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| Number | Title | Issue Date |
| 8187827 | Diagnostic methods for acute ischemic disease using activated hepcidin as an indicator An objective of the present invention is to provide methods of testing for acute ischemic diseases using active hepcidin as an indicator, methods for determining the timing to administer an agent for treating the disease, and kits for these methods. To accomplish th... | 05/29/2012 |
| 8178496 | Photoreactive regulator of glutamate receptor function and methods of use thereof The present invention provides a synthetic regulator of glutamate receptor function, which regulator is a light-sensitive (photoreactive) regulator. The present invention further provides a light-regulated glutamate receptor that includes a subject synthetic regulat... | 05/15/2012 |
| 8163511 | Methods for the identification of LRRK2 interacting molecules The invention features methods for the identification of leucine-rich kinase 2 (LRRK2) inhibitors using indol ligand 91. Generally, these methods include identifying compounds that compete with indol ligand 91 for binding to LRRK2. ... | 04/24/2012 |
| 8124365 | Identification of genotype-selective anti-tumor agents The present invention relate to methods of identifying a genotype-selective agent. In certain embodiments, the invention relates to agents that are selectively toxic to engineered human tumorigenic cells. ... | 02/28/2012 |
| 8105798 | Cytoplasmic activity of retinoid X receptor and its regulation by ligands and dimerization This invention relates to methods for identifying agents useful for treatment of diseases and pathological conditions affected by Retinoid X Receptor apoptosis. The invention also relates to methods for treating diseases and pathological conditions affected by RXR a... | 01/31/2012 |
| 8097431 | Methods and compositions for detecting steroids The present invention provides for methods and systems for detecting steroids. Examples of such steroids include estrogen, progesterone, androgen, testosterone, and derivatives and analogs thereof. Systems useful for carrying out the method include tripartite constr... | 01/17/2012 |
| 8030016 | Method for screening for vitamin D receptor ligands The present invention relates to a screening method for a compound and includes a step of detecting binding between a vitamin D receptor and CDP. A novel method enabling screening in vitro of a compound having strong bone forming action and low side effects, a compo... | 10/04/2011 |
| 7977064 | Disheveled PDZ modulators The invention provides modulators of Dvl PDZ-ligand interaction, and methods of identifying and using these modulators. ... | 07/12/2011 |
| 7923216 | In vivo modulation of neuronal transport A hybrid protein (GFP-TTC) comprising the non-toxic proteolytic C fragment of tetanus toxin fused to green fluorescent protein was used to analyze the functional synaptic organization of neural networks. When injected intramuscularly in vivo, the GFP-TTC hybrid prot... | 04/12/2011 |
| 7892772 | Targeted ubiquitination of proteins and screening methods using a new class of ubiquitin ligase proteins Members of the IpaH superfamily constitute a novel class of E3 ubiquitin ligases which are useful for engineering products which modulate trafficking and destruction of target proteins inside a cell and useful targets for identifying new antimicrobial molecules whic... | 02/22/2011 |
| 7888056 | Method of forming a peptide-receptor complex with zsig33 The present invention relates to a method of forming a peptide-receptor complex with zsig33 polypeptides and their receptors as well as antibodies. Methods of modulating gastric contractility, nutrient uptake, growth hormones, the secretion of digestive enzymes and ... | 02/15/2011 |
| 7771961 | Cytochrome c acetylation Modulation of cytochrome c acetylation, e.g., with a SIR polypeptide, enables interventions that modulate lifespan regulation and cell proliferation, e.g., by modulating apoptosis and/or mitochondrial function such as respiration. ... | 08/10/2010 |
| 7749720 | Methods of identifying compounds for producing insulin sensitization The invention herein provides a mode of treating metabolic syndrome, which includes Type 2 diabetes mellitus and insulin resistance in human and other subjects by identifying and administering an insulin sensitizing compound which modulates GRK2 function in the insu... | 07/06/2010 |
| 7745159 | Methods and compositions for diagnosing carcinomas The invention is directed to compositions and methods for the detection of a malignant condition, and relates to the discovery of soluble forms of mesothelin polypeptides, including mesothelin related antigen (MRA). In particular the invention provides a nucleic aci... | 06/29/2010 |
| 7704703 | Arf and Hdm2 interaction domains and the methods of use thereof The present invention discloses that the binding of Arf with Dm2, important components of the p53 tumor suppressor pathway, results in specific domains of both proteins undergoing a dramatic transition from dynamically disordered conformations to amyloid-like struct... | 04/27/2010 |
| 7695928 | Disheveled PDZ modulators The invention provides modulators of Dvl PDZ-ligand interaction, and methods of identifying and using these modulators. ... | 04/13/2010 |
| 7651844 | Method for screening agents capable of treating obesity The invention concerns a method for screening agents capable of treating, by way of prevention or cure, obesity or one of the disorders associated with obesity by modulating the expression of the SPARC protein or of its activity. The invention also concerns a method... | 01/26/2010 |
| 7629138 | Estrogen receptor genes and utilization thereof An estrogen receptor gene and utilization of the estrogen receptor gene. The estrogen receptor gene contains a nucleotide sequence coding for any of the following amino acid sequences: (a) the amino acid sequence of SEQ ID NO:1, (b) the amino acid sequence of SEQ ID... | 12/08/2009 |
| 7622272 | Functional role of adrenomedullin (AM) and the gene-related product (PAMP) in human pathology and physiology The methods of the present invention demonstrate that adrenomedullin (AM) is expressed in human cancer cell lines of diverse origin and functions as a universal autocrine growth factor driving neoplastic proliferation. The present invention provides for AM peptides ... | 11/24/2009 |
| 7611857 | IL-receptor like molecules and uses thereof The present invention provides for IL-17 receptor like polypeptides and nucleic acid molecules encoding the same. The invention also provides vectors, host cells, agonists and antagonists (including selective binding agents), and methods for producing IL-17 receptor... | 11/03/2009 |
| 7601510 | Development and use of fluorescent probes of unbound analytes A method for high throughput screening of probes is described. These probes are useful for characterization and measurement of unbound metabolites in a fluid sample, particularly characterization and measurement of levels of unbound free fatty acids. By practice of ... | 10/13/2009 |
| 7588907 | Ubiquitin mediated fluorescence complementation assay The present invention relates to methods and compositions for identifying covalent joining or modification of proteins. In particular, the present invention relates to covalent fluorescence complementation assays for the detection of modified (e.g., ubiquitinated) p... | 09/15/2009 |
| 7585641 | Immunoassay and method of use A method for performing an immunoassay is described. The method is particularly useful for detecting extracellular polysaccharide (EPS) and/or lipopolysaccharide (LPS) producing microorganisms. The method is particularly useful for detecting microorganisms which pro... | 09/08/2009 |
| 7579161 | Assay methods for suppressor of fused modulation of hedgehog signaling The present invention is directed to novel polypeptides having homology to a polypeptide suppressor of the Drosophila melanogaster fused protein and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells compris... | 08/25/2009 |
| 7579162 | Method of detection in homogeneous phase, especially of progesterone in mammals' milk, and corresponding kit Method for the qualitative and semi-quantitative detection of a ligand in a sample of a medium to be tested, by (1) diluting at least one lyophilized reaction medium in said sample, (2) incubating the sample in order to carry out an immunoenzymatic method, and (3) o... | 08/25/2009 |
| 7575883 | Cytochrome c acetylation Modulation of cytochrome c acetylation, e.g., with a SIR polypeptide, enables interventions that modulate lifespan regulation and cell proliferation, e.g., by modulating apoptosis and/or mitochondrial function such as respiration. ... | 08/18/2009 |
| 7569357 | High affinity TCR proteins and methods T cell receptors (TCRS) that have higher affinity for a ligand than wild type TCRs are provided. These high affinity TCRs are formed by mutagenizing a T cell receptor protein coding sequence to generate a variegated population of mutants of the T cell receptor prote... | 08/04/2009 |
| 7514233 | Integrase cofactor The present invention provides integrase interacting proteins including cofactors which promote strand transfer activity of viral integrase, more particularly HIV integrase, and methods and uses relating thereto. The present invention also relates to methods of iden... | 04/07/2009 |
| 7510848 | Prion protein binding materials and methods of use Prion protein binding materials and methods for using the binding materials to detect or remove a prion protein from a sample, such as a biological fluid or an environmental sample. The binding materials are capable of binding to one or more forms of prion protein i... | 03/31/2009 |
| 7504232 | Method of screening for inhibitors of osteopontin Amino acids (136 to 142) and amino acids (162 to 168) of human osteopontin constitute two sites at which osteopontin interacts with α4 integrins. Products capable of disrupting those interactions are useful in therapy, particularly in the treatment of inflammatory ... | 03/17/2009 |
| 7491505 | Method for analyzing tumor aggressivity comprising measurement of polymerized actin The invention concerns a method for analyzing tumor agressivity of cancer cells comprising measurement of the amount of stationary polymerized actin in a lysate of said cells. Advantageously, the measurement of the amount of stationary actin is carried out by fluore... | 02/17/2009 |
| 7442518 | Imaging regulated protein-protein interactions in cells and living animals by enhanced luciferase protein fragment complementation An enhanced firefly luciferase protein fragment complementation assay method is described that produces a robust and broadly applicable bioluminescence signal and demonstrates both modification-independent and phosphorylation-dependent protein interactions in intact... | 10/28/2008 |
| 7439032 | Methods to identify compounds useful for tumor sensitization to DNA damage Cdc25A is herein identified as a substrate for β-TrCP1- or β-TrCP2-mediated ubiquitination and subsequent degradation via the ubiquitin-proteasome pathway. In particular, it has been found that interfering with β-TrCP expression or function, or increasing β-TrCP... | 10/21/2008 |
| 7439028 | Methods and compositions to correlate infection with prostate cancer The present invention provides methods and compositions for identifying a subject at increased risk of having prostate cancer by detecting an antibody that specifically binds a Trichomonas α-actinin protein in a sample of the subject. ... | 10/21/2008 |
| 7429448 | Therapeutic use of the SMR1 protein and active derivatives thereof The present invention pertains to the use of a peptide molecule consisting in a maturation product of SMR1 (Submandibular rat protein 1) of structural formula QHNPR, as well as the biologically active derivatives of the said peptide, for preventing or treating disea... | 09/30/2008 |
| 7422863 | Molting hormone receptor and method for screening ligand to the receptor The present invention provides a completely novel molting hormone receptor, which is used for efficiently screening a substance that can be applied to a disinfestant or the like. An insect molting hormone receptor comprising the following polypeptide (a) and polypep... | 09/09/2008 |
| 7422862 | Methods for identifying modulators of apoptosis The invention provides a method of identifying an effective compound that modulates the binding of Humanin to Bax or Bid. The invention also provides a method of identifying an effective compound that modulates an activity of Bax or Bid. In addition, the invention p... | 09/09/2008 |
| 7413853 | Modulation of metabolism of steroids and xenobiotics In accordance with the present invention, there are provided methods for modulating Phase II conjugating enzymes such as, for example, UGTs. Phase II conjugating enzymes such as UGTs function in concert with Phase I monooxygenase enzymes such as cytochrome P450 enzy... | 08/19/2008 |
| 7410773 | Method of preparing an undifferentiated cell A method of increasing the relative number of cells expressing one or more stem cell markers in a cell population including committed cells is described. The method comprises: i. contacting the cell population with an agent that operably engages said committed cells... | 08/12/2008 |
| 7407771 | Cash (caspase homologue) with death effector domain, modulators of the function of FAS receptors Proteins capable of modulating or mediating the function of MORT-1 are disclosed. Also disclosed are DNA sequences encoding these proteins, the recombinant production of these proteins as well as their use. ... | 08/05/2008 |
