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| Number | Title | Issue Date |
| 6143506 | Diagnostic method for detection of periodontitis or peri-implantitis The invention relates to methods and test kits for diagnosis of periodontal disease activity in mammals, especially in human. The methods of the invention provide for rapid chair-side diagnosis of periodontitis, peri-implantitis and HIV (+)-infection/AIDS... | 11/07/2000 |
| 6140063 | In vitro screening assay for identification of compounds that inhibit cytopathicity of viral infection The present invention includes the method of treating a viral infection, specifically one occurring as a result of infection by a human immunodeficiency virus (HIV-1). The method of treatment depends upon the ligand binding of the Ah receptor. Transformat... | 10/31/2000 |
| 6136546 | Method for aiding in the diagnosis of in-frame deletion type congenital muscular dystrophy Disclosed are compositions and methods for aiding in the diagnosis of congenital muscular dystrophy associated with in-frame deletion in the laminin-2 댒 polypeptide chain in an individual. In a preferred diagnostic method embodiment, an experimenta... | 10/24/2000 |
| 6132959 | Method for early detection of HIV infection in babies Disclosed and claimed is a novel inexpensive and efficient method for the early detection of HIV infection in babies. The method utilizes a unique IgA capture ELISA procedure for detection of HIV-specific antibodies.... | 10/17/2000 |
| 6117646 | Assaying protein fragments in body fluids Type I collagen degradation products are assayed in a body fluid by conducting a competition immunoassay in which sample molecules compete with a peptide or isomerized peptide in binding to an immunological binding partner for the peptide or isomerized pe... | 09/12/2000 |
| 6107047 | Assaying protein fragments in body fluids Degradation of body proteins such as bone collagen is studied by detecting in body fluids isomerized peptide fragments of said proteins in which peptide bonding to the -carboxylic acid group of aspartic acid or asparagine has become isomerized to a... | 08/22/2000 |
| 6107045 | Antibodies to lipoproteins and apolipoproteins and methods of use thereof Compositions and methods using antibodies which are immunoreactive with specific apolipoproteins to determine the concentrations of lipoproteins such as HDL and LDL, and/or apolipoproteins in human blood, serum or plasma sample, are described. Monoclonal ... | 08/22/2000 |
| 6103538 | Colloidal gold immunoassay method Disclosed herein is a method for the detection of a target substance by a colloidal gold immunoassay, which comprises dissolving in an immunoreaction system a metal salt selected from the group consisting of sodium, potassium and lithium fluorides, sodium... | 08/15/2000 |
| 6103537 | Capillary assays involving separation of free and bound species The present invention concerns methods for masking inhomogeneity of a member of a specific binding pair (sbp) employed in a capillary electroseparation. The method comprises binding the sbp member to synthetic particles that become localized during capill... | 08/15/2000 |
| 6103483 | Molecule involved in binding of sperm to egg surfaces and procedures for use of this molecule to enhance or decrease potential fertility A purified polypeptide which provides for initial binding of sperm to oocyte investments and has an active amino acid sequence of SEQ ID NO:12 (Cys-Gln-Ser-Leu-Gln-Glu-Tyr-Leu-Ala-Glu-Gln-Asn-Gln-Arg-Gln-Leu-Glu-Ser-A sn-Lys-Ile-Pro-Glu-Val-Asp-Leu-Ala-Arg... | 08/15/2000 |
| 6100038 | Method for the enumeration of micronucleated erythrocyte populations with a single laser flow cytometer A single laser flow cytometric method for the enumeration of micronuclei in erythrocyte populations, wherein a sample of peripheral blood or bone marrow is obtained and the cell populations in the sample are fixed. Reticulocytes in the fixed samples are t... | 08/08/2000 |
| 6096563 | Dual particle immunoassay method and kit A dual particle immunoassay method and kit for detecting analyte in a sample in which the sample to be analyzed, a binding molecule specific for the analyte, and a particle coated with the analyte to be detected or coated with a second binding molecule ar... | 08/01/2000 |
| 6096508 | Method of reducing background in biotin-based assays This invention relates to an improvement in a method for detecting labeled molecules and especially biotinylated molecules and particularly relates to a method for reducing background signal problems in such detection methods.... | 08/01/2000 |
| 6090568 | Format for minimizing interferences in chemiluminescent thin-film immunoassays A multilayer dry immunoassay element comprising 1) a spreading layer having a sample application area and a signal read area and 2) a separate receptor layer residing on 3) a radiation-transmissive support characterized in that the spreading layer contain... | 07/18/2000 |
| 6090565 | Sphingoglycolipids as markers for multidrug resistant cancers The present invention involves the identification of sphingoglycolipid species that are indicative of multidrug resistance in certain types of cells, including cancer cells. The association of multidrug resistance with the expression of certain sphingogly... | 07/18/2000 |
| 6087188 | Two-site immunoassay for an antibody with chemiluminescent label and biotin bound ligand A method of detecting an antibody in a sample using a labelling compound and comprising the steps of mixing a ligand antigen, antibody or hapten bound to biotin with the sample; an antibody directed against the antibody to be detected bound to paramagneti... | 07/11/2000 |
| 6080552 | Detection of antibody production The present invention provides a method of detecting active antibody production in a blood sample by contacting, in the presence and absence of protein synthesis inhibitor, aliquots of the sample with a solid phase under conditions which permit antibody p... | 06/27/2000 |
| 6077681 | Diagnosis of motor neuropathy by detection of antibodies Methods of detecting antibody to GM1 ganglioside in a sample, comprising covalent linkage of GM1 ganglioside to a solid-phase reactant, are disclosed. The methods of detecting antibody to GM1 ganglioside can be used in methods of diagnosing motor neuropat... | 06/20/2000 |
| 6074835 | Diagnosis, prevention and treatment of ulcerative colitis, and clinical subtypes thereof, using histone H1 The present invention provides a method of diagnosing ulcerative colitis (UC) in a subject suspected of having inflammatory bowel disease by by obtaining a sample from the individual; contacting the sample with human histone H1, or pANCA-reactive fragment... | 06/13/2000 |
| 6071705 | Method of detecting neurological disease or dysfunction This invention relates to a method of detecting and diagnosing neurological disease or dysfunction using antibodies against a neurological form of Pancreatic Thread Protein (nPTP). Specifically, this invention is directed to a method of diagnosing Alzheim... | 06/06/2000 |
| 6068979 | Simplified sequential chemiluminescent detection A method for sequential chemiluminescent detection of two differently labeled analytes on a single blot is described. In the method, a uniquely labeled DNA is detected with a horseradish peroxidase (HRP) substrate followed by the detection of another uniq... | 05/30/2000 |
| 6060326 | Method to detect canine IgE and kit therefor The present invention includes a method to detect canine IgE using a canine Fc epsilon receptor (Fc&3xb5; R) to detect canine IgE antibodies in a biological sample from a canid. The present invention also relates to kits to perform such methods... | 05/09/2000 |
| 6057097 | Marker for pathologies comprising an auto-immune reaction and/or for inflammatory diseases The present invention comprises a marker for inflammatory diseases and/or pathologies comprising an autoimmune reaction, which is the plasmatic membrane and/or a portion therof, in particular the plasmatic DNA. The present invention concerns also the meth... | 05/02/2000 |
| 6048703 | Methods for detecting cell apoptosis Methods for the biochemical and immunohistochemical detection of cell apoptosis are described. The methods utilize the detection and measurement of polypeptide fragments generated during apoptosis. Conditions associated with apoptosis may be detected by t... | 04/11/2000 |
| 6046013 | Process for identifying specific antibodies associated with HLA A process is provided for the detection and identification of human antibody types which are specific for antigens such as platelet glycoproteins and Human Leukocyte Antigen (HLA). The process aids in detecting and identifying antibody types from a patien... | 04/04/2000 |
| 6046012 | Antibody to IL-12 receptor This disclosure relates to novel antibodies specific to the recently discovered receptor to human interleukin 12 (IL-12R). The antibodies to IL-12R, most preferably, the monoclonal antibodies to that protein, are useful in determining the status of the hu... | 04/04/2000 |
| 6040196 | Method of evaluating a testing element for antigens or antibodies An evaluating method of a testing element having an immobilized antigen or antibody on an immobilizing carrier thereof, which immobilized antigen or antibody has yet to react with another antigen or antibody, which involves contacting the testing element ... | 03/21/2000 |
| 6037185 | Non-competitive immunoassay with blocking of unoccupied specific binding sites on solid phase A non-competitive method for the determination of analytes. Initially the analyte is bound to a specific binding partner, after which the unoccupied binding sites of the binding partner are inactivated. The bound analyte is then dissociated from the bindi... | 03/14/2000 |
| 6030770 | Increasing the sensitivity in the immunochemical determination of an analyte The present invention relates to a process for the determination of an analyte, in which a sample optionally containing the analyte to be determined is brought into contact with a first receptor R1, which has a binding affinity for the analyte, immobilize... | 02/29/2000 |
| 6027943 | Immunoassay devices and materials An immunochemical assay device comprising a base member, an array disposed on the base member, and at least one assay indicia zone. The array comprises (i) a reservoir pad to receive sample liquid, (ii) a wicking membrane, and (iii) at least one filter zo... | 02/22/2000 |
| 6022963 | Synthesis of oligonucleotide arrays using photocleavable protecting groups Novel compounds are provided which are useful as linking groups in chemical synthesis, preferably in the solid phase synthesis of oligonucleotides and polypeptides. These compounds are generally photolabile and comprise protecting groups which can be remo... | 02/08/2000 |
| 6020209 | Microcapillary-based flow-through immunosensor and displacement immunoassay using the same A displacement-type flow immunoassay is performed using a microcapillary sage. The inner wall of the microcapillary passage has immobilized thereon antibodies to the antigen of interest. Labeled antigen is immunologically bound to the immobilized antibod... | 02/01/2000 |
| 6020147 | Chemical analysis apparatus and method A method and apparatus for the quantitative determination of an analyte in a liquid employs a liquid-permeable solid medium defining a liquid flow path. The medium includes a number of reactant-containing reaction zones spaced apart along the flow path an... | 02/01/2000 |
| 6020145 | Methods for determining the presence of carcinoma using the antigen binding region of monoclonal antibody BR96 The present invention relates to novel antibodies, antibody fragments and antibody conjugates and single-chain immunotoxins reactive with human carcinoma cells. More particularly, the antibodies, conjugates and single-chain immunotoxins of the invention i... | 02/01/2000 |
| 6017698 | Method of binding a biological material Subject matter of the invention is a method of binding a biological material to a solid phase by providing a sample liquid containing the biological material in a sample vessel (A) having an inner contour (A17); then a hollow body (C) which has a contour ... | 01/25/2000 |
| 6017767 | Assay device A chromatographic assay device for use with immunoassays allows rapid and convenient assays of analytes of biological interest, and permits extractions to be carried out in situ, avoiding the use of separate extraction vessels. The device has a wide dynam... | 01/25/2000 |
| 6013457 | Method for carrying out an immunoassay in a multiphase system The present invention relates to a method of carrying out an immunoassay in a multiphase system. Particularly, a sample containing an analyte is brought into contact with a receptor A and a tracer. The analyte can either from a complex with the tracer, or... | 01/11/2000 |
| 6010854 | Autoantibodies to neurotransmitter receptors A peptide containing 24 amino acid residues that binds to anti-neuronal-glutamate-receptor autoantibodies associated with Rasmussen's encephalitis and that blocks activation of the GluR3 subunit is described. Methods of making the peptide and treating Ras... | 01/04/2000 |
| 6007982 | Synthetic antigens for the detection of antibodies to hepatitis C virus Peptide sequences are provided which are capable of mimicking proteins encoded by HCV for use as reagents for screening of blood and blood products for prior exposure to HCV. The peptides are at least 5 amino acids long and can be used in various specific... | 12/28/1999 |
| 6004761 | Method for detecting cancer using monoclonal antibodies to new mucin epitopes Novel hybridoma cell lines producing monoclonal antibodies reactive with purified mucin antigens from normal and tumor sources are generated using mucins, including purified mucins from tumor sources. Epitopes on mucin antigens from normal and tumor sourc... | 12/21/1999 |
