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| Number | Title | Issue Date |
| 8148095 | Methods for predicting psychotropic drugs which elicit weight gain The atypical antipsychotic drugs (AAPDs) have markedly enhanced the treatment of schizophrenias but their use has been hindered by the major weight gain elicited by some AAPDs. We found that orexigenic AAPDs potently and selectively activate hypothalamic AMP kinase ... | 04/03/2012 |
| 8008034 | Reducing optical interference in a fluidic device This invention is in the field of medical devices. Specifically, the present invention provides portable medical devices that allow real-time detection of analytes from a biological fluid. The methods and devices are particularly useful for providing point-of-care t... | 08/30/2011 |
| 8003341 | Method of amplifying ATP and use thereof The ATP amplification method is a method for amplifying and detecting a very trace amount of exogenous ATP by allowing a fusion protein (PPK-ADK) of a polyphosphate kinase and an adenylate kinase, the fusion protein not containing ADP, to act on a mixture of ATP, AM... | 08/23/2011 |
| 7964370 | Analytical strip and detecting method using the same An analytical strip and a detecting method using the analytical strip are provided. The analytical strip includes a substrate having a channel thereon. The channel has a first region, a second region and a third region, which are connected sequentially. A first anti... | 06/21/2011 |
| 7745160 | Method of amplifying ATP and use thereof The ATP amplification method of the present invention is a method for amplifying and detecting a very trace amount of exogenous ATP by allowing a fusion protein (PPK-ADK) of a polyphosphate kinase and an adenylate kinase, the fusion protein not containing ADP, to ac... | 06/29/2010 |
| 7745161 | Amplification of enzymatic reactions for use with an enthalpy array Provided is a method of detecting characteristics of a reaction of interest, including instituting the reaction of interest, obtaining an amplified heat related to the reaction of interest, measuring the amplified heat, and determining the characteristics of the rea... | 06/29/2010 |
| 7723058 | Test system for the determination of in-vivo active hemostasis proteases in biological fluids and/or the usage thereof to determine the in-vivo activation of hemostasis The present invention describes a test system for the determination of in-vivo active hemostasis proteases in biological fluids and the use thereof to determine the in-vivo activation of hemostasis or to diagnose pancreatitis. EDTA and/or EGTA is added to the biolog... | 05/25/2010 |
| 7723057 | Screening assay for macromolecules that inhibit binding of sulfated glycosaminoglycan to beta amyloid A screening assay for selecting macromolecules that interfere with the binding of a sulfated GAG to beta amyloid, the assay comprising affixing a sulfated GAG to a substrate, co-incubating the macromolecule and a known amount of beta amyloid with the sulfated GAG, d... | 05/25/2010 |
| 7632652 | Enzyme-catalyzed metal deposition for the enhanced in situ detection of immunohistochemical epitopes and nucleic acid sequences The invention is directed to novel compositions of matter and methods of detecting in situ an immunohistochemical epitope or nucleic acid sequence of interest in a biological sample comprising binding an enzyme-labeled conjugate molecule to the epitope or sequence o... | 12/15/2009 |
| 7407764 | Plasma C5A levels as an indicator of asthma severity This invention provides the first blood test which characterizes asthma severity. More specifically, the present invention provides methods of determining the severity of acute asthma in a patient by determining the levels of C5a or C5a-desArg in the patient's blood... | 08/05/2008 |
| 7396658 | Methods for screening HIF like ouabain-resistant Na—K-ATPase agents The present invention relates to rapid, quantitative, specific, high through-put methods for screening test substances for their ability to inhibit activity of an ouabain-resistant Na+—K+-ATPase involved in a variety of biological processes s... | 07/08/2008 |
| 7374902 | Enzyme cycling based assays for alpha-methylacyl-CoA racemase The present invention provides a method for assaying alpha-methylacyl-CoA racemase activity. In the assay, a sample containing an alpha-methylacyl-CoA racemase or suspected of containing an alpha-methylacyl-CoA racemase is contacted with (2R)-2-methylacyl-CoA. If al... | 05/20/2008 |
| 7374897 | Enzyme cycling based assays for alpha-methylacyl-CoA racemase The present invention provides a method for assaying alpha-methylacyl-CoA racemase activity. In the assay, a sample containing an alpha-methylacyl-CoA racemase or suspected of containing an alpha-methylacyl-CoA racemase is contacted with (2R)-pristanoyl-CoA. If alph... | 05/20/2008 |
| 7371544 | Homogenous method for the detection of a polynucleotide, with e.g. cleavable lanthanide chelate label The present invention relates to a homogenous method for detecting at least one target polynucleotide in a sample comprising the steps of contacting a sample comprising said polynucleotide or polynucleotide forming nucleic acids or... | 05/13/2008 |
| 7361485 | Method for the detection of proteolytic enzymes The present invention provides an improved protease assay in which the proteases are detected on basis of their capability to cleave a modified pro-caspase which will yield an activated caspase which can then further be detected. Also part of the invention are the m... | 04/22/2008 |
| 7354733 | Method for sorting and separating living cells We disclose methods of sorting or separating mixtures of living cells (e.g., eukaryotic, prokaryotic, mammalian, pathogenic, bacterial, viral, etc.). We perform our methods by activating cell-selective photophoric labels, which photosensitize and chemically reduce a... | 04/08/2008 |
| 7355079 | Thyronamine derivatives and analogs and methods of use thereof Thyronamine derivatives and analogs, methods of using such compounds, and pharmaceutical compositions containing them are disclosed. Methods of preparing such compounds are also disclosed. ... | 04/08/2008 |
| 7354776 | Method of processing and testing powdered samples using immunochromatographic strip tests A method and kit for processing and testing powdered samples are provided herein. The powdered sample is combined with a fluid to produce a slurry or liquid suspension, and the slurry is contacted with an immunochromatographic test strip containing detectable reagen... | 04/08/2008 |
| 7354725 | Kinase peptides and antibodies The invention relates to novel kinase peptides and antibodies, as well as nucleic acids related to them. The peptides, antibodies and the nucleic acids are useful for the detection, staging and monitoring of the progression of a kinase-mediated disease, as well as f... | 04/08/2008 |
| 7348147 | Method and system for nucleic acid detection The present invention relates to a method of detecting nucleic acids comprising suspending at least one recognizable target nucleic acid in a suspending solution containing polymeric particles marked with a probe, wherein the probe has an affinity for the target nuc... | 03/25/2008 |
| 7344849 | Assay The present invention relates to assay methods for the determination of cobalamin or vitamin B12 in a body fluid and in particular to assay methods for the metabolically active pool of cobalamin, comprising contacting a cell free sample of a body fluid wi... | 03/18/2008 |
| 7321065 | Thyronamine derivatives and analogs and methods of use thereof Thyronamine derivatives and analogs, methods of using such compounds, and pharmaceutical compositions containing them are disclosed. Methods of preparing such compounds are also disclosed. ... | 01/22/2008 |
| 7316908 | Peptides from the E2 proteins of human papillomaviruses 16 and 18 for detecting and/or diagnosing cervical and other human papillomavirus associated cancers An isolated protein sequence or peptide from the E2, E6 or E7 early coding region of human papillomavirus (HPV) that is soluble in an aqueous medium, and characterized by a relative paucity of tryptophan, methionine and cysteine residues, and a relative abundance of... | 01/08/2008 |
| 7314709 | Compositions and methods for detecting and quantifying COX-2 activity by lipoamino acid metabolism A method of detecting an activity of a COX-2 enzyme in a subject that includes obtaining a sample of the subject; detecting an amino acid eicosanoid metabolite in the sample, wherein the presence of the amino acid eicosanoid metabolite indicates the activity of the ... | 01/01/2008 |
| 7300633 | Specimen collection container The present invention recognizes that sample handling devices, particularly those used for testing for substances of abuse, do not allow for a separation of the bulk sample from a sample thereof to be tested. The present invention provides such a device and methods ... | 11/27/2007 |
| 7294471 | Method for purifying cancer-specific proliferating cell nuclear antigen A method for purifying cancer-specific Proliferating Cell Nuclear Antigen (csPCNA) is described, as well as an immunoassay based thereon. ... | 11/13/2007 |
| 7279287 | Analytical method The instant invention describes an analytical assay to accurately measure an analyte in the presence of an interfering substance. ... | 10/09/2007 |
| 7279295 | Allergen The present invention relates to a novel allergen from timothy grass (Phleum pretense) pollen, Phl p11 as disclosed in SEQ ID NO:2, and use thereof as a reagent and in a diagnositic kit as well as for immunotherapy. ... | 10/09/2007 |
| 7276373 | Surrogate cell-based system and method for assaying the activity of hepatitis C virus NS3 protease The present invention concerns the development of a cell-based assay system having improved sensitivity to HCV NS3 protease activity when compared to known assays, which is useful for screening test compounds capable of modulating (particularly inhibiting) HCV NS3 p... | 10/02/2007 |
| 7270959 | Specimen collection container The present invention recognizes that sample handling devices, particularly those used for testing for substances of abuse, do not allow for a separation of the bulk sample from a sample thereof to be tested. The present invention provides such a device and methods ... | 09/18/2007 |
| 7270970 | Point of care diagnostic systems Systems and methods for medical diagnosis or risk assessment for a patient are provided. These systems and methods are designed to be employed at the point of care, such as in emergency rooms and operating rooms, or in any situation in which a rapid and accurate res... | 09/18/2007 |
| 7267939 | Detection of analytes using reorganization energy The invention relates to novel methods and compositions for the detection of analytes using the nuclear reorganization energy, λ, of an electron transfer process. ... | 09/11/2007 |
| 7267957 | Detection and amplification of ligands A system for the detection of ligands comprising at least one receptor and an amplification mechanism coupled to the receptor wherein an amplified signal is produced as a result of receptor binding a ligand. Examples of suitable amplification mechanisms include anti... | 09/11/2007 |
| 7257991 | Sample testing device A sample testing device has a buffer container that can hold buffer fluid, a filter with a securement for holding a test strip, the test strip, a test strip container having a receptacle to accommodate the filter, so that when the filter is held therein the test str... | 08/21/2007 |
| 7238495 | Enzyme cycling based assays for alpha-methylacyl-CoA racemase The present invention provides a method for assaying alpha-methylacyl-CoA racemase activity. In the assay, a sample containing an alpha-methylacyl-CoA racemase or suspected of containing an alpha-methylacyl-CoA racemase is contacted with (2R)-pristanoyl-CoA. If alph... | 07/03/2007 |
| 7238493 | Acetylation of pRb by p300 assay method for compounds which modulate this process The present invention is based upon the finding that the protein p300 has acetylation activity which is directed to the retinoblastoma tumour suppressor protein pRb by the presence in the cell of the adenovirus E1A protein. This represents a target for modulators of... | 07/03/2007 |
| 7238537 | Assays An analytical test device incorporating a dry porous carrier to which a liquid sample, eg. urine, suspected of containing an analyte such as HCG or LH can be applied indirectly, the device also incorporating a labelled specific binding reagent which is freely mobile... | 07/03/2007 |
| 7229771 | Polyethylene glycol-derivatized biomolecules and their use in heterogeneous detection methods The use of polyalkylene oxide modified reagents is disclosed in a method for the detection of an analyte or in suitable reagent kits for such methods. ... | 06/12/2007 |
| 7226777 | Turbidimetric immunoassay and an apparatus therefor According to the present invention, the expansion of measurable concentration range for an antigen in a sample solution can be achieved, without a step of dilution or the like. The concentration of an antigen contained in a sample solution is determined from the max... | 06/05/2007 |
| 7223330 | Biosensor, biosensor array and method for detecting macromolecular biopolymers with a biosensor The inventive biosensor has three electrodes, the first electrode having a retaining area for retaining probe molecules which bind with the macromolecular biopolymers. The second electrode and the third electrode are configured in such a way that the redox process i... | 05/29/2007 |
