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| Number | Title | Issue Date |
| 7919267 | Method for Identifying an inhibitor of plasmidic classic C beta-lactamase having extended-substrate specifity The present invention related to a method for crystallizing a CMY-10 being a β-lactamase with extended-substrate spectrum, a crystal of CMY-10, and a crystal structure of CMY-10. With utilization of three-dimensional structure of CMY-10 protein provided by the pres... | 04/05/2011 |
| 7892771 | Crystal structure of soluble glutaminyl cyclase A crystalline structure of glutaminyl cyclase (QC) is described. Also described are the methods of preparing the crystalline structure of QC and the methods for identifying candidate inhibitors of QC. In addition, a structural basis for the rational design or identi... | 02/22/2011 |
| 7790408 | Methods and compositions using stearoyl-CoA desaturase to identify triglyceride reducing therapeutic agents The use of screening assays based on the role of human stearoyl-CoA desaturase-1 (“hSCD1”) in human diseases, disorders or conditions relating to serum levels of triglyceride, VLDL, HDL, LDL, total cholesterol, or production of secretions from mucous membranes, ... | 09/07/2010 |
| 7662581 | Eg5 co-crystals This invention provides methods of identifying an Eg5 binding ligand. The ligand is identified by using the atomic coordinates of an Eg5 crystal to generate a three dimensional structure. The three dimensional structure is used in molecular modeling techniques and d... | 02/16/2010 |
| 7566548 | Methods for identifying therapeutic agents and for treating disease Included are methods of identifying compounds that mimic the interaction of Apoptin and APC1, e.g., binding of Apoptin to APC1, e.g., dissociation of APC1 from the APC/C, and compounds identified by the methods. Compounds that specifically mimic an interaction of Ap... | 07/28/2009 |
| 7504231 | Method of alleviating chronic pain via peripheral inhibition of neurotransmitter synthesis A composition having sustained pain-relieving properties such that the composition may be administered to a subject to alleviate chronic pain. The composition includes an effective amount of at least one inhibitor of neurotransmitter synthesis. A method for alleviat... | 03/17/2009 |
| 7470519 | Methods for detecting TAFIa or TAFIai The invention relates to a diagnostic assay for selectively measuring levels of the 35kD form of thrombin-activatable fibrinolysis inhibitor (TAFIa or TAFIai), or a derivative or variant thereof, but not the TAFI proenzyme (TAFI) or the N-terminal activation peptide... | 12/30/2008 |
| 7314726 | Beta secretase exosite binding peptides and methods for identifying beta secretase modulators The present invention provides peptides that specifically bind to BACE at a newly discovered exosite. The invention also provides methods for identifying peptides that bind to a BACE exosite. The invention further provides methods for identifying compounds that bind... | 01/01/2008 |
| 7267939 | Detection of analytes using reorganization energy The invention relates to novel methods and compositions for the detection of analytes using the nuclear reorganization energy, λ, of an electron transfer process. ... | 09/11/2007 |
| 7251525 | Treatment of arrhythmias via inhibition of a multifunctional calcium/calmodulin-dependent protein kinase This invention provides a method for treating or preventing arrhythmias in a human subject comprising the administration of an effective amount of a calcium/calmodulin-dependent protein kinase inhibitor. Also provided are pharmaceutical compositions comprising a cal... | 07/31/2007 |
| 7238779 | Acyl CoA:cholesterol acyltransferase (ACAT-2) Nucleic acid compositions encoding novel ACAT proteins, as well as the novel ACAT-2 proteins, (ACAT-2) are provided. Also provided are methods of producing the subject nucleic acid and protein compositions. The subject polypeptide and nucleic acid compositions find ... | 07/03/2007 |
| 7157553 | High throughput assays for the proteolytic activities of clostridial neurotoxins In this application is described substrates for high-throughput assays of clostridial neurotoxin proteolytic activities. Two types of substrates are described for use in assays for the proteolytic activities of clostridial neurotoxins: (1) modified peptides or prote... | 01/02/2007 |
| 7148003 | NIMA interacting proteins A novel class of NIMA interacting proteins (PIN), exemplified by Pin1, is provided. Pin1 induces a G2 arrest and delays NIMA-induced mitosis when overexpressed, and triggers mitotic arrest and DNA fragmentation when depleted. Methods of identifying other Pin protein... | 12/12/2006 |
| 7141385 | Microcantilever apparatus and methods for detection of enzymes, enzyme substrates, and enzyme effectors An apparatus and a method are provided for detecting an enzyme, or or for detecting a substrate of an enzyme or for detecting an enzyme effector such as an inhibitor, by measuring a change in deflection of a microcantilever having a substrate or an enzyme, respectiv... | 11/28/2006 |
| 7135298 | Screening assay for agents that alter target of Rapamycin activity The present invention provides an assay for the identification of agents which can modulate TOR-mediated phosphorylation of substrate proteins. The assays of the invention utilize substrate proteins whose amino acid sequence contains the Ser/Thr motif recognized by ... | 11/14/2006 |
| 7081350 | Methods for identifying ecdysteroid synthesis inhibitors using the drosophila P450 enzyme shade The invention relates to methods and materials useful for identifying inhibitors of ecdysteroid biosynthetic enzymes, specifically the Drosophila P450 enzyme, shade. These methods and materials can be used, for example, to identify molecules having insecticid... | 07/25/2006 |
| 7070941 | Methods and compositions for tagging via azido substrates The invention provides methods and compositions for azide tagging of biomolecules. In one embodiment of the invention, proteins are tagged by metabolic incorporation of prenylated azido-analog substrates. Examples of such analogs are azido farnesyl diphosphate and a... | 07/04/2006 |
| 7067127 | GIcNAc phosphotransferase of the lysosomal targeting pathway The present invention provides nucleotide and amino sequences of the lysosomal targeting pathway enzyme GlcNAc-phosphotransferase, methods of producing and methods of purifying this enzyme. ... | 06/27/2006 |
| 7045283 | Methods of high-throughput screening for internalizing antibodies This invention provides methods of identifying ligands that are internalized into a cell. The methods typically involve i) contacting the cell with a reporter non-covalently coupled to a ligand; ii) dissociating the reporter from the ligand and removing dissociated ... | 05/16/2006 |
| 7034107 | High throughput assays for the proteolytic activities of clostridial neurotoxins In this application is described substrates for high-throughput assays of clostridial neurotoxin proteolytic activities. Two types of substrates are described for use in assays for the proteolytic activities of clostridial neurotoxins: (1) modified peptides or prote... | 04/25/2006 |
| 7018523 | Detection of analytes using reorganization energy The invention relates to novel methods and compositions for the detection of analytes using the nuclear reorganization energy, λ, of an electron transfer process. ... | 03/28/2006 |
| 7018792 | Influenza sensor A sensor for the detection of tetrameric multivalent neuraminidase within a sample is disclosed, where a positive detection indicates the presence of a target virus within the sample. Also disclosed is a trifunctional composition of matter including a trifunctional ... | 03/28/2006 |
| 7014851 | Process for inhibiting platelet aggregation An object of the present invention is to provide a platelet aggregation inhibitor without side effects and a supplement food effective for inhibiting platelet aggregation. The platelet aggregation inhibitor has nattokinase as an active ingredient and has Bacillus... | 03/21/2006 |
| 7008666 | Method of inhibiting overactivity of phagocytes or lymphocytes in an individual The invention relates to a method of inhibiting myeloperoxidase activity in neutrophils in an individual by administering to the individual an effective amount of a lignan, where said lignan is enterolactone. The invention is further directed to a method inhibiting ... | 03/07/2006 |
| 7001737 | Urinary trypsin inhibitor assay containing a chelating agent Disclosed is an assay for determining the presence and concentration of trypsin inhibitor in urine samples. The assay reagents, which may be used either in the liquid or dry states, include trypsin, a trypsin substrate and a polycarboxylic chelating agent. The inclu... | 02/21/2006 |
| 6951682 | Porous coatings bearing ligand arrays and use thereof Articles comprising substantially uniform porous coatings, which may be photopatterned, are provided. The use of such porous coatings increases the surface density of attached compounds within, for example, ligand arrays prepared by methods such as regionally select... | 10/04/2005 |
| 6946547 | Ecstasy-class analogs and use of same in detection of ecstasy-class compounds The present invention provides a system for the improved detection of ecstasy-class compounds in biological samples. New ecstasy-class analogs are provided for detection of such ecstasy-class drugs. These analogs are compounds, or salts thereof, of a 2-amino-methyle... | 09/20/2005 |
| 6939720 | Multiplexed analysis of clinical specimens apparatus and method A method for the multiplexed diagnostic and genetic analysis of enzymes, DNA fragments, antibodies, and other biomolecules comprises the steps of constructing an appropriately labeled beadset, exposing the beadset to a clinical sample, and analyzing the combined sam... | 09/06/2005 |
| 6916622 | Regions of papilloma virus E1 helicase involved in E1 oligomerization There is provided an amino acid sequence comprised within the PV E1 protein region A delineated by amino acids 352 and 439, and any derivative variant or fragment thereof, necessary for the oligomerization of the E1 protein. This amino acid sequence is capable of se... | 07/12/2005 |
| 6913895 | Methods for assaying transglycosylase reactions, and for identifying inhibitors thereof This invention relates to the field of bacterial transglycosylase reactions. The invention is directed to methods for assaying for transglycosylase activity, methods of identifying inhibitors of transglycosylase activity, inhibitors identified by such methods, and m... | 07/05/2005 |
| 6911318 | Bacterial transglycosylases: assays for monitoring the activity using Lipid II substrate analogs and methods for discovering new antibiotics This invention provides a direct method for monitoring bacterial transglycosylase activity using labeled substrates produced by chemo-enzymatic synthesis wherein the labels are selected to permit the detection of both polymeric and non-polymeric products simultaneou... | 06/28/2005 |
| 6905856 | Soluble GlcNAc phosphotransferase The present invention relates to a soluble GlcNAc phosphotransferase, a method of making the same and a method of phosphorylating with the same. ... | 06/14/2005 |
| 6825000 | Immunoassay reagent and immunoassay method An immunoassay reagent is obtained whereby a microscale substance such as an antigen or antibody can be assayed at a high sensitivity, and whereby a need to separate a reacted substance, e.g., an immunoreacted substance, from an unreacted substance can be eliminated... | 11/30/2004 |
| 6821744 | Method, assay, and kit for quantifying HIV protease inhibitors A method for quantifying an HIV protease inhibitor in a sample includes combining HIV protease, a conjugate comprising an HIV protease inhibitor analog, and a sample suspected of containing an HIV protease inhibitor. The HIV protease and the conjugate are capable of... | 11/23/2004 |
| 6803188 | Tandem fluorescent protein constructs This invention provides tandem fluorescent protein construct including a donor fluorescent protein moiety, an acceptor fluorescent protein moiety and a linker moiety that couples the donor and acceptor moieties. The donor and acceptor moieties exhibit fluorescence r... | 10/12/2004 |
| 6794156 | Cell growth, induction and lysis in an antibody-coated microplate for use in an ELISA A competitive assay to determine the presence and concentration of an intracellular analyte (e.g., cAMP) in a sample is provided. All of the steps of the assay can be performed on the same assay plate, thereby eliminating the need to transfer the cells from a tissue... | 09/21/2004 |
| 6787325 | Complexes containing crosslinked avidin, analytical method with the use of crosslinked avidin and analytical reagents and kits Provided are novel complexes containing a crosslinked avidin, an analyzing method and analyzing reagents and kits whereby a compound to be analyzed can be quickly, conveniently and accurately analyzed while taking advantage of the avidin-biotin reaction. The complex... | 09/07/2004 |
| 6762280 | High throughput assays for the proteotytic activities of clostridial neurotoxins In this application is described substrates for high-throughput assays of clostridial neurotoxin proteolytic activities. Two types of substrates are described for use in assays for the proteolytic activities of clostridial neurotoxins: (1) modified peptides or prote... | 07/13/2004 |
| 6693175 | Method for diagnosing bone dysbolism A method of diagnosing metabolic bone diseases, especially osteoporosis and arthrosis characterized by determining the concentration of osteoclastgenesis inhibitory factor (OCIF) in humor. Monoclonal antibodies recognizing equally both of monomer type and dime... | 02/17/2004 |
| 6686171 | Competitive chemiluminescent assay for cyclic nucleotide monophosphates A competitive assay for the concentration of a cyclic nucleotide such as cyclic adenosine monophosphate combines, in a reaction chamber provided with a capture antibody, an antibody for the cAMP or other cyclic nucleotide, the sample to be assayed and a c... | 02/03/2004 |
