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| Number | Title | Issue Date |
| 4307190 | Immunoassay using ascitic fluid A liquid, particularly but not exclusively a liquid of human origin such as blood serum or urine, is immunoassayed for antibodies, antigens or antibody: antigen complexes, using as a reagent in the analysis an active fraction from mouse ascitic fluid. Thi... | 12/22/1981 |
| 4305923 | Method for quantitative analysis for limonin Method for determining the amount of limonin in a sample by subjecting a mixture of the sample and a known amount of a labeled limonin derivative to reaction with limonin-specific antibodies, analyzing to determine the amount of reaction product of antibo... | 12/15/1981 |
| 4302537 | Reagent and method for the determination of peroxidase The present invention provides a method for the determination of peroxidase in the presence of a compound, the enzyme-catalysed oxidation of which with a peroxy compound results in the emission of light, which is measured, wherein 7-dimethylaminonaphthale... | 11/24/1981 |
| 4299812 | Immunoassay of thyroxine in neonates using dried blood samples In the immunoassay of thyroxine using dried blood samples spotted on filter paper, the assay in this invention is run at a pH of 9.2 to 10.0, preferably at about 9.5, rather than the pH range of about 8.4 to 8.7 generally used in the art. The advantage of... | 11/10/1981 |
| 4299815 | Carcinoembryonic antigen determination An improved process for the determination of carcinoembryonic antigen in a sample of serum or plasma is disclosed. The improved process, in essence, comprises negating potentially interfering substances in the sample by diluting the sample with water and ... | 11/10/1981 |
| 4298686 | Method of immunoenzymatic assay utilizing Ɗ5,3-keto-steroid isomerase The invention relates to a novel enzymatic labelling agent for immunoenzymatic assays. The labelling agent is Ɗ5, 3-keto-steroid isomerase. The enzymatic activity bound to the antibody can be revealed advantageously by: (1) direct reading on t... | 11/03/1981 |
| 4298685 | Diagnostic reagent A sample, e.g. serum, containing an antigen, hapten or other biological substance is mixed with antibodies raised against that substance which have been tagged with biotin, and with a known amount of that substance labelled with an enzyme. After the compe... | 11/03/1981 |
| 4292403 | Detection and/or determination of IgM, IgA, IgD and IgE immunoglobulins The present invention relates to (1) a method for the detection and/or determination of an antigen specific immunoglobulin of a peculiar IgX class, in which X means M, A, D or E, comprising: (a) contacting and reacting the test-medium with either insolubi... | 09/29/1981 |
| 4289747 | Immunological determination using lectin A method for the determination of one or more components of an immunological conjugate, e.g., antigens, of a fluid sample in a competitive or sandwich technique in which the conjugate is labelled and separated from its reactive mixture by reversible attac... | 09/15/1981 |
| 4283383 | Analysis of biological fluids Biological fluids, such as serum, are analyzed for the presence, nature and/or amount of antibodies, antigens and antibody:antigen complexes therein using as a reagent, insolubilized rheumatoid factor or insolubilized Clq. These reagents are themselves no... | 08/11/1981 |
| 4280816 | Macroencapsulated immunosorbent assay technique and element therefor A process for the immunoassay of antigens in a biological sample wherein an element comprised of particulate supported antibody loosely encapsulated and confined within a porous filter membrane material is utilized for addition to the biological sample. T... | 07/28/1981 |
| 4277560 | Enzyme immunoassays using immobilized reagents in a flowing stream This invention relates to a method and apparatus for the rapid quantitative determination of an antigen contained in aqueous biochemical samples, for example, blood. The method comprises a series of sequentially arranged stages through which a buffered st... | 07/07/1981 |
| 4267270 | Method for the determination of antigens and antibodies using site-deactivating media An improved immunoassay sample determination process for determining the presence of a component of an antigen-antibody reaction in a sample is disclosed which substantially eliminates non-specific interactions between the sample and the reaction vessel w... | 05/12/1981 |
| 4250253 | Composition adapted for the determination of tri-iodo thyronine and diagnosis method employing same A composition for diagnostic use is disclosed, more particularly for the dosage of tri-iodo thyronine in human blood serum: the subject composition comprises tri-iode thyronine as such and an enzyme which is covalently bonded to tri-iodo thyronine. A diag... | 02/10/1981 |
| 4248965 | Immunochemical process of measuring physiologically active substances Immunochemical measurement by either (1) the reaction of the measurement substance with the insolubilized substance and then the reaction of the reaction product of the first procedure with the labeled substance or (2) the reaction of the measurement subs... | 02/03/1981 |
| 4243749 | Immunoassay employing an enzyme label According to the present invention there is provided a sensitive quantitative assay for the determination of a hapten "X" which comprises: preparing a conjugate of the hapten X which conjugate is adapted to ellicit antibody formation, and injecting a mamm... | 01/06/1981 |
| 4238565 | Specific binding assay with a prosthetic group as a label component A specific binding assay for determining a ligand in a liquid medium employing an organic prosthetic group residue, such as a residue of flavin adenine dinucleotide, flavin mononucleotide, or heme, as a label component in the labeled conjugate. Preferably... | 12/09/1980 |
| 4235960 | Competitive enzyme-linked immunoassay A competitive enzyme-linked immunoassay for a soluble analyte in which the analyte in the unknown sample and the same analyte attached to a solid phase (immunosorbent) compete for a selected quantity of a soluble first antibody to the substance; a second ... | 11/25/1980 |
| 4234680 | Method for terminating a peroxidase catalyzed reaction Addition of a low concentration of an alkali metal metabisulfite completely stops color development in a peroxidase-labeled immunoassay wherein the peroxidase catalyzed reaction comprises oxidation of an achromatic substrate to the corresponding chromatic... | 11/18/1980 |
| 4228237 | Methods for the detection and determination of ligands A method for determining the presence of a ligand in a liquid medium which utilizes enzyme labeled avidin and biotin labeled reagent in a specific binding process wherein the ligand to be detected is contacted with an insoluble phase containing specific b... | 10/14/1980 |
| 4214048 | Reagent suitable for enzyme immuno assay A novel maleimidobenzoic acid N-hydroxysuccinimide ester of the formula: ##STR1## which is suitable as a binding agent for binding an enzyme and an antigen to give an enzyme-labeled antigen of the formula: ##STR2## wherein X and Y are different ... | 07/22/1980 |
| 4185084 | Immunochemical measuring method using second antigenic substance An immunochemical measuring method using a second antigenic substance and a labeled antibody to the second antigenic substance. An unknown amount of an antigen (Ag 1) to be measured and a given amount of a conjugate (Ag 1-Ag 2) coupled a second antigen (Ag 2) ... | 01/22/1980 |
| 4169012 | Stabilized peroxidase reagent for enzyme immunoassay New and useful stable peroxidase compositions are disclosed which are particularly useful as reagents in enzyme immunoassay (EIA) tests. The novel peroxidase compositions contain polyvalent ions of groups 3 and 4 of the Periodic Table. These novel composi... | 09/25/1979 |
| 4166767 | Insolubilized antibody An insolubilized antibody suitable for an enzyme immuno assay or radio immuno assay, which has characteristic infrared absorptions at around 1,040 cm-1, 1,540 cm-1 and 1,640 cm-1 and is prepared by chemically binding an an... | 09/04/1979 |
| 4143124 | Antigen-antibody analysis with solid phase RF and C1q Biological fluids, such as serum, are analyzed for the presence, nature and/or amount of antibodies, antigens and antibody:antigen complexes therein using as a reagent, insolubilized rheumatoid factor or insolubilized C1q. These reagents are themselves no... | 03/06/1979 |
| 4141687 | Automatic apparatus and method for the assay of fluid samples Method and apparatus suitable for automatic assay of fluid samples, particularly immunoassays, in which a reaction product of the assay is bound to a magnetically attractable particle and separated from the reaction mixture by use of a magnetic trap. The ... | 02/27/1979 |
| 4133639 | Test article including a covalently attached diagnostic reagent and method A body suitable for use in the quantitative detection of an unknown quantity of a biologically derived sample suitably by radioimmunoassay, fluorometric detection, or by spectrophotometry. The body includes a handle attached to a nonparticulate, nonswella... | 01/09/1979 |
| 4128628 | Automated immunoassay An automated immunoassay apparatus which provides: time controlled incubation of a multiplicity of sample solutions, each of which comprise a mixture of (a) a sample, possibly containing an antigen or antibody intended to be assayed; (b) a solution of a k... | 12/05/1978 |
| 4111754 | Immunological testing devices and methods A self-supporting plastic structure having a plurality of through-passages, each passage being of cross-sectional shape and area such that walls thereof provide a large amount of surface area relative to a substantially small amount of space cross-section... | 09/05/1978 |
| 4069352 | Immunoadsorbent polymeric material and method of making same Gamma globulins from antisera having a titer so low in selected antibodies that the antibodies adsorbed on a surface of polymeric material are ineffective for use in immunoassay, are cross-linked, then adsorbed on the polymeric surface to provide an immun... | 01/17/1978 |
| 4017597 | Unitized solid phase immunoassay kit and method A unitized solid phase kit for radioimmunoassay is disclosed. All of the necessary assay reagents are incorporated in a single tube wherein all phases of the assay procedure are performed, requiring only the addition of the patient's sample. Antibody is b... | 04/12/1977 |
