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| Number | Title | Issue Date |
| 6346390 | Receptor derived peptides involved in modulation of response to ligand binding Oligopeptides having an amino acid sequence corresponding to a receptor's extracellular domain, and having sequence similarity to regulatory peptides from MHC class I antigens, enhance the physiological response of ligand binding to the corresponding rece... | 02/12/2002 |
| 6344338 | Deposit assessment of Bacillus thuringiensis delta-endotoxin The invention relates to an immunochemical method for detecting deposit of Bacillus thuringiensis delta-endotoxin or pesticidally-active fragment thereof on a plant or tree. The invention further relates to kits for using such a method.... | 02/05/2002 |
| 6344333 | Reagent-free immunoassay monitoring electrode assembly The present invention relates to an apparatus to perform reagent-free assays, which apparatus utilizes an all solid probe having an enzyme label that acts on a substrate by obtaining electrons directly from the electrode by bioelectrocatalysis.... | 02/05/2002 |
| 6344331 | Water immiscible solvent based binding systems A biphase immunoassay method is provided in which a water immiscible liquid is qualitatively or quantitatively measured by mixing a sample of the water immiscible liquid with an aqueous solution containing a specific binding partner of the analyte. Bindin... | 02/05/2002 |
| 6344326 | Microfluidic method for nucleic acid purification and processing Integrated microfluidic devices comprising at least an enrichment channel (10) and a main electrophoretic flowpath (12) are provided. In the subject integrated devices, the enrichment channel and the main electrophoretic flowpath are positioned so that wa... | 02/05/2002 |
| 6342396 | Method for isolating, in particular for detecting or quantifying an analyte in a medium The present invention relates to a method for at least one of detecting, quantifying or isolating at least one analyte from a liquid medium in which the analyte is distributed and comprises providing a reagent comprised of particles having a receptor for ... | 01/29/2002 |
| 6342395 | Compact assay system with digital information A compact assay system having a solid support has at least one capture binding agent on the support surface. By applying a combination of different binding agents on the support surface, the present invention can conduct multiple chemical reactions on the... | 01/29/2002 |
| 6342361 | Method of assaying collagen fragments in body fluids, a test kit and means for carrying out the same A method of assaying type II collagen fragments in body fluids, including bringing a sample of body fluid in contact with at least one immunological binding partner for the collagen fragments, said binding partner being immunoreactive with synthetic pepti... | 01/29/2002 |
| 6342348 | Neurturin receptor NTNR, NTNR extracellular domain (ECD), NTNR variants, chimeric NTNR (e.g., NTNR immunoadhesin), and antibodies which bind thereto (including agonist and neutralizing antibodies) are disclosed. Various uses for these mole... | 01/29/2002 |
| 6326214 | Immunity testing device An immunity testing device formed of a thin sheet of material folded to three portions, and the two end portions; named "front cover"0 and "back cover"; fold back to different sides of the center part; named base seat; to provide protection on both sides ... | 12/04/2001 |
| 6323042 | Microcapillary-based flow-through immunosensor and displacement immunoassay using the same A displacement-type flow immunoassay is performed using a microcapillary passage. The inner wall of the microcapillary passage has immobilized thereon antibodies to the antigen of interest. Labeled antigen is immunologically bound to the immobilized antib... | 11/27/2001 |
| 6322992 | Method for the determination of a specific binding ligand using a vanadium bromoperoxidase as a signal-generating enzyme An analytical element can be used to sensitively and rapidly detect a wide variety of specific binding ligands in either a competitive or sandwich assay format. The assays are carried out using a vanadium bromoperoxidase-labeled immunoreactant and a chemi... | 11/27/2001 |
| 6319676 | Diagnostic detection device and method The invention provides an improved test cell for detecting the presence of an analyte in a liquid sample. The device has an elongate casing defining a liquid sample inlet, a reservoir volume, a test volume, and a window through the casing at the test volu... | 11/20/2001 |
| 6319665 | Home test kit and method with telephone verification of results Self-testing for a disease or physiological condition is achieved by having the individual being tested obtain a sample of physiological fluid, e.g., blood, urine, sputum or saliva, from him or herself. The sample is introduced into an assay system which ... | 11/20/2001 |
| 6316205 | Assay devices and methods of analyte detection Assay devices, kits, and methods for detection of one or more analytes in a sample are provided. The assay device features the controlled release of reagents and hence is particularly suitable for binding assays such as immunoassays. The assay device achi... | 11/13/2001 |
| 6312901 | Spatially addressable, cleavable reflective signal elements, assay device and method A cleavable signal element for use in quantitative and qualitative assay devices and methods is described. Binding of the chosen analyte simultaneously to a first and a second analyte-specific side member of the cleavable signal element tethers the signal... | 11/06/2001 |
| 6309888 | Detection and determination of the stages of coronary artery disease A method having clinically sufficient degree of diagnostic accuracy for detecting the presence of coronary artery disease in a human patient from the general population and for distinguishing between the stages of the disease in that patient is disclosed.... | 10/30/2001 |
| 6309832 | Method to detect IgE The present invention includes a method to detect IgE using a human Fc epsilon receptor (Fc&3xb5; R) to detect IgE antibodies in a biological sample from a cat, a dog, or a horse. The present invention also relates to kits to perform such metho... | 10/30/2001 |
| 6309844 | Anti-apo-B-48 monoclonal antibody, hybridoma producing the same, and method for measuring apo-B-48 using the same A novel monoclonal antibody which specifically binds to apo-B-48 is disclosed. The monoclonal antibody specifically binds to apo-B-48 but does not bind to apo-B-100.... | 10/30/2001 |
| 6306616 | Adsorption type confirmatory assays The invention relates to an assay system for the improved detection of analytes, and the ability to distinguish them from cross-reacting substances. Samples giving a positive reaction in a direct assay test are treated with a neutralizing antibody that in... | 10/23/2001 |
| 6303361 | Human glandular kallikrein-1 (hK2) A new form of human glandular kallikrein-1 (hK2) found from cloning a prepro-hK2 cDNA from a human protrate cancer tissue cDNA library. The new form differs in sequence from the prior art form in that Arg226 is substituted by Trp. A baculovirus... | 10/16/2001 |
| 6303325 | Method for detecting analytes The invention relates to methods of determining the presence or amount of an analyte in a sample suspected of containing the analyte, said method comprising the steps of: (a) bringing together in an aqueous medium to form a mixture: (i) the sample; (ii) a... | 10/16/2001 |
| 6300143 | Electrochemiluminescent assays for eukaryotic cells Disclosed are immunomagnetic electrochemiluminescence assays for eukaryotic cells, particularly human cells. A competitive binding assay is disclosed which enables affinity measurements of antibodies specific for eukaryotic cell membrane proteins. Such an... | 10/09/2001 |
| 6300141 | Card-based biosensor device A diagnostic card device for use in detecting or quantitating an analyte present in a liquid sample, comprising a card substrate having a sample introduction region, a biosensor, and a sample-flow pathway communicating between the sample-introduction regi... | 10/09/2001 |
| 6300083 | Assaying D-amino acids in body fluids The rate of degradation in vivo of a body protein is determined by measuring the amount of a D-amino acid containing fragment of the protein in a body fluid using an antibody capable of discriminating between the D-amino acid containing fragment and its L... | 10/09/2001 |
| 6284472 | Method for extending the range of an immunoassay Calibrating an immunoassay by generating two reaction rate measuring curves, from samples having higher and lower relative levels of antigen, extrapolating a combination of the curves to cover sample concentrations known to contain an excess of antigen re... | 09/04/2001 |
| 6281004 | Quality control for cytochemical assays The invention describes quality control devices for assays that measure analytes in cells and tissue samples, and methods of use thereof. In particular, the quality control device comprises a matrix affixed with synthetic controls in different concentrati... | 08/28/2001 |
| 6277964 | Anti-PAH monoclonal antibodies and cell lines producing the same The present invention provides monoclonal antibodies suitable for monitoring polycyclic aromatic hydrocarbons (PAHs) by an immunoasay, hybridoma cell lines producing said antibodies, and an immunoassay for analyzing PAHs in a sample using said monoclonal ... | 08/21/2001 |
| 6274334 | Monoclonal antibody, cell line and immunoassay for ractopamine A hybridoma cell line has been produced for secreting a monoclonal antibody that binds ractopamine and is effective to detect ractopamine levels of about 1 ng/mL or lower. This monoclonal antibody may be used for the detection and quantitative determinati... | 08/14/2001 |
| 6274329 | Method for the detecting thyroid autoantibodies Method for the determination of thyroid autoantibodies Method for the determination of thyroid autoantibodies in a biological sample obtained from a patient in the differential diagnosis of diseases which are associated with changes of the thyroid and/or ... | 08/14/2001 |
| 6270985 | ELISA serodiagnosis of pig pleuropneumonia serotypes 5a and 5b The present invention relates to an ELISA diagnostic kit for the assay of A. pleuropneumoniae serotypes 5a and 5b antibodies in the serum of pigs comprising in separate packaging, at least one of the following: a) a plate or solid support having bound the... | 08/07/2001 |
| 6268160 | Method of screening for anti-malarial compounds The plastid DNA of the malaria parasite Plasmodium falciparum has been sequenced and found to contain a gene encoding an EF-Tu protein. Inhibitors of the protein are effective as anti-malarial compounds and the protein can be used to screen for such inhib... | 07/31/2001 |
| 6265227 | Method for assaying antigen related to disorders caused by mental stress The invention relates to the development of a method for assaying an antigen which is associated with disorders caused by mental stress in a human body fluid by way of an immunoassay technique which utilizes an antibody against a mental stress related pro... | 07/24/2001 |
| 6258551 | Method for carrying out an immunoassay in a multiphase system The present invention relates to a method of carrying out an immunoassay in a multiphase system. A sample containing an analyte is brought into contact with a receptor A and a tracer. The analyte can either form a complex with the tracer, or counteract th... | 07/10/2001 |
| 6258548 | Single or multiple analyte semi-quantitative/quantitative rapid diagnostic lateral flow test system for large molecules Lateral flow device and method are provided for performing semi-quantitative visual or instrument-based detection in a test sample of a large molecule analyte that contains two binding domains, and ଲ. The device contains two reagents, a cont... | 07/10/2001 |
| 6258363 | Varicella zoster virus (VZV) immunoreactive protein VP26 and its diagnostic use Varicella zoster virus (VZV) immunoreactive protein VP26 and its diagnostic use are described. The invention relates to immunoreactive peptides which are homologous with the region of amino acid positions 12 to 235 of the varicella zoster virus protein VP... | 07/10/2001 |
| 6254830 | Magnetic focusing immunosensor for the detection of pathogens A magnetic focusing immunosensor for the detection of pathogens comprising a laser, an exciting fiber and a collecting fiber, a fiber optic magnetic probe in communication with the collecting and exciting fibers and means for detecting, collecting and mea... | 07/03/2001 |
| 6248598 | Immunoassay that provides for both collection of saliva and assay of saliva for one or more analytes with visual readout A device that provides for both the collection of saliva and detection of at least one analyte therein, e.g., a drug, is provided. This device provides for rapid analysis of saliva samples, while also providing a convenient assay method that does not requ... | 06/19/2001 |
| 6248229 | Detection of analytes using reorganization energy The invention relates to novel methods and compositions for the detection of analytes using the nuclear reorganization energy, λ, of an electron transfer process.... | 06/19/2001 |
| 6238875 | Diagnostic methods useful in the characterization of lymphoproliferative disease characterized by increased EPR-1 A new class of cellular receptors extensively homologous but not identical to coagulation factors V and VIII is identified. These new cell surface receptors are designated effector cell protease receptors (EPRs) and include EPR-1, which is shown to bind p... | 05/29/2001 |
