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| Number | Title | Issue Date |
| 5888757 | Cell wall assay Disclosed are methods that can be used to (1) measure the level of polysaccharide in a sample; (2) measure the ability of a compound to degrade a polysaccharide; (3) measure the ability of a compound to modulate polysaccharide synthesis; and (4) identify ... | 03/30/1999 |
| 5888746 | Tumor diagnosis and prognosis A method for diagnosis or prognosis of a cancer is disclosed. The method comprises (i) detecting in a first biological sample protein tyrosine phosphate (PTP) or PTP nucleic acid, and (ii) comparing the level of PTP or PTP�... | 03/30/1999 |
| 5885786 | Methods for screening of substances for inhibition of multidrug resistance The present invention provides for the screening of candidate substances to identify active compounds that inhibit multidrug resistance (MDR). The expression of glucosylceramides has been determined to be a marker of MDR. By measuring glucosylceramide exp... | 03/23/1999 |
| 5879881 | Solid phase system for use in ligand-receptor assays A solid phase system for use in ligand-receptor assays, particularly immunoassays using monoclonal antibodies, is disclosed. The solid phase system comprises a porous matrix in which microspheres, bound with a receptor capable of capturing a target ligand... | 03/09/1999 |
| 5876948 | Screening methods to identify neurotoxin inhibitors Method for treatment of a disease in a patient characterized by accumulation of ଲ-amyloid. The method includes identifying a patient potentially suffering from such a disease and contacting a neuron of the patient with a therapeutically effective am... | 03/02/1999 |
| 5877028 | Immunochromatographic assay device A chromatographic assay device for use with immunoassays allows rapid and convenient assays of analytes of biological interest, and permits extractions to be carried out in situ, avoiding the use of separate extraction vessels. The device has a wide dynam... | 03/02/1999 |
| 5874216 | Indirect label assay device for detecting small molecules and method of use thereof A chromatographic strip positive readout binding assay device and method suitable for quick, sensitive and reliable field testing for small molecules such as environmental contaminants, drugs of abuse, therapeutic drugs and hormones. The detectable label ... | 02/23/1999 |
| 5874233 | Methods of diagnosing a clinical subtype of Crohn's disease with features of ulcerative colitis The present invention provides a method of diagnosing a clinical subtype of Crohn's disease (CD) by determining whether perinuclear anti-neutrophil antibodies (pANCA) are present in a patient with CD, where the presence of pANCA indicates the clinical sub... | 02/23/1999 |
| 5872013 | Universally applicable detection system based on ultra small colloidal metal particles An aggregate for qualitatively or quantitatively determining bindable substances. Said aggregate comprises an ultra small colloidal particle and a specific binding agent characterized in that the mean diameter of the colloidal particle is below 2 nm. Pref... | 02/16/1999 |
| 5871931 | Methods for detecting mammalian tub protein and RNA The present invention relates to the identification of novel nucleic acid molecules and proteins encoded by such nucleic acid molecules or degenerate variants thereof, that participate in the control of mammalian body weight. The nucleic acid molecules of... | 02/16/1999 |
| 5869262 | Method for monitoring an inflammatory disease state by detecting circulating ICAM-R Methods for monitoring the progression of systemic lupus erythematosus (SLE) in a patient by detecting elevated levels of circulating ICAM-R wherein progression is indicated in an SLE patient whose circulating ICAM-R levels are increased as compared to no... | 02/09/1999 |
| 5866432 | Methods for diagnosis of periodontal diseases The present invention is related to a rapid and reliable method for making chair-side diagnoses of periodontal diseases and especially for predicting the risk of progressing of the periodontal diseases. The diagnosis and prognosis are performed using an i... | 02/02/1999 |
| 5866347 | Method of identifying persons susceptible to autoimmune neuropsychiatric disorders A method of identifying individuals who have, or who are at risk of developing, autoimmune neuropsychiatric disorders is disclosed. The invented method relies on detection of the B lymphocyte antigen, D8/17. The invented method can conveniently be carried... | 02/02/1999 |
| 5861257 | Monoclonal antibodies directed against the microtubule-associated protein tau, hybridomas secreting these antibodies, antigen recognition by these monoclonal antibodies and their applications The invention relates to a monoclonal antibody which forms an immunological complex with an epitope of an antigen belonging to normal human tau protein as well as abnormally phosphorylated human tau protein, with said tau protein being liable to be obtain... | 01/19/1999 |
| 5861264 | Anti-tryptase detection as a diagnostic for inflammatory diseases This invention provides methods of detecting mast cell mediated disease in an individual by detecting the presence in the individual of autoantibodies against mast cell specific proteins, such as tryptase and chymase. Specific mast cell mediated diseases ... | 01/19/1999 |
| 5861260 | Diagnostic methods for screening patients for scleroderma Disclosed are diagnostic methods for screening a patient for sclerotic disease. One diagnostic method includes obtaining a biological sample from the patient; obtaining a substantially pure CP140 polypeptide fragment; contacting the sample with the CP140 ... | 01/19/1999 |
| 5858682 | E2A/pbx1 fusion protein specific monoclonal antibodies A monoclonal antibody which specifically binds with an E2A/pbx1 fusion epitope.... | 01/12/1999 |
| 5858667 | Method for the enumeration of micronucleated erythrocyte populations with a single laser flow cytometer A single laser flow cytometric method for the enumeration of micronuclei in erythrocyte populations, wherein a sample of peripheral blood or bone marrow is obtained and the cell populations in the sample are fixed. Reticulocytes in the fixed samples are t... | 01/12/1999 |
| 5858326 | Methods of increasing amyloid deposition In vivo and in vitro methods of increasing amyloid deposition using amyloid-enhancing compounds are described. Methods of forming amyloid fibrils and screening for agents useful in treating amyloidosis are also described. Animals having non-naturally occu... | 01/12/1999 |
| 5856113 | Antigen and method for measuring anti-erythrocyte antibody Fragments of cell membrane of erythrocyte are used as an antigen for insolubilization in enzyme immunoassay to provide a highly sensitive, excellent quantitative method for measuring anti-erythrocyte antibody. The cell membrane fragments of erythrocyte ar... | 01/05/1999 |
| 5856106 | Determination of antibody production against administered therapeutic glycoproteins, especially monoclonal antibodies Disclosed are a composition and method for determining the levels of specific immune responsiveness to a glycoprotein in an individual being treated therewith by (i) contacting a body fluid sample obtained from the individual prior to glycoprotein treatme... | 01/05/1999 |
| 5851839 | Platelet aggregation inhibitors Peptides useful in inhibiting platelet aggregation are disclosed. These peptides contain the binding sequence Har-G-D and are disulfide-bridged cyclic compounds.... | 12/22/1998 |
| 5851783 | Method for diagnosing amyotrophic lateral sclerosis A method and kit are described that are useful in the diagnosis of amyotrophic lateral sclerosis or the evaluation of its progression. According to the method, a purified voltage-sensitive calcium channel complex is contacted with a biological fluid obtai... | 12/22/1998 |
| 5851781 | Reagents and methods for the detection and quantification of testosterone in fluid samples The present invention discloses novel immunogens, antibodies prepared from such immunogens, and labeled reagents useful in immunoassays for the detection and quantification of testosterone in a test sample. Also disclosed are immunoassays using these reag... | 12/22/1998 |
| 5851777 | Homogeneous sol-sol assay The present invention provides methods for detecting the presence of or determining the amount of a ligand in a fluid sample. The methods comprise providing a first reagent comprising a sol particle having a detectable physical property bound to the ligan... | 12/22/1998 |
| 5849504 | Nucleic acid probes and methods for detecting Pneumocystis carinii The invention features nucleic acid probes and methods for detecting Pneumocystis carinii (e.g., human or ferret P. carinii) in hybridization assays.... | 12/15/1998 |
| 5849480 | Process and device for assaying a hapten A device for assaying haptens includes a solid support linked through a nucleic acid fragment to a reagent that can compete with the hapten for binding to antibodies that bind to the hapten. A process for assaying a hapten uses this device.... | 12/15/1998 |
| 5846959 | Treatment for atherosclerosis and other cardiovascular and inflammatory diseases A method for the treatment of cardiovascular diseases and noncardiovascular inflammatory diseases that are mediated by VCAM-1 is provided that includes the removal, decrease in the concentration of, or prevention of the formation of oxidized polyunsaturat... | 12/08/1998 |
| 5846746 | Antibody to ocular and vaginal surface epithelium A monoclonal antibody has been produced that binds to apical cells of human ocular surface and vaginal epithelia. The antigen recognized by this monoclonal antibody is a mucin-like cell surface glycoprotein. The antibody is of diagnostic use in the evalua... | 12/08/1998 |
| 5843690 | Immunoassay and kit for in vitro detection of soluble DesAABB fibrin polymers An in vitro immunoassay to detect and quantitate soluble crosslinked and non-crosslinked DesAABB fibrin polymers in a sample from a subject. The assay can be used to support a diagnosis of, to evaluate, and to monitor, in a mammalian subject, a thrombotic... | 12/01/1998 |
| 5840506 | Methods for the diagnosis and prognosis of cancer The invention provides diagnostic and prognostic methods which comprise determining the level of expression of the tumor suppressor gene pRb2/p130. Because the relative level of pRb2/p130 expression correlates with tumor grade and patient prognosis, these... | 11/24/1998 |
| 5840498 | Antibiotic cryptdin peptides and methods of their use The present invention provides substantially purified cryptdin peptides having a consensus amino acid sequence: X1 -C-X2 -C-R-X3 -C-X4 -E-X5 -C-X6 -C-C-X7 wherein X1 is 3 t... | 11/24/1998 |
| 5837465 | Luciferase labelling method Luciferase is conjugated to a chemical entity, particularly to a specific binding agent such as an antibody, antigen or a nucleic acid, and more particularly an antibody, by (a) mixing the luciferase with one or more of D-luciferin, magnesium ions and ade... | 11/17/1998 |
| 5834220 | Assay for cardiac troponin I An assay, and kit, for the quantitation of cardiac troponin I in human biological fluid is provided. The assay involves a sandwich assay employing an antibody specific for cardiac troponin I as one binding partner for cardiac troponin I and troponin C as ... | 11/10/1998 |
| 5834179 | Morphogenic protein compositions of matter Disclosed are novel compositions of morphogenic proteins constituting soluble forms of these proteins, antibodies that distinguish between soluble and mature forms, and method for producing these morphogenic proteins and antibodies.... | 11/10/1998 |
| 5834215 | Method for detecting antipolymer antibodies and diagnosing silicone related disease (SRD) fibromyalgia and chronic fatigue syndrome (CFS) The present invention provides for a method of detecting antipolymer antibodies, and a method for detecting silicone related disease, fibromyalgia, and chronic fatigue syndrome.... | 11/10/1998 |
| 5830667 | Human P450 IID6 cytochrome-derived peptide fragments, anti-peptide fragment antibodies, applications thereof in the diagnosis of autoimmune hepatitis Human P450 IID6 cytochrome-derived peptide fragments, anti peptide anti fragment antibodies and applications thereof in the diagnosis of autoimmune hepatitis and more especially in the differential diagnosis between autoimmune hepatitis and other chronic ... | 11/03/1998 |
| 5830681 | Immunoassays for and monoclonal antibodies to prothrombin activation peptide F1.2 Monoclonal antibodies and fragments thereof, with binding specificity for an epitope on the carboxy terminus of prothrombin activation peptide F1.2, which can be used in immunoassays to predict thrombosis by measuring the extent of activation of prothromb... | 11/03/1998 |
| 5827674 | Hybridoma producing a monoclonal antibody for N-peptide The present invention relates to a sandwich immunoassay for rapidly and readily measuring N-peptide using two kinds of monoclonal antibodies recognizing different portions of the N-peptide. The method for measuring N-peptide or a precursor thereof include... | 10/27/1998 |
| 5827669 | Sheets, kits and methods for detecting antigens or antibodies A detection sheet capable of detecting an antigen or antibody in a biological fluid with a high sensitivity in a simple operation, as well as a detection kit and detection method using the detection sheet. The detection sheet comprises (a) a fibrous aggre... | 10/27/1998 |
