Did You Know...
...that several people are credited with the invention of the flush toilet? Most people have heard of Thomas Crapper (1837-1910), the sanitary engineer who invented the valve-and-siphon arrangement that made the modern toilet possible. Another claimant to "the throne" was British inventor Alexander Cumming who patented a toilet in 1775. Then there's a nameless Minoan (a native of ancient Crete) who lived 4,000 years ago who supposedly was ahead of his time and created the first flush toilet!
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| Number | Title | Issue Date |
| 8293492 | Lenalidomide and thalidomide immunoassays Novel conjugates and immunogens derived from lenalidomide and antibodies generated by these immunogens are useful in immunoassays for the quantification and monitoring of thalidomide and lenalidomide in biological fluids. ... | 10/23/2012 |
| 8173382 | Assay for cardiac troponin autoantibodies The invention provides among other things methods and kits based on assaying for cardiac troponin autoantibodies, either in conjunction with an assay for cardiac troponin and/or as an independent indicator of cardiac pathology, such as myocarditis, cardiomyopathy, a... | 05/08/2012 |
| 8133694 | Functional vitamin D derivatives and method of determining 25-hydroxy- and 1α, 25-dihydroxy vitamin D The preparation of vitamin D compounds of formula (I) with a label attached to a spacer group in the 3 position is disclosed. In the above formula (I), O represents the oxygen atom of an ether group; Y represents hydrogen o... | 03/13/2012 |
| 8133695 | Fluorescence polarization hERG assay Disclosed are assays, methods, and kits for the screening of test compounds for their capability to induce cardiotoxicity in a subject. In particular, whether a test compound has the effect to prolong the Q-T interval as measured by an electrocardiogram in a human. ... | 03/13/2012 |
| 8114621 | Lenalidomide and thalidomide immunoassays Novel conjugates and immunogens derived from lenalidomide and antibodies generated by these immunogens are useful in immunoassays for the quantification and monitoring of thalidomide and lenalidomide in biological fluids. ... | 02/14/2012 |
| 8088594 | Risperidone immunoassay Novel conjugates and immunogens derived from risperidone and antibodies generated by these immunogens are useful in immunoassays for the quantification and monitoring of risperidone and paliperidone in biological fluids. ... | 01/03/2012 |
| 8076097 | Imatinib immunoassay Novel conjugates and immunogens derived from imatinib and monoclonal antibodies generated by these immunogens are useful in immunoassays for the quantification and monitoring of imatinib or its pharmacologically active salts in biological fluids. ... | 12/13/2011 |
| 8053205 | Doxorubicin immunoassay Novel conjugates of doxorubicin and novel doxorubicin immunogens derived from the 13 and 14 positions of doxorubicin and antibodies generated by these doxorubicin linked immunogens all of which are useful in immunoassays for the quantification and monitoring of doxo... | 11/08/2011 |
| 7993869 | Method for detecting gluten Provided is a mAb-based method for the detection of T cell stimulatory epitopes known to be involved in CD. The method has many advantages compared to the existing methods for the detection of gluten since it is the first method that can; (i) detect T cell stimulato... | 08/09/2011 |
| 7947465 | Simultaneous assay for determining drugs Bodily fluid is analyzed for the presence of drugs of a selected panel of drugs in a simultaneous assay in which sample of the fluid is incubated with additional amounts of all drugs of the panel, antibodies specific to each of the drugs of the panel, and microparti... | 05/24/2011 |
| 7749723 | Universal readout for target identification using biological microarrays A method and apparatus for implementing the method is provided. The method involves performing an indirect competitive binding assay on a microarray to identify biological or chemical targets and screen for compounds of interest. The microarray comprises a common li... | 07/06/2010 |
| 7745162 | Compositions and methods for measuring levels of bioactive human hepcidin The invention provides compositions and methods for measuring human serum hepcidin levels. The invention provides methods for the oxidative refolding of a hepcidin polypeptide to a form that is mature, bioactive and folded as in the native configuration and molecula... | 06/29/2010 |
| 7732160 | Methamphetamine derivatives and conjugates for immunoassay Compounds of methamphetamine derivatives having a meta-substituted alkyl linker on the benzene ring and a protective group on the nitrogen of the methamphetamine hapten. Such compounds have the structure. wherein R1 | 06/08/2010 |
| 7723063 | Methods for measuring levels of bioactive human hepcidin The present invention concerns a method for the oxidative refolding of a hepcidin polypeptide to a form that is mature, bioactive and folded as in the native configuration and molecular mass; a method for measuring the level of native, bioactive hepcidin in a verteb... | 05/25/2010 |
| 7678551 | Immunoassays for lamotrigine Generally, the present invention relates to lamotrigine analogs that have substituents at the triazine 3-position and on the benzene 4-position and 5-position. The lamotrigine analogs can include immunogenic moieties that can be used to prepare anti-lamotrigine anti... | 03/16/2010 |
| 7655429 | Immunoassays for topiramate Topiramate analogs have substituents at the sulfamate group, 9-position, or 10-position. Topiramate analogs may include immunogenic moieties to prepare anti-topiramate antibodies, or antigenic moieties for immunodiagnostic assays. Also, the topiramate analog can inc... | 02/02/2010 |
| 7655428 | Latent protein C assays and their uses for diagnosis and/or prognosis in systemic inflammatory response syndromes The present invention relates to methods and compositions for measuring latent protein C in test samples, particularly patient samples. The methods and compositions described are sensitive for latent protein C, relative to activated protein C. ... | 02/02/2010 |
| 7638291 | Immunoassays for topiramate Generally, the present invention relates to topiramate analogs that have substituents at the sulfamate group or at the 9-position or 10-position. The topiramate analogs can include immunogenic moieties that can be used to prepare anti-topiramate antibodies, or antig... | 12/29/2009 |
| 7569358 | Doxorubicin immunoassay Novel conjugates of doxorubicin and novel doxorubicin immunogens derived from the 13 and 14 positions of doxorubicin and antibodies generated by these doxorubicin linked immunogens all of which are useful in immunoassays for the quantification and monitoring of doxo... | 08/04/2009 |
| 7566549 | Immunoassay for LSD and 2-oxo-3-hydroxy-LSD The present invention provides hapten derivatives useful for the preparation of antigens, antibodies and reagents for use in immunoassays for the detection of LSD and 2-oxo-3-hydroxy LSD. In the present invention, the 2-oxy LSD nucleus is derivatized out of the indo... | 07/28/2009 |
| 7459281 | Docetaxel immunoassay Novel conjugates of docetaxel and novel docetaxel immunogens derived from the 7 and 10 positions of docetaxel and monoclonal antibodies generated by these docetaxel linked immunogens are useful in immunoassays for the quantification and monitoring of docetaxel in bi... | 12/02/2008 |
| 7442514 | Mutants of the factor VII-activating protease and detection methods using specific antibodies Mutants of the DNA sequence coding for the protease (FSAP) which activates blood clotting factor VII and single-chain plasminogen activators, the mutants comprising a G/C base exchange at nucleotide position 1177 and/or a G/A base exchange at nucleotide position 160... | 10/28/2008 |
| 7442516 | Antibody specific to central nervous system tau protein The present invention provides an antibody which specifically recognizes a CNS tau protein but not a peripheral tau protein. More specifically, the present invention provides an antibody obtainable by using a polypeptide comprising an amino acid sequence of a connec... | 10/28/2008 |
| 7432046 | Methods for the determination of antibody IgG avidity The present invention relates to methods of determining anti-infectious agent IgG avidity, for example, human anti-cytomegalovirus and human anti-toxoplasma IgG avidity, using a competitive assay format. ... | 10/07/2008 |
| 7429357 | Apparatus, system, and method of detecting an analyte utilizing pyroelectric technology A system for the measurement of a target analyte is provided including a detection apparatus and a reading apparatus. The detection apparatus, or “carrier”, includes a pyroelectric transducer (“pyroelectric film”) and one or more reagent concentrations (“r... | 09/30/2008 |
| 7429458 | Methods of using bioelastomers Bioelastomers are disclosed for use in methods of binding compounds including immunoassay methods, in biosensors and methods or regenerating biosensors, and in methods for targeting the delivery of a compound to a particular location within an animal subjects. In ge... | 09/30/2008 |
| 7425310 | Apparatus, system, and method of detecting an analyte utilizing pyroelectric technology A system for the measurement of a target analyte is provided including a detection apparatus and a reading apparatus. The detection apparatus, or “carrier”, includes a pyroelectric transducer (“pyroelectric film”) and one or more reagent concentrations (“r... | 09/16/2008 |
| 7423131 | Busulfan immunoassay Novel conjugates of busulfan and novel busulfan immunogens derived from α-substituted derivatives of busulfan and antibodies generated by these busulfan linked immunogens are useful in immunoassays for the quantification and monitoring of busulfan in biological flu... | 09/09/2008 |
| 7416855 | Immunoassay methods for detecting interleukin-1 β converting enzyme like apoptosis protease-3 Disclosed are human interleukin-1 β converting enzyme like apoptosis proteases-3 and 4 and DNA (RNA) encoding such polypeptides. Also provided is a procedure for producing such polypeptides by recombinant techniques and antibodies and antagonists against such polyp... | 08/26/2008 |
| 7410807 | Pregnancy and sex identification test based on saliva or other bodily fluids A method of testing an animal for pregnancy or sex identification comprising the steps of first, providing a first vessel containing a liquid and having a removable surface wherein said removable surface is at least partially coated with an antibody and then introdu... | 08/12/2008 |
| 7390627 | Assays, antibodies, and standards for detection of oxidized and MDA-modified low density lipoproteins Immunoassays for malondialdehyde-modified low density lipoprotein (MDA-modified LDL) and oxidized low density lipoprotein (OxLDL), monoclonal antibodies (and the cell lines for them) for use in the assays, and a storage-stable standard (which may be used as a calibr... | 06/24/2008 |
| 7390628 | Microparticle-based diagnostic methods The present invention concerns novel materials and methods to detect low frequency surface changes utilizing modified microspheres. Upon exposing the surface to the modified microspheres of the subject invention, the microspheres selectively adhere to any targeted s... | 06/24/2008 |
| 7390626 | Methods and kit for diagnosing tick borne illnesses ELISA, Western Blot, and a peptide-based ELISA were applied to clinical specimens from patients with clinical symptoms of tick borne diseases, including Lyme disease. Peptides from different components of Borrelia during different cycles, including peptides f... | 06/24/2008 |
| 7374891 | Methods to identify compounds that modulate rage Provided are methods to detect of modulators of the Receptor for Advanced Glycated Endproducts (RAGE). The invention comprises a method for detection of RAGE modulators comprising: adsorbing a RAGE ligand onto a solid surface; adding a compound of interest and a pro... | 05/20/2008 |
| 7374950 | Immunoassay device for diagnosing congestive heart failure and predicting mortality in congestive heart failure patients An immunochemical assay device for determining the presence of NT-proBNP alone or conjunctively with Cardiac Troponin I comprising a base member, an array disposed on the base member, and at least one assay indicia zone. The array comprises (i) a reservoir pad to re... | 05/20/2008 |
| 7368543 | Diagnosis and treatment of hepatic disorders The present invention encompasses methods and compositions useful in diagnosing and treating hepatic disorders, especially those characterized by inflammation. The method comprises administration of an agent which prevents the interaction of MAdCAM with a MAdCAM bin... | 05/06/2008 |
| 7368277 | Method for assay of antibodies and antibody assay device The invention relates to a technology by which antibodies directed to sources of infection in body fluids can be assayed with high accuracy, expediency and specificity. More particularly, the invention provides an antibody immunoassay method in which the antigen-ant... | 05/06/2008 |
| 7361481 | Diagnosis of lysosomal storage disorders using saposins and other markers Methods for assaying a lysosomal enzyme activity present in a blood sample obtained from a patient. The method combines the blood or plasma sample in a buffer with at least one binding reagent capable of reacting with alpha-glucosidase present in the blood sample to... | 04/22/2008 |
| 7358096 | Immobilisation of proteins The immobilization of proteins at solid surfaces facilitated by incorporation of a polypeptide segment which is capable of adopting a folded structure is described. Materials comprising proteins so immobilized and uses thereof are also described. ... | 04/15/2008 |
| 7358225 | Cloning and recombinant production of CRF receptor(s) In accordance with the present invention, there are provided novel G-protein-coupled receptor proteins (CRF-R) characterized by having sufficient binding affinity for corticotropin releasing factor (CRF) such that concentrations of £ 10 nM of CRF occupy 3 | 04/15/2008 |
