Quotables
"Radio has no future."
Lord Kelvin, British mathematician and physicist ; 1897
PatentStorm News
Make the Most of Our Site
See this month's Top Inventors and Most Cited Patents.
Stay on top of the latest innovations by subscribing to an RSS feed.
Registered users: Manage your profile.
| Number | Title | Issue Date |
| 8124364 | Biotin derivatives A method for the conditioning of an extracorporeal device is described, as well as method for extracorporeal extraction of toxic material from mammalian body fluids in connection with diagnosis or treatment of a mammalian condition or disease, in which methods reage... | 02/28/2012 |
| 8076096 | Alteration of cell membrane with FasL Methods and compositions are provided for the persistent modification of cell membranes with exogenous proteins so as to alter the function of the cell to achieve effects similar to those of gene therapy, without the introduction of exogenous DNA. DNA sequences, the... | 12/13/2011 |
| 7981632 | Sequentially arranged streptavidin-binding modules as affinity tags The present invention relates to sequentially arranged streptavidin-binding binding modules which may in particular be used as affinity tags. The affinity tags comprise at least two individual modules capable of mediating avidic binding to streptavidin. ... | 07/19/2011 |
| 7939283 | Analyte binding turbidity assay Assays, such as immunoassays, and related articles are disclosed. ... | 05/10/2011 |
| 7879573 | Isolation of analytes The disclosure features, inter alia, methods and compositions for detecting, isolating, and/or analyzing one or more analytes such as, but not limited to, biomolecules (e.g., proteins, glycoproteins, lipids (e.g., sphingolipids), and carbohydrates). Such methods and... | 02/01/2011 |
| 7842475 | Stabilization of solid support assay reagents Reagents are disclosed for use in assays for analytes. The reagents are dry assay reagents that may be readily reconstituted for use in the assays. The dry assay reagents comprise a solid support and one or more molecules of a receptor immobilized on the solid suppo... | 11/30/2010 |
| 7776562 | Reversible MHC multimer staining for functional purification of antigen-specific T cells The present invention relates to a new method for reversible staining and functional isolation or characterization of cells, e.g. antigen-specific T cells. With this technique, the original functional status of cells can be substantially maintained after their ident... | 08/17/2010 |
| 7507550 | Analytical sandwich test for determining NT-proBNP The present invention concerns an immunological test for determining NT-proBNP comprising at least two antibodies to NT-proBNP, wherein at least one of the antibodies to NT-proBNP is a monoclonal antibody. One of these antibodies is directed at least against parts o... | 03/24/2009 |
| 7473535 | Chemical reagents and methods for detection and quantification of proteins in complex mixtures The invention provides a reagent comprising an affinity tag, a detectable moiety, a linker, an isotope tag and a reactive group. The invention also provides methods of using a reagent of the invention. The methods can be used to label a polypeptide in a sample by co... | 01/06/2009 |
| 7462462 | Peptide capable of binding to nanographite structures It is intended to provide a peptide or a phage recognizing nanographite structures and thus enabling efficient recognition, binding, separation and alignment of nanographite structures such as carbon nanohorns or carbon nanotubes, an artificial protein or a chimeric... | 12/09/2008 |
| 7435555 | Asparagine hydroxylation of the CAD domain of a HIF protein A target asparagine residue of HIF 1 alpha and 2 alpha is hydroxylated at high oxygen tension to render HIF as a weak transcription factor. An asparagine hydroxylase hydroxylation motif and binding motif is proposed. A method of screening for agonists or antagonists... | 10/14/2008 |
| 7435386 | Reagentless and reusable biosensors with tunable differential binding affinities and methods of making The biosensor comprises a modular biorecognition element and a modular flexible arm element. The biorecognition element and the flexible arm element are each labeled with a signaling element. The flexible arm contains an analog of an analyte of interest that binds w... | 10/14/2008 |
| 7399636 | Diagnostic kit for predicting pregnancy outcome The present invention provides a method of predicting pregnancy outcome in a subject by determining the amount of an early pregnancy associated molecular isoform of hCG in a sample. The present invention further provides a method for determining the amount of early ... | 07/15/2008 |
| 7393698 | Magnetic fine particles and process for producing the same The present invention relates to magnetic fine particles having immobilized thereto a polymer having an upper critical solution temperature, and a process for producing the same, a method of separating or concentrating a microorganism, a method of purifying, detecti... | 07/01/2008 |
| 7358062 | Method for diagnosing atrophic gastritis The press device for a paper web, such as a calender, contains a flexible moving element (1a) forming an endless structure, said element forming the shell (1) of a roll, the press device including further a counter roll. Inside the moving elemen... | 04/15/2008 |
| 7354733 | Method for sorting and separating living cells We disclose methods of sorting or separating mixtures of living cells (e.g., eukaryotic, prokaryotic, mammalian, pathogenic, bacterial, viral, etc.). We perform our methods by activating cell-selective photophoric labels, which photosensitize and chemically reduce a... | 04/08/2008 |
| 7349158 | Diffraction grating-based encoded micro-particles for multiplexed experiments Microparticles 8 includes an optical substrate 10 having at least one diffraction grating 12 disposed therein. The grating 12 having a plurality of colocated pitches Λ which represent a unique identification digital code that is detected... | 03/25/2008 |
| 7344847 | Nanoscale patterning and immobilization of bio-molecules A support for immobilizing target molecules comprises a substrate having a plurality of binding regions for binding select target molecules, with target-molecule-capturing agent immobilized at the binding regions. The binding regions are intersperse among other non-... | 03/18/2008 |
| 7344849 | Assay The present invention relates to assay methods for the determination of cobalamin or vitamin B12 in a body fluid and in particular to assay methods for the metabolically active pool of cobalamin, comprising contacting a cell free sample of a body fluid wi... | 03/18/2008 |
| 7341844 | Methods for diagnosing autism The invention relates to the use of Reelin as a marker for diagnosing psychiatric conditions. The disclosed tools and techniques can facilitate the diagnosis of psychiatric disorders including major depression, bipolar disorder, schizophrenia and autism. ... | 03/11/2008 |
| 7342091 | Soluble cyclic analogues of β amyloid peptide The invention concerns a peptide having the biological activity of an inhibitor of amyloid formation and its diagnostic and medical use. ... | 03/11/2008 |
| 7335401 | Method for producing microparticles loaded with proteins The present invention concerns a method for producing microparticles loaded with proteins which is characterized in that the microparticles are loaded in suspension under strongly alkaline conditions. The invention also concerns microparticles which can be produced ... | 02/26/2008 |
| 7335478 | Reactivation-based molecular interaction sensors This invention provides methods and systems for linking the functional activation of a responder molecule to the interaction of two or more binding ensemble members of interest either in vitro or in vivo, and thereby producing a signal, phenotype, or other functiona... | 02/26/2008 |
| 7332352 | Separation particles A composition comprising colloidal Fe3O4 particles coated with streptavidin is disclosed. These particles can be used in a method for separating biotinylated compounds from a solution in which the biotinylated compounds bind to the streptavidin... | 02/19/2008 |
| 7332351 | Method of making nanoparticles Disclosed are silica-coated nanoparticles and a process for producing silica-coated nanoparticles. Silica-coated nanoparticles are prepared by precipitating nano-sized cores from reagents dissolved in the aqueous compartment of a water-in-oil microemulsion. A reacti... | 02/19/2008 |
| 7332567 | Fret protease assays for clostridial toxins The present invention provides clostridial toxin substrates useful in assaying for the protease activity of any clostridial toxin, including botulinum toxins of all serotypes as well as tetanus toxins. A clostridial toxin substrate of the invention contains a donor ... | 02/19/2008 |
| 7332288 | Methods and reagents for the rapid and efficient isolation of circulating cancer cells A highly sensitive assay is disclosed which combines immunomagnetic enrichment with multiparameter flow cytometric and immunocytochemical analysis to detect, enumerate and characterize carcinoma cells in the blood. The assay can detect one epithelial cell or less in... | 02/19/2008 |
| 7332613 | Capture and release based isotope tagged peptides and methods for using the same The invention provides non-affinity based isotope tagged peptides, chemistries for making these peptides, and methods for using these peptides. In one aspect, tags comprise a reactive site (RS) for reacting with a molecule on a protein to form a stable association w... | 02/19/2008 |
| 7329536 | Piezoimmunosensor An apparatus comprising one or more piezoelectric mass sensors for use in diagnostic and analytic processes, in particular for immunochemical detection of diagnostically relevant analytes in real time, is described. Each piezoelectric mass sensor comprises a piezoel... | 02/12/2008 |
| 7321881 | Methods and systems for predicting occurrence of an event Embodiments of the present invention are directed to methods and systems for training a neural network having weighted connections for classification of data, as well as embodiments corresponding to the use of such a neural network for the classification of data, in... | 01/22/2008 |
| 7314726 | Beta secretase exosite binding peptides and methods for identifying beta secretase modulators The present invention provides peptides that specifically bind to BACE at a newly discovered exosite. The invention also provides methods for identifying peptides that bind to a BACE exosite. The invention further provides methods for identifying compounds that bind... | 01/01/2008 |
| 7303924 | Method of functionalising solid supports The invention relates to: a method of functionalizing solid supports; the functionalized solid supports thus obtained; and the use thereof, in particular for the immobilization of biological molecules, such as nucleic acids, polypeptides, lipids, carbohydrates and h... | 12/04/2007 |
| 7300761 | Methods and device for detecting prostate specific antigen (PSA) An immunoassay device and assay to detect an antigen, such as PSA, in a biological sample. The device comprises a solid support having multiple reaction zones containing capture antibodies directed to the antigen. Exposure of a test sample to a mixture of incubation... | 11/27/2007 |
| 7297554 | Immunoassay system A competitive immunoassay, dye and method for rapidly detecting the presence of one or more target ligands within a fluid sample suspected of containing such ligand or ligands. The immunoassay comprises a protein-binding membrane, a first absorbent pad, a second abs... | 11/20/2007 |
| 7294471 | Method for purifying cancer-specific proliferating cell nuclear antigen A method for purifying cancer-specific Proliferating Cell Nuclear Antigen (csPCNA) is described, as well as an immunoassay based thereon. ... | 11/13/2007 |
| 7291474 | Hydrolytic substrates for an analyte-dependent enzyme activation system Disclosed are compounds of the general formulas: wherein Y is a moiety capable of being cleaved by a hydrolytic enzyme; L is a detectable label; X is a linking group; Z is a halogen; and R is hydrogen, an alkyl, ... | 11/06/2007 |
| 7292336 | Method and instrument for detecting biomolecular interactions Method and apparatus for detecting biomolecular interactions. The use of labels is not required and the methods may be performed in a high-throughput manner. An instrument system for detecting a biochemical interaction on a biosensor. The system includes an array of... | 11/06/2007 |
| 7285391 | Methods for predicting pregnancy outcome in a subject by hCG assay The present invention provides a method of predicting pregnancy outcome in a subject by determining the amount of an early pregnancy associated molecular isoform of hCG in a sample. The present invention further provides a method for determining the amount of early ... | 10/23/2007 |
| 7282345 | C-erbB-2 external domain: GP75 Disclosed are methods and compositions for identifying malignant tumors that overexpress the c-erbB-2 oncogene. Assays useful for diagnosis and prognosis of neoplastic disease are provided which detect the external domain of c-erbB-2, the glycoprotein gp75 and quant... | 10/16/2007 |
| 7279283 | Cobalamin assay The invention provides an assay method for the determination of transcobalamin II (TC II) bound cobalamin in a body sample, comprising contacting a cell free sample of a body fluid with an immobilised or immobilizable specific binding ligand for TC II or cobalamin b... | 10/09/2007 |
