokine polypeptide covalently attached to a heterologous polypeptide, the encoded chimeric polypeptide, and uses thereof. ... | 07/08/2008 |
| 7393683 | Mammalian host cell modified by RNAi to inhibit α 1,6-fucosyltransferase The present invention relates to a cell for the production of an antibody molecule such as an antibody useful for various diseases having high antibody-dependent cell-mediated cytotoxic activity, a fragment of the antibody and a fusion protein having the Fc region o... | 07/01/2008 |
