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| Number | Title | Issue Date |
| 6461827 | Methods and kits for detecting or predicting ischemic disorders The present invention provides a method for detecting or predicting ischemic disorders in a subject by using as an indication the concentration of human lipocalin-type prostaglandin D synthase (hPGDS) in body fluid samples from the subject. More specifica... | 10/08/2002 |
| 6458528 | Diagnosis of feline immunodeficiency virus infection using ENV/GAG polypeptide markers Methods for determining whether a feline is infected with feline immunodeficiency virus ("FIV"). The methods involve the use of an antibody-binding composition that includes two enhanced polypeptides, one containing an immunogenic fragment of the FIV gag ... | 10/01/2002 |
| 6455324 | Embossed test strip system The invention provides a method for measuring the amount of analyte in a sample of biological fluid using a simple low sample volume reagent test strip with a built in metering system. The test strip may comprise a microtitration zone to prevent oversampl... | 09/24/2002 |
| 6455245 | Mystery swine disease diagnostic kits Composition of matter comprising the causative agent of Mystery Swine Disease, Lelystad Agent, in a live, attenuated, dead, or recombinant form, or a part or component of it. Vaccine compositions and diagnostic kits based thereon. Recombinant nucleic acid... | 09/24/2002 |
| 6451980 | Signal enhancement of bispecific antibody-polymer probe for immunoassay use An immunoassay method including reacting a sample from a patient with a bispecific antibody, wherein the bispecific antibody includes one antibody specific for a compound to be detected and a second antibody specific for a compound foreign to said patient... | 09/17/2002 |
| 6451619 | Monitoring methods and devices for use therein Methods, devices and test kits for monitoring the ovulation cycle, involve testing the body fluid, e.g. urinary, concentration of one or more analytes. Preferably estrone-3-glucuronide and luteinizing hormone are both measured, and a reference concentrati... | 09/17/2002 |
| 6451547 | Process for differential diagnosis of Alzheimer's dementia and device therefor A method for diagnosing Alzheimer's disease(AD) is disclosed. The method involves directly detecting the presence of a biochemical marker, specifically human glutamine synthetase, in bodily fluid, preferably blood or a blood product. The detection is by a... | 09/17/2002 |
| 6451545 | Monoclonal antibody specific to anti-human fibrin monomer, process for producing the same, hybridomas, and immunoassay method Provided are a monoclonal antibody making it possible to detect a native fibrin monomer, which is produced at the initial state of blood coagulation, and soluble fibrin; a hybridoma; and an immunoassay for detecting the initial stage of blood coagulation ... | 09/17/2002 |
| 6451522 | Anti-CCR2 antibodies and methods of use therefor The present invention relates to an antibody or functional fragment thereof which binds to a mammalian (e.g., human) CC-chemokine receptor 2 (CCR2) or a portion of the receptor and blocks binding of a ligand to the receptor. The invention further relates ... | 09/17/2002 |
| 6448021 | Method of inhibiting cell function associated with CCR2 by anti-CCR2 amino-terminal domain antibodies The present invention relates to an antibody or functional fragment thereof which binds to a mammalian (e.g., human) CC-chemokine receptor 2 (CCR2) or a portion of the receptor and blocks binding of a ligand to the receptor. The invention further relates ... | 09/10/2002 |
| 6440748 | Process and device for carrying out fluorescence immunoassays The invention concerns a device and a method for carrying out fluorescence immunoassays, wherein from at least one light source light is directed onto a surface at one end of a light waveguide and with the light coupled into the light waveguide by evanesc... | 08/27/2002 |
| 6436651 | Optical diffraction biosensor The present invention provides an inexpensive and sensitive device and method for detecting and quantifying analytes present in a medium. The device comprises a metalized film upon which is printed a specific, predetermined pattern of analyte-specific rec... | 08/20/2002 |
| 6436636 | Methods for identifying pharmacologicals for the treatment of heart failure Methods are disclosed for treating heart failure. Methods are disclosed for screening pharmacologicals that inhibit the down-regulatory activity of AUF1 or AUF1-related polypeptide for ଲ-adrenergic activity. Methods are disclosed for treating a pati... | 08/20/2002 |
| 6432633 | Immunoassay method of HIV-1p24 antigen and reagent therefor An immunoassay method of the HIV-1p24 antigen by sandwich method, using at least one polyclonal antibody recognizing the HIV-1p24 antigen and at least two monoclonal antibodies recognizing the HIV-1p24 antigen, is provided together with a reagent therefor... | 08/13/2002 |
| 6429026 | One-step all-in-one dry reagent immunoassay The invention relates to a novel competitive or non-competitive immunoassay comprising the steps of immobilizing an assay specific component on a solid phase in a reaction well, adding a labelled assay specific component, drying said components, adding the sam... | 08/06/2002 |
| 6429018 | Prenatal screening for Down's syndrome using hyperglycosylated gonadotropin A prenatal screening method for Down's syndrome involves assaying for hyperglycosylated gonadotropin in biological test samples such as urine, plasma or serum obtained from pregnant women. Hyperglycosylated gonadotropin comprises a variant population of c... | 08/06/2002 |
| 6410252 | Methods for measuring T cell cytokines The present invention relates to devices and methods for detecting cellular products, and in particular for measuring secreted cellular products, including cytokines. Microwells comprising hydrophobic membranes are described having greater capability to d... | 06/25/2002 |
| 6410247 | Nuclear matrix protein fluid assay Disclosed is a method for detecting and quantitating soluble nuclear matrix proteins in body fluids and extracellular media. The method is useful for monitoring the viability of cells and tissue, for evaluating the progress of a disease or its treatment, ... | 06/25/2002 |
| 6406920 | Processes and apparatus for carrying out specific binding assays A process for carrying out a specific binding assay (for example an immunoassay) in which (a) a sample under assay, possibly containing a substance being tested for, is reacted with (b) a specific binding partner for the substance being tested for, immobi... | 06/18/2002 |
| 6406873 | PAI-2 and T-PA as diagnostic markers of periodontal disease The existence and the extent of periodontal disease can be diagnosed by measuring plasminogen activator inhibitor 2 (PAI-2) and/or tissue plasminogen activator (t-PA) levels in gingival crevicular fluid (GCF). Levels of PAI-2 and t-PA in GCF rise sharply ... | 06/18/2002 |
| 6406869 | Fluorescent capture assay for kinase activity employing anti-phosphotyrosine antibodies as capture and detection agents A method for determining the level of tyrosine kinase activity in a biological sample is disclosed. The method employs an anti-phosphotyrosine antibody as both the capture agent and the detecting agent. The detecting antibody is labeled with a lanthanide ... | 06/18/2002 |
| 6406865 | Method of inhibiting interaction of cells bearing CCR2 by Anti-CCR2 amino-terminal domain antibodies The present invention relates to an antibody or functional fragment thereof which binds to a mammalian (e.g., human) CC-chemokine receptor 2 (CCR2) or a portion of the receptor and blocks binding of a ligand to the receptor. The invention further relates ... | 06/18/2002 |
| 6406858 | System for the reduction of interferences in immunoassays The present invention is an improvement to the method of determining the concentration of an analyte in body fluid using at least two immunoreactants which specifically bind with separate epitopes of the analyte one of which immunoreactant is immobilized ... | 06/18/2002 |
| 6399748 | In-vitro method for prognosticating the illness development of patients with carcinoma of the breast and/or for diagnosing carcinoma of the breast The present invention is directed to a method of prognosticating the illness development of patients with carcinoma of the breast and/or for diagnosing carcinoma of the breast, the method comprising a qualitative determination of T1 protein and/or T1-mRNA... | 06/04/2002 |
| 6395497 | Method of inhibiting leukocyte trafficking by anti-CCR2 amino-terminal domain antibodies The present invention relates to an antibody or functional fragment thereof which binds to a mammalian (e.g., human) CC-chemokine receptor 2 (CCR2) or a portion of the receptor and blocks binding of a ligand to the receptor. The invention further relates ... | 05/28/2002 |
| 6395494 | Method to determine TGF-ଲ A method for treating or preventing cardiovascular pathologies by administering a compound of the formula (I): ##STR1## wherein Z is C.dbd.O or a covalent bond; Y is H or O(C1 -C4)alkyl, R1 and R2 are individual... | 05/28/2002 |
| 6391540 | Method for detecting antibodies in a sample The present invention is directed to assays for detecting antibodies in a sample in a single incubation step. The assays employ universal solid phases and/or universal detectable markers, and facilitate the detection and differentiation of antigens from t... | 05/21/2002 |
| 6391652 | Immunoassay method and immunoassay kit An immunoassay method comprising bringing an immobilized phase comprising, at different positions on a water-absorbable base material, at least two first immunity substances capable of specifically binding with at least two kinds of assay target substance... | 05/21/2002 |
| 6391569 | Method to detect Dirofilaria immitis infection The present invention includes a method to detect D. immitis infection in a host animal using a D. immitis Di33 protein to detect anti-D. immitis Di33 antibodies in a bodily fluid of the animal. Also included is a method to detect D. immitis infection in ... | 05/21/2002 |
| 6391568 | Method for determining platelet reactivity in a whole blood sample The present invention provides a method for the quantification and assessment of platelet activation in whole blood samples and monitoring of antiplatelet pharmacologic agents. The method for quantifying platelet activation includes exposing platelets to ... | 05/21/2002 |
| 6387707 | Array Cytometry A method and apparatus for the manipulation of colloidal particulates and biomolecules at the interface between an insulating electrode such as silicon oxide and an electrolyte solution. Light-controlled electrokinetic assembly of particles near surfaces ... | 05/14/2002 |
| 6383765 | Polypeptides of feline T-cell lymphotropic lentivirus An isolated envelope polypeptide of Feline Immunodeficiency Virus (FIV) that reacts specifically with a gp-130 envelope specific monoclonal antibody. Immunoassays using such isolated polypeptides are also disclosed.... | 05/07/2002 |
| 6379975 | Methods and reagents for determining protein S The present invention is concerned with an assay for free protein S comprising addition of a ligand specific for free protein S to a biological fluid sample to form a protein S/ligand complex, and subsequent determination of the amount of said complex for... | 04/30/2002 |
| 6379918 | Composition, formulae, devices and methods for control of specificity and inclusivity of microorganisms containing closely related antigen epitopes Compositions, formulae, devices and methods for the detection of target microorganisms, such as by visual immunoprecipitate assay, enzyme linked immunoassay, chemiluminescence, immunoblotting, or similar detection technology, wherein detection requires th... | 04/30/2002 |
| 6379909 | Method of detecting an antibody in a liquid sample The invention relates to a method of evaluating the immunological status of a subject comprising the steps of 1) determining the content of an antibody in a liquid sample from the subject using an immunoassay, wherein the reaction between the antibody of ... | 04/30/2002 |
| 6379902 | Mycrobacterial proteins, microorganisms producing same and uses of said proteins in vaccines and for detecting tuberculosis Mycobacterium tuberculosis protein having a molecular weight of 28 779 Da, and hybrid proteins containing at least portions of its sequence. These proteins may in particular be used in vaccines or for the detection of specific tuberculosis antibodies.... | 04/30/2002 |
| 6376207 | Assay and reagents for quantifying hBNp The present invention provides reagents and assays for the quantification of hBNP in biological fluid samples such as plasma or serum. Antibodies are provided which are monospecific to epitopes comprising the amino acid sequences 5-13, 1-10 and 15-25 of h... | 04/23/2002 |
| 6376206 | Specific antibodies to troponin T, their production and use in a reagent for the determination of myocardial necrosis An immunoassay for the determination of myocardial necroses using antibodies to troponin T and a binding partner B for troponin T or for the an antibody, whereby either the antibody or the binding partner B is labelled with a determinable group. The immun... | 04/23/2002 |
| 6376187 | Electronically-indexed solid-phase assay for biomolecules Disclosed are materials and methods for detecting biomolecules in samples employing transponders associated with the bead(s) used as the solid phase in the assay, and information pertinent to the assay is encoded on the transponders memory elements. A ded... | 04/23/2002 |
| 6372516 | Lateral flow test device A immunochromatographical test device including a cap, an absorbent pad, a membrane, a test strip, a holder, and a housing is disclosed. The housing contains the membrane and the test strip which contains immunoreagents. Secured to the holder is the absor... | 04/16/2002 |
