Did You Know...
...that after Parker Brothers executives turned down the game of Monopoly because it had "52 fundamental errors" (including taking too long to play), a copy of the game wound up in the home of the company president who stayed up until 1 a.m. to finish playing it? He was so impressed by the game that the next day he wrote to inventor Charles Darrow and offered to buy it!
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| Number | Title | Issue Date |
| 6596497 | Screening of antiviral compounds targeted to the HIV-1 gp41 core structure A method for the screening of antiviral compounds targeted to the HIV gp41 core structure comprising capturing polyclonal antibodies from an animal other than a mouse directed against a trimer of a heterodimer containing an N-peptide and a C-peptide onto ... | 07/22/2003 |
| 6593085 | Assay method and apparatus A method of assaying for an analyte including the steps of: (i) passing a sample suspected of containing an analyte and reagents comprising a target ligand-analyte receptor conjugate and a detectable tracer containing a label for the analyte through filte... | 07/15/2003 |
| 6593137 | Antibodies specific for fullerenes This invention provides a hybridoma produced by the fusion of a mouse antibody-producing cell and a mouse myeloma which is designated 1-10F-8A and deposited with the ATCC under Accession Number PTA-279, said hybridoma producing a monoclonal antibody which... | 07/15/2003 |
| 6589798 | Method and system for analyte determination The invention relates to methods, kits and systems for determining an analyte in a liquid sample as well as the use thereof for concentration analysis and screening purposes. In one method, a specific binding partner to the analyte is permitted to compete... | 07/08/2003 |
| 6589754 | Immunoassay element and process for immunoassay An immunoassay element for quantitatively analyzing a macromolecular antigen by determining the change in enzymatic activity caused by a reaction between the macromolecular polymer antigen and an enzyme-labelled antibody. The immunoassay element comprises... | 07/08/2003 |
| 6582970 | Simple immunochemical semi-quantitative assay method and apparatus The present invention relates to a simple immunochemical semi-quantitative assay method according to chromatography, which comprises trapping a certain amount of an analyte in a sample with a predetermined amount of a fixed antibody for the analyte before... | 06/24/2003 |
| 6579687 | Methods for the assay of troponin I and T complexes of troponin I and T and selection of antibodies for use in immunoassays Methods and compositions are described for the detection and quantitation of cardiac specific troponin I and troponin T in samples. Cardiac-specific troponin isoforms exist in various forms in the blood, including free and complexed forms. By selecting an... | 06/17/2003 |
| 6576433 | Method for identification of cell growth or differentiation factors The present invention relates to novel immortalized precursor cell populations derived from embryonic stem cell populations and methods to produce such cell populations. Also disclosed is an assay to identify regulatory compounds capable of controlling ce... | 06/10/2003 |
| 6573108 | Biochemical and immunochemical assay device An assay device comprising: (a) a substrate comprising: (i) a porous material capable of chromatographically transporting a liquid; and (ii) one or more test reagents for an assay provided on the porous material; and (b) a transparent water-impermeable co... | 06/03/2003 |
| 6569635 | Growth state-specific immunofluorescent probes for determining physiological state and method of use A novel method for examining bacterial growth state is carried out by measuring the levels of conserved cytosolic proteins specific for alternative growth states, using bacterial specific antibody fluorochrome-coupled probe. Utilizing the method of the in... | 05/27/2003 |
| 6555388 | Binding protein capture assay This invention relates to binding protein assays. In particular, this invention relates to binding protein assays for B12 and folate in serum or plasma. More specifically, this invention provides a sequential assay that uses a combination of specific bind... | 04/29/2003 |
| 6548306 | Placental protein 13 The full amino acid and DNA sequences of placental protein 13 (PP13) are disclosed. Also described are various PP13 derived peptide fragments, and a recombinant method for the production of PP13. PP13 may be used in a screening and a diagnostic method for... | 04/15/2003 |
| 6544734 | Multilayered microfluidic DNA analysis system and method A multilayered microfluidic DNA analysis system includes a cell lysis chamber, a DNA separation chamber, a DNA amplification chamber, and a DNA detection system. The multilayered microfluidic DNA analysis system is provided as a substantially monolithic s... | 04/08/2003 |
| 6544749 | Antibodies to leukemia inhibitory factor and their use in immunoassays The invention relates to monoclonal antibodies to human leukemia inhibitory factor. The disclosed monoclonal antibodies are believed to recognize unique epitopes on hLIF and are useful in the treatment of conditions wherein the presence of hLIF causes or ... | 04/08/2003 |
| 6544728 | Methods and kits for diagnosing human immunodeficiency virus type 2 (HIV-2), proteins of HIV-2, and vaccinating agents for HIV-2 A method for diagnosing an HIV-2 (LAV-II) infection and a kit containing reagents for the same is disclosed. These reagents include cDNA probes which are capable of hybridizing to at least a portion of the genome of HIV-2. In one embodiment, the DNA probe... | 04/08/2003 |
| 6541277 | Immunoassay devices and materials An immunochemical assay device comprising a base member, an array disposed on the base member, and at least one assay indicia zone. The array comprises (I) a reservoir pad to receive sample liquid, (ii) a wicking membrane, and (iii) at least one filter zo... | 04/01/2003 |
| 6537760 | Receptor binding assay for detecting TSH-receptor auto-antibodies In a competitive receptor binding assay for detecting TSH-receptor auto-antibodies in a biological sample, the sample is reacted in a reaction mixture which contains (i) a TSH-receptor or TSH-receptor preparation; (ii) a primary competitor, for example la... | 03/25/2003 |
| 6537744 | Use of biomarkers in saliva to evaluate the toxicity of agents and the function of tissues in both biomedical and environmental applications Sensitive methods using a variety of biomarkers in oral saliva of humans and animals to detect, measure, and quantify the presence of infectious and non-infectious agents and the functional status of living tissues in both (1) biomedical and (2) environme... | 03/25/2003 |
| 6534325 | Immunoassay for the detection of amphetamines, methamphetamines and methylenedioxy designer amphetamines The present invention provides an immunoassay method for the highly sensitive detection of amphetamines, methamphetamines, and methylenedioxy designer amphetamines in urine samples. Commercially available reagents for the determination of amphetamines and... | 03/18/2003 |
| 6506885 | Monoclonal antibodies to the drug tilmicosin and a method for detecting the same Hybridoma cell lines have been generated which produce and secrete monoclonal antibodies which selectively bind to tilmicosin. These hybridomas may be obtained by using as an immunization agent or immunogen, 23-deoxo-23-demycinosyl tilmicosin which has be... | 01/14/2003 |
| 6503703 | Identification and use of antiviral compounds that inhibit interaction of host cell proteins and viral proteins required for viral replication The present invention relates to the identification of host cell proteins that interact with viral proteins required for virus replication, and high throughput assays to identify compounds that interfere with the specific interaction between the viral and... | 01/07/2003 |
| 6500625 | Methods for diagnosing cancer or precancer based upon hnRNP protein expression The present invention is a purified and isolated epithelial protein, peptide and variants thereof whose increased presence in an epithelial cell is indicative of precancer. One epithelial protein which is an early detection marker for lung cancer was puri... | 12/31/2002 |
| 6500674 | Method for the diagnosis of brain/neurological disease using monoclonal antibodies specific for PHF-tau, hybridomas secreting them, and antigen recognition by these antibodies and their applications A method for the diagnosis of brain/neurological disease involving abnormally phosphorylated tau protein using at least one antibody chosen from the group consisting of monoclonal antibody AT180 secreted by the hybridoma deposited at ECACC on Dec. 22, 199... | 12/31/2002 |
| 6495352 | Sol-gel method for encapsulating molecules A method for encapsulating organic molecules, and in particular, biomolecules using sol-gel chemistry. A silica sol is prepared from an aqueous alkali metal silicate solution, such as a mixture of silicon dioxide and sodium or potassium oxide in water. Th... | 12/17/2002 |
| 6495376 | Methods and compositions for regulating protein-protein interactions The invention relates to methods and compositions of WW-domains as phosphoserine and phosphothreonine binding modules. The WW-domain containing polypeptides of the invention can be used, for example, to regulate cell growth; to treat neurodegenerative dis... | 12/17/2002 |
| 6495335 | Compositions and methods for diagnosing alzheimer's disease The present invention provides methods and compositions for the diagnosis of Alzheimer's disease. In particular, the present invention provides modified beta-amyloid peptides, antibodies that specifically bind to the modified beta-amyloid peptides, and me... | 12/17/2002 |
| 6495144 | EBNA2 peptides and methods of using same The present invention provides peptides having substantial homology with the CBF1/RBPJk interaction domain of EBNA2. The peptides preferably comprise between about ten and twenty amino acids. The peptides are able to compete with the native EBV EBNA2 prot... | 12/17/2002 |
| 6492185 | Immunoassay for detection of very low density lipoprotein and antibodies useful therefor The present invention provides a method for directly measuring apolipoprotein B-100 (apoB) or cholesterol associated with very low density lipoprotein (VLDL) in a fluid sample. In one embodiment the method involves the specific capture of intact VLDL part... | 12/10/2002 |
| 6492125 | Method to assess library X library interactions Particulate labels that can be individually identified comprise particulate supports to which are bound at least two distinguishable signal-generating moieties, such as fluorophores emitting at different wavelengths, which signals are detectable and measu... | 12/10/2002 |
| 6489131 | Interference reduction by rheumatoid factors The invention concerns a method for the determination of an analyte in which rheumatoid factors or rheumatoid-factor-like substances are added as an interference reducing reagent to reduce of avoid a hook effect. The invention in addition concerns suitabl... | 12/03/2002 |
| 6482600 | Breast cancer associated nucleic acid sequences and their associated proteins This invention relates to the discovery of the association of certain nucleic acid sequences and proteins with breast cancer, the use of such sequences as a diagnostic indicator and treatments based on the association.... | 11/19/2002 |
| 6479302 | Method for the immunological determination of an analyte The invention concerns a method for the immunological determination of an analyte in a sample using magnetic particles coated with the analyte to be determined or analyte-specific bonding partners and directly detectable non-magnetic particles coated with... | 11/12/2002 |
| 6479246 | Competitive binding assay immunoassay for platelet antigens in whole blood A competitive binding assay kit and process for the immunological detection of a blood antigen of specified phenotype (for example phenotypes of human platelet antigen HPA) in a sample of whole blood. The kit contains a substrate having purified blood ant... | 11/12/2002 |
| 6475805 | Method for detection of an analyte A test device, system and method, the device composed of an elongated, toothbrush-shaped, transparent, plastic housing and a lateral-flow test strip for the detection of an analyte, such as a beta-lactam in milk, in the housing, the housing having an expa... | 11/05/2002 |
| 6472228 | Composition and methods for synthesis of novel tracers for detecting amphetamine and methamphetamine in samples This invention relates to novel tracers and their synthesis and use in an immunoassay for the detection of controlled drugs such as amphetamine (APM), methamphetamine (MAPM) and their derivatives, in a biological or aqueous sample. In particular, this inv... | 10/29/2002 |
| 6465194 | Monoclonal antibodies to 4,4'-dinitrocarbanilide and a method for analyzing for the drug nicarbazin Hybridoma cell lines have been generated which produce and secrete monoclonal antibodies which selectively bind to 4,4'-dinitrocarbanilide (DNC), the active agent of nicarbazin. These hybridomas may be obtained by using as an immunization agent or immunog... | 10/15/2002 |
| 6465259 | Non radioactive receptor assay suitable for quantitative and qualitative analysis of trace amounts of receptor binding analyte A method for quantitatively and/or qualitatively assaying an analyte in a sample, wherein the analyte is a receptor binding compound, has low detection limits equivalent to those of radioreceptor assays. The method comprises the steps of a) contacting the... | 10/15/2002 |
| 6465172 | HIV immunogenic complexes comprising GP120 covalently bound to CD4 or concanavalin A A vaccine and a method of raising neutralizing antibodies against HIV infection. The vaccine comprises a complex of gp120 covalently bonded to CD4 or to succinyl concanavalin A. Also disclosed are immunological tests using the complex or antibody thereto ... | 10/15/2002 |
| 6461873 | Caffeine detector The caffeine detector uses a paper chromatographic technique to measure the concentration of caffeine in a beverage. The device includes a well or other receptacle for containing a predetermined test volume of the beverage. A paper strip is suspended so t... | 10/08/2002 |
| 6461828 | Conjunctive analysis of biological marker expression for diagnosing organ failure A diagnostic tool is disclosed for accurately and rapidly diagnosing the condition of an ailing organ. Although applicable to numerous organ and organ systems, this application particularly illustrates the concept of conjunctive marker utilization as it r... | 10/08/2002 |
